Gene 12346 (Tetrahymena)

12346

Species: Tetrahymena
Alias: 65.m00164, TTHERM_00522310, PreTt12346, 389, 12346, 3717.m00043
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
12346.AA Protein None 899 None Fasta, JSON
12346.kin_dom Protein Kinase Domain None 114 None Fasta, JSON
12346.NA RNA None 2700 None Fasta, JSON

Protein domain

Protein domains of 12346.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HisKA 12346.AA HisKA 145-210 23 1.1e-14 56.04 SMART 1-89 (89) Show / Hide 
Range on Protein: 145-210
Range on HMM: 1-89/89
Sequence Identity: 23% (21 aa)

YKDQLLASVTHELKTPLNGILAIVQAAE-----------HEEDIVEI------------RKQLQCIKESGCMLEIILNDILDYSRLQKQ
 |.|.||.. |||.|||..|.. .....           .. |  ..            |. |. |....  .. ..||.||.||.. .
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG
HisKA 12346.AA HisKA 145-210 30 2.3e-14 53.06 Pfam 1-69 (69) Show / Hide 
Range on Protein: 145-210
Range on HMM: 1-69/69
Sequence Identity: 30% (21 aa)

YKDQLLASVTHELKTPLNGILAIVQAAEH--EEDIVE-IRKQLQCIKESGCMLEIILNDILDYSRLQKQ
 | |.||.. |||.|||..|.. .....   . |  . .|. |. |....  .. ..||.||.||.. .
AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG
Kinase 12346.AA HisK 256-369 39 4.4e-61 209.25 In-house 1-164 (164) Show / Hide 
Range on Protein: 256-369
Range on HMM: 1-164/164
Sequence Identity: 39% (65 aa)

SDSNRLKQIIFNLMTNAIKFTERG------EIKIIVKKSS--------------------------SNCVQITVQDTGVGIPENLQKKLFKLYG------
|| ||.|||..||..||.|||. |       |||.|....                          .|..||.|||||.|.||..|||.||..|      
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH

-----TFDHSNG-SNRHGVGLGLVITKNLVELLGPS------NYINLESTVGKGSSFTFEIYNK
     ||.|.|. .|.||.||||.| .||...|||.      . | ..|.|||||.|.|.|||.
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN
Kinase 12346.AA HATPase_c 256-369 34 9.8e-31 109.19 Pfam 1-120 (120) Show / Hide 
Range on Protein: 256-369
Range on HMM: 1-120/120
Sequence Identity: 34% (43 aa)

SDSNRLKQIIFNLMTNAIKFTER-GEIKIIVKKSSSNCVQITVQDTGVGIPE------NLQKKLFKLYGTFDH-SNGSNRHG--VGLGLVITKNLVELLG
 | .||.|.. ||..||||.|.  |.|.. |..   . |.|||.|.|.|||.       .. ..|  ....|  |. ... |   |||| | . .||..|
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIVEQHG

PSNYINLESTVGKGSSFTFEIYNK
 .  | .||..|.|. |||..  .
GT--IWVESEPGGGTTFTFTLPLE
Kinase 12346.AA HATPase_c 256-370 27 6.4e-29 103.31 SMART 1-130 (130) Show / Hide 
Range on Protein: 256-370
Range on HMM: 1-130/130
Sequence Identity: 27% (40 aa)

SDSNRLKQIIFNLMTNAIKFTER--------------GEIKIIVKKSSSNCVQITVQDTGVGIPE------NLQKKLFKLYGTFDH--------SNGSNR
 | .||.|.. ||..||||.|.               |.|.. |.       .|||.|.|.|||.       .....|  ....|         |. ...
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKY

HG--VGLGLVITKNLVELLGPSNYINLESTVGKGSSFTFEIYNKL
 |   |||| | |..||..| .  | .|      . |||..  ..
GGGLTGLGLSICKRIVEQHGGT--IWVE------TTFTFTLPLER
REC 12346.AA REC 697-819 24 2.6e-25 91.32 SMART 1-150 (150) Show / Hide 
Range on Protein: 697-819
Range on HMM: 1-150/150
Sequence Identity: 24% (39 aa)

TKILIVDDT----YLNITALR------LILGKCQNL-------VIEEAFHGQ-------QAIEKIEESQKQND--------PFQLVFMDMNMP-------
 .||||||      ..  .||      ..| |           |..||  |.       .|.|...| .....        |..|..||..||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

IMDGVQAIIIIRQKIKEGLLSDLKIAVCSAFGDLQSKMKCIKAGADLHIEKPINKYEMEQQL
 ||| ...  ||           .| ...|..| . . ....||||  | ||..  |. . .
GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
Response_reg 12346.AA Response_reg 699-820 33 8.2e-23 84.28 Pfam 1-115 (115) Show / Hide 
Range on Protein: 699-820
Range on HMM: 1-115/115
Sequence Identity: 33% (42 aa)

ILIVDDTYLNITALRLILG-KCQNL-VIEEAFHGQQAIEKIEESQKQNDPFQLVFMDMNMPIMDGVQAIIII-RQKI-KEGLLSDLKIAVCSAFGDLQSK
.|||||  |.  .|| ||  |   . |..||  |..|.|...| .     . |..||.||| ||| ...  | ||.   .     ..| .|.|.||.. .
VLIVDDHPLMREGLRQILEQK-EGYEVVAEADDGEEALEWWQEHH-----PDLIIMDINMPGMDGLELCRRIRRQHPHPQ-----TPIIMCTAHGDEDDA

MKCIKAGADLHIEKPINKYEMEQQLL
 ....|||. .| ||... |. . . 
VEALQAGANDYITKPFDPDELHAAIR