Gene 17649 (Tetrahymena)

17649

Species: Tetrahymena
Alias: PreTt17649, 200.m00062, 17649, TTHERM_01020820, 3756.m00258, 282
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
17649.AA Protein None 388 None Fasta, JSON
17649.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
17649.NA RNA None 1167 None Fasta, JSON

Protein domain

Protein domains of 17649.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17649.AA PKA 76-334 61 2.1e-188 632.21 In-house 1-263 (263) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-263/263
Sequence Identity: 61% (165 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIFALKMLKKTEIVRLNQVEHINSEKKILQSVKHPFIV-QMKQSFQDDKYIYMLFEYIQGGELFSRLRKEGRFS
|||..|||||.||||.... |...  ...|.|||||.|||||.||||...||.|||..|||||| .|...||||.|.||..||..|||.||.|||.||||
FEIIQTLGTGSFGRVMLCRHKHSG--NYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFS

NDVGLFYTC-QILLALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFAKKLDNDRTFTLCGTPEYLAPEIIKGSRVGYGKSVDWWALGILVFEMLSGY
|....|| . || |||.|||...|.||||||||.||||.|.|||||||||||.|. ||.||||||||||||||.... |.||||||||||||..|||.||
NPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKN-GHGKSVDWWALGILIYEMLAGY

PPFYDN--EPIGIYKKIIAGIIEFPRFFDNKA---KDLIRKLLNPDLNYRLGVHD-KGQSVSKHKWF
|||||.  .|..||.||..| |.|||.||..|   ||||.|||..||..|.| .. ..... .||||
PPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 17649.AA AGC 76-334 31 4.2e-175 457.3 In-house 1-395 (395) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-395/395
Sequence Identity: 31% (128 aa)

FEIFATLGTGTFGRVRQVKLKGD----TNKEIFALKMLKKTE-IVRLN--QVEHINSE------------KKILQSVK----------HPFIVQ-MKQSF
||.  ..|.|.||.|..|. |..    ......|.|.||| . ||...  .|||...|            ..||. ..          |||||. .. ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDKY--IYMLFEYIQ---------GG-ELFSRLR---KEGRFSNDVGLFYTCQ-------ILLALQYLHQ-HDIVYRD-LKPENLLIDKEGNIKITDFG
||...  .|.. ||..         || |||..|.   |||||. ..  ||...       |.|||.|||. ..|..|| |||||.|.|..|.||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKKLDN----------------------------------------------------DRTFTLCG--TPEYLAPEIIKGSRVGYGKSVDWWA--LGIL
..|.. |                                                    ||| |.||  ||||.||||.      |||..|||.  ||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

VFEMLSGYPPFYDNE----------PIGIYKKIIAG------IIEFP----------RFFDNKAKDLIRKLLNPDLNYRLGVHDKG------QSVSKHKW
 .|||.||||||...          |  ...||. |       ..||          |.|.. |||||.|||..| . ||| ....      . . .|.|
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase 17649.AA Akt 76-334 45 4.90000000001e-123 395.16 In-house 1-264 (264) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-264/264
Sequence Identity: 45% (122 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIF-ALKMLKKTEIVRLNQVEHINSEKKILQSVKHPFIVQMKQSFQDDKYIYMLFEYIQGGELFSRLRKEGRFS
|..   || |.||.| .|| | .  .... |.|.|||  |.  |||||.  |..||| ..|||||... |||. ...|.  .|..|||||. |....|||
FDFLKVLGKGSFGKVFLVKKKDT--QKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFS

NDVGLFYTCQILLALQYLHQHDIVYRD-LKPENLLIDKEGNIKITDFGFAKKL---DNDRTFTLCGTPEYLAPEIIKGSRVGYGKSVDWWA-LGILVFEM
 |   || ..| ||...||...|.||| |||||.|.||.|.|..|||| .|.    |.|.| |.|||||||||||..|  .|..|.||||. ||.. .||
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG--NGHTKAVDWWGSLGCVMYEM

LSGYPPFYDNEPIGIYKKIIAGIIEFP--RFFDNKAKDLIRKLLNPDLNYRLG-VHDKGQSVSKHKWF
. | ||||.      .|||  . ..||  .......||||..||| | . |||  ..  | .  | ||
MCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 17649.AA SGK 76-334 38 1.6e-122 380.33 In-house 1-283 (283) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

FEIFATLGTGTFGRVRQVKLKGD----------------TNKEIFALKMLKKTEIV-------RLNQVEHINSEK-KILQSVKHPFIVQMKQSFQDDKYI
|..  ..| | ||.| ||| |.|                 .. ..|.| |.|  |.       . ... || .|. .||. .||||||. . .|| ... 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMLFEYIQGGELFSRLRKEGRFSNDVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFAK--KLDNDRTFTLCGTPEYLAPEIIKGS
|.  .|..|||.|. |..|..|. |.  ||. .| .|| |||  ||.||||||||.| | .|....|||| .|    .|| ||| ||||||||||.... 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

RVGYGKSVDWWALGILVFEMLSGYPPFYDNEPIGIYKKIIAGIIEFPRFFDNKAKDLIRKLLNPDLNYRLGVHDKGQSVSKHKWF
  .....|||| ||.. .||..| ||||..     | .|| . . .|... |.|.|||  ||. |   |||  . .  . .| .|
--PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 17649.AA AktR 76-334 43 1.3e-116 393.73 In-house 1-268 (268) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-268/268
Sequence Identity: 43% (117 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIFALKMLKKTEIVRLNQVEHINSEKKILQ-SVKHPFIVQMKQSFQDDKYIYMLFEYIQGGELFSRLRKEGRFS
|.. . || |.||.|  |. |  .|....|.||.||..|...|| .|.  |..|..  ..|||||.....||...... . ||..|||||. |.|...||
FHVYKCLGKGAFGKVYLVQKKR-DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFS

NDVGLFYTCQILLALQYLHQH-DIVYRDLKPENLLIDKEGNIKITDFGFAK--KL--DNDRTFTLCGTPEYLAPEIIKGSRVGYGKSVDWWALGILVFEM
... .|| .||||||.||||| .|.||||||||.|.|..|..|||||| .|  .   ..... ..||||||.|||.|. . .|..|||||||.||...||
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-KGHNKSVDWWAFGIFIYEM

LSGYPPFYD--NEPIGIYKKIIAGIIEFPRF--FDNKAKDLIR-KLLNPDLNYRLG-VHDKGQSVSKHKWF
..|.||||.  .. . ...||.  ...||    | ...||||  |||. . | |||      . . .|.||
VTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 17649.AA S_TKc 76-334 38 9.5e-104 351.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-231/231
Sequence Identity: 38% (105 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIFALKMLKKTEIVRLNQVEHINSEKKILQSVKHPFIVQMKQSFQDDKYIYMLFEYIQG--GELFSRLRKEGR-
.||  ..| |.||.|.... |.   ..|.|.|..|          ||| .| .||.. .||.||... .||| ...|| .||. |  |.||....| || 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FSNDVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFAKKLDNDRTFTLCGTPEYLAPEIIKGSRVGYGK-SVDWWALGILV
     |.  .  ||..||..||.|.|.| |..|||||||.|.|.  .|||.|||.|..|      |.||||.|.|||..     |||| ..|||..|...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCIL

FEMLSGYPPFYDNEPIGIYKKIIAGIIEFPRFFDNKAKDLIRKLLNPDLNYRLGVHDKGQ---SVSKHKWF
.|||.|||||.  ..  ..|||           .  |||.|||.|. | . |... .  |    . .| ||
YEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17649.AA PKG 76-334 46 8.3e-102 344.52 In-house 1-260 (260) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-260/260
Sequence Identity: 46% (123 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIFALKMLKKTEIVRLNQVEHINSEKKILQSVKHPFIVQMKQSFQDDKYIYMLFEYIQGGELFSRLRKEGRFSN
..| |||| | ||||  |.....   ..||||..|| .||   | ||| |||.|... . .|||..   | |.||.||| |   |||| . ||. |.| .
LKIIATLGVGGFGRVELVQYNHQK-SRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDD

DVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFAKKL-DNDRTFTLCGTPEYLAPEIIKGSRVGYGKSVDWWALGILVFEMLSGYP
.   ||.  .. |. |||.. |.|||||||||. |..| .|. |||||||.  . .| | |||||| |||||     |   |||.||||||..| | | |
KTTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNK--GHDRSVDYWALGILMCELLTGNP

PFYDNEPIGIYKKIIAGI--IEFPRFFDNKAKDLIRKLLNPDLNYRLGVHDKG-QSVSKHKWF
||  ..|. .|  |  ||  .||||.   .|...|.||       |||   .| . . |||||
PFSGSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase 17649.AA Ciliate-E2b 76-334 36 7.1e-99 301.03 In-house 1-272 (272) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-272/272
Sequence Identity: 36% (99 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIFALKMLKKTEIVRLNQVEHINSEKKILQSVKHPFIVQMKQSFQDDKYIYMLFEYIQGGELFSRLRKEG--RF
...   || | || | .|. . .. |...|.|  .| .|.  |   |. .||..|. ..||||.. ..||.||...|.. |...|.|||. .|  |   .
MIYIKKLGFGQFGSVYLVW-NTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLL

SNDVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFAKKLD--ND---RTFTLCGTPEYLAPEIIK---GSRVGYGKSVDWWALGIL
|  . .||. .|.|.|.|||.  |.|||.|||| ..|..| .|. |.| || ..  |.   ||||..|||.|.|||||.       ||. .|| |..|| 
STYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGIC

VFEMLSGYPPFYD--NEPIGIYKKIIAG--IIEFPRFFDNKAK--DLIRKLLNPDLNYRLGVHDKGQSVSKHKWF
 .|...||.|.     .|. ||..|| .   |.|| .. .| .  .|. ..|.     |||     ..   |.||
LYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG--GSYSWLKSHPWF
Kinase 17649.AA RSK 79-334 40 2.4e-98 333.04 In-house 1-278 (278) Show / Hide 
Range on Protein: 79-334
Range on HMM: 1-278/278
Sequence Identity: 40% (114 aa)

FATLGTGTFGRVRQVKLK-GDTNKEIFALKMLKKTEIVRLNQ-VEHINSEKKILQSVK-HPFIVQMKQSFQDDKYIYMLFEYIQGGELFSRLRKEGR---
   ||.| .| | ... . .  .. |.| | ||| .||. .  ..|   | .||. .. |||||. . .||.....|.  ||. ||||| .|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSNDVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDK---EGNIKITDFGFAKK--LD-NDRTFTLCGTPEYLAPEIIKG--SRVGYGKSVDWWALGI
|| |   ||  .| ||...|||..|..||||||| | |    || ||.|||||.|.  .| | .| | |.| ||.|||..|    ..|..|..||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LVFEMLSGYPPFYD---NEPIGIYKKIIAGI--IEFP--RFFDNKAKDLIRKLLNPDLNYRLG-----VHDKGQSVSKHKWF
| .|||.|.|||.    | .  | |.|  |    ..|   .  . |||||||.|  | . |||     . .    . .|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEE----IKQHPWF
Kinase 17649.AA Ciliate-E2 76-334 27 5.9e-92 311.81 In-house 1-365 (365) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-365/365
Sequence Identity: 27% (104 aa)

FEIFATLGTGTFGRVRQVKLKGD---------------------TNKEIFALKMLKKTEIVRLNQVEHIN----------SEKKILQSVKHPFIVQMKQS
...   .|.|.|| |...| . .                     ... |.|.|..|| .|  ..|..||.           ||.||....||.|..|. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DDKYIYMLFEYIQGGELFSRLR------------------KEGR--FSNDV-GL-----FYTCQILLALQYLHQHD-IVYRDLKPENLLIDKEGNI
||  ||..||. .||.|||.||....                  || .  .   . |      || ..|.|||.|||.   |..||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KITDFGFAKKLDND---------------------------------RTFTLCGTPEYLAPEIIKGSRVG-------YGKSVDWWALGILVFEMLSGYPP
||.|||..||.|.|                                  ..|.||||.|.||||..|   .       |....|.|.||.. .|||.|.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYDNEPIGIYKKIIAGIIEFPRF------------------FDNKAKDLIRK----LLNPDLNYRLGVHDKGQSVSKHKWF
|        ...|. . |.|| .                   ....||||.|    .|. | . |..     . . .|.||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase 17649.AA CAMK 81-334 23 6.3e-92 296.46 In-house 1-425 (425) Show / Hide 
Range on Protein: 81-334
Range on HMM: 1-425/425
Sequence Identity: 23% (102 aa)

TLGTGTFGRVRQVKLKGDTN----------KEIFALKMLKKTEIV-------------------------RLNQVEHINSEKKILQS-------VKHPFI
|||.|.|| |. .. | .|.          .. .| |...|. .                          | .  . . .| .|...       ..|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQMKQSFQD-------------------DKYIYMLF---EYIQGGEL----FSRLRKE---------------GRFSNDVGLFYTCQILLALQYLHQHDI
... . ..|                   ||..|| .   ||..||||    |.....                |||. .   .|  ||. |..|.|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VYRDLKPENLLIDKE-----------------GNIKITDFGFAKKLD-------------------------NDRTFTLCGTPEYLA-PEIIKGS-----
| |||||||.|.|.                  .||||.|||||.|.|                         ..   | |||||| | ||...|.     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------RVGYGKSVDWWALGILVFEMLSGYPPFYDN-------------EPIGIYKKIIAGIIEFPRFFDNK------------------------AKD
       . .||...| |..|.. . ||.||||||.              ..  ...||..|  .|| ..  .                        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRKLLNPDLNYRLGVHDKGQSVSKHKWF
||||.|..| . |. ...    . .|.|.
LIRKMLQVDPEKRMTIEQ----CLNHPWM
Kinase 17649.AA Pkinase 76-334 32 9.5e-92 315.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 76-334
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIFALKMLKKTEIVRLNQVEHIN-SEKKILQSVKHPFIVQMKQSFQDDKYIYMLFEYIQGG----ELFSRLR--
..|  ..| |.||.|.. . ||.    |.|.| .|| ..    ...|.. || .|.....||.||... .|.|...||| .|| .||    .||....  
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KEGRF--SNDVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDKEGNI----KITDFGFAKK--LDNDRTFTLCGTPEYLAPEIIKGSRVGYGKSVDWW
..|.|  | ..  ||  ||| .|.|.|.. |..|||||||.|||..|.|    ||.|||.||.  . |... |.||||.|.|||.|. .. .||..||.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR-GGQYYGPKVDMW

ALGILVFEMLSGYPPFYDN------EPIGIYKKIIAGIIEFPRFFD---------------------NKAKDLIRKLLNPDLNYRLGVHDKGQSVSKHKW
..|....|||.|.|||..       ... ....|  ....|... .                       .||.|...|..| . |..     . . .|.|
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPW

F
|
F
Kinase 17649.AA TyrKc 76-328 19 6.3e-15 18.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 76-328
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FEIFATLGTGTFGRVRQVKLKGDTNKEIFALKMLKKTEIVRLNQVEHINSEKKILQSV--KHPFIVQMKQSFQDD-------KYIYMLFEYIQGGELFSR
 .   .|| | ||.|.. ..|     .  | ||||.        .| . .| .|. ..  .|| ||..     ..       . .....||  .| | ..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRKEGR-FSNDVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFAKKLDND-------RTFTL----CGTP----EYLAPEIIKGSR
||| .. ....  | .  ||    .|||.. .. |||   | |..... .||.||| ......|        . .     .|        .||| |. ..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

VGYGKSVDWWALGILVFEMLS-GYPPFYD-----NEPIGIYKKIIAG-IIEFPRF--------FDNKAKDLIRKLLNPDLNYRLGVHDKGQSV
  .    | |. |.. .|... | .| ..      ... ..... .|   . |             .  .....  . | . |    .  .  
--FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 17649.AA Pkinase_Tyr 76-229 30 5.9e-10 34.34 Pfam 1-164 (270) Show / Hide 
Range on Protein: 76-229
Range on HMM: 1-164/270
Sequence Identity: 30% (51 aa)

FEIFATLGTGTFGRVRQVKLK--GDTNKEIFALKMLKKTEIVRLNQ--VEHINSEKKILQSV-KHPFIVQMKQSFQ-DDKY--IYMLFEYIQGGELFSRL
 ..  .|| | ||.|.. ..|  .| .|   | ||||  |     |   |   .| ||. .  .|| ||..      ...   ||. .|| ..| | . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RK----EGRFSNDVGLFYTCQILLALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFAKKLDND
||    .....    | .  ||  ...||... .. |||   | |..... .||.||| |. . ||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase 17649.AA S_TK_X 335-388 16 3.9e-07 30.94 SMART 1-79 (79) Show / Hide 
Range on Protein: 335-388
Range on HMM: 1-79/79
Sequence Identity: 16% (13 aa)

RGVDWESVFN--KDIPAPWTPQLR----NEQDASCFE-KYPD-----SQEGARSLPR-------------DLQHLFEDF
||.||. ..|  | |..|..|...    ...|.| |. ....     .     ....             .   .. .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 17649.AA Pkinase_Tyr 260-291 25 1.873886 2.16 Pfam 198-232 (270) Show / Hide 
Range on Protein: 260-291
Range on HMM: 198-232/270
Sequence Identity: 25% (9 aa)

WALGILVFEMLS-GYPP-FYDNEPIGIYKKI-IAG
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WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG