Gene 26009 (Tetrahymena)

26009

Species: Tetrahymena
Alias: TTHERM_00290770, 26.m00361, 614, PreTt26009, 3688.m00153, 26009
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
26009.AA Protein None 369 None Fasta, JSON
26009.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
26009.NA RNA None 1110 None Fasta, JSON

Protein domain

Protein domains of 26009.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26009.AA AGC 35-294 30 2.7e-162 423.42 In-house 1-395 (395) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-395/395
Sequence Identity: 30% (121 aa)

FELVNVIGQGRYGTVLLVKKK------DSGNFFAMKVIKKSL---IKKRNLQHRIMTE------------RNILTLCKS---------SKLITK-LQYSF
||.. |||.| .|.| ||.||      |.| ..||||.||.    |||.| ....|||            ||||..|..         .  |.| | |||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QNRSN--YFYLLEYCP---------GG-DLAYYMQ---RKGKLTEKDAKFYAAQ-------LILTLEFLHS-QNIIYRD-LKPENILIDKNGYFKLGDFG
|. ..   . ..||.|         || .| ...|   ..|...|. |.||||.       ..| ||.||| ..||.|| |||||||.|..|. || |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SAVQNITLE---------------------------------------------------ESQVLCG--TPQYFAPEMITREGHGKGVDLWA--LGCIIF
.. .... .                                                     . .||  ||.| |||..    .|| .| |.  |||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELVFGVTPFEETT----------QAQLYERIQ------NGKVFFDVN------DDVKVTNYFKDLINKLLAKDPKERIGTKS-------FDDIKNHPWF
|...| .||   .          .......|.      | || |. .      .|.....  ||||.||| |||..|.|..        ...|||||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 26009.AA PKA 35-294 45 9.5e-159 533.68 In-house 1-263 (263) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-263/263
Sequence Identity: 45% (122 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFFAMKVIKKSLIKKRNLQHRIMTERNILTLCKSSKLITKLQYSFQNRSNYFYLLEYCPGGDLAYYMQRKGKLTEK
||.....|.|..|.| |...|.|||..|||..||. |.... ......|.|||...|......|....||.........||.|||.. .|....|.....
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DAKFYAA-QLILTLEFLHSQNIIYRDLKPENILIDKNGYFKLGDFGSAVQNITLEESQVLCGTPQYFAPEMITRE-GHGKGVDLWALGCIIFELVFGVTP
.|||||| | .|.||.||||||||||||||||||||||..|..|||  .....  ....|||||.|.|||.|... ||||.|| ||||..|.|...|..|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFG-FAKKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FEET--TQAQLYERIQNGKVFFDVNDDVKVTNYFKDLINKLLAKDPKERIGTKSF--DDIKNHPWF
|...  ...|.||.|.|||..|. ..|... |||||||.|||..|...|.|....  .|||||.||
FYDHNRDPMQIYEKICNGKIKFPRHFDSDA-NYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 26009.AA AktR 35-294 44 1.6e-122 413.31 In-house 1-268 (268) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-268/268
Sequence Identity: 44% (119 aa)

FELVNVIGQGRYGTVLLVKKK-DSGNFFAMKVIKKSLIKKRNLQHRIMTERNILTLCKSSKLITKLQYSFQNRSNYFYLLEYCPGGDLAYYMQRKGKLTE
|.. ...|.| .|.| ||.|| |.. ..|||.|||. |..||..|.. |||||.  |..   | || |.||.... |...||||||.| .. ..|.|..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

KDAKFYAAQLILTLEFLHSQ-NIIYRDLKPENILIDKNGYFKLGDFGSAV-QNI--TLEESQVLCGTPQYFAPEMITR-EGHGKGVDLWALGCIIFELVF
..|.||.|| .| ||.||.. |||||||||||||.|..|. |..||| .  |..    |. . .||||.|.||||||. .||.| ||.||.|. |.|.|.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GVTPFEETTQAQLYERIQNGKVFFDVNDDVKVTNYFKDLIN-KLLAKDPKERIG--TKSFDDIKNHPWF
| .||.   | |....|..    . ... ..... .||||. ||| |.|..|.|  ......||.||||
GCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 26009.AA Akt 35-294 44 2e-108 347.71 In-house 1-264 (264) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-264/264
Sequence Identity: 44% (119 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFF-AMKVIKKSLIKKRNLQHRIMTERNILTLCKSSKLITKLQYSFQNRSNYFYLLEYCPGGDLAYYMQRKGKLTE
|....|.|.| .| |.||||||..... ||||.||. | ..|    ..||||||  |. .  |..| ||||.  . .  ..||.||.| |..|||.. .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

KDAKFYAAQLILTLEFLHSQNIIYRD-LKPENILIDKNGYFKLGDFGSAVQN-ITL-EESQVLCGTPQYFAPEMITREGHGKGVDLWA-LGCIIFELVFG
. |.||.|..|| .|.|||.|||||| |||||||.||.|. .| ||| . .| |.  .. . .|||| | |||..   ||.| || |. |||...|. .|
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

VTPFEETTQAQLYERIQNGKVFFDVNDDVKVTNYFKDLINKLLAKDPKERIG-TKS-FDDIKNHPWF
  || .  . |... |.|..| |  .   .. .  ||||..|| ||||.| | ...  ..||.||||
RPPFYNQDHHQMFKKIKNQPVKFPDK--DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 26009.AA SGK 35-294 39 3.6e-104 322.62 In-house 1-283 (283) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

FELVNVIGQGRYGTVLLVKKKDS------------------GNFFAMKVIKKSLIK-------KRNLQHRIMTER-NILTLCKSSKLITKLQYSFQNRSN
|.. .|||.| .| |..||.||                   . |.||||..|  |        |...|  ||.|| .|| . |.  .. .| |.||.   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIV-NLHYAFQTKWK

YFYLLEYCPGGDLAYYMQRKGKLTEKDAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDKNGYFKLGDFGSAVQNI-TLEESQVLCGTPQYFAPEMITR
 .  ..|  ||.. |..|| ... |  |.||||.... || ||||.|||||||||||| |  |. .| ||| . ..| | ..    |||| | |||..  
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

EGHGKGVDLWALGCIIFELVFGVTPFEETTQAQLYERIQNGKVFFDVNDDVKVTNYFKDLINKLLAKDPKERIGTK-SFDDIKNHPWF
..|.. || | |||. .|. .|  ||.    .|.|. | |..  .  .    ..|  .|||. ||.||||.| |||  | .|||||.|
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ----MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 26009.AA S_TKc 35-294 34 6.6e-96 325.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFFAMKVIKKSLIKKRNLQHRIMTERNILTLCKSSKLITKLQYSFQNRSNYFYLLEYCPG--GDLAYYMQRKGK--
.|....||.| .|.| ....|..|  .|.|.||           .|. |..||      . | || ..||. ....  .|||.|  |||  |....|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LTEKDAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDKNGYFKLGDFGSAVQNITLEESQVLCGTPQYFAPEMITREGHGK-GVDLWALGCIIFE
    ..| .|.||..|... ||..||..||.|||||||||.|.    |..|||.| |         .|||| | |||..   |.||  .| |..|||..|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LVFGVTPFEETTQAQLYERIQNGKVFFDVNDDVKVTNYFKDLINKLLAKDPKERIGTKSFDD----IKNHPWF
.. | .||.  ........|               .  .||.|.|.| |||..|..          ||.||||
MLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26009.AA RSK 38-294 38 3.2e-92 312.68 In-house 1-278 (278) Show / Hide 
Range on Protein: 38-294
Range on HMM: 1-278/278
Sequence Identity: 38% (108 aa)

VNVIGQGRYGTVLLVKKK---DSGNFFAMKVIKKSLIKKRNL-QHRIMTERNILTLCKSSKLITKLQYSFQNRSNYFYLLEYCPGGDLAYYMQRKGK---
. | ||| || | |..|.   |.|  .||||.||. |..|.  . . ||||||| .|.... | .| |.||  .  .  .|||.||.| .  |...    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LTEKDAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDK---NGYFKLGDFGSAVQNITLEESQVL---CGTPQYFAPEMIT----REGHGKGVDLWALG
..|..|.||.|...|..|.||.| ||.||||||||| |    .|  || ||| . |.  ....| .   |.| .| ||||..    ..||.| .|.| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

CIIFELVFGVTPFEE---TTQAQLYERIQNGKVFFDVNDDVKVTNYFKDLINKLLAKDPKERIG--TKSFDDIKNHPWF
....|. .| .||      ..... .|||.||  ..   . .... .||||.|.| .||. |.|   .  ..||.||||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 26009.AA Pkinase 35-294 33 7.8e-92 316.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFFAMKVIKKSLIKKRNLQHRIM-TERNILTLCKSSKLITKLQYSFQNRSNYFYLLEYCPGG----DLAYYMQ--R
.... .||.| .|.| . ..|..|  .|.|.|||. .|.  .|...  .|  |.  . ... | .| ..|......   .|||.||    ||. |..  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KGKL--TEKDAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDKNGYF----KLGDFGSAVQ--NITLEESQVLCGTPQYFAPEMIT-REGHGKGVDLWA
.|..  .|...|||. |..  ||..||..||.|||||||||||.||.     |..|||.| |  .   .  ...|||| | ||| |  ....|. || |.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCIIFELVFGVTPFEET------TQAQLYERIQNGKVFFDVNDDVKVT-----------------NYFKDLINKLLAKDPKERIGTKSFDDIKNHPWF
.|||..|...| .|| .       .| |...||  ... ||   .  .                    .||.|...|.||||.|..   ...|..||||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 26009.AA Ciliate-E2-Unclassified 35-294 27 1.2e-89 304.14 In-house 1-352 (352) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-352/352
Sequence Identity: 27% (99 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFF-----AMKVIKKSLIKKRNLQHRIMTERNILTLCK------------------SSKLITKLQYSFQNRSNYFY
.... .|||| .|.| ....|. . ..     ..|.....  ...| . .|| | ...   |                   . .| |. | ||.. | . 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

LLEYCPGGDLAYYMQRKGK-----------------LTEKDAK-----FYAAQLILTLEFLHSQN-IIYRDLKPENILIDKNG---YFKLGDFGSAVQNI
 .|||.|||| .|.. ..|                 .||. ||     ||.||... ||.||..| ||.||.||||||.|.||   | |. |||.. ...
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

TL----------------EESQVLCGTPQYF----APEMITREGHG----KGVDLWALGCIIFELVFGVTPFEETTQAQ----------------LYERI
.                 ....  ||||.|     |||.. .....    . .| |.||.|..|..||  ||. ... |                ||. |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

QNGKVFFDVNDD----VKVTNYFKDLIN----KLLAKDPKERIGTKSFDDIKNHPWF
......|.  .      .. .  ||.||    |.| |.|..||   .|..|.|||||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI---TFEQILNHPWF
Kinase 26009.AA Ciliate-E2 35-294 25 7.4e-85 288.23 In-house 1-365 (365) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-365/365
Sequence Identity: 25% (99 aa)

FELVNVIGQGRYG-----TVLLVKK------------------KDSGNFFAMKVIKKSLIKKRNLQHRIM----------TERNILTLCKSSKLITKLQY
......|||| .|     .| .|.|                  |. ....|||..||. |.  .   .||           |.||| . . .. | |. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

SFQ--NRSNYFYLLEYCPGGDLAYYM-------------------QRKGKLTEKDAK-------FYAAQLILTLEFLHSQN-IIYRDLKPENILIDKNGY
.||  ...|... .||| |||| .|.                   .  ...... ..       ||.|..|| ||.|||.| ||.||.||||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

FKLGDFGSA-------------VQNITLEESQV--------------------LCGTPQYFAPEMITREG---------HGKGVDLWALGCIIFELVFGV
 |. ||| .             .|.  . . ..                    .|||| | |||.. ...         ... .|.|.||.|..|..|| 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

TPFEETTQAQLYERIQNGKVFFDVN--------------DDVKVTNYFKDLINK----LLAKDPKERIGTKSFDDIKNHPWF
.||        .. |...|. |. .              .  |...  ||||.|    .| |||..||.  ....|.|||||
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 26009.AA MAST 35-179 43 1.6e-51 155.33 In-house 1-147 (337) Show / Hide 
Range on Protein: 35-179
Range on HMM: 1-147/337
Sequence Identity: 43% (64 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFFAMKVIKKSLIKKRNLQHRIMTERNILTLCKSSKLITKLQYSFQN--RSNYFYLLEYCPGGDLAYYMQRKG-KL
|| . .|. | || | |||.|... .||||||... . ..| .  .. ||||||  .    . |. ||||   .  ..  .||  ||| |  ..  |  .
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQ-NPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCM

TEKDAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDKNGYFKLGDFG
 |  ||.| |...| ||.|||. |. |||||.|.|||.||  || |||
PEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase 26009.AA MAST 35-179 45 3.3e-50 159.87 In-house 1-144 (334) Show / Hide 
Range on Protein: 35-179
Range on HMM: 1-144/334
Sequence Identity: 45% (66 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFFAMKVIKKSLIKKRNLQHRIMTERNILTLCKSSKLITKLQYSFQNRSNYFYLLEYCPGGDLAYYMQRKGKLTEK
|| . .|. | || | |||.|... .|||||||||   ..| ..  ..|||||.. . .  . |. |||| .....  .||  |||.|  ..  | . | 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQ-NPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEW

DAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDKNGYFKLGDFG
 ||.| |...| ||.|||. |. |||||.|.|||.||  || |||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase 26009.AA MAST 194-294 39 1.2e-39 118.34 In-house 229-337 (337) Show / Hide 
Range on Protein: 194-294
Range on HMM: 229-337/337
Sequence Identity: 39% (43 aa)

CGTPQYFAPEMITREG-HGKGVDLWALGCIIFELVFGVTPFEETTQAQ-LYERIQN--GKVFF-DV---NDDVKVTNYFKDLINKLLAKDPKERIGTKSF
||||.| ||| |...| .|| || |..| |..|.  |..|| . |.   . . | |   .. . ..   ||| ...   .|||.|||...||.|.|..  
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

DDIKNHPWF
|.||.|| |
DEIKQHPFF
Kinase 26009.AA MAST 193-294 39 1.1e-37 118.88 In-house 224-334 (334) Show / Hide 
Range on Protein: 193-294
Range on HMM: 224-334/334
Sequence Identity: 39% (44 aa)

LCGTPQYFAPEMITREG-HGKGVDLWALGCIIFELVFGVTPFEETTQAQLYERIQNGK---VFF----DVNDDVKVTNYFKDLINKLLAKDPKERIGTK-
.||||.|.||| |...| ||| || |..| |..|.  |..|| . |.  ... | | .   . .    | ||| . .   .|||.|||. ||..|.|.. 
CCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANN

SFDDIKNHPWF
  |..|.|| |
GADEVKQHPFF
Kinase 26009.AA TyrKc 35-294 21 1e-11 -33.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 35-294
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FELVNVIGQGRYGTVLLVKKKDSGNFFAMKVIKKSLIKKRNLQHRIMTERNILTLC--KSSKLITKLQYSFQNR------SNYFYLLEYCPGGDLAYYMQ
 .|  ..| | .|.| . . |      | |..|..       .  .| | .|..    .   ..  . .  |          .. ..||.|.|||  | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RKGK-LTEKDAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDKNGYFKLGDFGSAVQNITLE------ESQVLC----GTPQ-----YFAPEMITREG-
.... |. ||   .. |     |.|||.|.| |||   |.|...|.  | .||| .  .|. .      ..        |.         ||| | ..| 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR-DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

HGKGVDLWALGCIIFELV-FGVTPFEE-----TTQAQLYERIQNGKVFFDVNDD-----VKVTNYFKDLINKLLAKDPKERIGTKSFDDIKNHPWF
     | |. |  ..|.  .| .| ..      . ....|....|.      .|     |  .    ... .  . ||..|    .| .|  |  |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP---TFSEI--HECF
Kinase 26009.AA Pkinase_Tyr 113-179 39 0.00209 12.16 Pfam 86-156 (270) Show / Hide 
Range on Protein: 113-179
Range on HMM: 86-156/270
Sequence Identity: 39% (28 aa)

LEYCPGGDLAYYMQR----KGKLTEKDAKFYAAQLILTLEFLHSQNIIYRDLKPENILIDKNGYFKLGDFG
.||.|.|||  | ..    |..|| ||   ...|    .|.|.|.|.| |||   |.|...|.  | .|||
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 26009.AA Pkinase_Tyr 35-49 26 1.204569 2.81 Pfam 1-15 (270) Show / Hide 
Range on Protein: 35-49
Range on HMM: 1-15/270
Sequence Identity: 26% (4 aa)

FELVNVIGQGRYGTV
 ..  ..|.| .|.|
ITFGKKLGEGAFGEV