Gene 20667 (Tetrahymena)

20667

Species: Tetrahymena
Alias: PreTt20667, 3700.m00063, 12.m00341, 527, TTHERM_00149080, 20667
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
20667.AA Protein None 671 None Fasta, JSON
20667.kin_dom Protein Kinase Domain None 254 None Fasta, JSON
20667.NA RNA None 2016 None Fasta, JSON

Protein domain

Protein domains of 20667.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20667.AA MARK 418-671 50 1e-156 515.66 In-house 1-262 (262) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-262/262
Sequence Identity: 50% (133 aa)

FKFLKELGHGSYATVRSALHKKTNFVVAVKSYNKSKLLDPQKKQNLDREIKILQNLNHKYIIKLYKVIE--NSQS-INLVMEYSSSIPLSVYLKQKSGKR
.|.||..||||||.|. |.||.|.  ||.| |.| || |||...|. |||.|.. |.|..||||..|||  ..|  |.|.||| |. .|  |.|.... |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LHELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNR--KIKLIDFGFSIQVQPSCKLTMFCGTPNYMAPEIINKKGYS-FEVDIWALGILLYKLL
||| ||..|||||..|| |.|.|...|||||.||||| .|.  .||.|||||||...| .||..||||| ||||||..|| |  ..||||.||..|| ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGYYPFAGKE--NKQLYKNILKCQPDYPMFISPSAQNLLQSILKEDPEQRKQLEDILQDEWF
.||.|| |.   .|.|||.||....|.|...|....||.|..|. .||.| ..|.|....|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 20667.AA CAMKL 418-671 37 7.4e-132 423.14 In-house 1-297 (297) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-297/297
Sequence Identity: 37% (112 aa)

FKFLKELGHGSYATVRSALH-KKTNFVVAVKSYNKSKLL-DPQKKQN-----------LDREIKILQNLN---HKYIIKLYKVIENSQS------INLVM
....|.||.||...|. |.| . |.  ||.| ..|.|.  ||..|.|           . |||.|.. ||   |. ||||| |||...       |.|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYSSSIP--LSVYLKQKSGKR--LHELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNR--KIKLIDFGFSIQVQP-----SCKLTMFCGTPNYM
|| |.    |  |.... ..|  ..| ||. .||||..|| |.|.....|||||.||||. .|   .||.||||||.. .|       ||..|||.|.||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEIINK--KGYS-FEVDIWALGILLYKLLTGYYPFA-------GKENKQLYKNILKCQPDYPM---FISPSAQNLLQSILKEDPEQRKQLEDILQDEWF
||||...  | |  ..||||..|..|| ...||.||        ||.|. ..... .|.  ||    ..| ....|....|. .||.|  ...|....|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 20667.AA CAMK 423-671 24 4.8e-115 372.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 423-671
Range on HMM: 1-425/425
Sequence Identity: 24% (106 aa)

ELGHGSYATVRSALHKKTN------------FVVAVKSYNKSKLLD-------------------------PQKKQNLDREIKILQN-------LNHKYI
.||.||...|. . ||.|.              ||.| ..|.|| |                         |....|. |||.|...       |.|. |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYKVIE------------NSQS--------INLVM---EYSSSI----PLSVYLKQKSG-------------KRLHELEAKVIFRQILEAVLYLHKKR
|||| |.|            . .         . .||   || |       |  |......             .|..| ||. .||||..|| |.|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDIKLENILINSN-----------------RKIKLIDFGFSIQVQPSC------------------------KLTMFCGTPNYMA-PEIINK-----
..|||.|.||||...|                  .||.|||||.....|.                         |.. ||||| ||| ||..|.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGYSFEVDIWALGILLYKLLTGYYPFAGK-------------ENKQLYKNILKCQPDYPMF----------------ISPS--------AQ
         ..|....|.|..|..|| .|.||.|| |.             . ..|...|.|.. |.| .                || .        ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLLQSILKEDPEQRKQLEDILQDEWF
.|....|. |||.|  .|..|...|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 20667.AA Aur 418-671 38 1.6e-109 290.06 In-house 1-257 (257) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-257/257
Sequence Identity: 38% (98 aa)

FKFLKELGHGSYATVRSALHKKTNFVVAVKSYNKSKLLDPQKKQNLDREIKILQNLNHKYIIKLYKVIENSQSINLVMEYSSSIPLSVYLKQKSGKRLHE
|.. | ||.|..  |. | ||||.| .| |  .|. .   . ...| |||||   ||| .|.|.|   ...| | |..|| .   |  .|...  ||. |
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

LEAKVIFRQILEAVLYLHKKRVIHRDIKLENILIN-SNRKIKLIDFGFSIQVQPSCKLTMFCGTPNYMAPEIINKKGYSFEVDIWALGILLYKLLTGYYP
 .|  ...|| .|. |.|.| .|||||| ||||.  .| .||. ||| |.. ... . . ||||  ||.||... ... ..||||.||.|.| |..|. |
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FAG-KENKQLYKNIL-KCQPDYPMFISPSAQNLLQSILKEDPEQRKQLEDILQDEWF
|.. .. .. |..|. |.. ..| .||. |. | . ||. ||.||  |..|..  |.
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 20667.AA S_TKc 418-671 32 1.2e-95 324.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

FKFLKELGHGSYATVRSALHKKTNFVVAVKSYNKSKLLDPQKKQNLDREIKILQNLNHKYIIKLYKVIENSQSINLVMEYSSS--IPLSVYLKQKSGKR-
...|...|.|....|. . ||||. .||.|  .          ... |||.||.. .|..|.||| |... ... .|||| .     |  |.|.. ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LHELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNRKIKLIDFGFSIQVQPSCKLTMFCGTPNYMAPEIINKKGYSF-EVDIWALGILLYKL
   ..| .|. ...||..|. |.|....||||.| ||||...   ||..|||.. |.      | |||||.|||||..   ||.. ..|.|..|..|| .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGYYPFAGKENKQLYKNILKCQPDYPMFISPSAQNLLQSILKEDPEQRKQLEDILQ-------DEWF
|.|| ||   . ....|.|.          ||.| .... .|. |||.|    ..||       ..||
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20667.AA Pkinase 418-671 30 1.2e-89 308.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

FKFLKELGHGSYATVRSALHKKTNFVVAVKSYNKSKLLDPQKKQNLD-REIKILQNLNHKYIIKLYKVIENSQSINLVMEYSSSI----PLSVYLKQKSG
..... .| ||...|. . ||.|. .||||  .|..  . ......  .||.|...|||..|..|| . |....| .||||         |. |.. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRL--HELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNRKI----KLIDFGFSIQ--VQPSCKLTMFCGTPNYMAPEIIN-KKGYSFEVDIWAL
...   | |.| ...|||... |.|....||||.|.|||||..|  |    |..|||.. |    ..  .| |||||.|||||.|.  ..|. .||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILLYKLLTGYYPFAGK------ENKQLYKNILKCQPDYPMFIS---------------------PSAQNLLQSILKEDPEQRKQLEDILQDEWF
|..|| .|.|. || |.      . .|....|........ . .                     .... .. ..|. ||..|   |.|||..||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 20667.AA AMPK 418-671 39 7.2e-87 257.93 In-house 1-254 (254) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-254/254
Sequence Identity: 39% (101 aa)

FKFLKELGHGSYATVRSALHKKTNFVVAVKSYNKSKLLDPQKKQNLDREIKILQNLNHKYIIKLYKVI-ENSQSINLVMEYSSSIPLSVYLKQKSGKRLH
.   | .| |..  |  . |. |.  ||.|  || |. | . .. . |||.||. ..|  ||.|| || |  . | .|||| |   |  |  ..  .|| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKH--GRLQ

ELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNRKIKLIDFGFSIQVQPSCKLTMFCGTPNYMAPEIINKKGY-SFEVDIWALGILLYKLLTGYY
| ||.  | ||. .| |.|.  . ||| |.||.|.. | .||. ||| |   .   .|   || |.| |||.|  | | . |||||  |. || .| || 
EREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYL

PFAGKENKQLYKNILKCQPDYPMFISPSAQNLLQSILKEDPEQRKQLEDILQDEWF
||   .  .|||.|.....  | |.||.|..|....|. ||..| . .|| ...||
PFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 20667.AA Ciliate-E2 418-671 28 3.8e-86 292.51 In-house 1-365 (365) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-365/365
Sequence Identity: 28% (107 aa)

FKFLKELGHGSYATVRSALHKKT-----------------------NFVVAVKSYNKSKLLDPQKKQNLDREIK----------ILQNLNHKYIIKLYKV
.||.| .| |....|. . ..|.                       .. .|.|...|...    ..... |||.          ||..|||..|||.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--NSQSINLVMEYSSSIPLSVYLKQKSGKRLHE---------LEAKVIFRQILE---------------AVLYLHKKR-VIHRDIKLENILINSNRKI
 .  . ..| ||||| .   |  |.|... ||.||          |.| |..|||.               |. |||.|  .||||||.||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLIDFGFSIQVQPS---------CKLTMF-----------------------CGTPNYMAPEIINKKG---------YSFEVDIWALGILLYKLLTGYYP
|.||||.| .....         ||. ||                       ||||.||||||.|.|.         |....|||.||..|| .|.|..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FAGKENKQLYKNILKCQPDYPMF------------------ISPSAQNLLQS----ILKEDPEQRKQ-LEDILQDEWF
|        ...|..|. |.| .                  .|.....|..     .|. |||.| .  |.||. .||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 20667.AA Ciliate-E2-Unclassified 418-671 27 4.2e-83 282.41 In-house 1-352 (352) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-352/352
Sequence Identity: 27% (99 aa)

FKFLKELGHGSYATVRSALHKKTNFVV-----AVKSYNKSKLLDPQKKQNLDREIKILQNLN-------------------HKYIIKLYKVIENSQSINL
.|..| .|.|....|. . |||..  .     . |. ......  .|. .. .|.|...|..                   | .|.|.. . .. | | .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYSSSIPLSVYLKQKSG---------------KRLHELEAK-----VIFRQILEAVLYLHKK-RVIHRDIKLENILINSNR---KIKLIDFGFSIQVQ
||||     |. |.|....               |.. | .||      .|.|||..  |||.|  .||||||.||||...|    .||.||||.|.. |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

----------------PSCKLTMFCGTPNYM----APEIINKKGYS----FEVDIWALGILLYKLLTGYYPFAGKENKQ----------------LYKNI
                ...... ||||||||    |||.. ...|.    ...|||.||..|| .|.||||| ..  .|                ||.||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LKCQPDYP--------MFISPSAQNLLQ----SILKEDPEQRKQLEDILQDEWF
.......|        . .||.|.....    ..|| .|..| ..|.||.  ||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20667.AA ULK 418-671 30 1.2e-79 270.94 In-house 1-329 (329) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-329/329
Sequence Identity: 30% (102 aa)

FKFLKELGHGSYATVRSALHKKT----NFVVAVKSYNKSKLLDPQKKQN-------LDREIKILQNLN----HKY----IIKLYKVIENSQS--INLVME
.   ..||.||...|  . .|||    | .||.|   |.|.   .. |.       |..||||.. |.    ||.    |.|||.. |.|..  | ..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YSSSIPLSVYLKQK--------SGKRLHELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINS-NRK-----------IKLIDFGFSIQVQPS-----
|     |. |.|..         .||| | ||. .|.|||..  .|||...||||||..||||.  . |           .|. ||||. .|. .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-CKLTM----FCGTPNYMAPEIIN----KKGYS-FEVDIWALGILLYKLLTGYYPFAGKENKQLY-----KN----------ILKCQPDYP-----MFIS
  . .     .|||| ||||.|..    .| |. ...||| ||...| .|.|..|| .  . ..|     |.          | | ....|       ||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PSAQNLLQSILKEDPEQRKQLEDILQDEWF
|  ..|..  |. |...|   |.... .||
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20667.AA PLK 418-671 36 4.5e-79 257.14 In-house 1-258 (258) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-258/258
Sequence Identity: 36% (95 aa)

FKFLKELGHGSYATVRSALHKKTNFVVAVKSYNKSKLLDPQKKQNLDREIKILQNLNHKYIIKLYKVIENSQSINLVMEYSSSIPLSVYLKQKSGKRLHE
.. .. || |  | .  . . .|. |.|.|   || .  |  .. ...||.|  .|.|. | |.... |... . .|.|| .   |  |.|..  ||| |
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRR-AKRLTE

LEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNRKIKLIDFGFSIQVQP--SCKLTMFCGTPNYMAPEII--NKKGYSFEVDIWALGILLYKLLTG
 |.. . .|| ....|||..|.||||.|| |...|.|  .|. ||| . .. .   .| || |||||| |||.   ||.|.|.|||.|.||. .| ||.|
PEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTM-CGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIG

YYPFAGKENKQLYKNILKCQPDYPMF--ISPSAQNLLQSILKEDPEQRKQLEDILQDEWF
  ||  |. |. ||.| ...  .|    ||..|..|.|..|. .|..|  .. |||...|
KPPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 20667.AA ULK 418-671 30 1e-77 264.53 In-house 1-324 (324) Show / Hide 
Range on Protein: 418-671
Range on HMM: 1-324/324
Sequence Identity: 30% (99 aa)

FKFLKELGHGSYA-TVRSALHKKT---NFVVAVKSYNKSKLLDPQKK-------QNLDREIKILQNLN---HKY--IIKLYKVIENSQS--INLVMEYSS
.   ..||.||.. .|  . .|||   | .||.|  .|.|. . ...       |.|..||.|.. |.   |..  |.|||.. |.|..  | ..|||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

SIPLSVYLKQK-------SGKRLHELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINS-NRK-----------IKLIDFGFSIQVQPS----CKLTM
   |. |.|..        .||| | ||. .|.||...  .|||. .||||||..||||.  . |           .|. ||||. .|.      .... 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

FC------GTPNYMAPEIIN----KKGYS-FEVDIWALGILLYKLLTGYYPFAGKENKQLY----KN----------ILKCQPDYPM-----FISPSAQN
..      ||| ||||.|..    .| |. ...||| ||...| .|.|.||| .  . ..|    |           | . . ..|.      |||  ..
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLQSILKEDPEQRKQLEDILQDEWF
|..  |. |...|   |.|.. .||
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 20667.AA TyrKc 418-666 24 1.7e-28 101.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 418-666
Range on HMM: 1-280/280
Sequence Identity: 24% (70 aa)

FKFLKELGHGSYATVRSALHKKTNFVVAVKSYNKSKLLDPQKKQNLDREIKILQNL--NHKYIIKLYKVIENS-------QSINLVMEYSSSIPLSVYLK
 ...|.||.| . .|. .  |     ||||. ....      .. . ||..|. .|  .|. |..|| |.  .       . . .|||| .   |  ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QKSGKRLHELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNRKIKLIDFGFSIQVQPS-----CKLTMFC----GTP-----NYMAPEIINKKGY
 . .| |   .   .  || .   |||.|..||||.   |.|...|. .|  ||| |  .         | .       |.        |||| ||.. .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SFEVDIWALGILLYKLLT-GYYPFAG-----KENKQLYKNILKC----QPDY--PMF----ISPSAQNLLQSILKEDPEQR---KQLEDIL
... |.|. |.... ..| |  |  |     ..|....... .     ||..  |       ..   .. ..  .||||.|   ... ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 20667.AA Pkinase_Tyr 418-629 27 2.1e-28 96.79 Pfam 1-228 (270) Show / Hide 
Range on Protein: 418-629
Range on HMM: 1-228/270
Sequence Identity: 27% (64 aa)

FKFLKELGHGSYATVRSALHK----KTNFVVAVKSYNKSKLLDPQK--KQNLDREIKILQNL-NHKYIIKLYKVIE-NSQS--INLVMEYSSSIPLSVYL
 .|.|.||.|.. .|. .  |    .|.  ||||. .     ...   .. . ||.||. .| .|. |..|| |.   ...  | .||||     |  ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KQK--SGKRLHELEAKVIFRQILEAVLYLHKKRVIHRDIKLENILINSNRKIKLIDFGFSIQV-----Q-PSCKLTMFCGTPNYMAPEIINKKGYSFEVD
...  ....|   .   . .|| ..  ||. |. ||||.   |.|...|...|  ||| .  .        . . ...      |||| || . .. . |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP--IKWMAPECINYGKFTTKSD

IWALGILLYKLLT-GYYP-FAGKENKQLYKNI
.|. |.|.. ..| |  | ..|  | ..|. |
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI