Gene 20618 (Tetrahymena)

20618

Species: Tetrahymena
Alias: 20618, 532, PreTt20618, TTHERM_00147600, 12.m00292, 3700.m00015
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
20618.AA Protein None 2540 None Fasta, JSON
20618.kin_dom Protein Kinase Domain None 251 None Fasta, JSON
20618.NA RNA None 7623 None Fasta, JSON

Protein domain

Protein domains of 20618.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 20618.AA HEAT 44-74 19 17.288273 2.09 Pfam 1-31 (31) Show / Hide 
Range on Protein: 44-74
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

IYHGLIKLINSNDINEKYNSLIGIEQISYVV
|   |.|..|..| . .....  . |.. ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 20618.AA HEAT 178-204 22 10.71377 2.81 Pfam 5-31 (31) Show / Hide 
Range on Protein: 178-204
Range on HMM: 5-31/31
Sequence Identity: 22% (6 aa)

LWNLIKHKTTLLREAALSFFDVLLKQI
| ......    ||||.. . .|....
LLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 20618.AA HEAT 270-291 13 5.191123 3.9 Pfam 10-31 (31) Show / Hide 
Range on Protein: 270-291
Range on HMM: 10-31/31
Sequence Identity: 13% (3 aa)

KDENSNIQKTVIEALPALAKFK
.|............| .|... 
NDPDWEVREAACWCLGQLCEHC
HEAT 20618.AA HEAT 516-538 21 5.122556 3.92 Pfam 1-23 (31) Show / Hide 
Range on Protein: 516-538
Range on HMM: 1-23/31
Sequence Identity: 21% (5 aa)

VKDNVLDYLDNKNKNIRKAAAKA
. . .|  |. .. ..|.||...
ILPHLLKCLNDPDWEVREAACWC
HEAT 20618.AA HEAT 560-586 22 10.226708 2.88 Pfam 1-26 (31) Show / Hide 
Range on Protein: 560-586
Range on HMM: 1-26/31
Sequence Identity: 22% (6 aa)

ILEKFMSVAISDSEDEIRQTMLKSLNE
||. ..  ...|...|.|.. ...| .
ILPHLL-KCLNDPDWEVREAACWCLGQ
HEAT 20618.AA HEAT 597-627 25 2.416588 5.05 Pfam 1-31 (31) Show / Hide 
Range on Protein: 597-627
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

YLKKLFLCVNDSNTQVQQLVLTILCRLSRYN
 |  |. | ||.. .|.. ..  |..|... 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 20618.AA HEAT 725-756 28 6.4e-05 20.89 Pfam 1-31 (31) Show / Hide 
Range on Protein: 725-756
Range on HMM: 1-31/31
Sequence Identity: 28% (9 aa)

IFPIFLQAMQDKSSTAKREAAVKSLVDILKYT
|.|..|....|. .   ||||...|...... 
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
DUF3385 20618.AA DUF3385 721-757 23 13.924831 0.34 Pfam 145-181 (181) Show / Hide 
Range on Protein: 721-757
Range on HMM: 145-181/181
Sequence Identity: 23% (9 aa)

YMDEIFPIFLQAMQDKSST-AKREAAVKSLVDILKYTG
....| | |||.|.  ...  .||    .|... .. .
FLPQIIPPFLQVMR-TCPPCSLREFYFQQLCTLVSIVK
DUF3385 20618.AA DUF3385 759-800 37 1.4e-13 49.62 Pfam 1-43 (181) Show / Hide 
Range on Protein: 759-800
Range on HMM: 1-43/181
Sequence Identity: 37% (16 aa)

VVLPYYKYPSFLEIILSLMKNE-VNVEMRQQCMRLIGCLGAID
|. |||.||. |...... |.|  | ..|. .....| |||.|
VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALD
HEAT 20618.AA HEAT 769-800 18 22.40199 1.7 Pfam 1-31 (31) Show / Hide 
Range on Protein: 769-800
Range on HMM: 1-31/31
Sequence Identity: 18% (6 aa)

FLEIILSLMKNEVNVEMRQQCMRLIGCLGAID
.|...|.... . . | |... . .| |  . 
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
DUF3385 20618.AA DUF3385 947-1006 28 2.4e-09 34.69 Pfam 91-159 (181) Show / Hide 
Range on Protein: 947-1006
Range on HMM: 91-159/181
Sequence Identity: 28% (20 aa)

EDYYSKITIKALLK-ILCDQSLNEHHS-LAVQTL----SCII--GVLQTRT-KNFLDLLIPIFIKIVRQ
..||. . |..|.. || |.|| .||.  .||.       |.   ..  .    ||.  || |.. .|.
DEYYPTVVINSLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRT
FAT 20618.AA FAT 1510-1604 28 3.1e-22 74.7 Pfam 1-118 (408) Show / Hide 
Range on Protein: 1510-1604
Range on HMM: 1-118/408
Sequence Identity: 28% (34 aa)

MHLAANAAMNLGNWEL--LENFCDNLP-----------EENSQ-----DKQFWQAAISI--SKGQYE--EAKNLISESINKLDSQVSG-LLLESYSRAYE
  |||.|| .||.|..  .........            |.|.     |..| ||  ..   ..|..  ||. .|.. .. ||   .  |  ||| |.| 
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

SILRLQQLFEMQEIIDIK
 . |.|.| |..||| .|
VMVRVQMLAELEEIIQYK
FAT 20618.AA FAT 1624-1697 28 3.1e-18 61.3 Pfam 120-216 (408) Show / Hide 
Range on Protein: 1624-1697
Range on HMM: 120-216/408
Sequence Identity: 28% (28 aa)

QDAEI--------EQKRKQLRDIWADRLYGN-PKDIDTWQKILSVRQLYLS--------------KKDDLNTWLKFCRLALKNNQMHICKKTLEELY
|...         ..|.|..|. | .|| |   .... || ||..||...|              ...|...|.|| .|. |...|  |.||| .||
QCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLY
FAT 20618.AA FAT 1733-1853 24 2e-14 48.52 Pfam 280-408 (408) Show / Hide 
Range on Protein: 1733-1853
Range on HMM: 280-408/408
Sequence Identity: 24% (34 aa)

KMEEILQSE-NKIDNKLTA-KMYLKMGNWIRDK---T-DELNSFNMKKIGEFYQKAKDFKPDYYK-TWHHFGLLNFDAINMKQ--------DDTII-EQK
..|.| ..  ..  .|| | . |.| | | .     . ...|  . . | . |..|  | |. ||  ||. .| || .... |        .   . .. 
NLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN---YTHMI

RVYIKNALEGFMRSITLGTSSEHKSPYILQDSLRLLS
  .. .|...| .|| |. .       ..|| ||||.
IQHVVPAVKCFFHSIALSQG-----SNSRQDTLRLLW
Rapamycin_bind 20618.AA Rapamycin_bind 1960-2060 44 6.5e-41 130.95 Pfam 1-100 (100) Show / Hide 
Range on Protein: 1960-2060
Range on HMM: 1-100/100
Sequence Identity: 44% (45 aa)

ELNRTAILIKEQWLEGIKEAWERYTIDKGAHTHLIKILQGLHEMMKVPPESLSEISFHQNFGGEIFEAESWLERYKITEDAICLCQAFDIYYRIYSKLDV
|| |.|||  |.| ||. ||.  |  |. .. .  .||. ||||.. .||...||||.| || .  || .|...|| |.|  ||.||.||||... ... 
ELIRVAILWHEMWHEGLEEASRQYFGDHNIE-KMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRK

Q
|
Q
Kinase 20618.AA FRAP 2127-2377 86 2.2e-217 728.48 In-house 1-251 (251) Show / Hide 
Range on Protein: 2127-2377
Range on HMM: 1-251/251
Sequence Identity: 86% (217 aa)

EYHFLLKGREDIRQDERVMQLFALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGWVHNCDTLQVLIREYRKAYHIRENPEYNLMEQKCSNYSVLPL
||||||||.|||||||||||||.||||||||||||.||.|.||||||||||.||||.||||.||||..|||.|||.||||.|.|||.|...|..|..|||
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL

PNKVEIFRYIMENTKGEELKKILWLKSPNSEIWLERRTNYTRSLATMSIAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKVPFRLT
.||||||||||.|||||.|||.|||||||||||.||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||.|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMLVNAMEACQIEGNYRNTCELVLKVIRENKESLIAVLEAFVYDPLFYWRL
||||||||||.||||||||||||.|||||.|||..||||||||||||||||
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 20618.AA PIKK 2098-2367 46 3.8e-159 535.01 In-house 1-290 (290) Show / Hide 
Range on Protein: 2098-2367
Range on HMM: 1-290/290
Sequence Identity: 46% (136 aa)

KISCFQPKLEVLFSKMNPRKLFVYGSDSKEYHFLLKGREDIRQDERVMQLFALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGWVHNCDTLQVLIR
 |  . . ..|. .|  |.|.   |.| |||..|.||.||.|||.|||||| |.|..|...||..|..|.|..||.||.| ..||..||.||.||. ...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYRKAYHIRENPE--------------------YNLMEQKCSNYSVLPLPNKVEIFRYIMENTKGEELKKILWLKSPNSEIWLERRTNYTRSLATMSIAG
......|||...|                    ...|.|.| .|. .|| .|||.||..|.||... .||..|.|.|..|||.|||.|||||.|.|...|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKVPFRLTRMLVNAMEACQIEGNYRNTCELVLKVIRENKESLIAVLEAF
||||||||||.|||....||.|||||||.|||.||.|...||||||||||..||||.....||..|..|| |....|...|.|..|.|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 20618.AA PI3_PI4_kinase 2127-2377 27 2.4e-85 294.63 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2127-2377
Range on HMM: 1-300/300
Sequence Identity: 27% (85 aa)

EYHFLLKGREDIR--QDERVMQLF-----------------------ALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGWVHNCDTLQVLIREYR-
.|.|..|| .| |  ||.|.||..                        |.|... .. .. ......| |..||.. . |...||.||.|.. ..|.|. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

----------KAYHIRENPEYNLMEQKCSNYSVLPLPNKVEIFRYIMENTKGEELKKILWLKSPNS-EIWLERRTNYTRSLATMSIAGYILGLGDRHPSN
          . . .. .|..   .          . .|||.|.. . .|... | . .| ..|.  |.|.|.|.|..||.| |....||||.||||..|
KCKHKHFNKEHKMWMKMWPDWWHLM----------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDN

IML--QRYTGKIVHIDFGDCFE-VAMRREKFPEKVPFRLTR------MLVNAM------EACQIEGNYRNTCELVLKVIRENKESLIAVL-------EAF
||.   . ||...|||||.||. ..| ....||.||||.|.      ..|.||      .  . .| .| .|. .. ..|.........|       |..
IMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECM

VYDPLFYWRL
|.|.|. || 
VHDGLPMWRS
Kinase 20618.AA PI3Kc 2129-2450 24 1.1e-83 285.23 SMART 1-336 (336) Show / Hide 
Range on Protein: 2129-2450
Range on HMM: 1-336/336
Sequence Identity: 24% (89 aa)

HFLLKGREDIRQDERVMQLFALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGWVHNCDTLQVLIREYRK------AYHIRE---------------
....|...| |||.|.||.| |.|...... |. . || ...|..||.. ..|...|| ||.||  . ..|.|      .||..                
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

NPEYNLMEQKCSNYSVLPLPNKVEIFRYIMENTKGEELKKILWLKSPNS-EIWLERRTNYTRSLATMSIAGYILGLGDRHPSNIMLQRYTGKIVHIDFGD
...    ....  |  . . .... |.    ..|.. |.. .| ..|.. |.| |.|.|.|||.| .....||||.||||..|||| . ||...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEVAMRREKFP----EKVPFRLTRMLVNAME----ACQIEGNYRNTCELVLKVIRENKESLIAVLEAFVYDPL-FYWRLITISGEEQGDKANEKKEKGD
.|. ......|.    |.||||||...|..|.      . .|..| .|. .....|..........|..||||. . ||                     
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-------------------

AVYQANKKRESRPQSLLE-VSMVNQVSYVGS-----IIQQGTSQAIQKYIKKAQKSKIN
     ....  | .  |. .|  .   |.       .|.   .  . ...  ... . .
----EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 20618.AA ATR 2097-2367 29 9.5e-53 177.88 In-house 1-267 (267) Show / Hide 
Range on Protein: 2097-2367
Range on HMM: 1-267/267
Sequence Identity: 29% (80 aa)

VKISCFQPKLEVLFSKMNPRKLFVYGSDSKEYHFLLKGREDIRQDERVMQLFALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGWVHNCDTLQVLI
  |. |.  .|.| |   |.|. . ||| | |  . | ..|.|.| | |.   |||...    |  .. .... |..|||  . ... || |  ||. ..
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

REYRKAYHIRENPEYNLMEQKCSNYSVLPLPNKVEIFRYIMENTKGEELKKILWLKSPNSEIWLERRTNYTRSLATMSIAGYILGLGDRHPSNIMLQRYT
 .  |   ..    |.|  ..|.      . .|  .|| ..   .    .     . | .. |   | || || | ... |||.||||||  ||.... .
DKLWKEKKQYMQ-FYQL--RQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

GKIVHIDFGDCFEVAMRREKFPEKVPFRLTRMLVNAMEACQIEGNYRNTCELVLKVIRENKESLIAVLEAF
| .||.|.   |    . |  || ||||||. .|..| . . .| .|  || .....|.... ...|...|
GECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 20618.AA ATM 2258-2375 49 8.7e-40 124.55 In-house 132-248 (304) Show / Hide 
Range on Protein: 2258-2375
Range on HMM: 132-248/304
Sequence Identity: 49% (58 aa)

IWLERRTNYTRSLATMSIAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKVPFRLTRMLVNAMEACQIEGNYRNTCELVLKVIRENK
|| |.|  |||| || || ||||||||||  ||..      .|||| |  ||   .    || ||||||| .|  |    .|| .|  ||  . |.|  .
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

ESLIAVLEAFVYDPLFYW
| |. . |  .||||| |
ETLLTIVEVLLYDPLFDW
Kinase 20618.AA DNAPK 2097-2192 35 2.2e-20 70.78 In-house 2-97 (301) Show / Hide 
Range on Protein: 2097-2192
Range on HMM: 2-97/301
Sequence Identity: 35% (34 aa)

VKISCFQPKLEVLFSKMNPRKLFVYGSDSKEYHFLLKGREDIRQDERVMQLFALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGWVHNCDTL
|.|  |  .  |. |   |... . | | .|  |. || || ||| |. |||   |  .   |    ..|.   |.|||.    ||. || |  .|
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL
Kinase 20618.AA DNAPK 2257-2377 34 1.4e-19 67.84 In-house 181-301 (301) Show / Hide 
Range on Protein: 2257-2377
Range on HMM: 181-301/301
Sequence Identity: 34% (42 aa)

EIWLERRTNYTRSLATMSIAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKVPFRLTRMLVNAMEACQIEGNYRNTCELVLKVIREN
| .|  |  . |. |   | ..||| ||||  | |    .| |. ||||  |  |      ||  ||||||  .| |    | | ..      .. .|  
ETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKD

KESLIAVLEAFVYDPLFYWRL
.  |.   . |. ||.| |  
RNILTNFCDVFINDPSFDWKN
Kinase 20618.AA SMG1 2106-2186 37 1.6e-16 51.08 In-house 1-81 (242) Show / Hide 
Range on Protein: 2106-2186
Range on HMM: 1-81/242
Sequence Identity: 37% (30 aa)

LEVLFSKMNPRKLFVYGSDSKEYHFLLKGREDIRQDERVMQLFALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGWV
. .|  |  |.||   ||| | | .| || ||.  |||.||  ...| .       |        ||. ||    ||. ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV
Kinase 20618.AA SMG1 2236-2309 44 1.7e-15 47.65 In-house 160-233 (242) Show / Hide 
Range on Protein: 2236-2309
Range on HMM: 160-233/242
Sequence Identity: 44% (33 aa)

IMENTKGEELKKILWLKSPNSEIWLERRTNYTRSLATMSIAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFE
.|| |    | | ||      . |      | || | ||. |||.||||||  |...   || .||||.  |||
LMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase 20618.AA ATM 2131-2185 47 2.8e-15 44.89 In-house 3-57 (304) Show / Hide 
Range on Protein: 2131-2185
Range on HMM: 3-57/304
Sequence Identity: 47% (26 aa)

LLKGREDIRQDERVMQLFALINRLLHNNPETEKKDLNIQRYSIIPLSINTGLLGW
| |||.|.|||  . | | . | ||  | || |. | |  | ..|||   | | |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
FATC 20618.AA FATC 2508-2540 57 3.4e-20 67.74 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2508-2540
Range on HMM: 1-33/33
Sequence Identity: 57% (19 aa)

ESLTYTEQVSKLINQATSHENICQAYIGWCPFW
|.|. ..||..||..||..||.||.||||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW