Gene 8643 (Tetrahymena)

8643

Species: Tetrahymena
Alias: 560, PreTt08643, 3697.m00066, 15.m00354, TTHERM_00188930, 8643
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: PDK1

Sequence

Name Sequence Type Origin Length Description Download
8643.AA Protein None 536 None Fasta, JSON
8643.NA RNA None 1611 None Fasta, JSON
8643.kin_dom Protein Kinase Domain None 294 None Fasta, JSON

Protein domain

Protein domains of 8643.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8643.AA PDK1 97-390 48 6.5e-216 668.64 In-house 1-307 (307) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-307/307
Sequence Identity: 48% (150 aa)

FSNNKNLGRGSFGEVILAKNKSN----NEFCAIKILEKSYLAREKKQYQVFIEKEVLTHIR-----FDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQ
|...||.|.||...|.||..|..    |...||||.||.|..||||...|..|||...|..     ..||..|...|.|.|.||||||||..|....|..
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKICEKRYIIREKKVKYVHREKEIMCHLNNECNGHPGIVKLYFTFQDEQCLYFVLEYCPNGDLLHYMK

HN-FKFLNQDTIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPEDLFQKINNIKKKFPQETDPMD--DEDSRTRSSTFV
.. |.....|...||||||...||.||.||||||||||||..|.||.|..|.||||.|||...||...|..|.....|.|....||  .||..||...||
KQPFGSFDMDCCRFYAAEIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDFGTAGFDKILPEYQSQQQNQFQQQFQQHNKGMDKPEEDKQTRCKSFV

GTAEYVSPELLEGEICTSSADLWALGCIIYRMFVGNTPFVDVNDATNNEFKVFNKVKACQYYIPDS--VPPEAADLIKNLLKRNPFERIGGGEPGVNDIN
|||||||||||....||.|.|.||||||||.|..|..||...|||||||...|.|...|||..||.  .||.|.||.|.||.|.|..|... ........
GTAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQPPFRGMNDATNNEYHTFQKIMKCQYDFPDNFRFPPCAKDLVKKLLVRDPNDRLTS-CDECGGYQ

TLKKHPFF
..|.||||
QIKAHPFF
Kinase 8643.AA AGC 97-390 27 1.3e-137 358.12 In-house 1-395 (395) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-395/395
Sequence Identity: 27% (113 aa)

FSNNKNLGRGSFGEVILAKNK------SNNEFCAIKILEKSY---LAREKKQYQVFIE------------KEVLTHIR----------FDGIIQ-LLGSF
|   | .|.||||.|.|.. |      ......|.|.|.|..   . ..... .. .|            ...|....           . |.. |  ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDNQF--LYFVLEYCE---------GG-EFSSYLQH--NFKFLNQDTIKFYAAE-------IVYILENLHK-NGIIHRD-LKPENLMLTKDNHLKIIDFG
.|..   ||||.||..         || |. ..||.  . . .. ....|||||       ||  || ||. .|||||| |||||..|..| |.|. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TCGFDRRIPED--------LFQKINNIKKKFPQETDPMDDEDSRT-------------------------RSSTFVG--TAEYVSPELLEGEICTSSADL
 |   .. .|.        .|..  | |.   ..   ||     |                         | .||.|  |.||..|| |    .. ..| 
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS--NMD-----TNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDW

WA--LGCIIYRMFVGNTPFVDVNDATN-----NEFKVFNKVKACQYYIPDS----------------VPPEAADLIKNLLKRNPFERIGGGEPGVN--DI
|.  |||..| | .| .|| . |. .|     |....|.|.. ..|.|..                 . ||| |||| ||...| .|.| |. ...  ..
WSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGA

NTLKKHPFF
. .|.||.|
EEIKNHPWF
Kinase 8643.AA S_TKc 97-390 27 1.5e-80 274.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

FSNNKNLGRGSFGEVILAKNKSNNEFCAIKILEKSYLAREKKQYQVFIEKEVLTHIRFDGIIQLLGSFKDNQFLYFVLEYCEG--GEFSSYLQHNFKF--
.   . .|.|.||.| ....|. .. .||||.            ..  | ..| . . . |..|...| | ..||.|.|||.|  |.  .|.... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNQDTIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPEDLFQKINNIKKKFPQETDPMDDEDSRTRSSTFVGTAEY
   ..  ...||...|.  || .|..|||||||||||..|..  |.||.||| . .                                   .||.|| .|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------------------TTFCGTPWY

VSPELLEGEICTS-SADLWALGCIIYRMFVGNTPFVDVNDATNNEFKVFNKVKACQYYIPDSVPPEAADLIKNLLKRNPFERIGGGEPGV--NDINTLKK
..||.|     .  ..| |..|||.| |..| .||        .....|.|..          .||| |.|...|...| .|..  |      ||   |.
MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI---KC

HPFF
||.|
HPWF
Kinase 8643.AA Ciliate-E2 97-390 22 1.4e-71 244.14 In-house 1-365 (365) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-365/365
Sequence Identity: 22% (91 aa)

FSNNKNLGRGSFGEVILAKNKSNNE-----------------------FCAIKILEKSYLAREKKQYQVF----------IEKEVLTHIRFDGIIQLLGS
.  .| .|.|.|| | ..|......                       . |.||..|. .   |.  ...          .||..| .. .. ||..  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DNQFLYFVLEYCEGGEFSSYLQHNFKF----------LNQDTIK---------------FYAAEIVYILENLHKNG-IIHRDLKPENLMLTKDNHL
|.  |.. .|.|.|||.||.  .|...| |.          ..   ||               ||.|.|.  || ||... |||||.||||...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIIDFGTCGFDRRIPEDLFQKINNIKKKFPQETDPMDDEDSRTRS-----------STFVGTAEYVSPELLE---------GEICTSSADLWALGCIIYR
||||||.. .      | ... . . |.  ..      ..||| .            |..||..|..|| |.         ..  . ..|.|.||.|.|.
KIIDFGLSKK-----YDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MFVGNTPFVDVNDATNNEFKVFNKVKACQYYIP------------------DSVPPEAADLIKN----LLKRNPFERIGGGEPGVNDINTLKKHPFF
|  |..||             ... | |.. .|                  .....|. ||||.    .|...| .||.       ... ...||.|
MLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-------GWEQILNHPWF
Kinase 8643.AA CAMK 102-390 20 1.1e-69 223.54 In-house 1-425 (425) Show / Hide 
Range on Protein: 102-390
Range on HMM: 1-425/425
Sequence Identity: 20% (90 aa)

NLGRGSFGEVILAKNKSNN------------EFCAIKILEKSYLA-------------------------REKKQYQVFIEKEVLTH-------IRFDGI
 |||||||.| |...|...            . .||||..|. |                          |.|.. .|. | |.. .       ..   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLLGSFKD-------------------NQFLYFVL---EYCEGG----EFSSYLQHNFKF--------------LNQDTIKFYAAEIVYILENLHKNGI
|.|.  . |                   ....|.|.   |||.||    .  .|.. . ..              .. .  ..|   |.  .. .|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENLMLTKD-----------------NHLKIIDFGTCGFDRRIPEDL----FQKINNIKKKFPQETDPMDDEDSRTRSSTFVGTAEYVS-PELL
.||||||||..|...                 | .||||||   . ..  ...    ..  . . ..  |    ......    .||.|| ||.. ||.|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN--Q----WTTPTEGQKMKTFCGTPEYMAAPEVL

EGEI--------------CTSSADLWALGCIIYRMFVGNTPFVDVNDA--------TNNEFKVFNKVKACQYY-IPDSVPP-------------------
.|.               .. ..| |..|.| | | .|  || . .|         ..|. . | |.....|. .|. ..|                   
NGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH

----EAADLIKNLLKRNPFERIGGGEPGVNDINTLKKHPFF
    |. |||...|...| .|.         |   ..||..
FVSQECKDLIRKMLQVDPEKRM--------TIEQCLNHPWM
Kinase 8643.AA Pkinase 97-390 24 1.2e-67 235.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-293/293
Sequence Identity: 24% (81 aa)

FSNNKNLGRGSFGEVILAKNKSNNEFCAIKILEKSYLAREKKQYQVFI--EKEVLTHIRFDGIIQLLGSFKDNQFLYFVLEYCEGG----EFSSYLQ-HN
.   . .|.||||.| ....|....  |.||..|.  ....|... .   | ... ... . |..|...| |.. .|.|.||||||    . ..|.. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

FKFL--NQDTIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTKDNHL----KIIDFGTCG-FDRRIPEDLFQKINNIKKKFPQETDPMDDEDSRTRSST
 . .    ...|||. .|.  || .|..|||||||||||... ...|.    ||.||| .  ||                           . . .  .|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------------------Y-NNS-MTT

FVGTAEYVSPELLE-GEICTSSADLWALGCIIYRMFVGNTPFVDV--NDATNNEFKVFNKVKACQYYIPDSVP---------------------PEAADL
|.|| .|..||..  |.  ....| |..|||.| |. |..|| .    |  ... ....... ...  . . .                     .|. |.
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF

IKNLLKRNPFERIGGGEPGVNDINTLKKHPFF
||..|...| .|..        .  ...||.|
IKWCLCKDPKKRPT--------AEQILQHPWF
Kinase 8643.AA RSK 100-390 29 1.4e-64 220.83 In-house 1-278 (278) Show / Hide 
Range on Protein: 100-390
Range on HMM: 1-278/278
Sequence Identity: 29% (92 aa)

NKNLGRGSFGEVILAKNK---SNNEFCAIKILEKSYLAREKK-QYQVFIEKEVLTHIR-FDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQHNFKF--
 | ||.|..|.| | . .    ..   | |.|.|. ... .| .  .. | ..| ...    |..|  .|.... || ..|||.|||.   ||.   |  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LNQDTIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTK---DNHLKIIDFGTCGFDRRIPEDLFQKINNIKKKFPQETDPMDDEDSRTRSSTFVGTAEY
.  |. .||.||||  .| ||. ||||||||||| ...    . |.|..||| |                             . |   .  ||..|.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--------------------------RCDHNQWTMTFCYTIEY

VSPELLE----GEICTSSADLWALGCIIYRMFVGNTPFVDVNDATNNEFKVFNKVKACQ--YYIP--DSVPPEAADLIKNLLKRNPFERIGGGEPGVNDI
. ||.|     ..  . ..|.| ||...| |..|..||    .  ||  ....... ..    .|  ... .|| |||. .|.|.|  |.|.|  ....|
MAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PND-NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEI

NTLKKHPFF
   |.||.|
---KQHPWF
Kinase 8643.AA AktR 97-390 30 8.4e-63 214.96 In-house 1-268 (268) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-268/268
Sequence Identity: 30% (92 aa)

FSNNKNLGRGSFGEVILAKNK-SNNEFCAIKILEKSYLAREKKQYQVFIEKEVLT-HIRFDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQHNFKFLN
|   |.||.| ||.|.|.. |  |... |.|.. |. . ..... ..  |. ..  .... .|..|  .|...  |.|..|||.|||  ..|... || .
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QDTIKFYAAEIVYILENLHKN-GIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPEDLFQKINNIKKKFPQETDPMDDEDSRTRSSTFVGTAEYVSPE
. ...||.|.|.  || ||..  || |||||||..| .| |.||.|||                            .|...| ...|  |.|| ||..||
E-QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-----------------------LQFMMHYDEKAYS--FCGTPEYMAPE

LLEG-EICTSSADLWALGCIIYRMFVGNTPFVDVNDATNNEFKVFNKVKACQ-YYIPDSVPP--EAADLIK-NLLKRNPFERIG-GGEPGVNDINTLKKH
 .   .  . |.|.||.|. || | .|..|| . |. ...... .     .|  ..|.....  .. |||.  ||..|| .|.| .     |..  .|.|
MITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKI-----KQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYY----CNGWEEIKSH

PFF
|.|
PWF
Kinase 8643.AA MAST 97-390 26 1.2e-61 197.4 In-house 1-334 (334) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-334/334
Sequence Identity: 26% (93 aa)

FSNNKNLGRGSFGEVILAKNKSNNEFCAIKILEKSYLAREKKQYQVFIEKEVLTHIRFDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQHNFKFLNQD
|   | ...| .| | |.|.|. |.. |.|.. ||.... . . ||..|. .|. .. . .  .  ||   . |..|.|| ||| . | | |..  . ..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLL-HMYGYFDEW

TIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPEDLFQKINNIKKK------FPQETDPMDDEDSRTRS----------
. |.| ||.|  || ||. ||.||||||.|. .... | |. |||   .      .. ...|....       |  .||||.. .  ...          
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKV------GFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGN

----------------------------STFVGTAEYVSPELLEGEI-CTSSADLWALGCIIYRMFVGNTPFVDVNDATNNEFKVFNKVKACQ---YYIP
                               .|| .| .||.. |.     . | |..| |.|. .|| .||.| .       ..|....        .|
TNKNQIQQQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPE-----EIFQNILNRNCNEIEWP

DS--------VPPEAADLIKNLLKRNPFERIGGGEPGVNDINTLKKHPFF
.          .||| |||..||  .| .|.| .  |. ..   |.||||
EGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANN-GADEV---KQHPFF
Kinase 8643.AA Ciliate-E2-Unclassified 97-390 23 1.7e-57 197.35 In-house 1-352 (352) Show / Hide 
Range on Protein: 97-390
Range on HMM: 1-352/352
Sequence Identity: 23% (90 aa)

FSNNKNLGRGSFGEVILAKNKSNNEFC-----AIKILEKSYLAREKKQYQVFIEKEVLTH------------------IRFDGIIQLLGSFKDNQFLYFV
.  .| .|.|.||.| ....|... .      ..|| ... .  ..|.  ....||.  .                  .    |. ..  |.| | .|.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCEGGEFSSYLQHNFK----------------FLNQDTIK-----FYAAEIVYILENLHKNG-IIHRDLKPENLMLTKDN---HLKIIDFGTC-GFDR
.||||||. . |.... |                 .    .|     ||.|.|.  || ||... |||||.||||.......   ..|||||| .   . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

RIPEDLFQKINNIKKKFPQETDPMDDEDSRTR----------SSTFVGTAEYV----SPELLEGEICTSS----ADLWALGCIIYRMFVGNTPFVDVNDA
 . .| ..                       .          ..||.|| .|     .||.|.|.    |    .| |.||.|.| |  |. || | |. 
NNNCD-TNQ----------------------QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCE

TNN-----------EFKVFNKVKACQYY--------IPDSVPPEAADLIK----NLLKRNPFERIGGGEPGVNDINTLKKHPFF
 ..           .. .... |.....        ||. ..|||.|.|.     .|| || .||        ... ...||.|
QHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI--------TFEQILNHPWF
Kinase 8643.AA PKA 97-241 43 4.8e-47 162.61 In-house 1-146 (263) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-146/263
Sequence Identity: 43% (64 aa)

FSNNKNLGRGSFGEVILAKNKSNNEFCAIKILEKSYLAREKKQYQVFIEKEVLTHIRFDGII-QLLGSFKDNQFLYFVLEYCEGGEFSSYLQHNFKFLNQ
|   . ||.|||| | |...|.. ...|.|.| |..  |.| .  |  || .|. |..  |. .. ..|.|...||.|.||..|||  |||... .| |.
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DTIKFYAA-EIVYILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFG
.. ||||| .||  || ||.  ||.|||||||... |. |.|| |||
HA-KFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFG
Kinase 8643.AA RSK-Unclassified 97-241 35 2.8e-41 127.06 In-house 1-146 (283) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-146/283
Sequence Identity: 35% (52 aa)

FSNNKNLGRGSFGEVILAKNKSNNEFCAIKILEKSYLAREKKQYQVFIEKEVLTHIRFDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQ-HNFKFLNQ
|   . .|.|.||.| | . |  .   |.|.|.|. . | .|   |  |....       |..|  ||  .  || ..||| ||.|   ||    | .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DTIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFG
| ..|||.|..  || ||| ..| |||||.| .| .. | .  ||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFD
Kinase 8643.AA RSK-Unclassified 273-390 35 3e-24 72.65 In-house 174-283 (283) Show / Hide 
Range on Protein: 273-390
Range on HMM: 174-283/283
Sequence Identity: 35% (42 aa)

DEDSRTRSSTFVGTAEYVSPELLEGEICTSSADLWALGCIIYRMFVGNTPFVDVNDATNNEFKVFNKVKACQYYIP--DSVPPEAADLIKNLLKRNPFER
|. .||.|  |.|| ||. ||.. .   |   | | || ..| | .| .|.       ||.  .|. .   .  .|    .  .. |||| ||.|||  |
DHGFRTNS--FCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPY-----YGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKR

IGGGEPGVNDINTLKKHPFF
 | .    .||   |.||||
LGCKMGDADDI---KRHPFF
Kinase 8643.AA PKA 303-390 36 7.9e-16 58.91 In-house 179-263 (263) Show / Hide 
Range on Protein: 303-390
Range on HMM: 179-263/263
Sequence Identity: 36% (33 aa)

SADLWALGCIIYRMFVGNTPFVDVNDATNNEFKVFNKVKACQYYIPDSVPPEA---ADLIKNLLKRNPFERIGGGEPGVNDINTLKKHPFF
| | ||||..|| | .| .|| | |    . .. ..|  ....  | .. . |    ||||.|| ... .|.|  . |||||   |.|..|
SVDWWALGILIYEMLAGYPPFYDHN---RDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDI---KNHKWF
Kinase 8643.AA TyrKc 97-381 19 8.2e-12 -31.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 97-381
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

FSNNKNLGRGSFGEVILAKNKSNNEFCAIKILEKSYLAREKKQYQVFIEKEVLTHI--RFDGIIQLLGSFKDN-------QFLYFVLEYCEGGEFSSYLQ
 . .| ||.| |||| ... |   . .|.| | ..       .     | ......  . . |..|.|   .        . |. |.||...|   .||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

HNFKFLNQDTIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPED-LFQKINNIKKKFPQETDPMDDEDSRTR--SSTFV
 . . |. ..   ..  |    | ||....|||||   | ....... || ||| .   | | .|                    .|  . .   .. ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS---RDIYDDDQQG--------------ESKDYYRKKEHKGGKTM

GTAEYVSPELLEGEICTSSADLWALGCIIYRMF-VGNTPFVD-VNDATNNEFKVFNKVKAC-QYYIPDS--------VPPEAADLIKNLLKRNP-----F
      .|| .   ..|.  | |. |  .. .|  | .|  . .     . . |...||.     .|..         |.|  ...|   ...|     |
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

ERIGGGEPGVNDI
. |      . ..
SEI------HECF
Kinase 8643.AA Pkinase_Tyr 97-241 26 4.7e-09 31.28 Pfam 1-156 (270) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-156/270
Sequence Identity: 26% (42 aa)

FSNNKNLGRGSFGEVILAKNK----SNNEFCAIKILEKSYLAREKK--QYQVFIEKEVLTHI-RFDGIIQLLGSFK-DNQF--LYFVLEYCEGGEFSSYL
 . .| ||.|.|||| ... |    ...  .|.|.| |   | ..   .   . | ...... . . |..|.|    . .   .| |.||...|   .||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QHN---FKFLNQDTIKFYAAEIVYILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFG
. .    . |.  ..  ....|   .| |. ...|||||   | ..|..|. || |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 8643.AA APH 207-246 18 9.5e-05 17.07 Pfam 162-205 (248) Show / Hide 
Range on Protein: 207-246
Range on HMM: 162-205/248
Sequence Identity: 18% (8 aa)

YILENLHKNGIIHRDLKPENLMLT--KDNHLK--IIDFGTCGFD
.......  ...|.|..| |.|..   |.     .||.......
WLEAHWPPPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDACWG
PDK1_PH 8643.AA PDK1_PH 435-529 28 1.4e-38 134.46 In-house 1-112 (112) Show / Hide 
Range on Protein: 435-529
Range on HMM: 1-112/112
Sequence Identity: 28% (32 aa)

TSMRPLI--TGRVLKKVAWL-----IYK----PRQLILQEEPPKLVYYDPMTNVKKGEIPLS-KNVKIELQ-----DKSRFTIVGPKKKYFFKELDHPAN
|......  .|.. .|..|.     ...    .|........|.|.|.||||.|.|||||.| |....|..     ....|.|..|...|.|......||
TPWHQFLMPEGEHILKCGWVYKRKGLFAKPKKKRRQLILTDGPRLFYVDPMTMVIKGEIPWSSKDLYVEYKPDRKNNFKHFFIHTPNRTYYFEDPKGCAN

IWVEKVSKLIKD
.|.|...|..|.
KWCEAIEKVCKR
PH 8643.AA PH 439-530 23 6e-06 27.09 SMART 1-82 (82) Show / Hide 
Range on Protein: 439-530
Range on HMM: 1-82/82
Sequence Identity: 23% (22 aa)

PLITGRVLKKVAWLIYKPRQLILQEEPPKLVYYDPMTNVKKGEIPLSKNVKIELQDKSRFTIVGPKKKYFFKELDH-PANIWVEKVSKLIKDK
... | ..||     .|.| ..| .    |.||..    .||.||||.  ...  .   |.|.  .. |.|.  ..  .. |..   |.|.. 
VIKEGWLYKKS-K-RWKKRWFVLFN--DCLYYYKDK--KPKGSIPLSDC-TVRE-P--CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN