Gene 10726 (Tetrahymena)

10726

Species: Tetrahymena
Alias: 64.m00206, 356, 10726, TTHERM_00516340, PreTt10726, 3723.m00062
External Links: Tetrahymena Genome Database (TGD) ,
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
10726.AA Protein None 779 None Fasta, JSON
10726.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
10726.NA RNA None 2340 None Fasta, JSON

Protein domain

Protein domains of 10726.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 10726.AA Ank 265-297 45 2.2e-10 41.69 Pfam 1-33 (33) Show / Hide 
Range on Protein: 265-297
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DNWTALHFAASSGNHEIVEFLLQQGADPFSQSS
| .|.|| |...|..|.|..|||.|||.  |  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 10726.AA Ank 337-369 30 2.3e-07 30.8 Pfam 1-33 (33) Show / Hide 
Range on Protein: 337-369
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

DFNTALHLASENDQIQIVEFLIQNKANFSLKNH
| .|.||||........|..|.|. |.  ... 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase 10726.AA SGK 454-708 49 3.3e-197 615.14 In-house 1-283 (283) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-283/283
Sequence Identity: 49% (139 aa)

FRFISKLGQGSFGEVYLVEREKK--------------------LFAMKIQNKQQVV-------QKNLQRYVQTEK-KALSLFNHPFIIKLHYAFQNDWYL
|.|....|.||||.||.|.....                    ..|||...||...       .|..|.....|. ..|....||||..||||||..|.|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FMVMEYAEGGDMGNYLNKRNKLPEDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSKEGIKENTFTKSFCGSVAYLAPEVLAKR
..||.|..||.|...|......|||.||.|.|.||.|||.||.||||.|||||.|..||| |...||||||.|||||.|..|..|||...|||||||.|.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

PHSRTVDWYLLGTFLYELLVGIPPYYDNNKEILYDNIRRGPLKIPRSMSADAKDLIKQLLNRNPKERLGSKRDSEEIKEHQFF
||.|||||..||..|||...|.||.|..||...||||...||.||..||.||.|||..||...||.|||.|||..|||.|.||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 10726.AA AGC 454-708 29 4e-169 441.48 In-house 1-395 (395) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-395/395
Sequence Identity: 29% (119 aa)

FRFISKLGQGSFGEVYLVERE--------KKLFAMKIQNKQQ-VVQKN--LQRYVQTE------------KKALSLFN----------HPFIIK-LHYAF
|.|.  .|.||||.||||..         .|..|||. .|.  .|.|.   .....||            .. |.. |          ||||.| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QNDWY--LFMVMEYAE---------GG-DMGNYLN---KRNKLPEDEARIYTAQ-------IVLALEELHK-QDIIFRD-LKPDNVVLDHLGNAKLTDFG
|.. .  |..||||..         || ..  .|    |. ...|..||.|.|.       |||||| ||. ..|| || |||.|..||. |. ||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEGIKENTF--------------------------------------------------TKSFCG--SVAYLAPEVLAKRPHSRTVDWY--LLGTFLY
|.|||.....                                                   |..|||  .  |.|||.|    .....||.  .|| ..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLVGIPPYYDNN----------KEILYDNIR------RGPLKIP----------RSMSADAKDLIKQLLNRNPKERLGSKRD------SEEIKEHQFF
|.|.|.||.|..|          .. ....|.        ..|.|          |..| .||||||.||...|..|||....       ||||.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 10726.AA Akt 454-708 44 2.8e-133 428.44 In-house 1-264 (264) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-264/264
Sequence Identity: 44% (117 aa)

FRFISKLGQGSFGEVYLVE--REKKLF-AMKIQNKQQVVQKNLQRYVQTEKKALSLFNHPFIIKLHYAFQNDWYLFMVMEYAEGGDMGNYLNKRNKLPED
|.|.  ||.|||| |.||.    .|.. |||.  |.. .|||  ....||.. |   |||||..|||.||.  .|..||.|. ||.  ..| .... .||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

EARIYTAQIVLALEELHKQDIIFRD-LKPDNVVLDHLGNAKLTDFGLSKEG-IKENTFTKSFCGSVAYLAPEVLAKRPHSRTVDWYL-LGTFLYELLVGI
.|| | |.|.||.| ||...||.|| ||| |...|. |. .||||||.||. ||..  ||.|||. .|||||.| .  |...|||.  || ..||.. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPYYDNNKEILYDNIRRGPLKIP--RSMSADAKDLIKQLLNRNPKERLG-SKRDSEEIKEHQFF
||.|. ... ....|  .|.|.|  .  | ..||||..|||..||.|||  . | .|||.| .|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 10726.AA RSK-Unclassified 454-708 40 7.89999999999e-131 413.4 In-house 1-283 (283) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-283/283
Sequence Identity: 40% (116 aa)

FRFISKLGQGSFGEVYLVEREK--KLFAMKIQNKQQVVQKNLQRYVQTEKKALSLFNHPFIIKLHYAFQNDWYLFMVMEYAEGGDMGNYLN--KRNKLPE
|  .  .|||.||.||||.. .  ...|||. .|......|. .|| ||.  ... |||||..| ..||   ||...|||  |||..  |   |  .. |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSKEG-------IK--------------ENTFTKSFCGSVAYLAPEVLAKRPHS
|..|.| . ...||| |||.|.|.|||||||.||.. | ..||||.||...       .|              . . |.||||...|||||..    | 
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

RTVDWYLLGTFLYELLVGIPPYYDNNKEILYDNIRRGPLKIP--RSMSADAKDLIKQLLNRNPKERLGSKRD-SEEIKEHQFF
. |||..||  .||.|.|.|||| |||. .. || ....|.|    .| ...|||| ||.|||  |||.|.   ..|| |.||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 10726.AA AktR 454-708 42 1.1e-124 420.51 In-house 1-268 (268) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-268/268
Sequence Identity: 42% (114 aa)

FRFISKLGQGSFGEVYLVERE---KKLFAMKIQNKQQVVQKNLQRYVQTEKKALS-LFNHPFIIKLHYAFQNDWYLFMVMEYAEGGDMGNYLNKRNKLPE
|...  ||.| ||.||||..    .|..|||.  |.  ...|......||.. .  . |||||.||||.||.. .|| .||| .||.. ..|.|..|. |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DEARIYTAQIVLALEELHKQ-DIIFRDLKPDNVVLDHLGNAKLTDFGLSK-EGIK-ENTFTKSFCGSVAYLAPEVLAK-RPHSRTVDWYLLGTFLYELLV
..||.| |||.|||| ||.. .||.|||||.| .||  |. |.||||||| .... .. ...||||...|.|||.. |  .| ..|||. .|.|.||...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GIPPYYDNNKEILYDNIRRGP-LKIPRS--MSADAKDLIK-QLLNRNPKERLG-SKRDSEEIKEHQFF
|.|| |..|.......|.  . .|.| .   |  .||||. .||..||..||| .. . ||||.| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 10726.AA RSK 457-708 39 2.4e-114 386.17 In-house 1-278 (278) Show / Hide 
Range on Protein: 457-708
Range on HMM: 1-278/278
Sequence Identity: 39% (111 aa)

ISKLGQGSFGEVYLVERE-----KKLFAMKIQNKQQVVQKNL-QRYVQTEKKALSLFN-HPFIIKLHYAFQNDWYLFMVMEYAEGGDMGNYLNKRNK---
.. ||||..|.|.|. .      ....|||. .|  .||..  .|.. || . |.. . ||||..|||||| . .|...||| .||...  | |.     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDH---LGNAKLTDFGLSKEG-IKENTFTKSFCGSVAYLAPEVLA---KRP-HSRTVDWYLLGT
. ||||..| |.||||.| ||.|.||.|||||.|...|.    |  ||||||..|.. ...|  |..||....|.|||.|.   ..  |.. .||. || 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

FLYELLVGIPPYYD---NNKEILYDNIRRGP--LKIP--RSMSADAKDLIKQLLNRNPKERLGS-KRDSEEIKEHQFF
 .||.|.| ||..    ||.. . ..|..|   |..|   ..|..|||||...| |.|. |||. ..| ||||.|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 10726.AA RSK 454-708 34 5.7e-99 335.1 In-house 1-271 (271) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-271/271
Sequence Identity: 34% (95 aa)

FRFISKLGQGSFGEVYLVERE-----KKLFAMKIQNKQQVVQKNLQRYVQTEKKALSLFNHPFIIKLHYAFQNDWYLFMVMEYAEGGDMGNYLNKRNKLP
. .....|||||..||.. .      ....||||  | ... |    .  .| . |.  .||||.||||.||   ...|.|. ..|||..  | |   ..
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHL----GNAKLTDFGLSKEGIKENTFTKSFCGSVAYLAPEVLAKRPHSRTVDWYLLGTFLYELL
|.|...| | | ||.| ||.|.|..|||||.|...|      | .|..|||..|. . ||  ...||....|.||||| .. |.. .||...|. .|| |
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

VGIPPYYDNNKEILYDNIRRGPLKI-------PRSMSADAKDLIKQLLNRNPKERLGS-KRDSEEIKEHQFF
 | .|.. .... . ..| | .| .       . . |. ||||. ..| |.|  |||.   . |.||.| .|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 10726.AA PKA 454-708 42 2.8e-93 316.2 In-house 1-263 (263) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-263/263
Sequence Identity: 42% (114 aa)

FRFISKLGQGSFGEVYLV--EREKKLFAMKIQNKQQVVQKNLQRYVQTEKKALSLFNHPFII-KLHYAFQNDWYLFMVMEYAEGGDMGNYLNKRNKLPED
| .|  ||.|||| |.|.     .. .|||. .||..|. . .  | .||. |.. .||||. |. . ||.| ||.|||||..||.|  || |. .....
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

EARIYTA-QIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSKEGIKENTFTKSFCGSVAYLAPEVLAKR-PHSRTVDWYLLGTFLYELLVGIP
.|..| | ||||||| ||.|.|| ||||| |  .|  |. |.|||| .|. ....|.|   ||   |||||..  . .| . |||  ||   ||.|.|.|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDDRTWT--LCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PYYDN--NKEILYDNIRRGPLKIPRSMSADA---KDLIKQLLNRNPKERLGSKR-DSEEIKEHQFF
| ||.  ..  .|. |. | .| ||... ||   |||||.||......|.|... ... ||.| .|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 10726.AA S_TKc 454-708 33 1.6e-90 307.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

FRFISKLGQGSFGEVYLVEREK--KLFAMKIQNKQQVVQKNLQRYVQTEKKALSLFNHPFIIKLHYAFQNDWYLFMVMEYAEG--GDMGNYLNKRNK---
.... |.|.|.||.||..   |  ...|.|| .          . .. | . |.  .||.|.||...||.  .|.|||||..|  ||.  |. ||..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSKEGIKENTFTKSFCGSVAYLAPEVLAKRPHSR-TVDWYLLGTFLYE
   .|| .|| |..||..||| .|.. || |||||.|. ||.  . |..||||...        ..|||.  |.|||||   ....  .||. .|  |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLVGIPPYYDNNKEILYDNIRRGPLKIPRSMSADAKDLIKQLLNRNPKERLGSKRDSE---EIKEHQFF
.|.| ||..  . . ....|.          | .|||.|...|...|..|..     .   .|| |..|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10726.AA Pkinase 454-708 29 1e-77 269.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 454-708
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

FRFISKLGQGSFGEVYLVEREKK--LFAMKIQNKQQVVQKNLQRYVQ-TEKKALSLFNHPFIIKLHYAFQNDWYLFMVMEYAEGG----DMGNYLN--KR
.....|.|.||||.||.  . .   ..|.|| .|.    . .|. .  .| . .  .|||.|..|...|... .. |||||.|||    |   |.   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NKL--PEDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNA----KLTDFGLSKEG-IKENTFTKSFCGSVAYLAPEVLA-KRPHSRTVDWYLL
...  .|.|.. |  ||. .|| .|.. || |||||.|. .|. |.     |..||||.|   .  |. ...|||.  |.||||.   ..... ||.. .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GTFLYELLVGIPPYYDN------NKEILYDNIRRGPLKIPRS---------------------MSADAKDLIKQLLNRNPKERLGSKRDSEEIKEHQFF
|  |||.| | ||...       ..  ....|...||. ...                     .| ..||.|| .|...||.|..     |.|..| .|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 10726.AA MAST 454-605 44 8.8e-63 190.36 In-house 1-157 (337) Show / Hide 
Range on Protein: 454-605
Range on HMM: 1-157/337
Sequence Identity: 44% (70 aa)

FRFISKLGQGSFGEVYLVERE--KKLFAMKIQNKQQVVQKNLQRYVQTEKKALSLFNHPFIIKLHYAFQN--DWYLFMVMEYAEGGDMGNYLNKRN-KLP
| ||  .. | .| ||||.    ...||||. |.|.   || .  |. |.  |.    ||. |. |.||   . ||.||||| |||| .  |.  .  .|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSKEGIKENT
|..|..|.|..||.|| ||...|. |||||||...| .|  ||||||||| |..  |
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKT
Kinase 10726.AA MAST 454-605 44 8e-60 191.39 In-house 1-154 (334) Show / Hide 
Range on Protein: 454-605
Range on HMM: 1-154/334
Sequence Identity: 44% (68 aa)

FRFISKLGQGSFGEVYLVERE--KKLFAMKIQNKQQVVQKNLQRYVQTEKKALSLFNHPFIIKLHYAFQNDWYLFMVMEYAEGGDMGNYLNKRNKLPEDE
| ||  .. | .| ||||.    ...||||. .|..   || .  ||.|. .|..   ||. |. |.|| . ||.||||| |||| .  |.  . ..|. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSKEGIKENT
|..|.|..||.|| ||...|. |||||||...| .|  ||||||||| |..  .
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDL
Kinase 10726.AA MAST 616-708 39 5.5e-40 119.4 In-house 234-337 (337) Show / Hide 
Range on Protein: 616-708
Range on HMM: 234-337/337
Sequence Identity: 39% (41 aa)

YLAPEVLAKRP-HSRTVDWYLLGTFLYELLVGIPPYYDNNKE-ILYDNIRR--GPLKIPRS--------MSADAKDLIKQLLNRNPKERLGSKRDSEEIK
|.||||. ... .. .|||. .|  .||.|||.||  . . | .. .||      .  |          ||..|.||||.||. |||.|||..  ..|||
YIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN-GADEIK

EHQFF
.| ||
QHPFF
Kinase 10726.AA MAST 608-708 37 1.9e-38 121.35 In-house 222-334 (334) Show / Hide 
Range on Protein: 608-708
Range on HMM: 222-334/334
Sequence Identity: 37% (42 aa)

KSFCGSVAYLAPEVLAKRP-HSRTVDWYLLGTFLYELLVGIPPYYDNNKEILYDNIRRGP---LKIPRS--------MSADAKDLIKQLLNRNPKERLGS
|. ||.  |.||||. ... |. .|||  .|  .||.|||.||  | . |....||        ..|          || .|.|||..||. .|..|||.
KQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

KRDSEEIKEHQFF
.  ..|.|.| ||
NNGADEVKQHPFF
Kinase 10726.AA TyrKc 454-702 21 2.9e-15 24.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 454-702
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FRFISKLGQGSFGEVYLVEREKKLFAMKIQNKQQVVQKNLQRYVQTEKKALSLF--NHPFIIKLHYAFQND-------WYLFMVMEYAEGGDMGNYL-NK
 ... ||| | |||||. .      | |  ..        ..    | . .. .  .|| |..|. .   .         |..||||...||  .|| ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RNKLPEDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSKEGIKE-------NTFTKSF--CGS----VAYLAPEVLAKRPHSRT
|.||. ..   .  ||    | ||.. .| |||   |. ... . .| .|||||...  .        . .|.   .|     .  .|||.. ..  .  
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDWYLLGTFLYELL-VGIPPYYD------NNKEILYDNIRRGPLKIPRS--------MSADAKDLIKQLLNRNPKERLGSKRDSEEI
 | .  |  ..|..  | .||..      .|.|.. .  ... ...| .        ....  ...||  ...|..|   .   |..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 10726.AA Pkinase_Tyr 454-598 27 1.4e-14 50.04 Pfam 1-159 (270) Show / Hide 
Range on Protein: 454-598
Range on HMM: 1-159/270
Sequence Identity: 27% (45 aa)

FRFISKLGQGSFGEVYLVERE------KKLFAMKIQNKQQVVQKN-LQRYVQTEKKALSLF-NHPFIIKLHYAFQ-----NDWYLFMVMEYAEGGDMGNY
 .|. |||.|.|||||. .        |   | |.  |..  ... ...    | | .. . .|| |..|. .       |  ....||||...||. .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

LNK----RNKLPEDEARIYTAQIVLALEELHKQDIIFRDLKPDNVVLDHLGNAKLTDFGLSK
| |    ...|.  .   . .||  ..| |. . .| |||   |. ... . .| .||||..
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR