Gene 1303 (Tetrahymena)
1303
Group:
Other
Family:
Ciliate-E2
Sequence
Protein domains of 1303.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PH | 1303.AA | PH | 36-140 | 15 | 8.1e-05 | 23.26 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 36-140 Range on HMM: 1-82/82 Sequence Identity: 15% (16 aa) QLKSTWMKKTKKSGKTKQRVFLIDDDSLYMCKSEKTDKISGVLELCCVKLDLLVSVEPKPIEASCSEPLFGFRMCRNGKTLEIYTKDQNLYKKWKNILIY .|. |..| . . . |.| | ...|.|| .|.. | .|.. | .... . .|. . ..|........ ..| . . VIKEGWLYKKS-K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDCTVRE-P----------------CFEIHH-DRTYYFQCESEEEMQEWMQAIQK KAIQS . .. AIHNN |
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| Kinase | 1303.AA | CAMK1 | 146-409 | 44 | 3.5e-174 | 510.78 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 146-409 Range on HMM: 1-276/276 Sequence Identity: 44% (124 aa) FIVTKMIGKGSFAKVYLATKKEN---GQQYAIKAFN-KEFMAG---QHKGKESLVNEIGIMRN---LHSEFLINLYEVYETTNSIYFVVDLLNGGELLHR ....|.||.|.|..|||.|.||. |.|||||... |.||.. | | .|.| |||.||.. .. .. |..||.||..| .|.|..|..||||..| YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ-K-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR VRDKGTINEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKSNDHDIV--VADFGLATFTDIKD-ILFKRCGTPGFVAPEVLLYKEGDPFYDVKC . .|| .|.| |..|...|||....|.|||.||||||||||...|..|..|. .|||||....| .. .....|||||.|||||| .|. | .|| .| IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKAC DIFSAGIIFYLLLVGKQPFQGKD-YKQILRANKACEIRYDTPEFDSISAQ-AKDLLKKMLEPKPTNRISASECLNHPFI |..|.|.|.| ||.| .||.... ...... .| ||.....|..|.|| | |||..|.|||. |..|.....|||||.| DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | 1303.AA | Ciliate-E2a | 146-409 | 48 | 8.3e-164 | 486.03 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 146-409 Range on HMM: 1-275/275 Sequence Identity: 48% (134 aa) FIVTKMIGKGSFAKVYLATKKENGQQYAIKAFNKEFMAGQHKGKESLVNEIGIMRNLHSEFLINLYEVYETTNSIYFVVDLLNGGELLHRVRDKGTINEQ . ..|.||||.|..||||..|..|.|.|.|.|.| .|. |.||||.. ||| |||.| .| ||||||. |..|.| ....||||... . .....| YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE --DLRNLMRNLLS-ALYHLHQKGIMHRDLKPENLLLK--SKSND--HDIVVADFGLATFT--DIKDILFKRCGTPGFVAPEVLLYKE--GDPFYDVKCDI . . .|..||. .| ..||..||||||||||.|.| ||... ||...||||||| |.|. .|..|||||.|||||| .|| ...||.|||. IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM FSAGIIFYLLLVGKQPFQGKDYKQILRANKACEIRYDTPE-FDSISAQAKDLLKKMLEPKPTNRISASECLNHPFI .|.|.|||.||.||.||.||.|..|| ||.|.| .. || . .| ..|||.|||||. | .||.| ..||||. WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 1303.AA | CAMK | 151-409 | 23 | 6.6e-106 | 342.32 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 151-409
Range on HMM: 1-425/425
Sequence Identity: 23% (100 aa)
MIGKGSFAKVYLATKKENG------------QQYAIKAFNKEFMAG------------------------QHKGKESLVNEIGIMRN-------LHSEFL
.|.|||.||.|.. |... |..||| .|. . . . | .... .|| ||.. |. . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
INLYEVYE------------TTNS--------IYFVV---DLLNGGEL----LHRVRDK---------------GTINEQDLRNLMRNLLSALYHLHQKG
|.|||||| | . .|.| .. |||| . ..... | ..|.. | ..| ..||. ..|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IMHRDLKPENLLLKSKSND--------------HDIVVADFGLATFTDI------------------------KDILFKRCGTPGFVA-PEVLLYK----
|.||||||||.|| ....| ..| ..|||.|.. | . . .||||...| ||||..|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
------EGDPFYDVKCDIFSAGIIFYLLLVGKQPFQGK-------------DYKQILRANKACEIRYDTPEFDSIS--------------------AQAK
|. | |. |||. |.|.| | .|.|. ||.|. ....... .... ... |.|. || ...|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DLLKKMLEPKPTNRISASECLNHPFI
||..|||.. |..|.....|||||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 1303.AA | Ciliate-E2 | 146-409 | 24 | 2.5e-100 | 339.6 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 146-409 Range on HMM: 1-365/365 Sequence Identity: 24% (95 aa) FIVTKMIGKGSFAKVYLATKKENGQQYA----------------IKAFNKEFMAGQHKGKESLVNEIGIMRNLH----------------SEFLINLYEV ... |.||.|.|..||.........|.| |.. .. .....|.. .|| ||| .. . ..|..||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YE--TTNSIYFVVDLLNGGELLHRVR------------DKGTINEQDLRNLMRNLLS---------------ALYHLHQKG-IMHRDLKPENLLLKSKSN .. ..|.||.| ....||.|... . | . ..|. ...|. .|. || .||.|. |.|||.||||.|. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- DHDIVVADFGLATFTDIK--------------------------------DILFKRCGTPGFVAPEVLLYKE-----GDPFYDVKCDIFSAGIIFYLLLV | ..||||... |.. .. . |||||..|||.| .|. . || ||||.|.|.|.| .| ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GKQPFQGKDYKQILRANKACEIRYDTPE--------------FDSISAQAKDLLKK----MLEPKPTNRIS-ASECLNHPFI || || .. .| |.|... || ....| ..|||.|| ||. .| .||. ....||||.. GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 1303.AA | S_TKc | 146-409 | 30 | 1.7e-94 | 321.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 146-409
Range on HMM: 1-231/231
Sequence Identity: 30% (85 aa)
FIVTKMIGKGSFAKVYLATKKENGQQYAIKAFNKEFMAGQHKGKESLVNEIGIMRNLHSEFLINLYEVYETTNSIYFVVDLLNG--GELLHRVRDKGT--
. . . ||||.|.|||....|. |...||| . |.. .|| |... | .....||.|... ...|.| ....| |.|... ...|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----INEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKSNDHDIVVADFGLATFTDIKDILFKRCGTPGFVAPEVLLYKEGDPFYDV-KCDIFS
..| . | .|. ...|| ..|..||.||||||||.|| . | ..|||||.. |||| ..||||| |. |||. |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWS
AGIIFYLLLVGKQPFQGKDYKQILRANKACEIRYDTPEFDSISAQAKDLLKKMLEPKPTNRISASECLN-------HPFI
|.|.| .|.|. ||. ....... . | .|||...|.|. |..|..| |.|. ||..
CGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 1303.AA | Pkinase | 146-409 | 28 | 1.6e-87 | 301.9 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 146-409 Range on HMM: 1-293/293 Sequence Identity: 28% (86 aa) FIVTKMIGKGSFAKVYLATKKENGQQYAIKAFNKEFMAGQHKGKESLVN--EIGIMRNLHSEFLINLYEVYETTNSIYFVVDLLNGG----ELLHRVR-- . . . ||.|||..||....| .|...|.| ..|. .. ...... || ||..|.... . ||...|. ..||.| ....|| .| .... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHE--KSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW DKGTI--NEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKSND-HDIVVADFGLATF--TDIKDILFKRCGTPGFVAPEVLLYKEGDPFYDVKC ..|.. |..... |. .|..|...|..||.||||||||.|.... . .. ..||||| . . . . .||||...||||.. |.. |. |. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKV DIFSAGIIFYLLLVGKQPFQGK------DYKQILRANKACEIRYDTPEFDSIS-----------------AQAKDLLKKMLEPKPTNRISASECLNHPFI |..|.|.|.| .| |. ||.|. | .|... .. .....| |. .||| .||..|..|...|. |..| ..|.||.. DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 1303.AA | CDPK | 146-409 | 36 | 3.8e-86 | 264.24 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 146-409 Range on HMM: 1-271/271 Sequence Identity: 36% (101 aa) FIVTKMIGKGSFAKVYLATKK-ENGQQY-AIKAFNKEFMAGQHKGK-ESLVNEIGIMRNLHSEFLINLYEVYETTNSIYFV--VDLLNGGELLHRVRDKG .. | .|||.| |.....| ..|. |.| .| ..| . ... ||| |...| | .||.|. . .|.| .. ||||. .. .|| YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRV--KDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKG TINEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKSNDH----DIVVADFGLATFTDIK-----DILFKRCGTPGFVAPEVLLYKEGDPFYDVK .|.. .. || .|||. . |...|.||||||||.|..||..| .|.| |.|... | . . . .||||| .||||| .. |. | HFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVL---QKK--YNEK CDIFSAGIIFYLLLVGKQPFQGKDYKQILRANKACEIRYDTPEFDSISAQAKDLLKKMLEPKPTNRISASECLNHPFI ||| |.|.| | ||.| || || ..|. . | .. ... ||.|.|| .|||| .|||.. | .|.||...|.|| . CDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | 1303.AA | DCAMKL | 146-409 | 32 | 4.8e-76 | 235.94 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 146-409 Range on HMM: 1-279/279 Sequence Identity: 32% (93 aa) FIVTKMIGKGSFAKVYLATKKENG-QQYAIKA-------------FNKEFMAGQHKGKESLV-NEIGIMRNLHSEFLINLYEVYETTNSIYFVVDLLNGG . . ..||.| || |......|.| ..|| | | .. . |||| .. ||. ||. . . | |||...| ...| | . || YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG ELLHRVRDKGTINEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKS-KSNDHDIVVADFGLATFTDIKD---ILFKRCGTPGFVAPEVLLYKEGDP | .. . . | | . .|..| .||..|| ..| |||.||||||.. . . .|||||. ... |. |||| ||||.| . | DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACH--VNGDFGPLYTVCGTPTYVAPEILM-ETG-- FYDVKCDIFSAGIIFYLLLVGKQPFQGK--DYKQILRANKACEIRYDTPEFDSISAQAKDLLKKMLEPKPTNRISASECLNHPFI | |.|| .||.| | ||.| ||.. | . . ... .. |. | ||..|||| ..||. | | .|.. . || . -YGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV |
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| Kinase | 1303.AA | CAMK-Unique | 146-409 | 22 | 7.3e-75 | 246.53 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 146-409
Range on HMM: 1-363/363
Sequence Identity: 22% (84 aa)
FIVTKMIGKGSFAKVYLATKKENGQQYAIKAFNKEFMAGQHKGKE-----------------SLVNEIGIMRNLHSEFLINLYEV----YETTN------
. . ||.|.| .|| .. .|.| .|.| ..|. .| |.|. .| .|..|.. . . .| ||.. ... .
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQ-THGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL
---------SIYFVVDLLNGGELLHRVRD--------------------KGTINE--QDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKSN----
.| | ....||.|. . . .| .| | ...|. ||||. ..|...| |||||.||..... .
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH
---------DHDIVVADFGLATFTD--IKD-ILFKRCGTPGFVAP--------------EVLLYKEGDPFYDVKC----DIFSAGIIFYLLLVGKQPFQG
...|...||||.. . ... .. ..|||| ..|| ||. . . || .| || | | | |..|.|. || .
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI----NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDC
KDYK--------QILRANKACEI-RYDTPEFDS---ISAQAKDLLKKMLEPKPTNRISASECLNHPFI
. . |... ..... ..|.. ... || .|||..|. .. .| |.||.| | |..|
ECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | 1303.AA | Ciliate-E2-Unclassified | 146-409 | 23 | 3.2e-73 | 249.57 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 146-409
Range on HMM: 1-352/352
Sequence Identity: 23% (83 aa)
FIVTKMIGKGSFAKVYLATKKENGQQY-----AIKAFNKE-----FMAGQHKGKESLVNEIG-------------IMRNLHSEFLINLYEVYETTNSIYF
... | ||.|.|.|||.. .|... || ..|. .. .. ... .. .|.. |..|. ..|....... .... ||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI
VVDLLNGGELLHRVRDKGT-----------------INEQDLR-----NLMRNLLSALYHLHQKG-IMHRDLKPENLLLKSKSNDHDIVVADFGLATFTD
| ....||.|. ..... . || . .... .|..| .||.|. | |||.||||.|.... . | ..|||.. . .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
----------------IKDILFKRCGTPGFV----APEVLLYKEGDPFYD----VKCDIFSAGIIFYLLLVGKQPFQGKDYKQ---------------IL
..... .||||.. ||||| . || ||||.| |.|.| .| |. ||......| .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQ----NYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL
RANK-ACEIRYDTPEF----DSISAQAKDLLK----KMLEPKPTNRISASECLNHPFI
. |. ...| .. .. . .| .|||... |||. .| .||.... ||||..
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 1303.AA | ULK | 146-409 | 27 | 2.1e-72 | 246.86 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 146-409
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)
FIVTKMIGKGSFAKVYLATKKEN----GQQYAIKAFNKE-FMAGQHKG-----KESLVNEIGIMRNLH----SEF----LINLYEVYETT--NSIYFVVD
... ...|||||.||| ...|.. ....|.| |. . .. ...| ||| ||. |. ... . ||...||. | ||....
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME
LLNGGELLHRVRDKGT----------INEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKS---NDHDIV--------VADFGLATFTDIK---
. ||| | . ... ..|| .. .. .|... .||...|.|||.||.| |.. . .. .||||.| . |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK--KVHPNGVLKIADFGFAKHVDNDNME
---DILFK----RCGTPGFVAPEVLLYK-EGDPFYDVKCDIFSAGIIFYLLLVGKQPFQGK--DYK-----QILRANKACE--IRYDTPEFD------SI
.. |||| . ||..| . |. |.|| ||||.| |.||| .|.|| ||.. |.. . .. . .. |. ..|. |
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI
SAQAKDLLKKMLEPKPTNRISASECLNHPFI
| . |||...||. ... ||| | .|||..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
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| Kinase | 1303.AA | ULK | 146-409 | 27 | 2.2e-72 | 246.76 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 146-409
Range on HMM: 1-324/324
Sequence Identity: 27% (90 aa)
FIVTKMIGKGSFA-KVYLATKKEN---GQQYAIKAFNKE-FMAGQHK-----GKESLVNEIGIMRNLH---SEF--LINLYEVYETT--NSIYFVVDLLN
... ...|||||. ||| ...|.. .|..|.| .| . ... ...| ||| ||. |. ... . ||...||. | ||..... |
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN
GGELLHRVRDKGT---------INEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKS---NDHDIV--------VADFGLATFTDIKDILFKRC
|| | . ... ..|| .. .. ..... .||...|.|||.||.|.|.. . .. .||||.| . | . |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK--KVHPNGVLKIADFGFAKHVDNNNMEQQMC
----------GTPGFVAPEVLLYK-EGDPFYDVKCDIFSAGIIFYLLLVGKQPFQGKDYKQIL--RANKACE-------IRYDTPEFD------SISAQA
||| . ||..| . |. |.|| ||||.| |.||| .| || ||.. . . .. |.. .|. || .
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC
KDLLKKMLEPKPTNRISASECLNHPFI
|||...||. ... ||| | .|||..
KDLIRRMLQYDEKDRISWEEIFNHPWF
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| Kinase | 1303.AA | TyrKc | 146-409 | 21 | 1.5e-13 | -3.58 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 146-409
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)
FIVTKMIGKGSFAKVYLATKKENGQQYAIKAFNKEFMAGQHKGKESLVNEIGIMRNL--HSEFLINLYEVYETT-------NSIYFVVDLLNGGELLHRV
|..| | | .||..| | .| |.| ... .| . .|. ||..| | . ...|| | . .. |. . .| |...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL
RDKGT-INEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKSNDHDIV-VADFGLATFTDIK-------DILFKRC--GTPGFV-----APEVLL
|... .. .|| . . . .||.|.. |||| | |.... .| ..||||. . . . | |. |. . . |||..
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN
YKEGDPFYDVKCDIFSAGIIFY-LLLVGKQPFQG-----KDYKQILRANKACEIRYDTPE-----FDSISAQAKDLLKKMLEPKPTNRISASECLNHPFI
|.. . | |..| |. . .. |.|| | .. ..... |. . . |. | .. .. |. . .| .| . ||. | ..
YGK----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 1303.AA | Pkinase_Tyr | 146-295 | 27 | 2.6e-13 | 45.71 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 146-295 Range on HMM: 1-158/270 Sequence Identity: 27% (44 aa) FIVTKMIGKGSFAKVYLATKK----ENGQQYAIKAFNKEFMAGQHKGKESLVNEIGIMRNL-HSEFLINLYEVYE-TTNS--IYFVVDLLNGGELLHRVR . |..|.|.| .||..| | ..... |.| . | | .|.. .|. ||..| | . ...|| | . || |. . .| ||. | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR D----KGTINEQDLRNLMRNLLSALYHLHQKGIMHRDLKPENLLLKSKSNDHDIVVADFGLA . |. .. .|| . . ... .|..|.. |||| | |... .. . ..||||| KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLA |
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