Gene 13773 (Tetrahymena)

13773

Species: Tetrahymena
Alias: 13773, 17.m00380, 865, PreTt13773, TTHERM_00203010
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
13773.AA Protein None 4351 None Fasta, JSON
13773.kin_dom Protein Kinase Domain None 265 None Fasta, JSON
13773.NA RNA None 13056 None Fasta, JSON

Protein domain

Protein domains of 13773.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 13773.AA HEAT 259-289 25 0.003149 15.04 Pfam 1-31 (31) Show / Hide 
Range on Protein: 259-289
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

IIDKVLGLISHNNRDVKENASDCLESLMALL
|.. .| ...... .|.|.|  || .|.  .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 13773.AA HEAT 414-444 16 58.27594 0.26 Pfam 1-31 (31) Show / Hide 
Range on Protein: 414-444
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

IISQLDKLYEDESQSLLRLCMVGFKQFSSFY
|.. | |. .|.. .  . .   ..|.....
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 13773.AA HEAT 738-750 30 55.263854 0.34 Pfam 19-31 (31) Show / Hide 
Range on Protein: 738-750
Range on HMM: 19-31/31
Sequence Identity: 30% (4 aa)

AAIECLQKIIKRS
||..|| .... .
AACWCLGQLCEHC
HEAT 13773.AA HEAT 888-918 19 0.019737 12.28 Pfam 1-31 (31) Show / Hide 
Range on Protein: 888-918
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

LLPRMVELTLNPDDKIKVYACEAIHAITIYM
.|| ....   ||....  ||... ..  ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 13773.AA HEAT 998-1029 25 0.010355 13.25 Pfam 1-31 (31) Show / Hide 
Range on Protein: 998-1029
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LLDNIMNFISSKDNNNLRELAANCLGQFIKWT
.|. ... .... . . || |..||||...  
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
HEAT 13773.AA HEAT 1048-1078 19 44.101823 0.68 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1048-1078
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

ALRRIISFSGQPDLSKRFGALLALKEVVNNI
 |  ...    || . |  |. .|.... ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
NUC194 13773.AA NUC194 1814-1853 28 0.13108 5.96 Pfam 68-117 (446) Show / Hide 
Range on Protein: 1814-1853
Range on HMM: 68-117/446
Sequence Identity: 28% (14 aa)

ESLYKALSLDKIKD---DVHKKLYPDTTQ-------GNELTKSLIKIAFE
| .|  |. | |.     . . .|.           |||||| |.| ...
EVMYSRLPKDEIHSDDCCINQAYYGSDHTTLGAPIEGNELTKALMKSCHD
NUC194 13773.AA NUC194 1885-1941 32 1.2e-05 20.06 Pfam 137-198 (446) Show / Hide 
Range on Protein: 1885-1941
Range on HMM: 137-198/446
Sequence Identity: 32% (20 aa)

RLFSCAVYNCLSQIITKTQNKENILNQFLFQ---QKNDHLWDLLIDGTQKE--FNFEIETNF
|.. || ||||  .|  |.....  . |||     ||  .|. ||| ....   .|..|...
RKYHCAAYNCLIALISCTFTELKFYHVFLFRENPEKNEYIWENLIDCDRCYLYDEFPQEIEV
NUC194 13773.AA NUC194 2034-2144 24 4.2e-08 28.59 Pfam 286-428 (446) Show / Hide 
Range on Protein: 2034-2144
Range on HMM: 286-428/446
Sequence Identity: 24% (35 aa)

QTGEN----------LEMDLINRHPCMPTVLTNID------KM---V-----QQFPLTE----AMPQWMTNLLEEVKKDSCSLGQKIFIIKIVLNKPLLF
...|.          |||| ||.|.|| |... |.      .    |     .|  .       || ||  |       . .|   .||.|.. | .  |
EIAEDMSMTQDDVMELEMDEINQHECMATMCGCIKFHMHRNNITPKVSILFGDQGAQPKPTVGDMPPWMKFLHQKLGNQQQHLNIRLFIAKVIINCEQWF

EKYSQQWFDVLVDYAK----LNDNGSKFFHYFLRDVTTTLIDW
. |  .|   | ...       .||    ||. .|.  |.  |
RPYAKFWIGPLMQLIVKLIECDGNGGRGLHYMVVDICVTILSW
Kinase 13773.AA DNAPK 3915-4210 66 5.2e-236 790.34 In-house 1-301 (301) Show / Hide 
Range on Protein: 3915-4210
Range on HMM: 1-301/301
Sequence Identity: 66% (201 aa)

HIKIQSFDSQILTLQSIRRPKRLCIYGSDEK----CYKGIEDLRLDQRIEQLFQVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEWVDKTSVLKEI
|..|  ||  .  . |.|||||. | | ||.    |||||||||.||||||||||||||||||||||..||.|.|.|||||||.|||.||||.|.|||.|
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI

LNKEFQEKMGSKEDIAQDNEGLRMRREWLKQLDRKGGLAEQHIKLQLEPSDKIEQAFNEQADLIPRDVFRNALERLASTCETYLYLKERFIRNYAVVCVS
||.|.|.|||.||.|.||.|...|.|.||||.|||...||.||..|.|..|||.|.|..|.|.|||||||.|..|...||||||||.|.|||||||.|.|
LNNEMQQKMGKKEYISQDREPPCMYRDWLKQMDRKHDVAEYHIMYQGENRDKIVQSFRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICIS

GYILGIGDRHLENFLVNYSNGDIVSIDFGYSFG-AGLGLAVPELMPFRLTRCFTNLMSPIGINGIFRQSMISSMMALKKKRNILLEFCEVFINDPLVDWV
..|||||||||.||.||..||||.|||||.||| |...|.|||||||||||||.|||||..||||..|.||.||||..|.||||..||.||||||..||.
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

K
.
N
Kinase 13773.AA PIKK 3917-4200 40 1.4e-156 526.53 In-house 1-290 (290) Show / Hide 
Range on Protein: 3917-4200
Range on HMM: 1-290/290
Sequence Identity: 40% (117 aa)

KIQSFDSQILTLQSIRRPKRLCIYGSDEK----CYKGIEDLRLDQRIEQLFQVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEWVDKTSVLKEILN
 |...|  .  . . ..||.. | |.|.|    ..||.||||.|||..||||.||.....||.||...|...|...|||....||.||||....||||..
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

KEFQEKMGSKEDIAQDNEGLRMRREWLKQLD-RKGGLAEQHIKLQLEPSDKIEQAFNEQADLIPRDVFRNALERLASTCETYLYLKERFIRNYAVVCVSG
...|.|....|..||.|....|.|.||||.. .|.....|....|..|.......|.||.. .|.|.|.....| ....|......|...|.|||.|..|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGIGDRHLENFLVNYSNGDIVSIDFGYSFG-AGLGLAVPELMPFRLTRCFTNLMSPIGINGIFRQSMISSMMALKKKRNILLEFCEVF
||||.||||.||.......|.||.||||..|. |. .|.|||..||||||...|.|.|.|..|.||......||.....|..|...||||
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 13773.AA PI3Kc 3947-4263 22 4.5e-47 163.63 SMART 4-336 (336) Show / Hide 
Range on Protein: 3947-4263
Range on HMM: 4-336/336
Sequence Identity: 22% (77 aa)

YKGIEDLRLDQRIEQLFQVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEWVDKTSVLKEILNKEFQEKM----------GSKEDIAQDNEGLRMRR
.|. .||| |.|. |.|..||.|   | .|.   | . ....||.    |..|||  .  | .|..|   .|.            ..  ..     .|  
FKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ-K-NM--

EWLKQLDRKGGLAEQHIKLQLEPSDKIEQAFNEQADLIPRDVFRNALERLASTC-ETYLYLKERFIRNYAVVCVSGYILGIGDRHLENFLVNYSNGDIVS
     ....  .   ..  | . ... .. | .... .. .|... . .   .  | .   ...|.| .|. |. .|||||||||..|...   .| .. 
--Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFH

IDFGYSFGAGLGLAVP-----ELMPFRLTRCFTNLMS----PIGINGIFRQSMISSMMALKKKRNILLEFCEVFINDPL-VDWVKLTKDKKMGTIMFSEN
||||. || | .. ..     |..|||||. . ..|.    | |  | ||. . . ..|..| .| ..  .|....||.  .| .  ||.|.  . | ..
IDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLD

IGHLDSTKTYNAEQ----SQSQQQYGLSTMEASQIADLMIHM
  . |   .  ..|       .   .  |... ...... ..
H-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 13773.AA PI3_PI4_kinase 3946-4210 21 6.1e-46 163.75 Pfam 1-300 (300) Show / Hide 
Range on Protein: 3946-4210
Range on HMM: 1-300/300
Sequence Identity: 21% (67 aa)

CY----KGIEDLR--LDQRIEQLF-----------------------QVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEWVDKTSVLKEILNKEFQ
 |    || .|||   |.|..|..                       ..||..   |  .  ..... .. .||.    |..|||. .  ..||  ... 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEI-PRTYM

EKMGSKEDIAQDNEGLRMRREWLKQLDRKGGLAEQHIKLQLEPSDKIEQAFNEQADLIPRDVFRNALERLASTC-ETYLYLKERFIRNYAVVCVSGYILG
.| ..| .  ...  ..|. .|.  .                   . .. |.... . |...... . .   .. |...  ...|.| .|. || .||||
VKCKHKHFNKEHKMWMKMWPDWWHLM-----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILG

IGDRHLENFLV--NYSNGDIVSIDFGYSFG--AGLGLAVPELMPFRLTR------CFTNLM------SPIGINGIFRQSMISSMMALKKKRNILLEFC--
.||||..|..|  . ..| .. ||||..|.  .. .. .||..|||.|.       . ..|       |.|  | ||... . . || .  |... .   
NGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKK

-----EVFINDPLVDWVK
     | .. |.|..| .
AVMRGECMVHDGLPMWRS
Kinase 13773.AA ATR 4097-4200 37 4.5e-33 109.75 In-house 164-267 (267) Show / Hide 
Range on Protein: 4097-4200
Range on HMM: 164-267/267
Sequence Identity: 37% (39 aa)

KERFIRNYAVVCVSGYILGIGDRHLENFLVNYSNGDIVSIDFGYSFGAGLGLAVPELMPFRLTRCFTNLMSPIGINGIFRQSMISSMMALKKKRNILLEF
.| ..| |||.|. |||.|.|||| .| |..  ||..| .|.   |. |  . |||..|||||.   . | |.. .|.||. ..  || ....|. .. .
RENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSV

CEVF
 . |
WDCF
Kinase 13773.AA ATM 4100-4208 40 4e-25 76.87 In-house 140-248 (304) Show / Hide 
Range on Protein: 4100-4208
Range on HMM: 140-248/304
Sequence Identity: 40% (44 aa)

FIRNYAVVCVSGYILGIGDRHLENFLVNYSNGDIVSIDFGYSFGAGLGLAVPELMPFRLTRCFTNLMSPIGINGIFRQSMISSMMALKKKRNILLEFCEV
. |  |   . |||||.||||  | |.|    ..| || |  |  |  |  || .||||||     |   |. |.||      |  ..     ||   ||
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEV

FINDPLVDW
 . ||| ||
LLYDPLFDW
Kinase 13773.AA FRAP 4102-4210 37 2.9e-20 71.22 In-house 142-251 (251) Show / Hide 
Range on Protein: 4102-4210
Range on HMM: 142-251/251
Sequence Identity: 37% (41 aa)

RNYAVVCVSGYILGIGDRHLENFLVNYSNGDIVSIDFGYSFGAGLGL-AVPELMPFRLTRCFTNLMSPIGINGIFRQSMISSMMALKKKRNILLEFCEVF
|  |.  . |||||.||||. | . .   | || ||||  |   .     ||. ||||||  .| |   ||.| .|      |  .. ... ..   | |
RSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAF

INDPLVDWVK
. |||  |  
VYDPLFYWRL
Kinase 13773.AA ATR 3917-4018 31 1.3e-17 56.24 In-house 2-107 (267) Show / Hide 
Range on Protein: 3917-4018
Range on HMM: 2-107/267
Sequence Identity: 31% (33 aa)

KIQSFDSQILTLQSIRRPKRLCIYGSDEKCY----KGIEDLRLDQRIEQLFQVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEWVDKTSVLKEILN
 |  ||  .  | |...||.. . ||| | |    |  .||| | |  .  ...| .   | . . ..... |. .||. .  ...|||. |  |. ||.
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

KEFQEK
| ..||
KLWKEK
Kinase 13773.AA SMG1 4100-4152 45 3e-12 36.71 In-house 190-242 (242) Show / Hide 
Range on Protein: 4100-4152
Range on HMM: 190-242/242
Sequence Identity: 45% (24 aa)

FIRNYAVVCVSGYILGIGDRHLENFLVNYSNGDIVSIDFGYSFGAGLGLAVPE
. |  ||. . |||.|.|||||.| |.    |..| ||.   |  |  | |||
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase 13773.AA FRAP 3947-4025 34 3.4e-11 37.5 In-house 6-83 (251) Show / Hide 
Range on Protein: 3947-4025
Range on HMM: 6-83/251
Sequence Identity: 34% (27 aa)

YKGIEDLRLDQRIEQLFQVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEWVDKTSVLKEILNKEFQEKMGSKEDI
 || ||.| | |. |||  .| . . .|. | |.|..  . |||.    ||. || .   |. || ... .|   ...|
LKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLH-ILIRDYRKKYHIRYNI
Kinase 13773.AA SMG1 3925-4002 34 7.8e-09 25.24 In-house 1-82 (242) Show / Hide 
Range on Protein: 3925-4002
Range on HMM: 1-82/242
Sequence Identity: 34% (28 aa)

ILTLQSIRRPKRLCIYGSDEKCY----KGIEDLRLDQRIEQLFQVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEWVD
|  |    .||.|   ||| | |    ||.||| || || |   ..| .|               . . |.    ||. |||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
Kinase 13773.AA ATM 3945-4000 30 8.2e-07 17.36 In-house 2-57 (304) Show / Hide 
Range on Protein: 3945-4000
Range on HMM: 2-57/304
Sequence Identity: 30% (17 aa)

KCYKGIEDLRLDQRIEQLFQVMNNIFEYDPQCQSKELNLSTFNIIPMTNILGLLEW
.  || .||| |  . | ||. | .         . | . |. ..|.    | |||
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
FATC 13773.AA FATC 4319-4351 42 2.2e-11 39.52 Pfam 1-33 (33) Show / Hide 
Range on Protein: 4319-4351
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

QFLEVHEQVDCLIDLAVDPNIIGRVWIGWAPII
. | |..|||.||. |.||. . . .|||.|  
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW