Gene 25428 (Tetrahymena)

25428

Species: Tetrahymena
Alias: 915, PreTt25428, 25428, TTHERM_00734050, 120.m00086
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: VWL

Sequence

Name Sequence Type Origin Length Description Download
25428.AA Protein None 899 None Fasta, JSON
25428.kin_dom Protein Kinase Domain None 205 None Fasta, JSON
25428.NA RNA None 2700 None Fasta, JSON

Protein domain

Protein domains of 25428.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Zf-CCCH 25428.AA zf-CCCH 7-33 37 1.9e-05 22.14 Pfam 1-27 (27) Show / Hide 
Range on Protein: 7-33
Range on HMM: 1-27/27
Sequence Identity: 37% (10 aa)

SSRLYCHYFQTTKSCKKEERCEFLHDQ
  .  |.||..| .|.  .|| | |.|
YKTELCRYFMRTGYCPYGDRCKFAHPQ
ZnF_C3H1 25428.AA ZnF_C3H1 7-33 25 0.000188 22.04 SMART 1-31 (31) Show / Hide 
Range on Protein: 7-33
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

SSR-LYCHYFQTTK---SCKKEERCEFLHDQ
...   | ||. .     |.. .|| |.|. 
RYKTPPCKYFMRRGPPWYCPYGDRCKFAHPP
VWA 25428.AA VWA 265-454 16 6.8e-08 33.46 SMART 1-193 (193) Show / Hide 
Range on Protein: 265-454
Range on HMM: 1-193/193
Sequence Identity: 16% (36 aa)

ELDLMFIVDCTGSM-SSWIDAVKLEITGIVAAIKNQHHGSQIRVSFVGYRDYGDSERYSIFNFSEDLEKFQDFISKVQ--------ACGGNDAAEDVAGG
.||..|..|..|||  .....||  |  .| ..        .||. |.. |  | .... .| . |...... | ..|        . || . .  .   
WLDIVFVIDGSGSMGPNNFQQVKQFI-KFVEQLD------GDRVGIVQFSD--DVRVEFPLN-YQDKDDVLKAIDNLQYKGKHDYFMGGGTNTG-ALQYA

FKQ-----ANSQNWKSQA-------KYAVLLADAPAH-GIQYHGDKADFYDRYPKGDPDGIDLKKEFQNLIKKGVKLYAVEIMN-STKMMYDIFQQYNKE
...     .. ... ...       |  ....|  .. |                   |  |..| ...| ..|||.... . |  .  .  | ..   |
MQNLFHERQG-RRGAGRPTKFWNVPKVIIVFTDGYSNDG-----------------PHDPEDIRKAARELRRSGVKIFVIGVGNDDM-ELRQIASCP-GE

-----------VNGQQLDITKLGN
           .. .  .|...  
HHFFDVYDYDDLPDIFQHIIDWLC
Kinase 25428.AA VWL 581-783 66 1.4e-186 560.96 In-house 1-206 (206) Show / Hide 
Range on Protein: 581-783
Range on HMM: 1-206/206
Sequence Identity: 66% (138 aa)

IKTSIRINTTPFAEGAMRYAFFAEDTLLKQNLVAKLNKKQNLNNPEQDKEDMIKDLESQFLCQHIVNCFNDRVSEHVQTTANLKNFVHCFIYELQNP-GS
|||..||...||||||||||..|.||.|.|..|||..|||...||...|||||||.||||.|||||||||||||||||||||..|||||.|||.... ..
IKTKVRISNIPFAEGAMRYAYHAKDTYLNQKMVAKQYKKQHKQNPKINKEDMIKDIESQFVCQHIVNCFNDRVSEHVQTTANILNFVHCYIYEVTHHYNH

NYKYYSAENYIQGEYVKFNNNAGWTNLRFDEPGLLSQALSHFSYQLTEGYLMIVDLQGVG-GLLTDPQIHCLDQ-HRFGAGNLGYQGMFKFFLSHQCNKY
|.|||..||||.|.|.|.||||||.|....|...||||.|||..|...||.|||||||.. |.||||||||||| |.||.|||||.||..||..||||||
NIKYYFVENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKY

CQNLNL
||.|.|
CQKLQL
Kinase 25428.AA Alpha 581-778 50 4.6e-145 415.8 In-house 1-215 (215) Show / Hide 
Range on Protein: 581-778
Range on HMM: 1-215/215
Sequence Identity: 50% (108 aa)

IKTSIRINTTPFAEGAMRYAFFAEDTLLKQNLVAKLNKKQNLNNPEQDKEDMIKDLESQFLCQHIVNCFNDRVSEHVQTTAN-------LKNFVHCFIYE
..|.|.....||.|||||||..|.|..|.|..|.|..|||.... .......|||.|.|..|.|.|..||.|..|...||..       .|.||||.|||
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

LQNP-GSNYKYYSAENYIQGEYVKFNNNAGWTN-LRFD-EPGLLSQALSHFSYQLTEGYLMIVDLQ-GVG-GLLTDPQIHC---LDQ-HRFGAGNLGYQG
|...  .|.||||.|||..|||.|.||||||.. |..| |...|.||.||...| ..|.||.|||| ||| ..||||||||   ||| ..|| ||.||.|
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEG

MFKFFLSH--QCNKYC
||.|| .|  |||.||
MFRFFYTHHVQCNHYC
Kinase 25428.AA Alpha_kinase 592-778 36 2.1e-81 281.58 Pfam 1-225 (225) Show / Hide 
Range on Protein: 592-778
Range on HMM: 1-225/225
Sequence Identity: 36% (82 aa)

FAEGAMRYAFFAEDT-----LLKQNLVAKLNKK-QNLNNP---EQDKEDMIKDLESQFLCQHIVNCFNDRVSEHVQTTANLKNFVHCF-IYELQNPGS--
||.||||..| ..||      . ||.|||..|| .|.|..   . .......| ..|..||.... ||.. .||.    ... |..|. .|||... .  
FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIE-FYDCCIVYELEDHNKPD

------------NYKYYSAENYIQG-EYVKFNNNAGWT---NLRFDEPGLLSQALSHFSYQLTEGYLMIVDLQGVG--G---LLTDPQIHCLDQHR---F
            ..||...|.||.| |.||.|||.||.   . | |. . ..||.|||.|. ..|..|..|.||||  .   .|||||||. |...   |
CYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYEMDF

--GAGNLGYQGMFKFFL-SHQCNKYC
  | ||||..|..|||  .|.||..|
DEGMGNLGQEGIEKFFQNQHKCNHIC
Alpha_kinase 25428.AA Alpha_kinase 577-778 26 1.7e-52 181.6 SMART 1-255 (255) Show / Hide 
Range on Protein: 577-778
Range on HMM: 1-255/255
Sequence Identity: 26% (70 aa)

QNSSIKTSIRINT---TPFAEGAMRYAFFAEDT-------LLKQNLVAKLNKKQNLNNPEQDKEDMIK--------DLESQFLCQHIVNCFND-RVSEHV
 |. ........    .|||.|||| .. ..|.       . .. .|||. ||.. .    |.|. ..        | | | .|.|..| ||  ..  ..
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTW--DEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-HNP

QTTANLKNFVHCFIYEL--------QNPGSNY-------------KY-YSAENYIQGEYVKFNNNAGWTNLRFD---------EPGLLSQALSHFSYQLT
    .   |. |.. ..        ..... .             .  .. | ...||.||.||| || |  .          | . . || ||..|. .
CP--KKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWS

EGYLMIVDLQGV----GG--LLTDPQIHCLD--QHRFGAGNLGYQGMFKFFLSHQCNKYC
.. ....|.|||    |   ..||||||  |     || ||||  |. ||| .||||..|
NHQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase 25428.AA Alpha-Unclassified 635-778 33 2e-34 109.6 In-house 61-215 (215) Show / Hide 
Range on Protein: 635-778
Range on HMM: 61-215/215
Sequence Identity: 33% (53 aa)

DLESQFLCQHIVNCFNDRVSEHVQTTANLKNFVHCFIYELQNPGSNYK-YYSAENYIQGEYVKFNNNAG-WTNL--RFDEPGLLSQALSHFSYQLTEGYL
| | |   || |  || |. |    |   . |    |  .  .  | | . | | |. ||.||..|| |   |.  . .| . . .. .|..|| | . .
DVERQMTAQHYVTEFNKRLYEQNIPT---QIFYIPPIFLIHREDKNIKGCISVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCD

MIVDLQG-VG------GLLTDPQIHCLDQHRFG--AGNLGYQGMFKFFLSH--QCNKYC
 ..|||| |.        .|||||| ..| |..   .| |.......| .|  |||.||
IVCDLQGWVDENDKKTWKMTDPQIHTIRQ-RYQGFKTNCGMRFIDYWFNNHHVQCNHYC
Kinase 25428.AA ChaK 679-778 34 2.4e-13 49.08 In-house 115-219 (219) Show / Hide 
Range on Protein: 679-778
Range on HMM: 115-219/219
Sequence Identity: 34% (36 aa)

SNYKYYSAENYIQGEYVKFNNNAGWTNLRFDEPGLLSQALSHFSYQLTEGYLMIVDLQGVGGLLTDPQIHCLDQHR-----FGAGNLGYQGMFKFFLSHQ
|  .... |... ||. |.||| |   .       .  | ||. |  | | |...||||||  |||| .   .. .     ||  |||   .  |   | 
SANQWFTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHH

CNKYC
||  |
CNSCC