Gene 9914 (Tetrahymena)

9914

Species: Tetrahymena
Alias: TTHERM_00275730, 9914, PreTt09914, 3690.m00154, 24.m00345, 600
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMK-Tt

Sequence

Name Sequence Type Origin Length Description Download
9914.AA Protein None 649 None Fasta, JSON
9914.kin_dom Protein Kinase Domain None 265 None Fasta, JSON
9914.NA RNA None 1950 None Fasta, JSON

Protein domain

Protein domains of 9914.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9914.AA CAMK-Tt 152-318 69 1.5e-133 450.0 In-house 225-396 (396) Show / Hide 
Range on Protein: 152-318
Range on HMM: 225-396/396
Sequence Identity: 69% (120 aa)

IASKIFKQILQSIKYMHDQLVCHRDLKPNNILATEDGLCVKITDFNISKFG---SQNKKDQLYN-QNLKMWTYTGTVSFSAPEIFSESE-YDQSVDIWSA
.|||||||||..|||||...||||||||||||..||| ||||||||.|||.   ...|||.|.| ||.|||||||||.|||||||.|.. ||...|.|||
VASKIFKQILDAIKYMHENYVCHRDLKPNNILCNEDGTCVKITDFNVSKFCDHYKNYKKDNLMNHQNIKMWTYTGTVAFSAPEIFNEDCCYDETIDMWSA

GVVLYTMLSGQEPFQAEYLKDLIQKIQTADYSFPAESWEHISEDAKDLIRKCLILNAEERIKPEQALLHPWI
|..|||||.|||||||||..|||.||..|||.||...|.||||.|||||.|||..|.|.||||.|.|.||||
GCILYTMLCGQEPFQAEYVHDLIKKICQADYNFPSHVWQHISEEAKDLIKKCLTINPEQRIKPDQMLQHPWI
Kinase 9914.AA CAMK 59-318 22 6.4e-104 335.8 In-house 1-425 (425) Show / Hide 
Range on Protein: 59-318
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

ILGEGCVGLVKKVRKISTG------------EYFACKTVKLK----------------------------DEETVMQVIREFKNIQK-------LNHPNI
.||.|  | ||... ..|.            . .|.| .. |                            ....  .| || .  .|       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKMYELFVDEV-----------------KRRIYTIM---ELVEAREM----FEVIRKLGS---------------YSEQIASKIFKQILQSIKYMHDQLV
.|.|| . |.                  ....| .|   |...  |.    |. |.. |.               ..|. |...|.||.. ..|.|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHRDLKPNNILATEDG----------------LCVKITDFNIS--KFGS--------QNKKDQLYNQ-------NLKMWTYTGTVSFSA-PEIFS-----
.|||||| ||| ....                  .||.||  .  ....        .. .  . ..       . ||.|. || .. | ||...     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------ESEYDQSVDIWSAGVVLYTMLSGQEPFQAE-------------YLKDLIQKIQTADYSFPAES------------WEHISED--------A
         .  |....|.||.||.||.||.|  ||...              ...| .||....|.|| .             | .||..        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDLIRKCLILNAEERIKPEQALLHPWI
||||||.|  . |.|.. ||.| |||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
S_TKc 9914.AA S_TKc 54-318 30 4.4e-86 293.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-231/231
Sequence Identity: 30% (87 aa)

YQEFEILGEGCVGLVKKVRKISTGEYFACKTVKLKDEETVMQVIREFKNIQKLNHPNIVKMYELFVDEVKRRIYTIMELVEA--REMFEVIRKLGS----
|.  ...|.|  | |.|.|...||...|.| .|        ...|| .  .| .||||||.|. |.|    ..| .||...    ..|..|.| |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--YSEQIASKIFKQILQSIKYMHDQLVCHRDLKPNNILATEDGLCVKITDFNISKFGSQNKKDQLYNQNLKMWTYTGTVSFSAPEIFSESEYDQ-SVDIW
  ..|  | ....||.. ..|.|.. ..|||||| ||| .|   ..||.|| ....                 |. ||  . |||..    |.  ..|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------------TTFCGTPWYMAPEVL---GYGKCKCDWW

SAGVVLYTMLSGQEPFQAEYLKDLIQKIQTADYSFPAESWEHISEDAKDLIRKCLILNAEERIKPEQALL-------HPWI
| |..|| ||.|. ||.   .. ...||               |..|||.|||||  . |.|.   .||        |||.
SCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase 9914.AA Pkinase 54-318 31 1.4e-81 282.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YQEFEILGEGCVGLVKKVRKISTGEYFACKTVKLKDEETVMQVI----REFKNIQKLNHPNIVKMYELFVDEVKRRIYTIMELVEAR----EMFEVIR--
|.  ...|.|  | |.| ....||. .|.|..|...|.  ....    .| .  ..|||||||..|. | |  |..|| .||..|      . |..|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KLGSY--SEQIASKIFKQILQSIKYMHDQLVCHRDLKPNNILATEDGLC---VKITDFNISKFGSQNKKDQLYNQNLKMWTYTGTVSFSAPEIFS-ESEY
. |..  ||. . ....|||. ..|.|.. ..|||||| |||  ..| .   |||.|| ..|. .       |  |  |.|..||  . |||.    ..|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

DQSVDIWSAGVVLYTMLSGQEPFQAE------YLKDLIQKIQTADYSFPAESWEHIS-----------------EDAKDLIRKCLILNAEERIKPEQALL
...||.||.|..|| ||.|. ||. .        . .|..|  ....|. . |  ||                 |..||.|..|| .. ..|. .||.| 
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPWI
|||.
HPWF
Kinase 9914.AA CAMK1 54-318 33 3.8e-81 235.61 In-house 1-276 (276) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-276/276
Sequence Identity: 33% (95 aa)

YQEFEILGEGCVGLVKKVRKIST---GEYFACKTVK-LK--DEETV---MQVIREFKNIQK---LNHPNIVKMYELFVDEVKRRIYTIMELVEAREMFEV
|. ....|.|  . |... ...|   |. .| |  .  |  .....   ... .|    .|   ..||||.|.|| .  | .. .| .||||   | |. 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWY--ESDNHFYLVMELVTGGELFDR

IRKLGSYSEQIASKIFKQILQSIKYMHDQLVCHRDLKPNNIL-ATE-DGLCVK--ITDFNISKFGSQNKKDQLYNQNLKMWTYTGTVSFSAPEIFSE---
| . |.|.|. |..| ||||. ..|||.. ..|||||| |.| ... ..  .|  | || .||. ...          .| |  || .. |||..     
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN--------LMKTACGTPGYVAPEVLECKKD

SEYDQSVDIWSAGVVLYTMLSGQEPFQAEY-LKDLIQKIQTADYSFPAESWEHISED-AKDLIRKCLILNAEERIKPEQALLHPWI
  ||...|.||.||..|..| | .||..|   . | .||  ..| ||   | .||.  |||.|.. | .. ..|.  ||.| ||||
KPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 9914.AA Ciliate-E2 54-318 25 1.5e-79 270.63 In-house 1-365 (365) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YQEFEILGEGCVGLVKKVRKISTGE-----------------------YFACKTVKLKDEETVMQVIREFKNIQ-------------KLNHPNIVKMYEL
|   ...|.|. | |.|........                       ..| |..| .. | ..|.|.... |.             .||||||.|||| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FVDEVKRRIYTIMELVEAREMFEVIRKL-----------GSYSEQIASKIFKQILQ---------------SIKYMHDQL-VCHRDLKPNNILATEDGLC
| .. .  || .||...  ..|. |..            ....|. ...|.|||||                ..|.| .  ..|||.||.|||       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

VKITDFNISKFGSQNKKDQLYNQNLKMWTYTG------------------------TVSFSAPEIFSESE---------YDQSVDIWSAGVVLYTMLSGQ
.||.|| .||. ... ......|  |.... .                        |  . ||||..  .         || ..||||.||.|| ||.|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

EPFQAEYLKDLIQKIQTADYSFPAE--------------SWEHISEDAKDLIRK----CLILNAEERIK-PEQALLHPWI
 ||        .|.|.  ...|| .              ||...|...||||.|    .|  . |.||  .||.| |||.
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 9914.AA CDPK 54-318 35 9.5e-79 241.19 In-house 1-271 (271) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-271/271
Sequence Identity: 35% (100 aa)

YQEFEILGEGCVGLVKKVRKI-STGEYF-ACKTV---KLKDEETVMQVIREFKNIQKLNHPNIVKMYELFVDEVKRRIYTIME--LVEAREMFEVIRKLG
|.  ..||.|  | |.|| .  .|...  | |..   ..||.|   |...|..   .| ||||.|.|| . ||  . .| .||  ...  | |..|   |
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDE--KNYYIVMETEYCTGGELFDYIIEKG

SYSEQIASKIFKQILQSIKYMHDQLVCHRDLKPNNIL--ATEDGL----CVKITDFNIS-KFGSQNKKDQLYNQNLKMWTYTGTVSFSAPEIFSESEYDQ
...|. |..|..|||. . |.|.. ..|||||| |||    .|.      .|. |. .| ||...  |     .. || .  ||.   |||.   . |..
HFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKI----EDKKMSQRCGTPYYIAPEVLQKK-YNE

SVDIWSAGVVLYTMLSGQEPFQAEYLKDLIQKIQTADYSFPAESWEHISEDAKDLIRKCLILNAEERIKPEQALLHPWI
..||||.||.||..|.|  || ..  .. ..|..   |||  . |.|||..|||||||.|  . . |.. .||| |||.
KCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 9914.AA Ciliate-E2-Unclassified 54-318 28 1.1e-75 257.74 In-house 1-352 (352) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-352/352
Sequence Identity: 28% (100 aa)

YQEFEILGEGCVGLVKKVRKISTGEYF-----AC-------KTVKLKDEETVMQVIREFK---NIQK----------LNHPNIVKMYELFVDEVKRRIYT
|   ...|.|. | |.|....... ..     ..       | .. || | ... .....   ..|.          ||||............ |  || 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMELVEAREMFEVIRKLGS-----------------YSEQIAS-----KIFKQILQSIKYMHDQL-VCHRDLKPNNILATEDGL--CVKITDFNISKFGS
.||..|  .... |.| ..                  .|| |.     ..|.|||| ..|.| .. ..|||.||.||| ...|   ..||.|| |||.  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QNKKDQLYNQ--------NLKMWTYTGTVSFS----APEIFSESEYDQS----VDIWSAGVVLYTMLSGQEPFQAEYLKD----------------LIQK
|| ... .||        . .||| .|| ..     |||.. . .||.|    .|||| ||.|| || |. ||...  ..                |.|.
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IQTADYSFPAESW----EHISEDAKDLIR----KCLILNAEERIKPEQALLHPWI
|.  ...|| ..|     |.|. |||.|.    |.|  | ..|| .||.| |||.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 9914.AA CAMK-Unique 54-318 24 5.4e-70 230.18 In-house 1-363 (363) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-363/363
Sequence Identity: 24% (90 aa)

YQEFEILGEGCVGLVKKVRKISTGEYFACKTVKLKDEETVMQVI--------------------REFKNIQKLNHPNIVKMYEL----FVDEVK------
|   .|.|.|  |.|...  ..||  .||| ||... .   |..                    ||    ....||||.| |.     |.|. .      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

-------RRIYTIMELVEAREMFEVIRK--------------------LGSYSE--QIASKIFKQILQSIKYMHDQLVCHRDLKPNNILATED-------
        ..|..||.......|..| |                     |..||    .. |. ..|. ..|||.| . |||||. ||.  .        
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------GLCVKITDFNISKFGSQNKKDQLYNQNLKMWTYTGTVSFSAP--------------EIFSESEYDQSV----DIWSAGVVLYTMLSGQEPFQ
         . .|..|| ...  ..||.. .      | |. || .. ||              |.  .. ||| .    |||| ||..|.||.|  || 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHM------MQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFD

AEYLK--------DLIQKIQTADY-SFPAESWEH---ISEDAKDLIRKCLILNAEERIKPEQALLHPWI
.|  .         ....|  .|| .|. . |.    ||. |||.. .|. .    |.. ...| |.||
CECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 9914.AA Ciliate-E2a 54-318 30 2.7e-69 203.11 In-house 1-275 (275) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-275/275
Sequence Identity: 30% (87 aa)

YQEFEILGEGCVGLVKKVRKISTGEYFACKTVKLKDEETV---MQVIREFKNIQKLNHPNIVKMYELFVDEVKRRIYTIMELVEAREMFEVIRKLGSYSE
|    ..|.|. | |...... ||. || | .. |....     ....| . ...|.|||| |.|| . ||  . .| .||..| .|... |.. ... |
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDE--NNYYLVMEYCEGGELYDKIKQCKRFFE

Q--IASKIFKQIL-QSIKYMHDQLVCHRDLKPNNILAT---EDG---LCVKITDFNISKFGSQNKKDQLYNQNLKMWTYTGTVSFSAPEIFSESE-----
    ...| .|.| | . ||| . . |||||| ||| .    ..   . .|| ||  ..| ...       .. .| .  ||  . |||..   |     
EIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD-------EKKYMFQKCGTPGYVAPEVLNNKEVLKHK

-YDQSVDIWSAGVVLYTMLSGQEPFQAEYLKDLIQKIQTADYSFPAES-WEHISEDAKDLIRKCLILNAEERIKPEQALLHPWI
 ||...|.||.||..|..|.|. ||...  .. .|..    ..|     || .| ..|||..| |  . ..||...||| ||| 
QYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 9914.AA CAMKL 54-318 32 6.3e-68 215.81 In-house 1-297 (297) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-297/297
Sequence Identity: 32% (100 aa)

YQEFEILGEGCVGLVKKVRK-ISTGEYFACKTVK--LKDEETVMQ-------------VIREFKNIQKLN---HPNIVKMYELFVDEVK----RRIYTIM
|.  . ||.|  | ||  .  . |||  | | ..   . ....|.             . || .  ..||   ||||.|.|| . .. .      || .|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELVEARE--MFEVIRKL----GSYSEQIASKIFKQILQSIKYMHDQLVCHRDLKPNNILATEDGL-CVKITDFNIS-KFGSQ-NKKDQLYNQNLKMWTYT
|...  |  .|. |.|     |. .|  | ..|.||.  ..|.|.. ..|||.|| ||| .|.|   .||.||  | ..  . ....|. .      |  
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLK------TFC

GTVSFSAPEIFSE--SEYD-QSVDIWSAGVVLYTMLSGQEPFQAEYLK-------DLIQKIQTADYSFPAESWEHISEDAKDLIRKCLILNAEERIKPEQ
|. .. |||||.    .|| . |||||.||.||.|. |. || .. ..        |  || .  | .|   | |.| |..||||| |  | |.|.. .|
GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPI--WYHVS-DCRDLIRKMLQVNPEKRPTIHQ

ALLHPWI
 . ||| 
IMNHPWM
Kinase 9914.AA CAMK-Tt 54-151 53 1e-65 224.66 In-house 1-137 (396) Show / Hide 
Range on Protein: 54-151
Range on HMM: 1-137/396
Sequence Identity: 53% (73 aa)

YQEFEILGEGCVGLVKKVRKISTGEYFACKTVKLKDEE-TV--------------------------------------MQVIREFKNIQKLNHPNIVKM
|.|.||||||||||||||..||.|..||||.|...||| ..                                      ||||||||||..||||||||.
YEEQEILGEGCVGLVKKVKRISDGQVFACKMVRTRDEEEIMNHQSYNSEISSGQHKCQSTGELFEITKFTYFKSISQSKMQVIREFKNIRELNHPNIVKV

YELFVDEVKRRIYTIMELVEAREMFEVIRKLGSYSEQ
|||..||.|.||||||||.||.||||||.|||.|||.
YELYIDETKGRIYTIMELIEAKEMFEVIHKLGHYSEK
Kinase 9914.AA MSK 57-318 28 1.7e-65 220.38 In-house 1-277 (277) Show / Hide 
Range on Protein: 57-318
Range on HMM: 1-277/277
Sequence Identity: 28% (81 aa)

FEIL---GEGCVGLVKKVRKISTGEYFACKTVK-------LKDEETVMQVIREFKNIQKLNHPNIVKMYELFVDEVKRRIYTIMELVEAREMFEVIRKLG
 . |   |.| .....|... .||  .| | ..        | .|.... ..  . .|  .|||||. .. | |. .   | .||..   |.|. ||| .
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQ--QHPNIVNLHYAFQDQCH--TYLVMEYCNGGELFTHIRKRE

SYSEQIASKIFKQILQSIKYMHDQLVCHRDLKPNNILATED--GLCVKITDFNISKFGSQNKKDQLYNQNLKMWTYTGTVSFSAPEIFS-----ESEYDQ
  .|. .. |. ..   ...||.  . |||||| ||| ...  .  ||..||  ..   |.......        . .|  . |||.       ...||.
HFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS-------PCFTLHYMAPEMLRRGYAQDGGYDE

SVDIWSAGVVLYTMLSGQEPFQ--AEYLK-------DLIQKIQTADYSFPAESWEHISEDAKDLIRKCLILNAEERIKPEQALLHPWI
..|.|| ||.|||||.|| |||  ..  .       .. ..|.... ||| . |. .|.||||||...|  . . | . .  . | |.
ACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase 9914.AA TyrKc 54-318 20 2.2e-13 -6.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 54-318
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YQEFEILGEGCVGLVKKVRKISTGEYFACKTVKLKDEETVMQVIREFKNIQKL--NHPNIVKMYELFVDE-----VKRRIYTIMELVEAREMFEVIRKLG
 .  ..||||. | | | . .   .  | |..|      ..  .|| .   ||  .|||||..|   ...         .. .||...     . .|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

S-YSEQIASKIFKQILQSIKYMHDQLVCHRDLKPNNILATEDGLCVKITDFNISKFGSQN----KKDQLYNQ----NLKMWTYTGTVSFSAPEIFSESEY
   . .   ..  || .   | |.. . ||||   |.| .|.. .|||.||  |...         .. | .    . |..     .   ||| . ....
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM---LPIRWMAPECINYGKF

DQSVDIWSAGVVLYTMLS-GQEPFQA-----EYLKDLIQKIQTADYSFPAESWE-----HISEDAKDLIRKCLILNAEERIKPEQALLHPWI
    |.|| ||... ... ||.|           ...|..... ..  . .. .     . ...  .....|   ..|.|  |  . .|  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR--PTFSEIHECF