Gene 12692 (Tetrahymena)

12692

Species: Tetrahymena
Alias: 12692, PreTt12692, 3713.m00040, 410, 43.m00210, TTHERM_00399490
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
12692.AA Protein None 1225 None Fasta, JSON
12692.kin_dom Protein Kinase Domain None 251 None Fasta, JSON
12692.NA RNA None 3678 None Fasta, JSON

Protein domain

Protein domains of 12692.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12692.AA Aur 32-282 43 1.3e-192 513.92 In-house 1-257 (257) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

KKNKTQLGVGSFGEVKLAIHKKSGTKFAIKIMNLKNMNSFQEIQGIEREVRVHSLLKHPNIIEYHDSFQENEFVFIVLDYASNGNLYSLLYKK--RSFSE
.... .|| |.||.|.||.|||.. .||.|.|. ....... .. ..||....| |.||||..... |.........|.||..|.||..|.|.  ..|.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

KEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDD-EFNIKVCDFGWCTEDI-ENPRNTFCGTYEYMAPEIVFRQPYDYRIDIWALGVLIYELLHGCAP
..|.||..|.|.|..|.|| ||.|||.||||||||. ..|||.|||||...   .| |.|||||..||.||.| .|..|...|||.||||.|||.|||.|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FKG--KTFKEIQRKIEKGDVQFSDQISDLSKQLICKVLQANPSRRISIEDIMSHAWM
|..  .... ..| ..|.|.||...||.  |.||.|.|| .|..|.....||.| |.
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 12692.AA MARK 32-282 40 1.3e-140 462.25 In-house 1-262 (262) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-262/262
Sequence Identity: 40% (106 aa)

KKNKTQLGVGSFGEVKLAIHKKSGTKFAIKIMNLKNMNSFQEIQGIEREVRVHSLLKHPNIIEYHDSFQ--ENEF-VFIVLDYASNGNLYSLLYKK--RS
 | ....| ||...||||.||..|.|.||||.. ...| .|... ..||......|.|||||.... ..  ...  ......|||.|.||. ....  . 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEF--NIKVCDFGWCTEDIENP-RNTFCGTYEYMAPEIVFRQPYD-YRIDIWALGVLIYELL
 .|.||...|.| ..|..|.||.||||||.||||||.|..   ||| .|||.... ...   ||||||..||||||. ..||| . .|||.|||. | ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

HGCAPFKGKT--FKEIQRKIEKGDVQFSDQISDLSKQLICKVLQANPSRRISIEDIMSHAWM
.|. ||.|.|  .||...|| .|. .. . .|.  ..||...|..||..|..||.||.| ||
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 12692.AA AGC 32-282 24 5.3e-114 295.67 In-house 1-395 (395) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-395/395
Sequence Identity: 24% (97 aa)

KKNKTQLGVGSFGEVKLAIHK------KSGTKFAIKIMNLKN---MNSFQEIQGIERE------------VRVHSLLK----------HPNIIE-YHDSF
 . .. .| ||||.| |. .|       .|  .|.|... |    ..  .... . .|             .. ....          ||.|.   | ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QENEF--VFIVLDYAS---------NG-NLYSLLY---KKRSFSEKEAYKYFSQ-------TCEAIKYLHS-INIVHRD-LKPENILLDDEFNIKVCDFG
| ..   ...|..|..          |  |.. |.   |...|.|..|  |...       .. |. ||||  .|.||| |||||||||.. .|| .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WCTEDIENP----------------------------------------------------RNTFCG--TYEYMAPEIVFRQPYDYRIDIWA--LGVLIY
 |.| . ..                                                     .||||  | |||||||.    |..  |.|.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLHGCAPFKGKT----------FKEIQRKIE------KGDVQFS----------DQISDLSKQLICKVLQANPSRRIS----------IEDIMSHAWM
|.| |. || |..           .|.  ||.      . .|.|           ...|.  | || | |. .|..|.           .|.|..| | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 12692.AA CAMK 37-282 25 1.8e-104 337.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 37-282
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

QLGVGSFGEVKLAIHKKSG------------TKFAIKIMNLKNMNSFQ-------------------------EIQGIEREVRVHSL-------LKHPNI
.|| ||||.|||.|||...            .|.||||.. | . . |                           . ..||......       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IEYHDSFQE-------------------NEFVFIVL---DYASNG----NLYSLLYKK---------------RSFSEKEAYKYFSQTCEAIKYLHSINI
|  .. ..                    ......|.   .|.|.|     |.. . ..               . |.|.|| .|| | |.|..|.|| ||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILLDDE-----------------FNIKVCDFGWCTEDIEN-------------------------PRNTFCGTYEYMA-PEIVFR------
||||||||||||||                  .|||..|||  .. ...                         . .||||| |||| ||.. .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QPYDYRIDIWALGVLIYELLHGCAPFKGK-------------TFKEIQRKIEKGDVQFSDQ----------------ISDL--------SKQ
        ..|.. .|.|..||. | .| |. || |.             . .|. .|| ||. .| .                 |||          |.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LICKVLQANPSRRISIEDIMSHAWM
||.| || .|..|..||....| ||
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 12692.AA S_TKc 32-282 33 2.5e-102 347.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

KKNKTQLGVGSFGEVKLAIHKKSGTKFAIKIMNLKNMNSFQEIQGIEREVRVHSLLKHPNIIEYHDSFQENEFVFIVLDYASN--GNLYSLLYKKRS---
 .   ..| |.||.|....|||.| ..||||..          . |.||.....  .||||. ..|.||. .....|..|...  |.|.... |...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEFNIKVCDFGWCTEDIENPRNTFCGTYEYMAPEIVFRQPYDY-RIDIWALGVLIYELL
   |.| .| .|. |.|.|..|.|| .|.||||||||||||.  .||.|||| ...      .||||| .|||||..   .|.. ..|.|..|...||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

HGCAPFKGKTFKEIQRKIEKGDVQFSDQISDLSKQLICKVLQANPSRRISIEDIMS-------HAWM
 |. ||   . ... .||           |.  |..|.| || .|..|... ...        | |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12692.AA CAMKL 37-282 34 2e-98 314.7 In-house 6-297 (297) Show / Hide 
Range on Protein: 37-282
Range on HMM: 6-297/297
Sequence Identity: 34% (102 aa)

QLGVGSFGEVKLAIH-KKSGTKFAIKIMNLKNMNSFQEIQG------------IEREVRVHSLLK---HPNIIEYHDSFQENEF------VFIVLDYASN
.|| ||||.||||.| .  |.| ||||.. | ..  . ..             |.||.. ...|.   |||||  .. ..  |.      ...|. |.|.
TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSG

GN--LYSLLYKK----RSFSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEF--NIKVCDFGWCTE-D-I----ENPRNTFCGTYEYMAPEIV
|.  |.  . |.    ....|.|| .|| | ..|..|.|| .|||||.||||||||.    |||..||| ... . .    ..  .||||...||||||.
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIF

FR--QPYD-YRIDIWALGVLIYELLHGCAPFK-------GKTFKEIQRKIEKGDVQFSD---QISDLSKQLICKVLQANPSRRISIEDIMSHAWM
 .  .||| . .|||..||. | .. |  ||.       ||. .   .......  . .   ..|   ..|| | || ||..|..|..||.| ||
QGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 12692.AA Pkinase 32-282 29 3.9e-91 313.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

KKNKTQLGVGSFGEVKLAIHKKSGTKFAIKIMNLKNMNSFQEIQGIE-REVRVHSLLKHPNIIEYHDSFQENEFVFIVLDYASNG----NLYSLLY--KK
 . . ..| ||||.|....||..| ..|.||..... .| .... .  .|....  |.||||....|.|...  . .|..|. .|     |....   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RSF--SEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEFNI----KVCDFGWCTE--DIENPRNTFCGTYEYMAPEIVF-RQPYDYRIDIWALG
..|  ||.|. .|. |......|.|| .|.||||||||||.|.. .|    |.|||| .       |. .|||||..|||||..  .|.|....|.|..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

VLIYELLHGCAPFKGK----------TFKEIQRKIEKGDVQFSDQIS-----------------DLSKQLICKVLQANPSRRISIEDIMSHAWM
...||.| |  ||.|.           ...| ... . | . .. ||                 .  |..|.. |. .|..|...|.|. | |.
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 12692.AA RSK 32-282 33 1e-83 284.42 In-house 1-278 (278) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-278/278
Sequence Identity: 33% (94 aa)

KKNKTQLGVGSFGEVKLAIHKKSGTKFAIKIMNLKNMNSFQE-IQGIEREVRVHSLLK-HPNIIEYHDSFQENEFVFIVLDYASNGNLYSLLYKKRS---
 | ..|.|.|..  ..  .|...|. .| |. . . .   |  .    .|... .. . ||.|...|..||... ......| . | |.  |.|...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDD---EFNIKVCDFGWCTE-DIE--NPRNTFCGTYEYMAPEIVF---RQP-YDYRIDIWALGV
|||.||  |...   |...||.  |.||||||||||.||   |  ||..||| | . ...  .. .|||.| ||||||..    .|  .|   |.| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYELLHGCAPFKG---KTFKEIQRKIEKGD--VQFS--DQISDLSKQLICKVLQANPSRRIS-----IEDIMSHAWM
|.||.| || ||.|   .. ||| ..|.||.  . .   . .|.  | || | |. .|..|..     .|.| .|.|.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 12692.AA Ciliate-E2 25-282 26 6.6e-80 271.77 In-house 1-365 (365) Show / Hide 
Range on Protein: 25-282
Range on HMM: 1-365/365
Sequence Identity: 26% (101 aa)

FEFIKDPKKNKTQLGVGSFGEVKLAIHKKSGTKFA-----------------------IKIMNLKNMNSFQEIQGIEREVR----------VHSLLKHPN
..|||       ..| |.|| |... ..| . .||                       .|||. .. ...  .. | ||..          . ..|.|||
YKFIK-------KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPN

IIEYHDSFQ--ENEFVFIVLDYASNGNLYSLLY---KKR--------SFSEKEAYKYFSQTCE---------------AIKYLHSIN-IVHRDLKPENIL
||.....||   .. ...|..|.. |.|.....   |||        .|.|||. ... | ..               |..|||| | |.|||.||||||
IIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

LDDEFNIKVCDFGWCT---------------EDIENPR-------------------NTFCGTYEYMAPEIVFRQP---------YDYRIDIWALGVLIY
.     ||..||| ..               . . . .                   ||.|||..||||||. ...         ||| .|||.|||..|
F-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

ELLHGCAPFKGKTFKEIQRKIEKGDVQFS------------------DQISDLSKQLICK----VLQANPSRRIS-IEDIMSHAWM
|.| |  ||        |..|......|.                  ...|.  |.|| |     || .|. ||. .|.|. | |.
EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 12692.AA ULK 32-282 28 4.6e-74 252.36 In-house 1-329 (329) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-329/329
Sequence Identity: 28% (94 aa)

KKNKTQLGVGSFGEVKLAIHKKS----GTKFAIKIMNLKNMNSFQE-------IQGIEREVRVHSLLK--------HPNIIEYHDSFQENEF--VFIVLD
   . .|| |||| |  ...||.    . |.|.|.. .. || ..        .| ...|...   ||        ||||....| |..  .  ..|...
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YASNGNLYSLLYKKRS----------FSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEFN------------IKVCDFGWCTE-DIE-----
|   |.| ... |..           .||.|| ..| | ... |.||. ||.|||.||.|||... .             .|..||| .   | .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-NPRNT----FCGTYEYMAPEIVF----RQPYD-YRIDIWALGVLIYELLHGCAPFKGKTFKEIQ-----RK----------IEKGDVQFS-----DQIS
 .   .    .|||  ||||.|.     ..||. |  ||| ||...||.| |  ||..  | . .     .           |.|   ||      .|||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DLSKQLICKVLQANPSRRISIEDIMSHAWM
. .|.|| . || ... |||.|.. .| |.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 12692.AA ULK 32-282 29 2.1e-73 250.17 In-house 1-324 (324) Show / Hide 
Range on Protein: 32-282
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

KKNKTQLGVGSFG-EVKLAIHKKS---GTKFAIKIMNLKNMNSFQE-------IQGIEREVRVHSLLK---HPN--IIEYHDSFQEN--EFVFIVLDYAS
   . .|| ||||  |  ...||.   . ..|.|....|.|| ..        .| ...|...   ||   |||  |....| |..    ...|...|  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGNLYSLLYKKRS---------FSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEFN------------IKVCDFGWCTE-DIENPRNTFC--
 |.| ... |..          .||.|| ..| | |.. |.||. ||.|||.||.|||. . .             .|..||| .   | .|   . |  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTYEYMAPEIVF----RQPYD-YRIDIWALGVLIYELLHGCAPFKGKTFKEIQ----RK----------IEKGDVQFSD-----QISDLSKQ
        ||  ||||.|.     ..||. |  ||| ||...||.| |  ||..  | . .    .           |..  .|| .     .||. .|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LICKVLQANPSRRISIEDIMSHAWM
|| . || ... |||.|.| .| |.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 12692.AA Ciliate-E2-Unclassified 25-282 26 2.7e-71 243.16 In-house 1-352 (352) Show / Hide 
Range on Protein: 25-282
Range on HMM: 1-352/352
Sequence Identity: 26% (97 aa)

FEFIKDPKKNKTQLGVGSFGEVKLAIHKKSGTKF-------AIKIMNLKNMNS-FQEIQGIEREVRVHS---------LLK-------HPNIIEYHDSFQ
...||       |.| |.||.|....||| . ..        |.| . |....   ||  .. |.  ..         ...       ||.|. ... ||
YKIIK-------QIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQ

ENEFVFIVLDYASNGNLYSLLYKKRS-----------------FSEKEAY-----KYFSQTCEAIKYLHSIN-IVHRDLKPENILLDDE---FNIKVCDF
  . ..||..|. .|.|   . |. .                 |.|..|      .|| | .....|||. | |.|||.||||||.|..   ..||..||
DKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF

GWCTEDIENPR-----------------NTFCGTYEYM----APEIVFRQPYD----YRIDIWALGVLIYELLHGCAPFKGKTFKE--------------
| . . ..|.                  .|||||..||    |||.  .| ||    | .|||.|||..||.| |  ||.... ..              
GISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYR

--IQRKIEKGDVQFS--------DQISDLSK----QLICKVLQANPSRRISIEDIMSHAWM
  ....| ....||.        ...|.  |    .|..| |. ||. ||..|.|. | |.
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 12692.AA Pkinase_Tyr 25-175 27 8.3e-21 71.1 Pfam 1-156 (270) Show / Hide 
Range on Protein: 25-175
Range on HMM: 1-156/270
Sequence Identity: 27% (46 aa)

FEFIKDPKKNKTQLGVGSFGEVKLAIHK----KSGTKFAIKIMNLKNMNSFQE--IQGIEREVRVHSLL-KHPNIIEYHDSFQ-ENEF--VFIVLDYASN
 .|.|        || |.||||.... |    . ... |.|..  |.  . ..  ..   ||... . | .||||. ..     . |   ..||. |. .
ITFGKK-------LGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH

GNLYSLLYK----KRSFSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEFNIKVCDFG
|.|.. | |    |.... |.  ..  | ...  ||.|.|..||||   |.|..... .|.||||
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 12692.AA TyrKc 32-280 21 6.5e-17 50.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 32-280
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

KKNKTQLGVGSFGEVKLAIHKKSGTKFAIKIMNLKNMNSFQEIQGIEREVRVHSLL--KHPNIIEYHDSFQEN-------EFVFIVLDYASNGNLYSLLY
 . . .|| | |||| ... |   .. |.| ..         .. . || |. . |  .||||.  .    .        | ..||. |...|.| . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KKRS-FSEKEAYKYFSQTCEAIKYLHSINIVHRDLKPENILLDDEFNIKVCDFGWCTEDIENP--------RNTF----CGT----YEYMAPEIVFRQPY
|.|  .. |.  ..  | ..   |||| |..||||   |.|..... .|..||| .  ||..           .     .|     .  ||||  .   .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DYRIDIWALGVLIYELLHGCAPFKG------KTFKEIQRKIEKGDVQFSDQI---------SDLSKQLICKVLQANPSRRISIEDIMSHA
    |.|. ||...|..  ...         .. .|. .....|.     .          .|   |.. .  ...|. | . ..| .  
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 12692.AA Pkinase_Tyr 210-243 32 0.417089 4.37 Pfam 196-232 (270) Show / Hide 
Range on Protein: 210-243
Range on HMM: 196-232/270
Sequence Identity: 32% (12 aa)

DIWALGVLIYELLHGC-AP-FKGKTFKEIQRKI-EKG
|.|. |||..|..  .  | ..| .  |. ..| |.|
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG