Gene 4145 (Tetrahymena)
4145
Sequence
Protein domains of 4145.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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HisKA | 4145.AA | HisKA | 179-246 | 31 | 2.3e-08 | 32.11 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 179-246 Range on HMM: 1-69/69 Sequence Identity: 31% (22 aa) FKKKILSSVSHELQTPLNCSIQLLEILQNSDILQETQ-KKMFVTPTLNSNQLLMYMINDIIDFAQIADG |.. |...|||| |||. . ..|.||... | . | . .. ... | . .|||. ||..| | AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
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HisKA | 4145.AA | HisKA | 179-246 | 22 | 1.2e-07 | 32.64 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 179-246 Range on HMM: 1-89/89 Sequence Identity: 22% (20 aa) FKKKILSSVSHELQTPLNCSIQLLEILQN---------SDILQETQK------------KMFVTPTLNSNQLLMYMINDIIDFAQIADG | . |...|||| |||. . ..|.||. .. |.. | . .. ... . . .|||. |...| | AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
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Kinase | 4145.AA | HisK | 293-398 | 32 | 6e-45 | 155.65 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 293-398 Range on HMM: 1-164/164 Sequence Identity: 32% (54 aa) SDPMRLKQVVINLIR---------------FISVNLD--------------------------LEDENLIKISIQDTGCGIPSQLGSNIFKGVED----- |||.|.||..|||| .|..... |...|||.||.||||||.| .. .||| . SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH -----YKNIQQKFN-TKGAGLGLTIANNIAMGLG------DNRKIEYTSQVDVGSVFTFFVLNR ..| |.|.| ..|.||||||.||.|.||| .||.|. |.|..|| |.|...|. QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN |
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Kinase | 4145.AA | HATPase_c | 309-398 | 23 | 1e-09 | 36.02 | Pfam | 27-120 (120) | Show / Hide |
Range on Protein: 309-398 Range on HMM: 27-120/120 Sequence Identity: 23% (25 aa) ISVNLDLEDENLIKISIQDTGCGIPS------QLGSNIFK-------GVEDYKNIQQKFNTKG--AGLGLTIANNIAMGLGDNRKIEYTSQVDVGSVFTF |.| .. .| . . |...|.|.||| .. ..|| ...| ||||.|.. |. .| |...|... |..||| ITVRVHRDD-DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD-------SR-RKYGGGLTGLGLYICRRIVEQHGGT--IWVESEPGGGTTFTF FVLNR . . TLPLE |
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Kinase | 4145.AA | HATPase_c | 293-399 | 20 | 1e-06 | 29.56 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 293-399 Range on HMM: 1-130/130 Sequence Identity: 20% (29 aa) SDPMRLKQVVINL----IRFISV---------------NLDLEDENLIKISIQDTGCGIPS------QLGSNIFKGVEDYKN-------IQQKFNTKG-- ||.||.||..|| |.. .... . |...|.|.||| .. ..|| .. .. ...| GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH---RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGGL AGLGLTIANNIAMGLGDNRKIEYTSQVDVGSVFTFFVLNRS ||||.|...|. .| |... ..||| . . TGLGLSICKRIVEQHGGT--IWVE------TTFTFTLPLER |
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Kinase | 4145.AA | HATPase_c | 293-306 | 64 | 0.814058 | 5.08 | Pfam | 1-14 (120) | Show / Hide |
Range on Protein: 293-306 Range on HMM: 1-14/120 Sequence Identity: 64% (9 aa) SDPMRLKQVVINLI || ||.||| ||. GDPDRLHQVVWNLV |
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REC | 4145.AA | REC | 790-915 | 26 | 1.4e-26 | 95.56 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 790-915 Range on HMM: 1-150/150 Sequence Identity: 26% (43 aa) PKILIVDDN----PFNLFALE------LRLKEYSYE--------VDKANSGM-------EAIEKVKNRYNNQKSCC----KQYKLIFMDIDMP------- ..||||||. | .. .|. . |.. || || | .| ||.|.... .. . ... ||.||| || MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG QKNGYETTLEIFDFFNSINEKCCPISACTAYVQEEEKKKAFNTGMSYYLTKPVLSEKLLKIL .|.|.. .| || ..||. .|| . .|. |. |.|||. | ||. . GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
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Response_reg | 4145.AA | Response_reg | 792-916 | 29 | 7.1e-20 | 73.76 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 792-916 Range on HMM: 1-115/115 Sequence Identity: 29% (38 aa) ILIVDDNPFNLFALELRLK-EYSY-EVDKANSGMEAIEKVKNRYNNQKSCCKQYKLIFMDIDMPQKNGYETTLEI-FDFFNSINEKCCPISACTAYVQEE .|||||.| .. .| |. .. | .|. | .| ||.|..... . ||.|||.|| .|.|.. .| . . .|| .|||. .|. VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH---------PDLIIMDINMPGMDGLELCRRIRRQHP-HPQ---TPIIMCTAHGDED EKKKAFNTGMSYYLTKPVLSEKLLKILI . .|. |. .|.|||. ..|.... DAVEALQAGANDYITKPFDPDELHAAIR |