Gene 29569 (Tetrahymena)
29569
Sequence
Protein domains of 29569.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 29569.AA | ATR | 1770-2027 | 53 | 6.4e-148 | 497.72 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 1770-2027 Range on HMM: 1-267/267 Sequence Identity: 53% (142 aa) VYMEKFDDVVRIMSSKQKPKLLTVQCSDGTKKKFLIKSQTQ-SENVYEQRTSELISFLNLILYKEQLGFYEMPSYTILRLNSQSCIVEWVDDTLTLKTIL |. |||.| |..| |||| .... ||| . | . . . |.|..|||.|.|...|.|...||.|..|....||.|.||.|||..|.||..|| AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL DQLWQEKKQKSQFYQLKLDSDKLSREEWNKQKSL--------PSVFQDFFNQRFLDSQQWYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEI |.||.||||..|||||....||.|||||.|||.. |..|.|.||.||.|.||||...|||.|.||.||..||.|||||||||||||.|||||. DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGEC VHIDYALIFGSGKQLNVPETIPFRLTKNMEFALGSFKSYGLFRKAMIDICMCFSKHLDDIIGFWDCF ||.||..||.||.|..|||..|||||.||.|..|..|.|||||.|...|.||...|.|||...|||| VHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
|||||||||
| Kinase | 29569.AA | PIKK | 1771-2027 | 30 | 1.2e-107 | 363.92 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1771-2027 Range on HMM: 1-290/290 Sequence Identity: 30% (90 aa) YMEKFDDVVRIMSSKQKPKLLTVQCSDGTKKKFLIKSQTQSENVYEQRTSELISFLNLILYKE---QLGFYEMPSYTILRLNSQSCIVEWVDDTLTLKTI . .|..| .| .||||| .. .|| .| | . . .||...|....| .|.|. | ......|.. .........||||...|||.| RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQ--DQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI LDQLWQEK-------------------------------KQKSQFYQLKLDSDKLSREEWNKQKSLPSVFQDFFNQRFLDSQQWYTAKENYLRTYASWCI ..|..|.| .|....||.. ...|........|...|..|...|...|.|...|....|||.|.||..|. YKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM LGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSGKQ-LNVPETIPFRLTKNMEFALGSFKSYGLFRKAMIDICMCFSKHLDDIIGFWDCF || .||||||..||.|....|||||||....|.|..| |.|||..|||||.||..|.|... .|.||.......||...| .........| VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
|||||||||
| Kinase | 29569.AA | PI3_PI4_kinase | 1816-2027 | 19 | 1.3e-37 | 136.08 | Pfam | 17-290 (300) | Show / Hide |
Range on Protein: 1816-2027 Range on HMM: 17-290/300 Sequence Identity: 19% (54 aa) EQRTSELI-----------------------SFLNLILYKEQLGFY---EMPSYTILRLNSQSCIVEWVDDTLTLKTILDQLWQEKK------QKSQFYQ ..|. ..| .. | .. |. . . | | .. ..... ..|||....|...|.. . ..| .. .... DMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHKHFNKEHKMWMK LKLDSD------KLSREEWNKQKSLPSVFQDFFNQRFLDS-QQWYTAKENYLRTYASWCILGYLIGLGDRHTDNILI--KKINGEIVHIDYALIFG--SG ...| . |. ..| .. | . .. ..| . | | .|..|. | .| .|...|..|.|||| |||.. .| .|...|||. ..|. . MWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKM KQLNVPETIPFRLTK------NMEFAL------GSFKSYGLFRKAMIDICMCFSKHLDDIIGFW-------DCF | ...||..|||.|. .| |. . .. ||.||. . .. ...|.. .. .. .|. KHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECM |
|||||||||
| Kinase | 29569.AA | ATM | 1905-2004 | 44 | 3.5e-25 | 77.07 | In-house | 118-217 (304) | Show / Hide |
Range on Protein: 1905-2004 Range on HMM: 118-217/304 Sequence Identity: 44% (44 aa) VFQDFFNQRFLDSQQWYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSGKQLNVPETIPFRLTKNMEFALGSFKSYGLFRK || | .||| |. . | | | | ||..|||||| |||| |.|||| | || | |||.|||||. . .| | ||. VFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRR |
|||||||||
| Kinase | 29569.AA | SMG1 | 1920-1979 | 53 | 1.7e-20 | 64.44 | In-house | 183-242 (242) | Show / Hide |
Range on Protein: 1920-1979 Range on HMM: 183-242/242 Sequence Identity: 53% (32 aa) WYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSGKQLNVPE |. | | | . ||.||||||| ||.|| ||.||||| | || ||||| WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
|||||||||
| Kinase | 29569.AA | PI3Kc | 1802-2085 | 20 | 1.2e-19 | 72.52 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1802-2085
Range on HMM: 1-336/336
Sequence Identity: 20% (70 aa)
KFLIKSQTQSENVYEQRTSELISFLNLILYKE----QLGFYEMPSYTILRLNSQSCIVEWVDDTLTLKTILDQLWQEKK---------------------
.. | . ..|. .... | |. |. .. .. | | .. ..... ..||| .. || .|.. . .||
AVIFKCGDDLRQ--DMRMMQMFRLMNKIWQKDKECRRRDLH-MRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKN
-----------QKSQFYQLKLDSDKLSREEWNKQKSLPSVFQDFFNQRFLDSQ-QWYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHID
.. .|| . . .| .| . . | |..|.| ..| |. |..|..|. | .| .|. .|. |.||||.|||.... .|...|||
MYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID
YALIFGSGKQLNVP-----ETIPFRLTKNMEFALG----SFKSYGLFRKAMIDICMCFSKHLDDIIGFWDCF-TNEL-EGCKKTNFNQLCNQIKNRIKMT
. |||.|. . .. |. |||||..| . | . .|.||. . . . . || . |. . .. ... ......|.
FGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLD
NFKSTEEGIDSLIQ-----ISKDDYC-----LRDMFKGWWPH
. .| || . | . ... . . .|| | .
H-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
|
|||||||||
| Kinase | 29569.AA | DNAPK | 1924-2030 | 36 | 2e-18 | 63.52 | In-house | 187-294 (301) | Show / Hide |
Range on Protein: 1924-2030 Range on HMM: 187-294/301 Sequence Identity: 36% (39 aa) KENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFG-SGKQLNVPETIPFRLTKNMEFALGSFKSYGLFRKAMIDICMCFSKHLDDIIG .| . |.|| || .. | |||| .| .. ||.|. ||. || . | ||| ||||| . | |... || | | | . REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTN FWDCFTNE | | | |. FCDVFIND |
|||||||||
| Kinase | 29569.AA | FRAP | 1920-1987 | 43 | 2.7e-14 | 49.02 | In-house | 133-201 (251) | Show / Hide |
Range on Protein: 1920-1987 Range on HMM: 133-201/251 Sequence Identity: 43% (30 aa) WYTAKENYLRTYASWCILGYLIGLGDRHTDNILIKKINGEIVHIDYALIFGSG-KQLNVPETIPFRLTK |. . || | | . ||..|||||| ||.. . | |||||. | . || ||||||. WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTR |
|||||||||
| Kinase | 29569.AA | DNAPK | 1770-1806 | 29 | 0.087578 | 2.05 | In-house | 2-38 (301) | Show / Hide |
Range on Protein: 1770-1806 Range on HMM: 2-38/301 Sequence Identity: 29% (11 aa) VYMEKFDDVVRIMSSKQKPKLLTVQCSDGTKKKFLIK | . ||. | .| | .|| . . | |..| VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYK |
|||||||||
| Kinase | 29569.AA | DNAPK | 1855-1878 | 48 | 0.147838 | 1.21 | In-house | 88-112 (301) | Show / Hide |
Range on Protein: 1855-1878 Range on HMM: 88-112/301 Sequence Identity: 48% (12 aa) VEWVDDTLTLKTILDQLWQEKK-QK .|||| | .|| || . |.| .| IEWVDNTVVLKDILNNEMQQKMGKK |
|||||||||
| Kinase | 29569.AA | SMG1 | 1779-1806 | 39 | 0.153529 | 0.69 | In-house | 1-28 (242) | Show / Hide |
Range on Protein: 1779-1806 Range on HMM: 1-28/242 Sequence Identity: 39% (11 aa) VRIMSSKQKPKLLTVQCSDGTKKKFLIK . |. | ||| | ||| .| | ITILPTKTKPKKLLFLGSDGKSYPYLFK |
|||||||||