Gene 13675 (Tetrahymena)

13675

Species: Tetrahymena
Alias: 17.m00282, TTHERM_00198070, 869, PreTt13675, 13675
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
13675.AA Protein None 629 None Fasta, JSON
13675.NA RNA None 1890 None Fasta, JSON
13675.kin_dom Protein Kinase Domain None 206 None Fasta, JSON

Protein domain

Protein domains of 13675.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13675.AA CK1-Unclassified 19-248 46 5.6e-148 439.8 In-house 3-244 (244) Show / Hide 
Range on Protein: 19-248
Range on HMM: 3-244/244
Sequence Identity: 46% (112 aa)

LKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDNEDIRSLDREVQILTRLQGLS-------NVPKLYWSGQENN--YNIMVLNLLGRDLAYYMKALK-KF
...|. .|||| .. .....|.|.|||||||.... .. |..|..|...||. .       ..||.||.|||..  |||||..|||..| ....  . ||
VIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRKF

SLKTVLMLMDQLITVLENVHNRSIIHRDLKPENILMG-RENESHMVYIIDYGISKIYR--DNSGRHITFKDNKPFIGTTRYASIAAHQGHELGRKDDLES
|||||||..||.|. .|..||...||||.||.|.||| .....|.|||||.|.|| |.  |. |.||....||...||.||||| ||.|.| .|.|||||
SLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLES

LGYVMIFLLKGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLC
||||.|..|||.|||||..  . |.| .   ..|. |    ||
LGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 13675.AA CK1 17-274 45 4.2e-139 468.42 In-house 1-271 (271) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-271/271
Sequence Identity: 45% (124 aa)

WILKKKVSSGSFGVVFIGMDKNTKEF--VAIKLEKEDNEDIRSLDREVQILTRLQG------LSNVPKLYWSGQE--NNYNIMVLNLLGRDLA-YYMKAL
  . .|. .||||... |.. ...|.  |||||||....    |..|..|...|||        ..|..||.|||  ..|||||..|||..|  ....  
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

KKFSLKTVLMLMDQLITVLENVHNRSIIHRDLKPENILMGR-ENESHMVYIIDYGISKIYRD-NSGRHITFKDNKPFIGTTRYASIAAHQGHELGRKDDL
.|||||||||..||.|. .| |||...||||.||.|.|||| ....|.|||||.|..| ||| ....|| ...||...||.||||| .|.|.| .|.||.
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

ESLGYVMIFLLKGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLCKD-LPNEFVKYLDYVKKLHFKSQPDYK
||||||....|.|.||||.|.  | |.| .  ...|..|   .|||. .||||. || |...|||. .|||.
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 13675.AA CK1 17-276 30 1.2e-107 363.87 In-house 1-339 (339) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-339/339
Sequence Identity: 30% (105 aa)

WILKKKVSSGSFG-VVFIG-----MDKNTK-----EFVAIKLEKEDNEDI-RSLDREVQILTRLQGL-------------------SNVPKLYWSGQENN
| ..||  .|.||  .. .     .|....     |..|.|.|......  ..| .|.|..  |||.                   .  |..|| ..|..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--YNIMVLNLLGRDLAYYMK---A-LKKFSLKTVLMLMDQLITVLENVHNRSIIHRDLKPENILMGR-------------ENESHMVYIIDYGISK-IYR
  ||.||. |||..|  ..|      .|||.||.||...|.. .|| .|.. .||||.||.|..|||             .||.. ||.||.|...  ||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DNSG------------RHITFKD---NKPFIG-TTRYASIAAHQGHELGRKDDLESLGYVMIFLLKGH--LPWQNLQNVTD-------KDKTQVVGDIKA
|..|            .|.....   .|.|.| |.||.||..|.|.|.||.|||.|..|..| .|||.  |||||.   .        | | .   . | 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

KTKSTDLCKD-----LPNEFVKYLDYVKKLHFKSQPDYKYL
.|..  ||.      .| || |...|...| ... |||...
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 13675.AA CK1-D 17-276 45 5.7e-89 301.88 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-261/261
Sequence Identity: 45% (120 aa)

WILKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDNEDIRSLDREVQILTRLQGLSNVPKLYWSGQENNYNIMVLNLLGRDLAYYMK-ALKKFSLKTVLM
. . .|. ||||| .. | . .| | ||||||    .    |. | ..   .||   .|.. | ||| .||.||..|||  |        .|||||||||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQ-LHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLM

LMDQLITVLENVHNRSIIHRDLKPENILMGRENESHMVYIIDYGISKIYRDNS-GRHITFKDNKPFIGTTRYASIAAHQGHELGRKDDLESLGYVMIFLL
| ||.|. .| .| |. ||||.||.| |||     .||||||.|..| |||    .|| ...||   || |||||  ||| |  |.|||||||||...  
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

KGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLCKDLPNEFVKYLDYVKKLHFKSQPDYKYL
.| |||| |. .| ..| . . . |..||  .||| .|.||..|..|...|.|  .||| ||
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 13675.AA CK1-A 17-276 42 2.2e-84 286.68 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-261/261
Sequence Identity: 42% (111 aa)

WILKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDNEDIRSLDREVQILTRLQGLSNVPKLYWSGQENNYNIMVLNLLGRDL-AYYMKALKKFSLKTVLM
. | .|. ||||| ...|.  .  | ||||.|...      |  | .. . |||   .|.. | |.| .||.||..|||  |   .    ..|..|||||
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQ-LIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLM

LMDQLITVLENVHNRSIIHRDLKPENILMGRENESHMVYIIDYGISKIYRDNSGR-HITFKDNKPFIGTTRYASIAAHQGHELGRKDDLESLGYVMIFLL
| ||.|. .| ||... ||||.||.| ||| .     ...||.|..| |||.  | || ... |  .|| ||||| ||.| |  |.||.||.||||..  
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

KGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLCKDLPNEFVKYLDYVKKLHFKSQPDYKYL
.|.|||| ..  | | |   . . |  |    |||  | ||  |. |...| |. |||| ||
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 13675.AA CK1-G 17-276 40 9.5e-75 252.77 In-house 1-266 (266) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-266/266
Sequence Identity: 40% (107 aa)

WILKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDNEDIRSLDREVQILTRLQGLS-NVPKLYWSGQENNYNIMVLNLLGRDLA-YYMKALKKFSLKTVL
.   ||.  |.||..| |    . |.||||.|    .    |  | .    | | . ..|. |. ||.  |||||..|||  |   .     |||.|||.
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQ-LHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVC

MLMDQLITVLENVHNRSIIHRDLKPENILMGR--ENESHMVYIIDYGISKIYRD-NSGRHITFKDNKPFIGTTRYASIAAHQGHELGRKDDLESLGYVMI
|.  |.|. .| || .. | || ||.| | ||  ... |...|||.|. | |.| . ..|| .   |   || || ||  | | |  | ||.|.|| . .
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

FLLKGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLCKD--LPNEFVKYLDYVKKLHFKSQPDYKYL
. | |.|||| |   . | . | .|| | ||   |||.   .| .| .|| || .| |  .||| ||
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 13675.AA TTBKL 17-280 31 2.8e-64 215.93 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-280
Range on HMM: 1-288/288
Sequence Identity: 31% (92 aa)

WILKKKVSSGSFGVVFIGMDKNT-KEFVAIKLEKEDNEDI-RSLDREVQILTRLQ--GLSNVPKLYWSGQENNYNIMVLNLLGRDLAYYM--KALKK-FS
|  .|.. .| ||.|. ..|... |.. | | ||  .|.. . .  ||..|..||  | . .||...||.. .|| ||. |.|..|   .     || ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVLMLMDQLITVLENVHNRSIIHRDLKPENILMGRENE----SHMVYIIDYGISKIYRDNSG-----------RHITFKD---NKPFIGTTRYASIAA
  |.. .. |.. .|  .|   .||||.|| |. .| . .    .. ||.||.|... |....|           .. . ..     || |||||.|...
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HQGHELGRKDDLESLGYVMIFLLKGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLCKD------LPNEFVKYLDYVKKLHFKSQPDYKYLKNMF
|.. |.||.||| |. |..| |..| |||.|.      ...  ..  | ..| .||.||      .| || |   ... | ....||| .. . |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNM------EDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 13675.AA Worm6 17-276 30 4e-63 216.02 In-house 1-279 (279) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-279/279
Sequence Identity: 30% (86 aa)

WILKKKVSSGSFGVVFIGMDKNTKE--FVAIKLEKE-DNEDIRSLDREVQILTRLQGLS--NVPKLYWSGQENN--YNIMVLNLLGRDLAYYMKAL--KK
| . ||. .|.|| |.   || .|.  ..|.|.||.  |. .. |..|. .|...      ...|.   |. .|  .| .|. |.|..|. ..|..  .|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLKTVLMLMDQLITVLENVHNRSIIHRDLKPENILMGR-----ENESHMVYIIDYGISK--IYRDNSGRHITFK-DNKPFIGTTRYASIAAHQGHELGR
||. | | .  | .  .| .||   ||||.|| |   ||      ||.| .|..|.|...   |... .  .| . .. .| ||.|||..|.|.| |..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KDDLESLGYVMIFLLKGHLPWQNLQNVTDKDKTQVVGDIKAKTKS----TDLCKDLPN-EFVKYLDYVKKLHFKSQPDYKYL
|||.||  |.|. ...| |||...   .|.|  ....  . ....    ... .  |  ||.. .||. .. . . ||||..
KDDCESWFYMMVEMIVGCLPWRHM---KDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 13675.AA TTBK 17-276 35 3.1e-56 193.14 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-257/257
Sequence Identity: 35% (94 aa)

WILKKKVSSGSFGVVFIGMDKNTK-EFVAIKLEKEDNEDIRSLDREVQILTRLQGLSNVPKLYWSGQENNYNIMVLNLLGRDLAYY--MKALKKFSLKTV
|  .||.  | || .. ..|  .. | ||||.|. .      |  || .| .|||   | . .  | ....| ||..|.|. ||         .||| | 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPK-QVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT

LMLMDQLITVLENVHNRSIIHRDLKPENILMGRE-NESHMVYIIDYGISKIYRDNSGRHITFKDNKPFIGTTRYASIAAHQGHELGRKDDLESLGYVMIF
| |  |..  .| .|.    ||| || |  |||   .   .|..|.|    |   .|   .      | || ||||| ||.  |.||.||| || |... 
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LLKGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLCKDLPNEFVKYLDYVKKLHFKSQPDYKYL
 ..| |||  .     ||| || | .| |    .| |..| ||  ..| .| | .. .|||. .
FVQGQLPWRKI-----KDKDQV-GEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 13675.AA Pkinase 17-222 28 6.8e-29 103.24 Pfam 1-214 (293) Show / Hide 
Range on Protein: 17-222
Range on HMM: 1-214/293
Sequence Identity: 28% (64 aa)

WILKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDNEDIRSLDR-----EVQILTRLQGLSNVPKLYWSGQENNYNIMVLNLLGR-----DLAYYMK--A
. ...|. |||||.|.....|.| . ||.|  | ..|.   . .     |.||. || .  |. .|| . .....  ||. ...      ||. |..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

LKKF--SLKTVLMLMDQLITVLENVHNRSIIHRDLKPENILMG-RENESHMVYIIDYGISKIYRDNSGRHITFKDNKPFIGTTRYASIAAHQ-GHELGRK
 ..|  | ... . | |..  ||  |...||||||||||||.  . . . .| |.| |..| ..     .     .. | || .|..   .. | . |.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

DDLESLGYVMIFLLKGHLPWQN
 |  |.| ... .| |..|...
VDMWSCGCILYEMLCGRPPFPG
Kinase 13675.AA S_TKc 17-478 14 5.3e-27 96.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-478
Range on HMM: 1-231/231
Sequence Identity: 14% (69 aa)

WILKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDNEDIRSLDREVQILTRLQGLSNVPKLYWSGQENNYNIMVLNLLGR---DLAYYMKALKK------
. . .|. .|.||.|. . .|.|.. ||||  |      ... ||.||| .  .  |. ||| . |. ..  ||. ...    ||  |.|  ..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FSLKTVLMLMDQLITVLENVHNRSIIHRDLKPENILMGRENESHMVYIIDYGISKIYRDNSGRHITFKDNKPFIGTTRYASIAAHQGHELGR-KDDLESL
|.  ..  .| |..  ||  |.. ||||||||||||. .      . |.| |.....             . |.||  | .         |. | |  |.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVMIFLLKGHLPWQNLQNVTDKDKTQVVGDIKAKTKSTDLCKDLPNEFVKYLDYVKKLHFKSQPDYKYLKNMFQKLGQQNNVRYNENDWDWSEHNQSKE
| ... .| |  |..     ...   ...|                                                                      
GCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------------------------------------------

GKSSDSKNNLNADGQDVQRSGVKKLSFTPIWSIGQIDSGYLAPPEAGNGQRNQKRNLSLTPSVRSTIRKSTGGSFMGTYSSINIKYVPTNIHKQGGSQIM
                                                                                                    
----------------------------------------------------------------------------------------------------

GSKFDVDDEKSNVKPIEEENKELDETTQTGFVEQEMDEYAGNAQTLDKKLQKLLNTQVKAQITNQMNLQ--------PFL
                                           . .|  ..|.|.   .  .|    ||        |..
-----------------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13675.AA Ciliate-E2 17-164 22 6.4e-25 82.46 In-house 1-206 (365) Show / Hide 
Range on Protein: 17-164
Range on HMM: 1-206/365
Sequence Identity: 22% (49 aa)

WILKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDN----------------------EDIRSLDREVQILTRLQ----GLSN------------VPKLY
 .. ||  .|.||.|. . ...... .|||... ..                       .|... .| .|. ...     . |            . |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMY

WSGQ---ENNYNIMVLNLLGRDLAYYMK------------ALKKFSLKTVLMLMDQLIT---------------VLENVHNRS-IIHRDLKPENILMGRE
.. |   .||. .    . | || .|.|            . |.|..| .. .| |..                 ||  |..  |||||.||||||.   
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

NESHMVYIIDYGISKIY
     . ||| |.||.|
-----IKIIDFGLSKKY
Kinase 13675.AA TyrKc 17-251 17 2.4e-07 -103.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-251
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

WILKKKVSSGSFGVVFIGMDKNTKEFVAIKLEKEDNEDIRSLDREVQILTRL--QGLSNVPKLYWSGQE-------NNYNIMVLNLLGRDLAYYMKALKK
  |.||  .| ||.|. |. |   . ||.|  |||   .. . || .|...|  .    |  .    |.         . | .    . ||  | .. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FSLKTVLMLMDQLITVLENV-------HNRSIIHRDLKPENILMGRENESHMVYIIDYGISKIYRDN-----SGRHITFKD--NKPFIGTTRYASIAAHQ
         |..|.     .       | . .|||||   |.| |...    | | | | |.   |      |.  .. |   .. .    |  .. . .
K------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GH-------------------ELGRKDDLE------SLGYVMIFLLKGHLPWQNLQN-------VTDKDKTQVVGDIKAK-----TKSTDLCKDL
 .                    .| .   .      |   |. .. .|. . |   .        .|.  . .  .  .         .......
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF