Gene 2171 (Tetrahymena)

2171

Species: Tetrahymena
Alias: 3724.m00064, 97.m00157, 354, PreTt02171, 2171, TTHERM_00658860
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
2171.AA Protein None 538 None Fasta, JSON
2171.kin_dom Protein Kinase Domain None 347 None Fasta, JSON
2171.NA RNA None 1617 None Fasta, JSON

Protein domain

Protein domains of 2171.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2171.AA AGC 139-485 26 8.20000000001e-156 406.27 In-house 1-395 (395) Show / Hide 
Range on Protein: 139-485
Range on HMM: 1-395/395
Sequence Identity: 26% (128 aa)

KKQQQSINRCSFGRVRLAKQK------STGEYVALKMLKKAE-ILRLK--QVDHIISE------------NTILSNIN----------HPFLVNLSTFYL
 .    | . |||.|.|.. |      .||.| |.|.|||.. |...|  .|.|...|              ||...|          |||.|.      
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVK------

HQQVIKMIGFTQDDRF--LYFVLEYVA---------GG-ELFTYLR---NKGKLDNPEALFYAAQ-------VYIFVCDLLSYDNHFETQQINLKIRLSY
     ..    ||..   ||||.||.          || |||..|.   ..|..| ..| ||||.       .                           
-----ILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLA------------------------

FLLQQIQQMSQNQSKIFFQNNLRKNTNILPRQYFYLTNQIKQPKIETKKRYFKVSMFEYLHN-KNIVYRD-LKPENILIGSDGYLKLTDFGFAKYCDS--
                                                        .||||. ..|..|| |||||||. .||..||||||..|   .  
--------------------------------------------------------LEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDG

---------------------------------------------------RTYTLCG--TPEYLAPEILLNKGHGKPVDWWC--LGILIYEMLAGIDPF
                                                   ||.|.||  ||||.|||||    .||..|||.  ||.|.||||.|. ||
EKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPF

NDE----------DPMAIYQKIL------KGKVKFP----------RNFDKNAKSLVKHLLVADLTKRYGNLKG-----GVNDIKTHRWF
...          .|| ..|||.      . |||||          |.|...||.|.|.||. | .|| |....     |...|| | ||
YGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 2171.AA PKA 339-485 68 2.1e-120 406.34 In-house 111-263 (263) Show / Hide 
Range on Protein: 339-485
Range on HMM: 111-263/263
Sequence Identity: 68% (105 aa)

VSMFEYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFAKYCDSRTYTLCGTPEYLAPEILLNK-GHGKPVDWWCLGILIYEMLAGIDPFNDE--DPMAIY
|...||||..||.||||||||||| ..|..|.|||||||..|.||.|||||||||||||...| ||||.||||.|||||||||||..||.|.  |||.||
VLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIY

QKILKGKVKFPRNFDKNA---KSLVKHLLVADLTKRYGNLKGGVNDIKTHRWF
.||..||.||||.||..|   |.|.|.||..||||||||.|.||||||.|.||
EKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 2171.AA Akt 343-485 49 5.5e-77 245.63 In-house 114-264 (264) Show / Hide 
Range on Protein: 343-485
Range on HMM: 114-264/264
Sequence Identity: 49% (74 aa)

EYLHNKNIVYRD-LKPENILIGSDGYLKLTDFGFAK---YCD-SRTYTLCGTPEYLAPEILLNKGHGKPVDWWC-LGILIYEMLAGIDPFNDEDPMAIYQ
|.||.|||.||| |||||||. .||...||||| .|     |  .|.|.||||||||||||...||.|.||||  ||...|||. |  || ..|    ..
EHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFK

KILKGKVKFP--RNFDKNAKSLVKHLLVADLTKRYGNLKGGVNDIKTHRWF
||. ..||||  .......|.|.. ||  | .|| |. ......|| | ||
KIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 2171.AA SGK 339-485 44 9.5e-74 226.99 In-house 135-283 (283) Show / Hide 
Range on Protein: 339-485
Range on HMM: 135-283/283
Sequence Identity: 44% (66 aa)

VSMFEYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFAK---YCDSRTYTLCGTPEYLAPEILLNKGHGKPVDWWCLGILIYEMLAGIDPFNDEDPMAIY
|.  |||| ..|.|||||||||| ...|...||||| .|        | | ||||||||||.|. ..|.. |||||||.. |||. |. || . .    |
VCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMY

QKILKGKVKFPRNFDKNAKSLVKHLLVADLTKRYGNLKGGVNDIKTHRWF
..|.... ..|...   |..| . ||  | .|| |  | .  .|| | .|
DNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase 2171.AA PKG 342-485 54 8e-71 241.61 In-house 113-260 (260) Show / Hide 
Range on Protein: 342-485
Range on HMM: 113-260/260
Sequence Identity: 54% (80 aa)

FEYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFAKYCDS--RTYTLCGTPEYLAPEILLNKGHGKPVDWWCLGILIYEMLAGIDPFNDEDPMAIYQKIL
|.|||.|||.||||||||.. . .||.|| ||||||   .  .|.| |||||| |||| |||||   ||.| ||||..| | |  ||   ||| .|. ||
FDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFSGSDPMKTYNIIL

KG--KVKFPRNFDKNAKSLVKHLLVADLTKRYGNLKGGVNDIKTHRWF
||  .. |||.  ..|. ..|.|     | | |..|.|.|||| |.||
KGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase 2171.AA AktR 341-485 46 2.1e-66 226.93 In-house 113-268 (268) Show / Hide 
Range on Protein: 341-485
Range on HMM: 113-268/268
Sequence Identity: 46% (72 aa)

MFEYLHNK-NIVYRDLKPENILIGSDGYLKLTDFGFAK--YC---DSRTYTLCGTPEYLAPEILLN-KGHGKPVDWWCLGILIYEMLAGIDPFNDEDPMA
..||||.. ||.||||||||||...||..|.|||| .|       | ..|..||||||.|||.... |||.|.||||..||.||||..|. ||....   
ALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQ

IYQKILKGK-VKFPRN--FDKNAKSLVK-HLLVADLTKRYGNLKGGVNDIKTHRWF
..|||..   .||| .  | ...|.|..  ||  . .|| |  . |  .|| | ||
MFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 2171.AA PKA 139-259 50 3.8e-65 222.73 In-house 1-111 (263) Show / Hide 
Range on Protein: 139-259
Range on HMM: 1-111/263
Sequence Identity: 50% (61 aa)

KKQQQSINRCSFGRVRLAKQKSTGEYVALKMLKKAEILRLKQVDHIISENTILSNINHPFLVNLSTFYLHQQVIKMIGFTQDDRFLYFVLEYVAGGELFT
 ...|.....|||||.|...|..|.|.|.|||||.|| |||||.|...|..||.||.|||.|.           ||....||||.||.|.|||.|||.|.
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVK-----------KMYWTFQDDRYLYMVMEYVPGGEMFS

YLRNKGKLDNPEALFYAA-QVY
|||..|...||.|.|||| |..
YLRKSGRFSNPHAKFYAASQIV
Kinase 2171.AA RSK 343-485 42 3.7e-64 219.47 In-house 118-278 (278) Show / Hide 
Range on Protein: 343-485
Range on HMM: 118-278/278
Sequence Identity: 42% (69 aa)

EYLHNKNIVYRDLKPENILIGS---DGYLKLTDFGFAKY--CD--SRTYTLCGTPEYLAPEILL----NKGHGKPVDWWCLGILIYEMLAGIDPFND---
|.|| . |..|||||||||  .   .| .|||||||.|.  ||  ..|.| |.| ||.|||.|     ..||.| .||| ||.|.||||.|  ||     
EHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPND

EDPMAIYQKILKGK--VKFP--RNFDKNAKSLVKHLLVADLTKRYGNLKGGVNDIKTHRWF
...  | ..|.|||  ...|   .  ..||.|....|  |  ||.|  ......|| | ||
NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 2171.AA Ciliate-E2 208-485 23 8.2e-59 200.52 In-house 91-365 (365) Show / Hide 
Range on Protein: 208-485
Range on HMM: 91-365/365
Sequence Identity: 23% (84 aa)

HQQVIKMIGFTQ--DDRFLYFVLEYVAGGELFTYLRNKGKLDNPEALFYAAQVYIFVCDLLSYDNHFETQQINLKIRLSYFLLQQIQQMSQNQSKIFFQN
|  .|||. . |  ||  .|.|.||. ||.|| |..|. |  | |                                                       
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE-----------------------------------------------------

NLRKNTNILPRQYFYLTNQIKQPKIETKKRYFKVSMF-----------------EYLHNKN-IVYRDLKPENILIGSDGYLKLTDFGFAKYCDS------
                  . |.....  |...|                     ||||.|| |..||.||||||.     .|..|||..|..|       
----------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRT

----------------------------RTYTLCGTPEYLAPEILLNKG---------HGKPVDWWCLGILIYEMLAGIDPFNDEDPMAIYQKILKGKVK
                             ..|.||||.|.||||| .|.         ... .|.|.||...|||| |  ||        .|.|...|..
HKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKID

FPRN------------------FDKNAKSLVKH----LLVADLTKRYGNLKGGVNDIKTHRWF
|| .                   ....| | |     .|. |  ||..    | ..|. | ||
FPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase 2171.AA Ciliate-E2b 342-485 41 1.4e-56 170.53 In-house 115-272 (272) Show / Hide 
Range on Protein: 342-485
Range on HMM: 115-272/272
Sequence Identity: 41% (67 aa)

FEYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFAKYCDS------RTYTLCGTPEYLAPEILL-----NKGHGKPVDWWCLGILIYEMLAGIDPFND--
.|||||.||.|||.|||||.. ..||.|| |.| ||. ..      ||.|..|||.|.||||.      .|| .  || | .||  ||.. |  |.    
LEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDV

EDPMAIYQKILKG--KVKFPRNF-DKNA-KSLVKHLLVADLTKRYGNLKGGVNDIKTHRWF
.||  |||.|.|.  ...||  . ||.| |.|.  .|      | |   |  .  |.| ||
QDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG---GSYSWLKSHPWF
Kinase 2171.AA Pkinase 343-485 32 2.6e-52 184.92 Pfam 122-293 (293) Show / Hide 
Range on Protein: 343-485
Range on HMM: 122-293/293
Sequence Identity: 32% (57 aa)

EYLHNKNIVYRDLKPENILIGSDGYL----KLTDFGFAK---YCDSRTYTLCGTPEYLAPEILL-NKGHGKPVDWWCLGILIYEMLAGIDPFNDE-----
||.|...|..|||||||||| ..|..    |..|||.||   |  ....|.||||.|.|||... ....|..||.| .|...|||| |  || ..     
EYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN

-DPMAIYQKILKGKVKFPRNFD---------------------KNAKSLVKHLLVADLTKRYGNLKGGVNDIKTHRWF
 |.|.....|......|..  .                     ...|...| .|  | .||..       .|. | ||
HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase 2171.AA S_TKc 139-485 25 1.7e-49 171.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 139-485
Range on HMM: 1-231/231
Sequence Identity: 25% (91 aa)

KKQQQSINRCSFGRVRLAKQKSTGEYVALKMLKKAEILRLKQVDHIISENTILSNINHPFLVNLSTFYLHQQVIKMIGFTQDDRFLYFVLEYVAG--GEL
 .  . | . .||.|.... |.||..||.|..|          .||..|  ||.. .||..|.|  .. .              .||.|.||. |  |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-------------DHLYMVMEYCDGDLGDL

FTYLRNKGK------LDNPEALFYAAQVYIFVCDLLSYDNHFETQQINLKIRLSYFLLQQIQQMSQNQSKIFFQNNLRKNTNILPRQYFYLTNQIKQPKI
|.|....|.      ..  .| ||..|.                                                                        
FDYIKKRGRHGLRFPFPE-HARFYMYQI------------------------------------------------------------------------

ETKKRYFKVSMFEYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFAKYCDSRTYTLCGTPEYLAPEILLNKGHGK-PVDWWCLGILIYEMLAGIDPFNDE
        ..  ||.|...|..|||||||||. .   .|..|||.|.      .|.||||.|.|||.|   |.|| ..||| .|...||||.|  ||   
--------CCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

DPMAIYQKILKGKVKFPRNFDKNAKSLVKHLLVADLTKRYGNLKGGV--NDIKTHRWF
.......||.          .. ||......|. | .||..  .      ||| | ||
QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2171.AA MAST 387-485 39 4.7e-42 125.83 In-house 229-337 (337) Show / Hide 
Range on Protein: 387-485
Range on HMM: 229-337/337
Sequence Identity: 39% (44 aa)

CGTPEYLAPEILLNKG-HGKPVDWWCLGILIYEMLAGIDPFNDEDPMA-IYQKILK--GKVKFPRN--------FDKNAKSLVKHLLVADLTKRYGNLKG
||||.|.|||..| .| .||||||| .|| .|| |.|. |||.. |   | |.|..   .. .|          . . |. |.| ||  .  || |    
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN--

GVNDIKTHRWF
|. .||.|. |
GADEIKQHPFF
Kinase 2171.AA AktR 150-258 36 1.1e-29 104.97 In-house 12-110 (268) Show / Hide 
Range on Protein: 150-258
Range on HMM: 12-110/268
Sequence Identity: 36% (40 aa)

FGRVRLAKQK-STGEYVALKMLKKAEILRLKQVDHIISENTILS-NINHPFLVNLSTFYLHQQVIKMIGFTQDDRFLYFVLEYVAGGELFTYLRNKGKLD
||.| |.. |  .....|.||.|| .| ...| .|.| | .|.   .||||.|.|  .             |... |.|..||..|||||..|..|.|..
FGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCF------------QTKEKLFFIMEYCPGGELFQHLKKKKKFS

NPEALFYAAQV
. .|.||.||.
EEQARFYFAQI
Kinase 2171.AA Akt 149-202 49 5e-22 67.12 In-house 11-65 (264) Show / Hide 
Range on Protein: 149-202
Range on HMM: 11-65/264
Sequence Identity: 49% (27 aa)

SFGRVRLAKQKSTGEYV-ALKMLKKAEILRLKQVDHIISENTILSNINHPFLVNL
|||.| |.|.|.|...  |.|.|||  |.  .|| |.. |. || ..||||.|||
SFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNL
Kinase 2171.AA Pkinase 149-258 30 2.3e-20 73.09 Pfam 11-117 (293) Show / Hide 
Range on Protein: 149-258
Range on HMM: 11-117/293
Sequence Identity: 30% (36 aa)

SFGRVRLAKQKSTGEYVALKMLKKAEILRLKQVDHII-SENTILSNINHPFLVNLSTFYLHQQVIKMIGFTQDDRFLYFVLEYVAGG----ELFTYLR--
|||.|.... |.||. ||.| .|| ..   |.. |.  ||  |. ..|||. | |  ..              .. .|.|.||. ||    .||.|..  
SFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------------KDHIYMVMEYCEGGLYVMDLFDYISTW

NKGKL--DNPEALFYAAQV
..|..  .  |. ||. |.
RHGCFYFSEWECKFYMYQI
Kinase 2171.AA Ciliate-E2b 150-258 30 9.3e-20 56.87 In-house 12-111 (272) Show / Hide 
Range on Protein: 150-258
Range on HMM: 12-111/272
Sequence Identity: 30% (34 aa)

FGRVRLAKQ-KSTGEYVALKMLKKAEILRLKQVDHIISENTILSNINHPFLVNLSTFYLHQQVIKMIGFTQDDRFLYFVLEYVAGGELFTYLRNKG--KL
|| | | .. |.| .| |.|  .|..|.     .|...|  .|  .||||....            |   .||...||..|.. |.|||...|. |   |
FGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKF------------IRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLL

DNPEALFYAAQV
   ...|| |..
STYDSQFYIASI
Kinase 2171.AA MAST 343-377 65 2.2e-19 55.25 In-house 116-150 (337) Show / Hide 
Range on Protein: 343-377
Range on HMM: 116-150/337
Sequence Identity: 65% (23 aa)

EYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFAK
||||.. || |||||.|.|| |.| .||||||..|
EYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSK
Kinase 2171.AA SGK 149-202 30 3.4e-17 49.2 In-house 11-90 (283) Show / Hide 
Range on Protein: 149-202
Range on HMM: 11-90/283
Sequence Identity: 30% (24 aa)

SFGRVRLAKQKST------------------GEYVALKMLKKAEIL-------RLKQVDHIISEN-TILSNINHPFLVNL
|||.| ..| |..                  .   |.| |.|. |.       . |.. || .|  .||.|..|||.|||
SFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNL
Kinase 2171.AA PKG 150-258 34 1.1e-14 54.26 In-house 12-109 (260) Show / Hide 
Range on Protein: 150-258
Range on HMM: 12-109/260
Sequence Identity: 34% (38 aa)

FGRVRLAKQKSTG-EYVALKMLKKAEILRLKQVDHIISENTILSNINHPFLVNL-STFYLHQQVIKMIGFTQDDRFLYFVLEYVAGGELFTYLRNKGKLD
|||| | . ..   .  |||..||..|   .| .||.||  |.   . .| | |  ||              |....|. .|   |||| | || .|. |
FGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTF-------------RDQKYVYMLMEACMGGELWTILRDRGHFD

NPEALFYAAQV
.. . ||.| |
DKTTRFYCACV
Kinase 2171.AA MAST 150-202 32 4e-13 35.79 In-house 12-64 (337) Show / Hide 
Range on Protein: 150-202
Range on HMM: 12-64/337
Sequence Identity: 32% (17 aa)

FGRVRLAKQKSTGEYVALKMLKKAEILRLKQVDHIISENTILSNINHPFLVNL
.|.| |.| |.|.. .|.| ...  ... .|||....| .||...  || |..
YGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKM
Kinase 2171.AA Akt 219-258 42 1.4e-12 36.47 In-house 70-109 (264) Show / Hide 
Range on Protein: 219-258
Range on HMM: 70-109/264
Sequence Identity: 42% (17 aa)

QDDRFLYFVLEYVAGGELFTYLRNKGKLDNPEALFYAAQV
|.   ||||..|. |||||..|. |.. . ..| ||.|..
QTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEI
Kinase 2171.AA SGK 219-258 42 2.7e-12 33.79 In-house 95-134 (283) Show / Hide 
Range on Protein: 219-258
Range on HMM: 95-134/283
Sequence Identity: 42% (17 aa)

QDDRFLYFVLEYVAGGELFTYLRNKGKLDNPEALFYAAQV
| .  ||||..|| |||.| .|.  ...  ..| ||||..
QTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEI
Kinase 2171.AA TyrKc 139-472 14 6e-11 -45.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 139-472
Range on HMM: 1-280/280
Sequence Identity: 14% (57 aa)

KKQQQSINRCSFGRVRLAKQKSTGEYVALKMLKKAEILRLKQVDHIISENTILSNI--NHPFLVNLSTFYLHQQVIKMIGFTQDD-------RFLYFVLE
 .  . . .. ||.|.... |   . || ||||.        .  ...|  |....  .|| .|.|            .|   ..         |. |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRL------------YGVCTQQGRNFMYIEPLMIVME

YVAGGELFTYLRNKGKLDNPEALFYAAQVYIFVCDLLSYDNHFETQQINLKIRLSYFLLQQIQQMSQNQSKIFFQNNLRKNTNILPRQYFYLTNQIKQPK
|...| |  |||....                                                                                    
YMPHGDLKDYLRKHRPK-----------------------------------------------------------------------------------

IETKKRYFKVSMF-----------EYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFAKYCDSR-------TYTLC----GTPE-----YLAPEILLNKG
       .... .           |||| ||.. |||   |.|.|...  | .||| ... ..         |       |.        .||| .  . 
-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HGKPVDWWCLGILIYEMLAGIDPFNDE------DPMAIYQKILKG-KVKFPRN--------FDKNAKSLVKHLLVADLTKR------YGNL
     | |  |....|..   ..   .      ..  ..... .|   . | |          .   .. |    .|  .|      .  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 2171.AA Ciliate-E2 149-202 21 8.3e-11 33.31 In-house 11-97 (365) Show / Hide 
Range on Protein: 149-202
Range on HMM: 11-97/365
Sequence Identity: 21% (19 aa)

SFGRVRLAKQKSTGE-----------------------YVALKMLKKAEILRLKQVDHII----------SENTILSNINHPFLVNL
.|| |...|......                       ..|.|..|| .|  .||..||.           |  ||...|||.....
NFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM
Kinase 2171.AA RSK 219-258 39 7.6e-08 25.15 In-house 71-113 (278) Show / Hide 
Range on Protein: 219-258
Range on HMM: 71-113/278
Sequence Identity: 39% (17 aa)

QDDRFLYFVLEYVAGGELFTYLRNKGK---LDNPEALFYAAQV
|..  || ..||. |||||| |....    ..  || ||.|..
QTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEI
Kinase 2171.AA RSK 149-202 33 2e-06 20.18 In-house 11-66 (278) Show / Hide 
Range on Protein: 149-202
Range on HMM: 11-66/278
Sequence Identity: 33% (19 aa)

SFGRVRLAKQKSTGEYVALKMLKKAEILRLKQ-VDHIISENTILSNIN-HPFLVNL
..  .|   .. || . | | ||||.| . .  . |   | .||. .. |||.|.|
KVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTL
Kinase 2171.AA MAST 219-257 30 2e-06 14.9 In-house 69-110 (337) Show / Hide 
Range on Protein: 219-257
Range on HMM: 69-110/337
Sequence Identity: 30% (13 aa)

QD--DRFLYFVLEYVAGGELFTYLRNKG-KLDNPEALFYAAQ
|   .. |..|.||. ||  .. ||. |  ..  .| .| |.
QTPCKKYLCMVMEYMEGGDCASLLRMYGNCMPEWMAKMYIAE
Kinase 2171.AA S_TK_X 486-537 18 1.8e-05 23.82 SMART 1-79 (79) Show / Hide 
Range on Protein: 486-537
Range on HMM: 1-79/79
Sequence Identity: 18% (15 aa)

ADMDWDALFH--KKIPPTYKPVVK----GKGDTSNYS-SYPD-----STELPKPIKPADDP---------------FIN
.. |||.|..  |.|.| .|| .|    . .||||    ...     .   | ... .. .               ...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 2171.AA Pkinase_Tyr 208-258 25 0.000956 13.31 Pfam 63-120 (270) Show / Hide 
Range on Protein: 208-258
Range on HMM: 63-120/270
Sequence Identity: 25% (15 aa)

HQQVIKMIGFTQ-DDRF--LYFVLEYVAGGELFTYLRN----KGKLDNPEALFYAAQV
|. .....|    ...   .| |.||...| | .|||.    |..|. .. | ...|.
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQI
Kinase 2171.AA Pkinase_Tyr 149-202 31 0.013191 9.45 Pfam 11-69 (270) Show / Hide 
Range on Protein: 149-202
Range on HMM: 11-69/270
Sequence Identity: 31% (19 aa)

SFGRVRLAKQK----STGEYVALKMLKKAEILRLKQ--VDHIISENTILSNI-NHPFLVNL
.||.|.... |    .|.  || ||||  |    .|   .  ..|  |.... .|| .|.|
AFGEVYKGTWKGDPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase 2171.AA Pkinase_Tyr 343-374 43 0.126916 6.12 Pfam 125-156 (270) Show / Hide 
Range on Protein: 343-374
Range on HMM: 125-156/270
Sequence Identity: 43% (14 aa)

EYLHNKNIVYRDLKPENILIGSDGYLKLTDFG
|||..||.. |||   |.|.....  | .|||
EYLESKNCIHRDLAARNCLVTENNVVKICDFG