Gene 26498 (Tetrahymena)

26498

Species: Tetrahymena
Alias: TTHERM_00433560, 48.m00261, 3831.m01599, 26498, PreTt26498, 105
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: AMPK

Sequence

Name Sequence Type Origin Length Description Download
26498.AA Protein None 1474 None Fasta, JSON
26498.kin_dom Protein Kinase Domain None 326 None Fasta, JSON
26498.NA RNA None 4425 None Fasta, JSON

Protein domain

Protein domains of 26498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26498.AA AMPK 15-340 48 2.5e-200 600.34 In-house 1-254 (254) Show / Hide 
Range on Protein: 15-340
Range on HMM: 1-254/254
Sequence Identity: 48% (159 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVDESDKIRVAREIQILRKIRHPNIIQLYEVNF
|..|||||.||||||||| |..|                               ..|||||||.|.|| |.... |..|||.||...|||.|||||||. 
YIIGKTIGEGTFGKVKMGTHILT-------------------------------GEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVI-

QNLYFGIIQQFEQFIKYQDQIVFNLLLKQIIESQTQLFLITEYAPNNELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKP
                              ||..|..|...||....||||.|||.          .||.||...||. ||.|.|||.|...||||||||
------------------------------IETPTDIFMVMEYVSGGELFDYIVKH----------GRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP

ENLLLDCNNNIKVVDFGLSNMYEDGQTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSNTTDLYKKIINDPVKLPKFLTDRSK
||||||.|.|||.||||||||..||..|||||||||||||||.|||.|.|...||||||.||||||||||||.|.||..|||||.|. ...||||....|
ENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAK

SILNGILEKNPEKRLTIEAIRKHDFC
......|...|.||.||..||.|...
DLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 26498.AA CAMKL 15-340 38 4.5e-138 443.29 In-house 1-297 (297) Show / Hide 
Range on Protein: 15-340
Range on HMM: 1-297/297
Sequence Identity: 38% (138 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVD-------------ESDKIRVAREIQILRKI
| .|||.|.|.|||||...|. |                               . ||||||.||.|| .             |||. |. |||||....
YRIGKTLGKGSFGKVKLATHIRTT------------------------------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKML

R---HPNIIQLYEVNFQNLYFGIIQQFEQFIKYQDQIVFNLLLKQIIESQTQLFLITEYAPNNE--LFDFIVKRNSQLFIKNKHNRLNERQSARFLLQIL
.   |||||.||||     .                          ||. ....|..||... |  |||.|||.           |. |..  |.  ||.
NIGKHPNIIKLYEVIETPEH-------------------------DIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRR------GRMPEHEARRYFRQIV

SAVEYLHQNNIVHRDLKPENLLLDCNN--NIKVVDFGLSNMYED-----GQTLKTACGSPCYAAPEMVSG--KRYEGLKTDIWSCGIILYAMLCGYLPFE
|||.|.|...|||||.||||.|||.|.  |||..|||.||||..     ||.||| ||||.|.|||...|  |.|.| |.||||||.|||||.||||||.
SAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFD

DS--------NTTDLYKKIINDPVKLP--KFLTDRSKSILNGILEKNPEKRLTIEAIRKHDFC
|         |.  ||.||. .  . |  ...  . .... ..|..||||| ||. |..| ..
DDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 26498.AA CAMK 20-340 27 1.3e-119 387.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 20-340
Range on HMM: 1-425/425
Sequence Identity: 27% (130 aa)

TIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVD-------------------------ESDKIRVARE
|.|||.||||| . |. |  .... .                 . ..| . ||||||.||.|. |                         ..|. .| ||
TLGRGSFGKVKLCIHKNTTGKERV-H----------------HI-YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRRE

IQILRK-------IRHPNIIQLYEVNFQNLYFGIIQQFEQFIKYQDQIVFNLLLKQIIES---------QTQLFLIT---EYAPNNEL----FDFIVKRN
|.|..|       ..|||||.||||   . ||. .  .                  .. .         ........   ||... ||    ||.||.. 
IEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFK-N--T------------------ND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHG

S------QLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCN-----------------NNIKVVDFGLSNMYED----------
.      |..|  .. |..||. .|.  ||.|||.|.|..|||||||||||.||| |                 ||||..|||..|....          
CYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDY

--------------GQTLKTACGSPCYAA-PEMVSG-------------KRYEGLKTDIWSCGIILYAMLCGYLPFEDS-------------NTTDLYKK
              || .|| ||.|.|.| ||...|             |.| | |.|.||||.|||.|||||.||...             |  .|..|
KGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEK

IINDPVK-LPKFLTD-----------------------RSKSILNGILEKNPEKRLTIEAIRKHDFC
|..      |.....                         |. ....|...||||.||| . .| . 
IMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 26498.AA AGC 15-340 20 8.9e-90 231.58 In-house 1-395 (395) Show / Hide 
Range on Protein: 15-340
Range on HMM: 1-395/395
Sequence Identity: 20% (96 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKV-AIKILDKDK-IVDES--DKIRVARE------------IQIL
. . |.||.|.||||    .  . .                          .. ..|. |.|.|.|.. ||.    .  .. .|             .||
FEFLKVIGKGSFGKVYLVRKKDGCH--------------------------KKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNIL

RKIR----------HPNIIQLYEVNFQNLYFGIIQQFEQFIKYQDQIVFNLLLKQIIESQTQ--LFLITEYAP---------NN-ELFDFIVKRNSQLFI
 |..          ||.|..                               .|.   ....   |... ||.|            |||  . .|   .  
EKCNHTHNHPIKSHHPFIVK-------------------------------ILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGR---R--

KNKHNRLNERQSARFLLQ-------ILSAVEYLHQ-NNIVHRD-LKPENLLLDCNNNIKVVDFGLS----------------------------------
  |  |..| ..  .. .       |..|.||||. ..|.||| |||||.||| . .|| .||||.                                  
--KEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTN

------------------NMYEDGQTLKTACG--SPCYAAPEMVSGKRYEGLKTDIWS--CGIILYAMLCGYLPFEDSNTT----------DLYKKII--
                  .. ..... .| ||  .| | |||..      |   |.||   |...| ||.|| || . |.           ....||.  
KCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNG

----NDPVKLP----------KFLTDRSKSILNGILEKNPEKRLT----------IEAIRKHDFC
    |..||.|          .....  |..... |.|.|||||.          .| |..| . 
RYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 26498.AA MARK 143-340 42 1.1e-78 256.85 In-house 66-262 (262) Show / Hide 
Range on Protein: 143-340
Range on HMM: 66-262/262
Sequence Identity: 42% (87 aa)

QIIE--SQTQ-LFLITEYAPNNELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCNN--NIKVVDFGLSNMYE
..||    .. ..|| |||.. ||.|.|...         . || |.   |.  ||.|||.|.|..||||||.||||.|.|.|.  |||  |||.|.  .
HVIEQDTEQHQIYLIMEYASGGELYDYIKAH--------PNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIP

DGQTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSN--TTDLYKKIINDPVKLPKFLTDRSKSILNGILEKNPEKRLTIEAIR
 || |.| ||.| |.|||....|.|.| |.||||.|..||.|.|||.||....    .||||| .   . | .. .  ..... .|  |||.| ||| | 
PGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIM

KHDFC
|| . 
KHPWM
Kinase 26498.AA S_TKc 15-340 29 5.4e-75 256.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-340
Range on HMM: 1-231/231
Sequence Identity: 29% (99 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVDESDKIRVAREIQILRKIRHPNIIQLYEVNF
| ....||.|.||||. . |.                                 . .|||||..          ... ||||||.| .||||..||.|  
YEILRKIGKGAFGKVYKCRHKK-------------------------------TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQ

QNLYFGIIQQFEQFIKYQDQIVFNLLLKQIIESQTQLFLITEYAPN--NELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDL
                                  . |....||...   .|||.|.||...     .. ...| . .... ||..|.||.|...|.||||
D---------------------------------DHLYMVMEYCDGDLGDLFDYIKKRGRHG----LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDL

KPENLLLDCNNNIKVVDFGLSNMYEDGQTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSNTTDLYKKIINDPVKLPKFLTDR
||||.|||   .||. ||||.  .      .| ||.| | |||..    | . | |.||||.||| ||||| ||.  .   ..|||           .. 
KPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPE

SKSILNGILEKNPEKRLTIEAIRK-------HDFC
 |......|.|.||||.|.  . .       | . 
AKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26498.AA QIK 143-340 40 3.3e-71 242.89 In-house 65-272 (272) Show / Hide 
Range on Protein: 143-340
Range on HMM: 65-272/272
Sequence Identity: 40% (85 aa)

QIIESQTQLFLITEYAPNNELFDFIVK--R-----------NSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCNNNIKVVD
|..|..  ....|||..| |.|| ..|  |             |...      ..|.. .|   ||.|||.|.|. |||||||| ||.||| | |||..|
QVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLM---GVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIAD

FGLSNMYEDGQTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSNTTDLYKKIINDPVKLPKFLTDRSKSILNGILEKNPEKRL
||.|| .. ||.|.| |||| ||||||  || |.| | |||| |..||.. || |||  .. . | ....   ...| |.     ..    |  .||.|.
FGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRY

TIEAIRKHDFC
||. |..|   
TIMQICQHRWM
Kinase 26498.AA CAMK1 146-340 37 1.6e-63 183.46 In-house 78-276 (276) Show / Hide 
Range on Protein: 146-340
Range on HMM: 78-276/276
Sequence Identity: 37% (79 aa)

ESQTQLFLITEYAPNNELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCN-NN--IK--VVDFGLSNMYEDGQ
|| . . |..|.  . |||| ||..             .|.. ..   ||||||||.|...||||||||||||.  . ..  ||  . ||||| ..... 
ESDNHFYLVMELVTGGELFDRIVEKG----------NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDE

-TLKTACGSPCYAAPEMVSG---KRYEGLKTDIWSCGIILYAMLCGYLPFEDSN-TTDLYKKIINDPVKLPKF----LTDR-SKSILNGILEKNPEKRLT
 ..|||||.| | |||.. .   | | . . |.||.|.|.| .|||| || |.|    |..||.. ..  |..      |   |  ... ||..|.||.|
NLMKTACGTPGYVAPEVLECKKDKPY-DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYT

IEAIRKHDFC
.| . .| . 
CEQCLNHPWI
Kinase 26498.AA Pkinase 141-340 30 2e-63 221.79 Pfam 65-293 (293) Show / Hide 
Range on Protein: 141-340
Range on HMM: 65-293/293
Sequence Identity: 30% (73 aa)

LKQIIESQTQLFLITEYAPNN----ELFDFIVKRNSQLFIKNKHNRL--NERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCNNNI----KVVDF
|. . |. . . ...||...     .|||.|           .|...   |..  ....|||...||.|...|.||||||||.|.| |..|    |. ||
LYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF

GLSNM--YEDGQTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDS------NTTDLYKKIINDPVKLPKFLT------------
||.    |  .. ..| ||.| |.||| . | .| | | |.||||.||| ||||..|| ..      .   ....|   |.. . . .            
GLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------DRSKSILNGILEKNPEKRLTIEAIRKHDFC
         .  |......|.|.|.||.|.| | .|.. 
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 26498.AA BRSK 151-340 43 6.3e-63 213.23 In-house 75-254 (254) Show / Hide 
Range on Protein: 151-340
Range on HMM: 75-254/254
Sequence Identity: 43% (82 aa)

LFLITEYAPNNELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCNNNIKVVDFGLSNMYEDGQTLKTACGSPC
|.|| |.    ||||. ||.           ||  .   .|  || ||... |  || ||||||||||||  ||||. |||.  .  ..  | | |||| 
LYLILEHVSGGELFDYLVKK----------GRLTPKEARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPH

YAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSNTTDLYKKIINDPVKLPKFLTDRSKSILNGILEKNPEKRLTIEAIRKHDFC
|| || ..|  | | | |.||||.||||.| | ||| | |   |  |. .    .| |      . | | .| .|.||.... |.||   
YACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase 26498.AA Ciliate-E2 146-340 26 2.8e-62 212.61 In-house 104-365 (365) Show / Hide 
Range on Protein: 146-340
Range on HMM: 104-365/365
Sequence Identity: 26% (73 aa)

ESQTQLFLITEYAPNNELFDFIVKR-NSQLFI--KNKHNRLNERQSARFLLQILS---------------AVEYLHQNN-IVHRDLKPENLLLDCNNNIK
.... ..|..||.  ..|||.| ..  .....  | . ....|.. ...  |||.               |.||||..| |.|||.||||.|.     ||
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IK

VVDFGLS----------------NMYEDGQ-----------------TLKTACGSPCYAAPEMVSGKRYEG--------LKTDIWSCGIILYAMLCGYLP
..|||||                ..| . .                 . .| ||.| | |||...|| |..         | ||||.|.||| ||.|..|
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEDSNTTDLYKKIINDPVKLPKF------------------LTDRSKSILNG----ILEKNPEKRLT-IEAIRKHDFC
|        ...|.. ....|..                  ...  | ...     .|.|.||||.| .| | .| . 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 26498.AA MELK 141-340 40 9.3e-60 202.8 In-house 62-254 (254) Show / Hide 
Range on Protein: 141-340
Range on HMM: 62-254/254
Sequence Identity: 40% (82 aa)

LKQIIESQTQLFLITEYAPNNELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCNNNIKVVDFGL---SNMYE
|  .|| . ..|.. || |  |.||.|...          .||.| ..  |. ||.||. |.|     ||||||||||.| . ..|..||||   .    
LYHYIETEDKIFMVMEYCPGGEMFDYIIRQ----------DRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRK

DGQTLKTACGSPCYAAPEMVSGKRYEGLKTDIWSCGIILYAMLCGYLPFEDSNTTDLYKKIINDPVKLPKFLTDRSKSILNGILEKNPEKRLTIEAIRKH
|   |.| |||| |||||...||.| |   |.|| ||.||...||.|||.| |   .||||.    . ||.|   || .|  .|  .|.||. .  . .|
DYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNH

DFC
.. 
PWV
Kinase 26498.AA CAMK1 15-112 26 1.9e-20 56.11 In-house 1-76 (276) Show / Hide 
Range on Protein: 15-112
Range on HMM: 1-76/276
Sequence Identity: 26% (28 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILD-KDKIVDESD--KIRVAREIQILRK---IRHPNIIQ
| .||.||||.|..|. . |  |                               . ..|||..| |. .  ...  . .. .||.|..|   | |||||.
YEFGKEIGRGAFSEVYLCTHKETQ---------------------------T-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIK

LYEV
.||.
FYEW
Kinase 26498.AA Pkinase 15-112 26 2.4e-16 58.86 Pfam 1-68 (293) Show / Hide 
Range on Protein: 15-112
Range on HMM: 1-68/293
Sequence Identity: 26% (26 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVDESDKIRVA-REIQILRKIRHPNIIQLYEV
| .|..||.|.||.|. . |  | .                               .||.||..|... .. |....  .||||.....||||..||..
YHIGRKIGSGSFGCVYKCHHKGTGK-------------------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDW
Kinase 26498.AA TyrKc 15-339 20 5.6e-16 35.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-339
Range on HMM: 1-280/280
Sequence Identity: 20% (74 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVDESDKIRVAREIQILRKI--RHPNIIQLYEV
   ||..|.| ||.|  |  .                                   .||.| | .|.      .    ||..|..|.  .||||..||  
ITLGKKLGEGAFGEVYKGTWK----------------------------------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLY--

NFQNLYFGIIQQ-FEQFIKYQDQIVFNLLLKQIIESQTQLFLITEYAPNNELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRD
       |.. | ...                   .  .|....||.|.  | |.. |.  .         |. ..   | .|| .  ||||..|..|||
-------GVCTQQGRN-----------------FMYIEPLMIVMEYMPHGDLKDYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRD

LKPENLLLDCNNNIKVVDFGLSNMYEDG-------QTLKTAC--GSP--C---YAAPEMVSGKRYEGLKTDIWSCGIILYAML-CGYLPFED-----SNT
|   | |.. |. .|. |||||   .|.       .. ...   |.         |||    ...   |.|.|| |. .. ..  |  | ..      . 
LAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSN

TDLYKKIINDPVKLPKFL---------TDRSKSILNGILEKNPEKRLTIEAIRKHDF
....... .     .            .|   .|     . .||.| | ..| ...|
QEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 26498.AA MARK 71-112 52 2.7e-12 36.66 In-house 26-67 (262) Show / Hide 
Range on Protein: 71-112
Range on HMM: 26-67/262
Sequence Identity: 52% (22 aa)

KVAIKILDKDKIVDESDKIRVAREIQILRKIRHPNIIQLYEV
||||||..| |. |   .  | |||.|..|. |||||.|..|
KVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHV
Kinase 26498.AA Ciliate-E2 15-112 25 2.3e-10 31.8 In-house 1-100 (365) Show / Hide 
Range on Protein: 15-112
Range on HMM: 1-100/365
Sequence Identity: 25% (27 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVDESDKIRVAREIQ----------ILRKIRHP
| . | ||.|.||.|. . .  . ..... ...   . .. .  |       . ....|.||. |..|   . .|.. |||.          ||... ||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQM-Q-----EKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHP

NIIQLYEV
|||..||.
NIIKMYEC
Kinase 26498.AA QIK 70-112 48 3.8e-10 35.76 In-house 25-66 (272) Show / Hide 
Range on Protein: 70-112
Range on HMM: 25-66/272
Sequence Identity: 48% (21 aa)

NKVAIKILDKDKIVDESDKIRVAREIQILRKIRHPNIIQLYEV
.||||||.|| .. ||.. ... ||.||.  ..||.|| ||.|
TKVAIKIIDKSQL-DEENLQKCYREVQIMKMLYHPHIIKLYQV
Kinase 26498.AA Pkinase_Tyr 15-110 23 5.6e-09 31.04 Pfam 1-70 (270) Show / Hide 
Range on Protein: 15-110
Range on HMM: 1-70/270
Sequence Identity: 23% (23 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENIQLTFFTQVSINISKDNKQTLQLILNNENNKVAIKILDKDKIVDESD--KIRVAREIQILRKI-RHPNIIQLY
   ||..|.| ||.|..|  .                               |.. .||.|.| |.   ....  .    ||..|.... .||||..||
ITFGKKLGEGAFGEVYKGTWKG---------------------------DPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 26498.AA Pkinase_Tyr 150-233 32 1.1e-08 30.07 Pfam 81-158 (270) Show / Hide 
Range on Protein: 150-233
Range on HMM: 81-158/270
Sequence Identity: 32% (27 aa)

QLFLITEYAPNNELFDFIVKRNSQLFIKNKHNRLNERQSARFLLQILSAVEYLHQNNIVHRDLKPENLLLDCNNNIKVVDFGLS
|.....||.|.  | |.  |.       .  ..|.  .   . .|| .. |||...|..||||   | |...|| .|. ||||.
QIYIVMEYMPHGDLLDYLRKHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 26498.AA BRSK 71-112 46 1.2e-08 25.57 In-house 26-68 (254) Show / Hide 
Range on Protein: 71-112
Range on HMM: 26-68/254
Sequence Identity: 46% (20 aa)

KVAIKILDKDKIV-DESDKIRVAREIQILRKIRHPNIIQLYEV
||||||  | |    ||   .| ||| |.. | ||.....|.|
KVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDV
Kinase 26498.AA MELK 69-112 43 6.2e-07 19.4 In-house 24-65 (254) Show / Hide 
Range on Protein: 69-112
Range on HMM: 24-65/254
Sequence Identity: 43% (19 aa)

NNKVAIKILDKDKIVDESDKIRVAREIQILRKIRHPNIIQLYEV
|..|||||.||...   .|  ||  |.. |...|| .| ||| .
NQMVAIKIMDKNQL--GHDLPRVKTEMDALKNLRHQHICQLYHY
Kinase 26498.AA MARK 15-37 47 1e-06 18.18 In-house 1-23 (262) Show / Hide 
Range on Protein: 15-37
Range on HMM: 1-23/262
Sequence Identity: 47% (11 aa)

YYVGKTIGRGTFGKVKMGLHTYT
| ..|||| |...||| ..|. |
YKMLKTIGHGSYAKVKLACHKHT
Kinase 26498.AA BRSK 15-37 47 8e-06 15.87 In-house 1-23 (254) Show / Hide 
Range on Protein: 15-37
Range on HMM: 1-23/254
Sequence Identity: 47% (11 aa)

YYVGKTIGRGTFGKVKMGLHTYT
| ..|| |.|. |.||.|.|  |
YRLEKTLGKGQTGLVKLGVHCVT
Kinase 26498.AA QIK 15-41 37 5.5e-05 15.68 In-house 1-27 (272) Show / Hide 
Range on Protein: 15-41
Range on HMM: 1-27/272
Sequence Identity: 37% (10 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENI
| ...|||.| |. ||.. |  | . .
YDIERTIGKGNFAVVKLARHRITKTKV
Kinase 26498.AA MELK 15-41 40 0.000498 9.31 In-house 1-27 (254) Show / Hide 
Range on Protein: 15-41
Range on HMM: 1-27/254
Sequence Identity: 40% (11 aa)

YYVGKTIGRGTFGKVKMGLHTYTMENI
| | ..|| | |.|||.  |  | . .
YEVHDEIGTGGFAKVKLACHILTNQMV
UBA_CAMKL 26498.AA UBA_CAMKL 362-400 46 3.7e-13 45.31 In-house 1-41 (41) Show / Hide 
Range on Protein: 362-400
Range on HMM: 1-41/41
Sequence Identity: 46% (19 aa)

DPLILQIIKNQY-GIDSEQARVMIQNNKH-NQITATYYLLL
|. |.|. .. . |.| |. .  ..|||. |.|||||||||
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL