Gene 29158 (Tetrahymena)

29158

Species: Tetrahymena
Alias: 3751.m00462, 154.m00116, TTHERM_00865280, PreTt29158, 29158, 291
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
29158.AA Protein None 957 None Fasta, JSON
29158.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
29158.NA RNA None 2874 None Fasta, JSON

Protein domain

Protein domains of 29158.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 29158.AA Ank 419-451 39 2e-07 31.05 Pfam 1-33 (33) Show / Hide 
Range on Protein: 419-451
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

NDWTPLHYACQNGNTKLVSQLLYHEATIDSESN
. .||||.||..|.|. |. ||.| | ..   .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 29158.AA Ank 485-516 33 8.8e-07 28.71 Pfam 1-33 (33) Show / Hide 
Range on Protein: 485-516
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

NGNTALHHACMNGNKRIVEMLLK-KPSLDYKIP
.|.|.|| ||..|....|.|||.   ... .  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 29158.AA Ank 452-484 39 2e-06 27.7 Pfam 1-33 (33) Show / Hide 
Range on Protein: 452-484
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

IKQTPLIVASIGGYEDVLQLLMTAGADINFQDS
  .||| .|.. |...|...|. .|||.| || 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase 29158.AA RSK-Unclassified 634-892 58 1.8e-219 696.79 In-house 1-283 (283) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-283/283
Sequence Identity: 58% (166 aa)

FIVHGLIGKGSFGEVYLVEKKDSQQLYAMKVLHKSKIMRHNLTRYALTERNVLSVTKHPFIVRLNFAFQTQDKLFLILKYCPGGDLGEHLQ--KEKRFTE
||.|.|||.|.||.||||.|||.||.||||||||.|..|||...|..||.|....|.|||||.|...|||||.|.|...||.|||...|||  |||.|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSKEG--------------------VLDHSTGAKSFCGSVAYLAPEMLKRCGHG
|.||.|..|.|.|||.|||.|.|.||||||||||..|||.|||||.||...                    ..||.....||||...||||||..||||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KAVDWYLLGVVMYELLVGIPPYYANNKEELFNNIEKGHLKLP--SFLSNDARSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
|||||..||.||||.|.|.||||.|||.|.|.||||.|.|.|  |..||..|.|.|.|||||||||||...||||.||.|.||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 29158.AA AGC 634-892 33 4.90000000001e-182 475.65 In-house 1-395 (395) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-395/395
Sequence Identity: 33% (135 aa)

FIVHGLIGKGSFGEVYLVEKK------DSQQLYAMKVLHKSK---IMRHNLTRYALTE------------RNVLSVTK----------HPFIVR-LNFAF
| .. .|||||||.||||.||      |....|||||| |..   |...|  ....||            ||.|.  .          |||||. | ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTQDK--LFLILKYCP---------GG-DLGEHLQ---KEKRFTEDRVRNYLAE-------ITLALEHLHK-KDVIFRD-LKPDNIVLDHEGHAMLTDFG
|..|.  |.... |.|         || .|  |||   ||.||.|.|.| |.||       |.||||.||. ...| || |||.||.||..|| .|||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEGVLDHSTG-------------------------------------------------AKSFCG--SVAYLAPEMLKRCGHGKAVDWY--LLGVVMY
|.|||. |.. |                                                 ...|||  .  |.|||.|    .|||.||.  .||..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLVGIPPYYANN----------KEELFNNIE------KGHLKLP----------SFLSNDARSLLKALLQRNPAKRLGSGKGD-----ADEIKAHQFF
|.|.|.||.|..|          ..|.|..|.      .  .|.|          ...|..|..|.| ||...|.||||.|..|     |.|||.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 29158.AA SGK 634-892 45 6.9e-155 482.07 In-house 1-283 (283) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-283/283
Sequence Identity: 45% (131 aa)

FIVHGLIGKGSFGEVYLVEKKDS------------------QQLYAMKVLHKSKIM-------RHNLTRYALTER-NVLSVTKHPFIVRLNFAFQTQDKL
|.   .|||||||.||.|..||                   ...|||||| |  |        . .. .. ..|| ..|.  |||||| | .||||..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLILKYCPGGDLGEHLQKEKRFTEDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSKEGVLDHSTGAKSFCGSVAYLAPEMLKR
.. . |  ||... |||.||.| |||.| | ||| .|||.||..|.|.|||||.||.|||.||. ||||||.|||.  .... ..|||...|||||.|. 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGI-KTNDTTFTFCGTPEYLAPEVLRK

CGHGKAVDWYLLGVVMYELLVGIPPYYANNKEELFNNIEKGHLKLPSFLSNDARSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
 .|...|||..|| |.||...|.||.| .||.... || .. |..| . ||||..|.. |||..| ||||. | |. ||| |.||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase 29158.AA Akt 634-892 50 5e-154 495.82 In-house 1-264 (264) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-264/264
Sequence Identity: 50% (133 aa)

FIVHGLIGKGSFGEVYLVEKKDSQQLY-AMKVLHKSKIMRHNLTRYALTERNVLSVTKHPFIVRLNFAFQTQDKLFLILKYCPGGDLGEHLQKEKRFTED
| .  ..|||||| |.||.|||.|..| ||||| |..|  .|  ....||||.|  ..||||| |...|||||||.... ||.||.|  |||...||.||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RVRNYLAEITLALEHLHKKDVIFRD-LKPDNIVLDHEGHAMLTDFGLSKEGVLDHSTGAKSFCGSVAYLAPEMLKRCGHGKAVDWYL-LGVVMYELLVGI
| | | ||| ||.||||.|..|.|| ||| ||..|..||  ||||||.||... .   .|.|||. .|||||.|.  ||.|||||.  ||.||||.. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPYYANNKEELFNNIEKGHLKLP--SFLSNDARSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
||.|. .....| .|  . .| |  ...|.....|.. ||...| ||||.|..||.|||.| .|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 29158.AA RSK 637-892 48 1.9e-153 516.05 In-house 1-278 (278) Show / Hide 
Range on Protein: 637-892
Range on HMM: 1-278/278
Sequence Identity: 48% (134 aa)

HGLIGKGSFGEVYLVEKK---DSQQLYAMKVLHKSKIMRHNL-TRYALTERNVLSVTK-HPFIVRLNFAFQTQDKLFLILKYCPGGDLGEHLQKEKR---
. . |.|..|.|.|. |.   |..|.||||||.|.||....  ||...||||.|. .. |||||.|. ||||..||.||. ||.||.|..||||||.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDH---EGHAMLTDFGLSKEGVLDHSTGAKSFCGSVAYLAPEMLK----RCGHGKAVDWYLLGV
|.||... |.|||.||.||||....|.|||||.||..|.   ||| .|||||..|....||.  ...||....|.||||||    ..||.||.||. |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYELLVGIPPYYA---NNKEELFNNIEKGH--LKLP--SFLSNDARSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
.|||.|.| ||...   ||..|....|.||.  |..|  ..||..|..|....|.|.|.||||.|..||.|||.|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 29158.AA AktR 634-892 46 4e-136 458.53 In-house 1-268 (268) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-268/268
Sequence Identity: 46% (124 aa)

FIVHGLIGKGSFGEVYLVEKK-DSQQLYAMKVLHKSKIMRHNLTRYALTERNVLS-VTKHPFIVRLNFAFQTQDKLFLILKYCPGGDLGEHLQKEKRFTE
| |. ..||| ||.||||.|| |.|..||||...|.|| . |. ....||||..    .|||||.| ..|||..|||.|..|||||.|  ||.|.|.|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DRVRNYLAEITLALEHLHKK-DVIFRDLKPDNIVLDHEGHAMLTDFGLSK-EGVLDHSTGAKSFCGSVAYLAPEMLKR-CGHGKAVDWYLLGVVMYELLV
...| | |.| ||||.||.. ..|.|||||.||.|| .||  .||||||| ... . .  |.||||...|.||||...  ||.|.|||. .|.. ||...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GIPPYYANNKEELFNNIEKGH-LKLPSF--LSNDARSLLK-ALLQRNPAKRLGSGKGDADEIKAHQFF
|.|| |..|....| .| .   .| |    .|. ...|..  ||..|| ||||... ...||| | .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 29158.AA RSK 634-892 38 4.2e-122 411.96 In-house 1-271 (271) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-271/271
Sequence Identity: 38% (105 aa)

FIVHGLIGKGSFGEVYLVEKK---DSQQLYAMKVLHKSKIMRHNLTRYALTERNVLSVTKHPFIVRLNFAFQTQDKLFLILKYCPGGDLGEHLQKEKRFT
...|  ||.|||..||.. |.   |..|.||||.. |...       .. .||..|.   |||||.|. .||.. |...|.  . ||||. .|.|.| |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHE----GHAMLTDFGLSKEGVLDHSTGAKSFCGSVAYLAPEMLKRCGHGKAVDWYLLGVVMYEL
|. |..|.|||.||.|.||......|||||.||..| |    ||. ..|||..|. ..|.  ....||....|.|||.||| ||..|.||...||.||| 
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LVGIPPYYANNKEELFNNIEKGHLKL-------PSFLSNDARSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
| | .|..........|.| .  | .       ..|.|  | .|| ..| |.|..|||.|  .. .|| | .|
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 29158.AA p70 634-892 41 4.90000000001e-110 371.86 In-house 1-299 (299) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-299/299
Sequence Identity: 41% (124 aa)

FIVHGLIGKGSFGEVYLVEKKD---SQQLYAMKVLHKSKIMRHNL-TRYAL-------------------------TERNVLSVTKHPFIVRLNFAFQTQ
|    ..||| .| |..| |     . ..|||||| | || |    |. .                           |||.|.  |||||. | .|||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

DKLFLILKYCPGGDLGEHLQKEKRFTEDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSKEGVLDHST---------GAKSFCG
 ||.||| | .|| |  || ..  . || .. ||.||..||||||....|.|||||.|. |.. ||  ||||||.|| . | .             .|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

SVAYLAPEMLKRCGHGKAVDWYLLGVVMYELLVGIPPYYANNKEELFNNIEKGH--LKLPSFLSNDARSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
   | |||.| ||||..||||. ||. ||  |.| ||. . |. .  . | ||   ||||  |....| |.|.|| |.|..|.|.| .|| .|..|.||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 29158.AA PKC 634-892 42 8.10000000001e-101 327.53 In-house 1-262 (262) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-262/262
Sequence Identity: 42% (112 aa)

FIVHGLIGKGSFGEVYLVEKKDSQQLYAMKVLHKSKIMRHNLTRYALTERNVLSV-TKHPFIVRLNFAFQTQDKLFLILKYCPGGDLGEHLQKEKRFTED
|  .  .|||||| | |.|.|.....||.||| |  |.       ..||. ||.  .|||| . |   |||.|.|| .. |. ||||  | |. .|| | 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSKEGVLDHSTGAKSFCGSVAYLAPEMLKRCGHGKAVDWYLLGVVMYELLVGIPP
. | | |||..||  ||.|..| |||| ||. ||||||  ..|||..||.... .| ...|||   |.||| |.    ||.|||  .|| |||...| .|
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDT-TSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSP

YYANNKEELFNNIEKGHLKLPSFLSNDARSLLKALLQRNPAKRLGSGKGD---ADEIKAHQFF
  . . .|||..| .     |  || .| |..|.....||.||||... .   ...|..|.||
FHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 29158.AA PKA 634-892 39 2.7e-97 329.52 In-house 1-263 (263) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-263/263
Sequence Identity: 39% (105 aa)

FIVHGLIGKGSFGEVYLVEKKDSQQLYAMKVLHKSKIMRHNLTRYALTERNVLSVTKHPFIVR-LNFAFQTQDKLFLILKYCPGGDLGEHLQKEKRFTED
|    ..|.|||| |.|. .|.| . ||||.| |..| | . .   ..|.|.|. .||||||. . . ||. ..|.... |.|||..  .|.|..||...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RVRNYLA-EITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSKEGVLDHSTGAKSFCGSVAYLAPEMLKRC-GHGKAVDWYLLGVVMYELLVGI
  . | | .|.|||| ||... | ||||| || .| .||  .|||| .|. .       .. ||   |||||....  ||||.|||  ||.. ||.|.|.
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD----RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

PPYYAN--NKEELFNNIEKGHLKLPSFLSNDA---RSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
|| |..  .. .... | .| .| |.....||   ..|.| |||... ||.|. |.... || | .|
PPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 29158.AA S_TKc 634-892 32 2.2e-93 317.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

FIVHGLIGKGSFGEVYLVEKKDSQQLYAMKVLHKSKIMRHNLTRYALTERNVLSVTKHPFIVRLNFAFQTQDKLFLILKYCPG--GDLGEHLQKEKR---
. .. .||||.||.||.. .|......|.|...          . .. |...|.  .||.||.|  .||. |.|.... ||.|  ||| ....| .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTEDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSKEGVLDHSTGAKSFCGSVAYLAPEMLKRCGHGK-AVDWYLLGVVMY
   |.| ..| |...| .|||..|.. .| |||||.|| ||.  | ...||||...         ..|||.  |.|||.|   |.|| ..||. .|...|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLVGIPPYYANNKEELFNNIEKGHLKLPSFLSNDARSLLKALLQRNPAKRLGSGKGDADE--IKAHQFF
|.|.| ||..  . ...|..|           | .|..... .||..|.||..  .  .||  ||.|..|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29158.AA Pkinase 634-892 25 6.5e-83 286.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

FIVHGLIGKGSFGEVYLVEKKDSQQLYAMKVLHKSKIMRHNLTRYAL-TERNVLSVTKHPFIVRLNFAFQTQDKLFLILKYCPGG----DLGEHLQ--KE
. ... ||.||||.||.  .|......|.|.. |...    . . .. .|  ..   .||.||||  .|.. |.. ... ||.||    || ....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRF--TEDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHA----MLTDFGLSK--EGVLDHSTGAKSFCGSVAYLAPEMLK-RCGHGKAVDWY
..|  .|. ...|. .|  .||..|.. .| |||||.|| .|..||      ..||||.|  .  . ... ...|||.  |.||| .. . ..|..||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

LLGVVMYELLVGIPPYYAN------NKEELFNNIEKGHLKLPSFLS---------------------NDARSLLKALLQRNPAKRLGSGKGDADEIKAHQ
 .|...||.| | ||..        .. .....| .. |. ... .                      ......| .|...|.||..     |..|. | 
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHP

FF
.|
WF
Kinase 29158.AA TyrKc 634-892 22 4.7e-15 20.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 634-892
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FIVHGLIGKGSFGEVYLVEKKDSQQLYAMKVLHKSKIMRHNLTRYALTERNVLSVT--KHPFIVRLNFAFQTQ--------DKLFLILKYCPGGDLGEHL
      .| | |||||. . |   .  | |.|....       .  . | ....    .|| |||| ..  ||        . |.... |.|.||| ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRL-YGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKEKR-FTEDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSKEGVLD------HSTGAKSF--CGS----VAYLAPEMLKRCGH
.| .. .. .   ..   |    |.||.| .| |||   |. .......  .|||||...  |      ...  |.   .|     .  .||| .. .  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GKAVDWYLLGVVMYELL-VGIPPYYA-----NNKEELFNNIEKGHLKLPSFL---------SNDARSLLKALLQRNPAKRLGSGKGDADEIKAHQFF
  . | .  ||.|.|..  | .||.       . .|.......|.   .            . .  .. |   ...|..|         ||  |..|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase 29158.AA Pkinase_Tyr 634-780 25 7.3e-09 30.64 Pfam 1-159 (270) Show / Hide 
Range on Protein: 634-780
Range on HMM: 1-159/270
Sequence Identity: 25% (41 aa)

FIVHGLIGKGSFGEVYLVEKK----DSQQLYAMKVLHKSKIMRHN-LTRYALTERNVLSVT-KHPFIVRLNFAFQ-TQDK--LFLILKYCPGGDLGEHLQ
 .    .|.|.|||||. . |    . ..  | |.| | . | .. . .  . | ....   .|| ||||  .    ..   ..... |.|.||| ..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EKRFTEDRVRNYLAEITLALEHLHKKDVIFRDLKPDNIVLDHEGHAMLTDFGLSK
|    ....|  .  .. ..|  ..|.|. |  | |||   |. .......  .||||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR