Gene 4146 (Tetrahymena)

4146

Species: Tetrahymena
Alias: TTHERM_00585400, 4146, PreTt04146, 3675.m00090, 80.m00192, 685
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
4146.AA Protein None 1738 None Fasta, JSON
4146.kin_dom Protein Kinase Domain None 114 None Fasta, JSON
4146.NA RNA None 5217 None Fasta, JSON

Protein domain

Protein domains of 4146.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HisKA 4146.AA HisKA 734-801 28 6.5e-09 34.05 Pfam 1-69 (69) Show / Hide 
Range on Protein: 734-801
Range on HMM: 1-69/69
Sequence Identity: 28% (20 aa)

FKNKILSSLSHELRTPLNCSLQMLETIYQSDILNQNQ-KKMFILPAINSNYLLLSMINDILDFAQLING
 |.. |...||||||||.  . ..|..  .. |.  |  . ..  ....   ....|||.|||... .|
AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG
HisKA 4146.AA HisKA 734-801 21 2.7e-08 34.8 SMART 1-89 (89) Show / Hide 
Range on Protein: 734-801
Range on HMM: 1-89/89
Sequence Identity: 21% (19 aa)

FKNKILSSLSHELRTPLNCSLQMLETIYQ---------SDILNQNQK------------KMFILPAINSNYLLLSMINDILDFAQLING
 |.. |...||||||||.  . ..|..           .. |.  |             . ..  ....   ....|||.||.... .|
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG
Kinase 4146.AA HisK 848-961 36 5.6e-58 198.93 In-house 1-164 (164) Show / Hide 
Range on Protein: 848-961
Range on HMM: 1-164/164
Sequence Identity: 36% (60 aa)

SDSMRLKQVIINLLSNAIKFTNQG------QISINVD--------------------------QEEKDLIRISISDTGCGISPEIGNQIFRGLE------
|| .|.||..|||.|||.|||..|      .|.|.|.                          ...|.||.||..|||||...|. ..||  ..      
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH

------FNYNNTQFNTEGAGMGLTIANNIAKGLS------GNRPIQFVSDMGKGSIFSFFVLDR
      || .| . |..|.| ||||.||.||||.      |||.||..|. ||||.|||.....
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN
Kinase 4146.AA HATPase_c 848-961 30 2.2e-26 94.09 Pfam 1-120 (120) Show / Hide 
Range on Protein: 848-961
Range on HMM: 1-120/120
Sequence Identity: 30% (39 aa)

SDSMRLKQVIINLLSNAIKFTNQ-GQISINVDQEEKDLIRISISDTGCGISP------EIGNQIFR-------GLEFNYNNTQFNTEG--AGMGLTIANN
 |  ||.||. ||..||||.| . |.|.. |.... | .||...|.|.||.|      |  ..||                .  ...|   |.||.|.. 
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD------SR-RKYGGGLTGLGLYICRR

IAKGLSGNRPIQFVSDMGKGSIFSFFVLDR
|.. . |   |.. |  |.|. |.| .  .
IVEQHGGT--IWVESEPGGGTTFTFTLPLE
Kinase 4146.AA HATPase_c 848-962 24 7.5e-23 83.16 SMART 1-130 (130) Show / Hide 
Range on Protein: 848-962
Range on HMM: 1-130/130
Sequence Identity: 24% (36 aa)

SDSMRLKQVIINLLSNAIKFTNQ--------------GQISINVDQEEKDLIRISISDTGCGISP------EIGNQIFR-GLEFNY-------NNTQFNT
 | .||.||..|||.||||.| .              |.|.. |.       ||...|.|.||.|      |. ..||  .  .         ...  ..
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKY

EG--AGMGLTIANNIAKGLSGNRPIQFVSDMGKGSIFSFFVLDRP
.|   |.||.|...|.. . |   |..       . |.| .  ..
GGGLTGLGLSICKRIVEQHGGT--IWVE------TTFTFTLPLER
REC 4146.AA REC 1606-1730 20 3.7e-19 70.87 SMART 1-150 (150) Show / Hide 
Range on Protein: 1606-1730
Range on HMM: 1-150/150
Sequence Identity: 20% (33 aa)

SNVLVIDDN----EFNLYALE------MRLKQYGFK--------VDTASSGI-------LGQQKVIEKHE------TDSCCKEYTIIFMDLDMP------
 ..|..||.    . .. .|.      . |.. |.         ||.| .|         . ... |..       ||   ... .|.||. ||      
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTD-QSEPPDLIIMDIMMPGDPFED

-VQNGFQTTINILDYYKQQNQKPPTISACTAFIQDSEKKKARQAGMKYYITKPVETSYLEKVI
   .|....  |             | ..||. ... . .|..||.  |||||..   | ..|
GGMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
Response_reg 4146.AA Response_reg 1608-1731 27 1e-12 48.08 Pfam 1-115 (115) Show / Hide 
Range on Protein: 1608-1731
Range on HMM: 1-115/115
Sequence Identity: 27% (35 aa)

VLVIDDNEFNLYALEMRLK-QYGF-KVDTASSGILGQQKVIEKHETDSCCKEYTIIFMDLDMPVQNGFQTTINI-LDYY-KQQNQKPPTISACTAFIQDS
||..||.. .. .|   |. ..|. .|..|..|  . ... |.|        . .|.||..||  .|....  |    .  |     . | .|||. ...
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH--------PDLIIMDINMPGMDGLELCRRIRRQHPHPQ-----TPIIMCTAHGDED

EKKKARQAGMKYYITKPVETSYLEKVIS
 . .| |||. .|||||.    | . | 
DAVEALQAGANDYITKPFDPDELHAAIR