Gene 18333 (Tetrahymena)
18333
Sequence
Protein domains of 18333.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 18333.AA | PKA | 211-477 | 59 | 5.2e-189 | 634.2 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-263/263 Sequence Identity: 59% (164 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLV-ELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN |.|..||||||||||.|.. |... . .|.||.|| |||.||||||...||.||..|||||.| ....||||. |.||..|.|.|||.||.|||.||||| FEIIQTLGTGSFGRVMLCRHKHSG-NYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSN DISLFYIT-EIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEMLSGHP ....||.. .|.|||.|||||||.||||||||.||||.||.||.|||||| .|. ||.|||||||||||||||. . |.||||||||||.||.|||.|.| PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKN-GHGKSVDWWALGILIYEMLAGYP PFYDC--DPMGIYQKIVNSVINFPEFFSLRA---KDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF ||||. |||.||.||.| |.||..|. .| |||..|||..... |.|.... ..|.||||||| PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKN--------GVNDIKNHKWF |
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| Kinase | 18333.AA | AGC | 211-477 | 31 | 1.2e-175 | 458.76 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-395/395 Sequence Identity: 31% (129 aa) FNIKTTLGTGSFGRVKLAKLKGNE-----KDVFALKMMKKIE-IVKLK--QVEHIKSE------------KKILSQIK----------HPFLVE-LKGTF |......|.||||.| |.. |... ....|.|..|| . ||..| .|||...| ..||.... |||.| |. .| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF QDEIY--IYMLFE----FVS-----GG-EIFSRLR---KEGRFSNDISLFYITE-------IYLALQYLHS-QNIVYRD-LKPENLLIDKEGHVKIADFG ||. . .|.. | .|. || | |..|. |||||. . . ||. | | |||.|||| ..|..|| |||||.|.|..||.|..||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG FAKIMDS----------------------------------------------------ARTYTLCG--TPEYLAPEIIQGAKTGYGKSVDWWA--LGVL ..|.. . .||.|.|| ||||.||||. |||..|||. ||.| LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL IFEMLSGHPPFYDC----------DPMGIYQKIV------NSVINFP----------EFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKN ..|||.|.||||. .|| ..||| | . || ..|| ||||..|||... | ||||... . . .. . ||| MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFG-D--KGAEEIKN HKWF |.|| HPWF |
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| Kinase | 18333.AA | SGK | 211-477 | 38 | 9.69999999999e-123 | 381.02 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-283/283 Sequence Identity: 38% (113 aa) FNIKTTLGTGSFGRVKLAKLKGN-----------------EKDVFALKMMKKIEIV-------KLKQVEHIKSEK-KILSQIKHPFLVELKGTFQDEIYI | .....| ||||.| ..| |. |....|.| .| |. | |.. ||..|. .||. .||||.| |. || . . FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL YMLFEFVSGGEIFSRLRKEGRFSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAK--IMDSARTYTLCGTPEYLAPEIIQGA |. ..| ||| |. |..|..|. | . || || .|| |||||.|.||||||||.| | .||... ||| .| | .. | | ||||||||||... YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLR-- KTGYGKSVDWWALGVLIFEMLSGHPPFYDCDPMGIYQKIVNSVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF | .....|||| || . .||..| ||||. . |..| |. ...| ..| |.|| ||. . . ||| . |. |||| .| KQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKR---------DFMEIKNHPFF |
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| Kinase | 18333.AA | Akt | 211-477 | 44 | 1.3e-119 | 384.03 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-264/264 Sequence Identity: 44% (123 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDVF-ALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN |... || ||||.| |.| | ..| .. |.|. || |.. .||||.| |..|| ..|||.| |. ||.. ..|. ....|||.|. |....||| FDFLKVLGKGSFGKVFLVKKKDTQK-WYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE DISLFYITEIYLALQYLHSQNIVYRD-LKPENLLIDKEGHVKIADFGFAK---IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWA-LGVLIFEML | ||. || ||...|||.||.||| |||||.|.||.||....||| .| | | .|.|.|||||||||||..| .|..|.||||. ||....||. DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG--NGHTKAVDWWGSLGCVMYEMM SGHPPFYDCDPMGIYQKIVNSVINFP--EFFSLRAKDLVRKLLNPNIESRLG-CQDQILSNVIDQDGNSIKNHKWF | ||||. | ..|| |. ..|| ...| .|||...||| . . ||| . | . ||.| || CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPN---------DAQEIKRHPWF |
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| Kinase | 18333.AA | AktR | 211-477 | 41 | 1.7e-108 | 366.71 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-268/268 Sequence Identity: 41% (116 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILS-QIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN | . || | ||.| |.. | ......|.|| || .|....| .|. |..|. ...|||.| |. .||.. ... . |.. |||.|. |.|...||. FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE DISLFYITEIYLALQYLHSQ-NIVYRDLKPENLLIDKEGHVKIADFGFAK---IM-DSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEML . ..||. .| |||.|||.. ||.||||||||.|.|..|||||.||| .| .| .. ..|..||||||.|||.|. |..|||||||.|..|.||. EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-KGHNKSVDWWAFGIFIYEMV SGHPPFYDCDPMGIYQKIVNSV---INFPEFFSLRAKDLVR-KLLNPNIESRLG--CQDQILSNVIDQDGNSIKNHKWF .|.||||. . ..||| .. ...|. || .|||. |||. | . ||| | . ... ||.|.|| TGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNG------WEE----IKSHPWF |
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| Kinase | 18333.AA | S_TKc | 211-477 | 36 | 3.5e-99 | 336.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 211-477
Range on HMM: 1-231/231
Sequence Identity: 36% (100 aa)
FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSG--GEIFSRLRKEGR--
. | ..| |.||.|.... |. . ..|.|..| |||..| .||.. .||..| |...||| ..|| .|...| |. |....| ||
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----FSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSARTYTLCGTPEYLAPEIIQGAKTGYGK-SVDWWALGVLIF
|. ||. .| .||.|.||..|..|||||||.|.|. |.||.|||.|... .|.||||.|.|||.. |||| ..|||..|....
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILY
EMLSGHPPFYDCDPMGIYQKIVNSVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
|||.| |||. ... ...||. | |||..||.|. . | |... . . ||. ||.| ||
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-E------ALQDEWDIKCHPWF
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| Kinase | 18333.AA | PKG | 211-477 | 44 | 9e-99 | 334.45 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-260/260 Sequence Identity: 44% (121 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSND ..| ||| | |||| | .... . . ||||.|||..||. .| ||| |||.|. . . .| | | || |. |.||| | |||. . ||. |.| .. LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK ISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAK-IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEMLSGHPP . ||. . |. |||..||.|||||||||. |..| .|. |||||| | . .|.| |||||| ||||| | |||.||||.|..| | | || TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEII--LNKGHDRSVDYWALGILMCELLTGNPP FYDCDPMGIYQKIVN--SVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF | ||| .|. | .. || . . .|.....|| | ||| | . .. || |||| FSGSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGIND--------IKKHKWF |
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| Kinase | 18333.AA | Ciliate-E2b | 211-477 | 35 | 6.6e-96 | 291.88 | In-house | 1-272 (272) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-272/272 Sequence Identity: 35% (101 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEG--RFS . . || | || | | . |.| .|.| .| .|.. |. .||..| ..|||.. .. .|.|. ..|.. ||..|.|.|. .| | .| MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS NDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSA-----RTYTLCGTPEYLAPEIIQ---GAKTGYGKSVDWWALGVLI |.||| .| |.|.|||.|||.|||.|||| ..|..|..|..|.| ||.|.. ||.|..|||.|.|||||| ||. .|| |..|. TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL FEMLSGHPPFYD--CDPMGIYQKIVNS--VINFPEFFSLRAK--DLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF .|...| .|. || |||.|.. |.|| ... . . .|. ..|. ..| ||| . | |.|.|| YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWL-----------KSHPWF |
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| Kinase | 18333.AA | RSK | 214-477 | 39 | 8.7e-94 | 317.89 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 214-477 Range on HMM: 1-278/278 Sequence Identity: 39% (112 aa) KTTLGTGSFGRVKLAKLKG--NEKDVFALKMMKKIEIVKLKQ-VEHIKSEKKILSQIK-HPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGR--- ||.|..| | | . .. . . ..| | || .||. . ..| . | .||. .. |||.|.|. .||.| ..|. |...||| | .|.||.. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC FSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDK---EGHVKIADFGFAKIM--D-SARTYTLCGTPEYLAPEIIQ-GA-KTGYGKSVDWWALGV || | ||. || ||...||.| |..||||||| | | |||.|. ||||.|.. | . .|.| |.| ||.|||.. . . |..|..||| ||| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV LIFEMLSGHPPFYD---CDPMGIYQKIVNSV--INFP--EFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF |..|||.|.|||. .. | ..| . ..| .. | ||||.||.| . . |||| || . ||.|.|| LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCG--------PQDAEEIKQHPWF |
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| Kinase | 18333.AA | PKC | 211-477 | 41 | 6.5e-90 | 291.61 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 211-477
Range on HMM: 1-262/262
Sequence Identity: 41% (111 aa)
FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQ-IKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN
|| . || |||| | ||..||... ..| | .|| |.. || ||..|.. |||||..| .|| . ... |.| || . .||.
FNFLKVLGKGSFGKVMLAERKGTDE-YYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKE
DISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAK--IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEMLSGH
|| || .|||.||...|.||||| .| |.|.|||.|||||| .| ... ..| | ||||.|.||||.|. . |||||||||.||| .||. |.
EHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQE--YGKSVDWWAFGVLMYEMMAGQ
PPFYDCDPMGIYQKIVNSVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
.|| .| . | | . . .| .| .|... .... | | ||||. | . | |. | |
SPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQD-----IREHPFF
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| Kinase | 18333.AA | Pkinase | 211-477 | 31 | 7.4e-90 | 309.62 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-293/293 Sequence Identity: 31% (97 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIK-SEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGG----EIFSRLR--K . |. ..| ||||.|.... ||..| ..|.| .|| .. . |...|.. || .|. ..||. |.|...|.|. .||| .|.. || . |.... . YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR EGRF--SNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHV----KIADFGFAK---IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWW .|.| | . ||...| .|.|.||..|..|||||||.|||..||. ||.|||.|| . . ..|.||||.|.|||.|. ..||..||.| HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMW ALGVLIFEMLSGHPPFYDC------DPMGIYQKIVNSVINFPEFFS---------------------LRAKDLVRKLLNPNIESRLGCQDQILSNVIDQD ..|....|||.|.|||... |.| ....| . |... . .||.....|... ..|.. SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------------- GNSIKNHKWF |..|.|| AEQILQHPWF |
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| Kinase | 18333.AA | Ciliate-E2 | 211-477 | 27 | 3.4e-87 | 295.97 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 211-477 Range on HMM: 1-365/365 Sequence Identity: 27% (107 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDV----------------------FALKMMKKIEIVKLKQVEHIK----------SEKKILSQIKHPFLVELKGT ... .|.|.|| |...| . . |.. .|.|.||| .| .||..|| ||.||.|..||...... . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FQ--DEIYIYMLFEFVSGGEIFSRLR------------------KEGR-FSNDISL-------FYITEIYLALQYLHSQN-IVYRDLKPENLLIDKEGHV || |. .||. .|...||. |.... || . .. | |||..| |||.||||.| |..||.||||.|. . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KIADFGFAKIMDS---------------------------------ARTYTLCGTPEYLAPEIIQGAK-------TGYGKSVDWWALGVLIFEMLSGHPP ||.|||..|. | ..|.||||.|.||||..| | .||....|.|.|||...|||.| || KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FYDCDPMGIYQKIVNSVINFPEF------------------FSLRAKDLVRK----LLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF | .|.| . |.||.. |. .||| .| .|. . | |.. . . |.||.|| F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------------GWEQILNHPWF |
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| Kinase | 18333.AA | Pkinase_Tyr | 211-422 | 27 | 1.6e-18 | 63.35 | Pfam | 1-228 (270) | Show / Hide |
Range on Protein: 211-422 Range on HMM: 1-228/270 Sequence Identity: 27% (65 aa) FNIKTTLGTGSFGRVKLAKLK----GNEKDVFALKMMKKIEIVKLKQ--VEHIKSEKKILSQI-KHPFLVELKGTFQ-DEIY--IYMLFEFVSGGEIFSR . .|| |.||.|.....| ... .| | ||.| | .| | .| ||..|. .|| .| | | .. ||. .|.. .| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY LRK----EGRFSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIM-DSART-YTLCGTPE---YLAPEIIQGAKTGYGKSV ||| ..... | . ..| ...||.|.|.. ||| | |......|||.||| |. . . .. |.. .||| |. | . LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKS DWWALGVLIFEMLS-GHPP-FYDCDPMGIYQKI | |. |||..|... | | ...... .|..| DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI |
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| Kinase | 18333.AA | TyrKc | 211-459 | 20 | 4.8e-16 | 36.78 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 211-459 Range on HMM: 1-280/280 Sequence Identity: 20% (59 aa) FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQI--KHPFLVELKGTFQDE-------IYIYMLFEFVSGGEIFSRL . .|| | ||.| ....| | ||.|. .| . .| .|.... .|| .| | | .. .....|....| ..| ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL RKEGR-FSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSA-------RTYTL----CGTP----EYLAPEIIQGAKT || .. .... | . . | .||||.|.. ||| | |......|||.||| .. .. .|. .| .||| | .. RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NY G-YGKSVDWWALGVLIFEMLS-GHPPFYD-----CDPMGIYQKIVNS-VINFPEF--------FSLRAKDLVRKLLNPNIESRLG---CQDQI | . | |. ||...|... | .| .. ... ..... . |. . .. .. . . |.| . ... GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 18333.AA | S_TK_X | 478-531 | 21 | 1.2e-11 | 45.9 | SMART | 1-79 (79) | Show / Hide |
Range on Protein: 478-531 Range on HMM: 1-79/79 Sequence Identity: 21% (17 aa) KGVNWDKIYH--KQIPSPWIPQLK----SIDDVSYFE-KYPESKDKQENPTKE-------------------IQKLFADF .|..|||.|. |.|. |..|..| | |.|.|. ...| ... . |. . ....| RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF |
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