Gene 11147 (Tetrahymena)
11147
Sequence
Protein domains of 11147.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11147.AA | RIO1 | 160-382 | 76 | 2.1e-194 | 652.12 | In-house | 1-225 (225) | Show / Hide |
Range on Protein: 160-382 Range on HMM: 1-225/225 Sequence Identity: 76% (172 aa) QVLDPRTRVILVKLLNKKIINEINGCLSTGKEANVYHASSSNGK--EYAIKIYKTSILVFKDREKYVAGEFRFRKGHCKSNPRKMIKLWAEKEIRNLKRI ||.|||||.|| |.| . || |||||.|||||.||||||..||| |||||||||||||||||||||.||||||.||||.|||||||.|||||.|||||| QVIDPRTRMILFKMLTRGIITEINGCISTGKETNVYHASETNGKRAEYAIKIYKTSILVFKDREKYVDGEFRFRHGHCKHNPRKMIKIWAEKEMRNLKRI YQSSIPCPEPLIVKSNVLMMEFIGKDGKAAPRLKDAENIELEQYSKIYLQLLRDMRTLYQDCRLVHGDLSEYNLLYYNEKLYMIDVSQSIEHDHAHSLEF |||.||||||..|||||||||||||||.|||||||....|..||...|.|....||..||||||||.||||||.||.|.||||||||||.||||.||||| YQSEIPCPEPIMVKSNVLMMEFIGKDGMAAPRLKDYQYKERDQYFHYYHQMIQYMRRMYQDCRLVHADLSEYNMLYHNDKLYMIDVSQSVEHDHPHSLEF LRRDIVNVNMYFKKKNVITFSLRDI ||.|..||||||.|.|||.|..||| LRMDCKNVNMYFMKHNVIIFPVRDI |
|||||||||
| Kinase | 11147.AA | RIO | 158-385 | 44 | 1.7e-154 | 519.55 | In-house | 1-247 (276) | Show / Hide |
Range on Protein: 158-385 Range on HMM: 1-247/276 Sequence Identity: 44% (111 aa) VEQVLDPRTRVILVKLLNKKIINEINGCLSTGKEANVYHASSSNGK-----------EYAIKIYKTSILVFKDREKYVAGEFRFRKGHCKSNPRKMIKLW .||..||.|| |. |..|. .. ....| ..|||...||.|..||. |.||||..|....||||.||..|||.|...|||.|.|.|..|| YEQTNDPYTRMIMYKMVNRGMVESVGNCIGVGKESDIYHCSNENGEDEKEDSKVIPTECAIKIHRTGRTSFKDRKKYRDGEFYFKHRHCKHNWRYMHRLW AEKEIRNLKRIYQSSIPCPEPLIVKSNVLMMEFIGKDGKAAPRLKDAENIELEQYSKIYLQLLRDMRTLYQDCRLVHGDLSEYNLLYYNEKL-------Y ||||.||.||.|||..|||||...|..||.||||..|...||........|.|.....|.|....||.|||.|||||.|..|.|......|. | AEKEMRNMKRLYQSGFPCPEPIDYKRHVLVMEFINHDQMPAPKYPMCQIHEHENMKHVYHQCMCYMRRLYQHCRLVHCDFNEFNMMWHDGKHDENDCGFY MIDVSQSIEHDHAHSLEFLRRDIVNVNMYFKKKNV-ITFSLRDIFDF |||..|..||||.|.|...|||...|||.|.|..| ..|..|..||| MIDFPQMVEHDHPHALWYFRRDCKCVNMFFMKRFVYEPFPEREMFDF |
|||||||||
| RIO | 11147.AA | RIO | 151-388 | 50 | 1e-131 | 444.77 | SMART | 1-253 (253) | Show / Hide |
Range on Protein: 151-388 Range on HMM: 1-253/253 Sequence Identity: 50% (128 aa) DKSDRATVEQVLDPRTRVILVKLLNKKIINEIN--GCLSTGKEANVYHASS----SNGKEYAIKIYKTSILVFKDREKYVAGEFRFRKGHCKSNPRKMIK || |.||.|.|.||||| .| |..|...| ||| ||.|||||||||||.. .||.|.|.|||.||...||....|. |.|||..| ...|.|||.. DKEDYATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGGDFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHGYHHINWRKMVR LWAEKEIRNLKRIYQSSIPCPEPLIVKSNVLMMEFIGKDGKAAPRLKDAENIELEQYS--KIYLQLLRDMRTLYQDCRLVHGDLSEYNLLYY------NE |||||| |||.|.|.. .|||.| .. .|| |||||.||..||||||.|..| | . ..| |....|| .|. |.|||.||||||.|| .. LWAEKEFRNLQRMYEAGVPCPKPIAWRRHVLVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHDLEDENDC KLYMIDVSQSIEHDHAHSLEFLRRDIVNVNMYFKKKNVITFS-LRDIFDFITD |...||.|||.|.|| ..||||.||| |.. .|..|.| ... |.||..||. KVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG |
|||||||||
| Kinase | 11147.AA | RIO1 | 193-382 | 49 | 1.3e-108 | 339.14 | Pfam | 1-200 (200) | Show / Hide |
Range on Protein: 193-382 Range on HMM: 1-200/200 Sequence Identity: 49% (98 aa) NVYHASS-SNGK-EYAIKIYKTSILVFKDREKYVAGEFRFRKGHCKSNPRKMIKLWAEKEIRNLKRIYQSSIPCPEPLIVKSNVLMMEFIG-KDGKAAPR ||||| | ..|| |.|.|||.|....||....|. ..|||| . ...|.|.|...||||| |||||.|. .|||.| .. .|| ||||| ||| .||| NVYHAYSMEDGKDECAVKIYRTGTTCFKKMKRYRDYDFRFRHRYHHHNWRYMVRMWAEKEFRNLKRMYEAGVPCPKPIDWNRHVLVMEFIGDKDGWPAPR LKDAE-NIE--LEQYSKIYLQLLR-DMRTLYQDCRLVHGDLSEYNLLYYNE-KLYMIDVSQSIEHDHAHSLEFLRRDIVNVNMYFKKKNVI--TFSLRDI |||.| ..| |. . || ...| || .||.|.||||||||||.|.. . |...||..|. |||| |.||||.||. |.. .|..| | ... |.| LKDVEMELELSEEEAEEIYDEIIREYMRRMYQECGLVHGDLSEYNILVHDDGKPWIIDWPQAVEHDHPHALEFLERDCRNIINFFRRKGVDERVMDFREI |
|||||||||
| Kinase | 11147.AA | RIO3 | 155-397 | 41 | 7.2e-71 | 238.1 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 155-397 Range on HMM: 1-254/254 Sequence Identity: 41% (107 aa) RATVEQVLDPRTRVILVKLLNKKIINEINGCLSTGKEANVYHAS----------SSNGK-EYAIKIYKTSILVFKDREKYVAGEFRFRKGHCKSNPRKMI .| |. .||.||... |..| ... | ||..||||. |.|| | . |||..||.. ||.|.||. .|||. | ||||. HSTAEKAVDPKTRLLMYKMVNSGMLETITGCIATGKESVVFHAYGGSMEDEKEDSKVIPTICAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIH KLWAEKEIRNLKRIYQSSIPCPEPLIVKSNVLMMEFIGKDGKAAPRLKDAENIELEQYSKIYLQLLRDMRTLYQDCRLVHGDLSEYNLLYYNEKLYMIDV ..|||||. || |. .. |||| ...| .|.| |||.| ||.||. .. |. . | | | || || .| ||| ||||||.|.. |...||| RMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVK-LNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDV SQSIEHDHAHSLEFLRRDIVNVNMYFKKKNVI-TFSLRDIFDFITDINIVPGTEA |||.| | | |||| || || .|.| | ..| |..|. .. .|| || SQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEA |
|||||||||
| Kinase | 11147.AA | Ciliate-C1 | 181-219 | 26 | 2e-05 | 9.46 | In-house | 2-46 (328) | Show / Hide |
Range on Protein: 181-219 Range on HMM: 2-46/328 Sequence Identity: 26% (12 aa) EINGCLSTGKEANVYHASSSNGK-EYAIKIYKT-----SILVFKD .| . .|. . | .. |.. ||.|. | | ||| KIMKTIGHGYTCKVFYCKMPNNQKVYAVKQFKNEYTSQQQLTFKD |
|||||||||
| Kinase | 11147.AA | Jak | 318-362 | 23 | 0.0008 | 9.59 | In-house | 136-186 (299) | Show / Hide |
Range on Protein: 318-362 Range on HMM: 136-186/299 Sequence Identity: 23% (12 aa) DCRLVHGDLSEYNLLYYNEKLY------MIDVSQSIEHDHAHSLEFLRRDI |.|..|||.. |.|. .|.. ....... |.....|.. ||. DKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDE |
|||||||||