Gene 14389 (Tetrahymena)

14389

Species: Tetrahymena
Alias: 14389, PreTt14389, 3825.m02767, 2.m02147, TTHERM_00035550, 163
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: NDR

Sequence

Name Sequence Type Origin Length Description Download
14389.AA Protein None 816 None Fasta, JSON
14389.NA RNA None 2451 None Fasta, JSON
14389.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of 14389.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14389.AA NDR 26-317 47 1.8e-216 675.07 In-house 1-350 (350) Show / Hide 
Range on Protein: 26-317
Range on HMM: 1-350/350
Sequence Identity: 47% (165 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATVD--NPWIVELYCSFQDSKHLYLVMEYLQGGDLMT---VLMKKD
.....|||.||||||...|.|.. | |.|.|.|.|.||..|||..|||||||..|..|  |||.|.||.||||...|||||||. |||.||   .|||.|
FEIIKIIGKGAFGEVWLVRKKDT-GHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMD

ILSEEESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLCKH---------------------------AEIKPKLLLGKEEEKIDFS
|..|.. .|| .|.|.||.|||||.|||||.||||.|. .||||||.|||||..                           .......  .......|..
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNW

K-NPTALLT-----------------KRPEVYKRNRHLAYSTVGTPDYIAPEVFGQ-QGYTEIVDWWSLGVILFEMLVGYPPFFSEEPSTTCQKIINWRN
. ||.. ..                 .........|.|||||||||||.||||| | .||.. .||||||.|..|||||||||.|..| .||.||.||..
NSNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQ

TF-----NIPREAELSKDAEDLIRRLIN-DPINRLGVNG--VHEIKAHPFF
|.     ..|.||.||..|.||||||.. ||..|||..|  |.|||.||||
TWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 14389.AA AGC 26-317 30 8.4e-181 472.39 In-house 1-395 (395) Show / Hide 
Range on Protein: 26-317
Range on HMM: 1-395/395
Sequence Identity: 30% (126 aa)

YDPLSIIGRGAFGEVRVCREKK-----QNGRIVAVKKMKKQE--------MLQKNQINH-------VRAERDVLATVD----------NPWIVE-LYCSF
.. | .||.|.||.|. .|.|.     ..|.. |.|..||..        |...... |       |..||..|....          .|.||  |..||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDSKH--LYLVMEYLQ---------GG-DLMTVLM---KKDILSEEESKFYASE-------LVMAIDSVHK-MNYIHRD-LKPDNILLGRDGHIKLSDFG
|| .|  ||.||||..         || .|.. |.   |. ...||...|||.|       .|.|... |. |..|||| |||.|||| .||||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKH-----------------AEIKPKLLLGKEEEKIDFSKNPTALLTKRPEVYKRNR------------HLAYSTVG--TPDYIAPEVFGQQGYTEIVD
|||                  .. ..|   . ..   ...   |    ..|.  .||.            ..... .|  ||.|.|||..    |.  .|
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS---NMD---T-NK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACD

WWS--LGVILFEMLVGYPPFFSEEPS----------TTCQKII------NWRNTFN------IPREAELSKDAEDLIRRLIN-DPINRLGVN-------G
|||  ||....|||.|||||....|            . |||.      ||. .|.      .| . ..|..| |||..|.. || .||| .       |
WWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKG

VHEIKAHPFF
. |||.||.|
AEEIKNHPWF
Kinase 14389.AA MAST 26-317 34 4.1e-111 340.81 In-house 1-337 (337) Show / Hide 
Range on Protein: 26-317
Range on HMM: 1-337/337
Sequence Identity: 34% (115 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATVDNPWIVELYCSFQD--SKHLYLVMEYLQGGDLMTVLMKKD-IL
.. . .|..||.| |   . .|  . ..| |....| .. |||...|..||..|. ..||..|....|||    |.|..||||..|||  . |      .
FEFIKCISKGAYGAVYLVK-HKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCM

SEEESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLCKH-----AEIKPKL-----LLGKEEEKIDFSKNPTALLT-----------
 |.. |.|  |.| ...  |..  .||||||||.|.  .||||| |||| |      .  ...      . ||.    . ... . ..            
PEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNK

-------------KRPEVYKRNRHLAYSTVGTPDYIAPEVFGQQG-YTEIVDWWSLGVILFEMLVGYPPFFSEEPST-TCQKIINWRNTFNIPRE-----
             . .|    | |   . .||||||||||   || |   |||||.|.|..| |||.|||. ..|   . |.|||  .  . | |     
NQIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPND

-AELSKDAEDLIRRLIN-DPINRLGVNGVHEIKAHPFF
  ..|..| |||..| . .|  ||| ||..||| ||||
DDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 14389.AA MAST 26-317 32 2.1e-108 350.64 In-house 1-334 (334) Show / Hide 
Range on Protein: 26-317
Range on HMM: 1-334/334
Sequence Identity: 32% (110 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATVDNPWIVELYCSFQDSKHLYLVMEYLQGGDLMTVLMKKDILSEE
..   .|..||.| |    ..|  ....|.|..||..|. ||....|..||..|| ..||..|....|||  ..|..||||..|||. . |     . |.
FEFIKPISKGAYGKVYL-VKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEW

ESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLCKH-----AEIKPKL-----LLGKEEEKIDFSKNPTALLT--------------
  |.| .|.|....  |..  .||||||||.|.  .||||| |||| |      .  ....     ... .    .......  ..              
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQI

----------KRPEVYKRNRHLAYSTVGTPDYIAPEVFGQQG-YTEIVDWWSLGVILFEMLVGYPPFFSEEPSTTCQKIINWR-NTFNIPRE------AE
          . .   . | |   . .||||||||||  .|| .   |||||.|.|..| |||.|||. ..|  . |.|.| . |   .| .       .
QQQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEA

LSKDAEDLIRRLIND-PINRLGVN-GVHEIKAHPFF
.|..| |||..| .  |  ||| | |..|.| ||||
MSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 14389.AA S_TKc 26-317 34 1.5e-103 351.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-317
Range on HMM: 1-231/231
Sequence Identity: 34% (107 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATVDNPWIVELYCSFQDSKHLYLVMEYLQG--GDLMTVLMKKDI--
|. | .||.||||.|. ||.||  |||||.|..|          .|.| |...|   . |.|| || .||| .|||.||||. |  |||.... |.    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSEEESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLCKHAEIKPKLLLGKEEEKIDFSKNPTALLTKRPEVYKRNRHLAYST
    ..| . .||. ... |..  |... |||||||.|||| .  |||..||||...                                        .. 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------------TTF

VGTPDYIAPEVFGQQGYTE-IVDWWSLGVILFEMLVGYPPFFSEEPSTTCQKIINWRNTFNIPREAELSKDAEDLIRRLIN-DPINRLGVNGVHE----I
.|||.|.||||.   ||.   .||||.|.||.|||.|||||   .. .. .||               |..| |.||.. . || .|...  . .    |
CGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

KAHPFF
|.||.|
KCHPWF
Kinase 14389.AA AktR 26-317 35 7.1e-98 331.46 In-house 1-268 (268) Show / Hide 
Range on Protein: 26-317
Range on HMM: 1-268/268
Sequence Identity: 35% (106 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLA-TVDNPWIVELYCSFQDSKHLYLVMEYLQGGDLMTVLMKKDILSE
.. . ..|.||||.|  ...|..|....| |  ||... ..||. |.. ||....  ...| || |. .||. ..|...||| .||.| ..| ||  .||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EESKFYASELVMAIDSVHKM-NYIHRDLKPDNILLGRDGHIKLSDFGLCKHAEIKPKLLLGKEEEKIDFSKNPTALLTKRPEVYKRNRHLAYSTVGTPDY
|...||... . |..  |.  | | |||||.||||. |||.|..|||| |                               .. . .. .||| .||| |
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK------------------------------LQFMMHYDEKAYSFCGTPEY

IAPEVFGQ-QGYTEIVDWWSLGVILFEMLVGYPPFFSEEPSTTCQKIINWR-NTFNIPREAELSKDAEDLIRR--LINDPINRLG--VNGVHEIKAHPFF
.|||.  . .|..  ||||..|. ..||..|.|||...   .  |||.. . | |..|  ...|. . ||| |  | ..| .|||   ||  ||| ||.|
MAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYP--SYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 14389.AA RSK 29-317 34 1.3e-97 330.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 29-317
Range on HMM: 1-278/278
Sequence Identity: 34% (107 aa)

LSIIGRGAFGEVRVCREK--KQNGRIVAVKKMKKQEMLQKNQ-INHVRAERDVLATVD-NPWIVELYCSFQDSKHLYLVMEYLQGGDLMTVLMKKDI---
|.  |.|..|.| .||..  ...|.| |.|  || .. |..  . |...||..|...   | ||.|. .||. ..|||.|||. ||.| | | |. .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSEEESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGR---DGHIKLSDFGLCKHAEIKPKLLLGKEEEKIDFSKNPTALLTKRPEVYKRNR--HLAYS
.||.| .||..|.|.|..  |.   |||||||.|||.     .|||||.|||.|| .                                 |..   ....
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF---------------------------------RCDHNQWTMT

TVGTPDYIAPEVFG----QQGYTEIVDWWSLGVILFEMLVGYPPFFS---EEPSTTCQKIINWRNTFNIPREAELSKDAEDLIRRLIN-DPINRLG--VN
 ..| .|.|||.      | |... .|||||||...|||.|.||| .   . .. . ..| . . ....|. ..||..| ||||..   || .|||   .
FCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQ

GVHEIKAHPFF
.. |||.||.|
DAEEIKQHPWF
Kinase 14389.AA DMPK 26-172 47 6.8e-93 229.71 In-house 1-147 (270) Show / Hide 
Range on Protein: 26-172
Range on HMM: 1-147/270
Sequence Identity: 47% (70 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATVDNPWIVELYCSFQDSKHLYLVMEYLQGGDLMTVLMKKD-ILSE
.. |..||||.|||| | |. || ... | |.|.| ||| . .   .. |||...  . .||. |.. ||| ..||.||||  |||| | . . .  ..|
FEILKVIGRGHFGEVQVVRH-KQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPE

EESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLC
.  .||  |.|.||.|.|.| |.||| ||||.|| | ||||| ||| |
DMARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase 14389.AA Pkinase 26-317 30 4.5e-76 263.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-317
Range on HMM: 1-293/293
Sequence Identity: 30% (102 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVR-AERDVLATVDNPWIVELYCSFQDSKHLYLVMEYLQGG----DLMTVLM--K
|  ...||.|.||.|. |..|. .|.|||||..||..   . ...|.| .|  ... .. | ||.||..|.|..|.|.||||..||    ||.....  .
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KDIL--SEEESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHI----KLSDFGLCKHAEIKPKLLLGKEEEKIDFSKNPTALLTKRPEVYKRNRH
.  .  ||.| |||. ... ...  |.|. |||||||.|||. ..|||    |..||||.|...                                 | .
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------------------Y-NNS

LAYSTVGTPDYIAPEVFG-QQGYTEIVDWWSLGVILFEMLVGYPPFFSE------EPSTTCQKIINWRNTFNIPREAELS-----------------KDA
 ... .|||.|.||||   .|.|.  ||.||.|.||.||| |.||| ..      ..    ..|   .. |..| . . |                 ...
-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

EDLIRRLIN-DPINRLGVNGVHEIKAHPFF
 |.|..... ||  |..    ..|. ||.|
KDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 14389.AA Akt 26-173 44 2e-60 191.8 In-house 1-149 (264) Show / Hide 
Range on Protein: 26-173
Range on HMM: 1-149/264
Sequence Identity: 44% (67 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIV-AVKKMKKQEMLQKNQINHVRAERDVLATVDNPWIVELYCSFQDSKHLYLVMEYLQGGDLMTVLMKKDILSE
 | | ..|.|.|| |  .. ||.....  | |  ||.  .||||. |. .|| .| ....| || |. |||....||.||.| .||.| . | .| . ||
FDFLKVLGKGSFGKVFLVK-KKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

EESKFYASELVMAIDSVHKMNYIHRD-LKPDNILLGRDGHIKLSDFGLCK
.. .||..|.. ||.  |..| | || ||| |||. .||||.| ||||||
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase 14389.AA GEK 26-172 51 1.5e-59 198.39 In-house 1-147 (269) Show / Hide 
Range on Protein: 26-172
Range on HMM: 1-147/269
Sequence Identity: 51% (76 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATVDNPWIVELYCSFQDSKHLYLVMEYLQGGDLMTVLMK-KDILSE
.. | .||||||||| | .  |. ... |.| ..| |||..  .   | |||||   |. || .|   ||| ..|||||.|  ||||.|.| | .| | |
FEILKVIGRGAFGEVAVVK-MKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPE

EESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLC
.  .|| .|.||||||||...|.|||.||||.|| . |||.| ||| |
DMARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSC
Kinase 14389.AA ROCK 26-172 43 7.9e-55 185.07 In-house 1-145 (263) Show / Hide 
Range on Protein: 26-172
Range on HMM: 1-145/263
Sequence Identity: 43% (64 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATVDNPWIVELYCSFQDSKHLYLVMEYLQGGDLMTVLMKKDILSEE
.. . .|||||||||.. |.|. . .. |.| . | ||...        |||..|    .|||.|.. ||| ..||.||.|. ||||. .. . |. .| 
FHMIKVIGRGAFGEVQLVRHKSSK-KVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEK

ESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLC
 ..||  |.|.|.|..| | .|||| ||||.|| . ||.|| ||| |
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase 14389.AA DMPK 218-317 41 1.6e-52 127.62 In-house 162-270 (270) Show / Hide 
Range on Protein: 218-317
Range on HMM: 162-270/270
Sequence Identity: 41% (45 aa)

VGTPDYIAPEVFGQQGYT------EIVDWWSLGVILFEMLVGYPPFFSEEPSTTCQKIINW-RNTFNIPREAE--LSKDAEDLIRRLINDPINRLGVNGV
|||||||.|||   ..          .||||.||...|||.|  ||  .    |  || |  .| .. | . .  .|..| |||..|. |. .||| ||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

HEIKAHPFF
 ..|.||||
EDFKCHPFF
Kinase 14389.AA ROCK 218-317 48 6.8e-36 119.54 In-house 160-263 (263) Show / Hide 
Range on Protein: 218-317
Range on HMM: 160-263/263
Sequence Identity: 48% (50 aa)

VGTPDYIAPEVFGQQG----YTEIVDWWSLGVILFEMLVGYPPFFSEEPSTTCQKIINWRNTFNIPREAELSKDAEDLIRRLINDPINRLGVNGVHEIKA
|||||||.|||   ||    |   .|||| || ..|||||  ||. .    |  ||.. .|  . | ..|.||.| |||.. . |  .||| ||| .||.
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase 14389.AA Akt 212-317 39 2e-35 110.65 In-house 157-264 (264) Show / Hide 
Range on Protein: 212-317
Range on HMM: 157-264/264
Sequence Identity: 39% (43 aa)

HLAYSTVGTPDYIAPEVFGQQGYTEIVDWWS-LGVILFEMLVGYPPFFSEEPSTTCQKIINWRNTFNIPREAELSKDAEDLIRRLIN-DPINRLG--VNG
. ...  ||| |.|||.  ..|.|  ||||. ||....||. | |||...   .  .|| |  .  ..|.   .|... |||..| | || .|||   |.
DKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKN--QPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPND

VHEIKAHPFF
..|||.||.|
AQEIKRHPWF
Kinase 14389.AA GEK 218-317 45 4.6e-33 108.04 In-house 162-269 (269) Show / Hide 
Range on Protein: 218-317
Range on HMM: 162-269/269
Sequence Identity: 45% (49 aa)

VGTPDYIAPEVF-----GQQGYTEIVDWWSLGVILFEMLVGYPPFFSEEPSTTCQKIINWRNTFNIPREAE---LSKDAEDLIRRLINDPINRLGVNGVH
|||||||.||.      |.  | .  |||||||...||| |  ||..|    |  ||.|... |..| . .   .|..|.||||.||  . .||| ||..
VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQ

EIKAHPFF
. | ||||
DFKKHPFF
Kinase 14389.AA S_TK_X 318-379 26 7.5e-15 56.58 SMART 1-79 (79) Show / Hide 
Range on Protein: 318-379
Range on HMM: 1-79/79
Sequence Identity: 26% (21 aa)

QGVDWKRLR----EKTPPYVPEVK----DEIDVSNFDKFEEEEPWISHENNRKSKNRQQNF---------PFIGYTFKK
 |.||..|.    | .||..|..|    ...|.||||. ..||..     .. . |....          ||.|.|.. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 14389.AA TyrKc 26-312 21 4.8e-13 -11.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-312
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YDPLSIIGRGAFGEVRVCREKKQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATV--DNPWIVELY-CSFQDS------KHLYLVMEYLQGGDLMTVL
   . ..|.||||||. .. |    . ||||..|.        .   . |  ..  .  ..| || || .  |..      . |..||||  .|||   |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

MKKDI-LSEEESKFYASELVMAIDSVHKMNYIHRDLKPDNILLGRDGHIKLSDFGLCKHAEIK---PKLLLGKEEEKIDFSKNPTALLTKRPEVYKR---
 |.   |. ..   ..       .  |..|.|||||   |.|.|.....| |||||..  . .                           . ..|.    
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------------------ESKDYYRKKEH

-NRH--LAYSTVGTPDYIAPEVFGQQG-YTEIVDWWSLGVILFEML-VGYPPFFSE--EPSTTCQKIINWRNTFNIPREAEL---------SKDAEDLIR
 ...  | .         |||.. . | .|.  | || || ..|..  | .|   .  .   . | .|..  . . ..  .          ...  ....
KGGKTMLPIR------WMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK

RLIND-PINRLGVNGVHEIK
.  .  | .|   . .||. 
QCWHEDPEDRPTFSEIHECF
Kinase 14389.AA Pkinase_C 335-381 33 1.9e-08 33.03 Pfam 1-46 (46) Show / Hide 
Range on Protein: 335-381
Range on HMM: 1-46/46
Sequence Identity: 33% (16 aa)

EVKDEIDVSNFD-KFEEEEPWISHENNRKSKNRQQNFPFIGYTFKKNM
.||...|.||||  |..| |  .   .| . . .|. ||.|.|..  .
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQE-PFRGFTYVNPD
Kinase 14389.AA Pkinase_Tyr 142-173 40 1e-07 26.78 Pfam 128-159 (270) Show / Hide 
Range on Protein: 142-173
Range on HMM: 128-159/270
Sequence Identity: 40% (13 aa)

HKMNYIHRDLKPDNILLGRDGHIKLSDFGLCK
. .|.|||||   |.|.......| .||||..
ESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 14389.AA Pkinase_Tyr 32-112 32 4e-07 24.75 Pfam 7-94 (270) Show / Hide 
Range on Protein: 32-112
Range on HMM: 7-94/270
Sequence Identity: 32% (29 aa)

IGRGAFGEVRVCREK---KQNGRIVAVKKMKKQEMLQKNQINHVRAERDVLATV-DNPWIVELYCSFQ-DSKH--LYLVMEYLQGGDL
.|.||||||. .. |   ....  ||||..| . | . | .    .|  .. .  ..| || ||     ....  .|.|||| ..|||
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL