Gene 19891 (Tetrahymena)
19891
Sequence
Protein domains of 19891.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HisKA | 19891.AA | HisKA | 696-759 | 30 | 1.6e-11 | 43.18 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 696-759 Range on HMM: 1-69/69 Sequence Identity: 30% (21 aa) KNQQMLANVTHDLKTPLNCITLMVEGMKL-----EKQYNEQTINMILENSNLLMCLIQDILDYSQIKKG .|.|||. |.|.|||. | ...| .. ..| .. .. |.. .. . ||.|.||.|.| | AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
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| HisKA | 19891.AA | HisKA | 696-759 | 22 | 8.8e-11 | 43.06 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 696-759 Range on HMM: 1-89/89 Sequence Identity: 22% (20 aa) KNQQMLANVTHDLKTPLNCITLMVEGMKL-----------EKQYNE--------------QTINMILENSNLLMCLIQDILDYSQIKKG .|.|||. |.|.|||. | ...| .. . . . . .. |.. .. . ||.|.||.|.| | AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
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| Kinase | 19891.AA | HisK | 874-992 | 38 | 2.4e-60 | 206.81 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 874-992
Range on HMM: 1-164/164
Sequence Identity: 38% (63 aa)
QDKNRIKQILINLISNALKFT------TEGYIEISCE--------------IKDLEEN------SNIKIVEFSVKDTGVGMNPHIKSQLFKVFN------
.|.|||||||||||||||||| .|||.|. | |. ..|| .. .....||.|||.||..... ..|| |.
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH
-----TFDQKGL--NKNGIGLGLTICKRLVTFLGPS------DHIDVESEVSKGSKFTFKVYKD
||... |..|.|||||||..|...|||. ..| |.||| |||.|.|..|..
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN
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| Kinase | 19891.AA | HATPase_c | 874-992 | 31 | 1.5e-25 | 91.16 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 874-992 Range on HMM: 1-120/120 Sequence Identity: 31% (41 aa) QDKNRIKQILINLISNALKFTTE-GYIEISCEIKDLEENSNIKIVEFSVKDTGVGMNP------HIKSQLFKVFNTFDQ--KGLNKNG--IGLGLTICKR | .|..|.. ||..||.|.| | | |..... | |...|.|.|.|. | . ...| | ..|. . | ||||.||.| GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-------DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRR LVTFLGPSDHIDVESEVSKGSKFTFKVYKD .| .| . |.||||. .|..|||.. .. IVEQHGGT--IWVESEPGGGTTFTFTLPLE |
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| Kinase | 19891.AA | HATPase_c | 874-993 | 25 | 7.5e-25 | 89.8 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 874-993 Range on HMM: 1-130/130 Sequence Identity: 25% (38 aa) QDKNRIKQILINLISNALKFTTE--------------GYIEISCEIKDLEENSNIKIVEFSVKDTGVGMNP------HIKSQLFKVFNTFDQ-------- | .|..|.|.||..||.|.| | | |... . ...|.|.|.|. | .. ...| | ..|. GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-------------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPD -KGLNKNG--IGLGLTICKRLVTFLGPSDHIDVESEVSKGSKFTFKVYKDL . . | ||||.||||.| .| . | || ..|||.. . . SRSRKYGGGLTGLGLSICKRIVEQHGGT--IWVE------TTFTFTLPLER |
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| REC | 19891.AA | REC | 1085-1203 | 20 | 8.3e-26 | 92.98 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 1085-1203 Range on HMM: 1-150/150 Sequence Identity: 20% (34 aa) FSMLIVDDQ----PFNIMAFK------IVLKNFKQI-------TITEAYNGK-------DAFEKFQKQ-------------KFDFVLMDYNMP------- . ||||| | . .. . . |. ...|| .|. .|.|..|.. ..| ..|| .|| MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG IMNGYESTKLIRMYEQQNNLVPSKIIIVSGFDEKQKEYQKAMLGGADDFLTKPVNFKIITEKL |.|.| .. || .||.....|. . ..|. ||||..|||.. . . ... GMDGIELCRRIR-----------PIIMLTAHDDEEDR-VRALEAGADDYITKPFDPEELLARI |
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| Response_reg | 19891.AA | Response_reg | 1087-1204 | 28 | 9.4e-22 | 80.49 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 1087-1204 Range on HMM: 1-115/115 Sequence Identity: 28% (34 aa) MLIVDDQPFNIMAFKIVLKNFKQI-TITEAYNGKDAFEKFQKQKFDFVLMDYNMPIMNGYESTKLI-RMYE-QQNNLVPSKIIIVSGFDEKQKEYQKAML ||||| | . .... |.. .. ..||..|..| |..|....| ..|| ||| |.|.| .. | | . | .||....... ..|. VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHHPDLIIMDINMPGMDGLELCRRIRRQHPHPQ-----TPIIMCTAHGD-EDDAVEALQ GGADDFLTKPVNFKIITEKLN ||.|..|||... . .... AGANDYITKPFDPDELHAAIR |
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