Gene 9468 (Tetrahymena)

9468

Species: Tetrahymena
Alias: PreTt09468, 9.m00489, 534, 3699.m00197, TTHERM_00129040, 9468
External Links: Tetrahymena Genome Database (TGD) ,
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
9468.AA Protein None 1572 None Fasta, JSON
9468.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
9468.NA RNA None 4719 None Fasta, JSON

Protein domain

Protein domains of 9468.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 9468.AA Ank 677-701 32 9.941801 3.28 Pfam 10-33 (33) Show / Hide 
Range on Protein: 677-701
Range on HMM: 10-33/33
Sequence Identity: 32% (8 aa)

VRQNSFSIIEQLLQHERADLRADTD
.| .. .... |||   ||. | .|
CRCGHTEVVKMLLQ-HGADVNAQDD
Ank 9468.AA Ank 706-738 27 7.6e-08 32.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 706-738
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

NQWSSIHYAAYNGNASILNLLISHDADVNITNN
. ..  |.|...|..... .|..| ||||....
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 9468.AA Ank 781-814 32 3.7e-07 30.06 Pfam 1-33 (33) Show / Hide 
Range on Protein: 781-814
Range on HMM: 1-33/33
Sequence Identity: 32% (11 aa)

NQNTALHFACKNNSAQCVRLLLLCKNIDVNLKNV
. .|.|| ||.......|..||  .. |||... 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 9468.AA Ank 739-780 23 0.012046 13.8 Pfam 1-33 (33) Show / Hide 
Range on Protein: 739-780
Range on HMM: 1-33/33
Sequence Identity: 23% (10 aa)

LEQTALMIAAEKQIFVFKFSTGFDEIVDICIKAGAEINRQDL
  .|.|..|...            |.|   ...||..| || 
DGFTPLHLACRCG---------HTEVVKMLLQHGADVNAQDD
Kinase 9468.AA AGC 1215-1472 33 6.1e-180 470.11 In-house 1-395 (395) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-395/395
Sequence Identity: 33% (134 aa)

FRIVNQIGRGSFGEVYLVEKK------GSDQYYAMKMLHKSK-VLGQN--LTKYAMTE------------RNVLSIMS----------HPFIVK-LMYAF
|...  ||.||||.||||.||      ....|||||.| |.. ..  .    ...|||            ||.|. ..          |||||| | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTSKD--LFLIMEYMP---------GG-DLSHALQ---RDKRFSEQRARIYLSE-------IMLAIKHLHK-HDIIYRD-LKPENIVIDGEGHAMLTDFG
|. .   |...|||||         || .| . ||   . .||.|.|||.|..|       | ||. .||. ..||.|| ||||||..| .|| .|||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKDGVYDH--------------------------------------------------YSTHSFCG--SLAYLAPEMLKRCGHGKAVDYYH--LGVLLY
|.| |. |.                                                    |..|||  .  |.|||.|    .|||.|..   ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGSPPFFSDS----------KDEICHNIE------FQEIRFP----------SYVSDNARNLISRLLVKNPQKRLGFGKND-----FEEIKKHPFF
||||| |||..|.          ..|. ..|.      .....||          ...|..|..||..||.|.| |||| |.||     .||||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 9468.AA RSK-Unclassified 1215-1472 48 2.7e-154 488.41 In-house 1-283 (283) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-283/283
Sequence Identity: 48% (138 aa)

FRIVNQIGRGSFGEVYLVEKKGSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLSIMSHPFIVKLMYAFQTSKDLFLIMEYMPGGDLSHALQ--RDKRFSE
|     ||.|.||.||||.||...| |||| |||.|.. .|..||.|||.|....  |||||.| ..|||.  |.|.||| .|||.  .||  ..|.|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

QRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDG--------------------VYDHYS-THSFCGSLAYLAPEMLKRCGHG
 ..|.|.||...|  .||| |.|||||||.||| . |||.|||||.||...                    . || . | ||||. .||||||..||||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KAVDYYHLGVLLYEMLTGSPPFFSDSKDEICHNIEFQEIRFP--SYVSDNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
|||| . ||...|||| | ||.  . |.|.  ||| ....||  ||.| |.| || .|| .|| |||| .. | ..||.||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 9468.AA Akt 1215-1472 49 6.6e-148 475.95 In-house 1-264 (264) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-264/264
Sequence Identity: 49% (131 aa)

FRIVNQIGRGSFGEVYLVEKKGSDQYY-AMKMLHKSKVLGQNLTKYAMTERNVLSIMSHPFIVKLMYAFQTSKDLFLIMEYMPGGDLSHALQRDKRFSEQ
|.... .|.|||| |.||.|| ....| |||.| |.. . .|  ....||||.|  . |||||.| |.|||.. |...|.|..||.|   |||..||||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RARIYLSEIMLAIKHLHKHDIIYRD-LKPENIVIDGEGHAMLTDFGLSKDG-VYDHYSTHSFCGSLAYLAPEMLKRCGHGKAVDYYH-LGVLLYEMLTGS
||| | .||.||| |||...||||| ||||||..| .||  ||||||.|.. . ||. | .|||. .|||||.|.  ||.|||| .  ||...|||..| 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFFSDSKDEICHNIEFQEIRFP--SYVSDNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
|||... ...  ..|  |...||  ...|.....|||.|| |.| |||| |.|| .||| ||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 9468.AA SGK 1215-1472 45 3e-142 442.33 In-house 1-283 (283) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-283/283
Sequence Identity: 45% (129 aa)

FRIVNQIGRGSFGEVYLVEKKGS------------------DQYYAMKMLHKSKVL-------GQNLTKYAMTER-NVLSIMSHPFIVKLMYAFQTSKDL
|.. . || ||||.||.|..|.                   |. |||| | |  ..         .. |. |.|| ..|. |.|||||.| ||||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLIMEYMPGGDLSHALQRDKRFSEQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDGVYDHYSTHSFCGSLAYLAPEMLKRC
.. |.|. ||..   ||| |.|.| |||.| .|| .|. .||. ||||||||||||. | .||. ||||||.| |. .   | .|||...|||||.|.  
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHGKAVDYYHLGVLLYEMLTGSPPFFSDSKDEICHNIEFQEIRFPSYVSDNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
.|...|| . || .||||..| |||.|  | .   ||  |....| ..|  |. ||  || |.|.||||  |.||.|||.||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase 9468.AA AktR 1215-1472 47 2.3e-139 469.28 In-house 1-268 (268) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-268/268
Sequence Identity: 47% (126 aa)

FRIVNQIGRGSFGEVYLVEKK-GSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLS-IMSHPFIVKLMYAFQTSKDLFLIMEYMPGGDLSHALQRDKRFSE
|.. . .|.| ||.||||.||  ....|||||..|.|   .|. ... ||||..  ...||||||| |.||| . ||.||||.|||.| . |...|.|||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QRARIYLSEIMLAIKHLHKH-DIIYRDLKPENIVIDGEGHAMLTDFGLSK-DGVY-DHYSTHSFCGSLAYLAPEMLKR-CGHGKAVDYYHLGVLLYEMLT
..||.| ..| ||. .||.| .|||||||||||..| .||  .|||||||  ..  .   ..||||. .|.||||...  ||.|.||.. .|...|||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GSPPFFSDSKDEICHNIEFQE---IRFPSYVSDNARNLIS-RLLVKNPQKRLGFGKNDFEEIKKHPFF
| |||..... .. ..| ...   . .|||.|.....||  .|| |||.|||| ..|..||||.||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 9468.AA RSK 1218-1472 46 6.8e-130 437.84 In-house 1-278 (278) Show / Hide 
Range on Protein: 1218-1472
Range on HMM: 1-278/278
Sequence Identity: 46% (129 aa)

VNQIGRGSFGEVYLVEKK---GSDQYYAMKMLHKSKVLGQNL-TKYAMTERNVLSIMS-HPFIVKLMYAFQTSKDLFLIMEYMPGGDLSHALQRDKR---
. . |.|..|.|.|. |.    ..|.|||| |.|.|.   .  |...|||||.|.    |||||.| ||||| . |.|||||..||.|   ||. |.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDG---EGHAMLTDFGLSKDGVYD-HYSTHSFCGSLAYLAPEMLK----RCGHGKAVDYYHLGV
||| .|..|..|| ||..|||...||.||||||||. |    ||| .|||||..| .. |    |..||....|.||||||    ..||.||.|.. |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLTGSPPFFS---DSKDEICHNIEFQE--IRFP--SYVSDNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
|.|||||| ||| .   ....||  .|.  .   ..|  .|.|..|..||...| ..|.|||| |..| ||||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 9468.AA RSK 1215-1472 39 7.1e-108 364.68 In-house 1-271 (271) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-271/271
Sequence Identity: 39% (107 aa)

FRIVNQIGRGSFGEVYLVEKK---GSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLSIMSHPFIVKLMYAFQTSKDLFLIMEYMPGGDLSHALQRDKRFS
. .   ||.|||..||.. |.    ..|.|||| . |...       .. .||..|.   ||||||| |.||. . ...||. | ||||   |.. | ||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGE----GHAMLTDFGLSKDGVYDHYS-THSFCGSLAYLAPEMLKRCGHGKAVDYYHLGVLLYEM
|. ...|..|| ||  .||...|..||||||||..| |    ||. ..|||..|  . |.   . .||.. .|.|||.||| ||..|.|.. .|||.|||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LTGSPPFFSDSKDEICHNIEFQEIRF-------PSYVSDNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
||| .|| .  .|.   .|  .           ....|| |  |....|  .|..||| | |. |.||.||.|
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 9468.AA p70 1215-1472 39 2.5e-101 342.94 In-house 1-299 (299) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-299/299
Sequence Identity: 39% (118 aa)

FRIVNQIGRGSFGEVYLVEKKG---SDQYYAMKMLHKSKVLG-QNLTKYAM-------------------------TERNVLSIMSHPFIVKLMYAFQTS
|  .  .|.| .| |..| |     . ..|||| | | |... |  |  .                           |||.|.   ||||..|.||||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

KDLFLIMEYMPGGDLSHALQRDKRFSEQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDGVYDHYS----------THSFCG
  |.|| ||..|| |   | |   . |  |. |||||..|..|||.|.||||||||||.  .  ||  ||||||.|  . |             ||.|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

SLAYLAPEMLKRCGHGKAVDYYHLGVLLYEMLTGSPPFFSDSKDEICHNIEFQE--IRFPSYVSDNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
   | |||.| ||||..|||.. ||.|.| ||||.|||  . . ..   |      .. | | .  .| || .|| ..|..|.| | .| ..|..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 9468.AA PKA 1215-1472 42 3.9e-101 342.3 In-house 1-263 (263) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-263/263
Sequence Identity: 42% (114 aa)

FRIVNQIGRGSFGEVYLVEKKGSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLSIMSHPFIV-KLMYAFQTSKDLFLIMEYMPGGDLSHALQRDKRFSEQ
| |.. .|.|||| |.|. .|.| .||||||| |...   . .   ..|.|.|. ..||||| |. . ||... |...||| |||.. . |.. .|||..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RARIYLS-EIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDGVYDHYSTHSFCGSLAYLAPEMLKRC-GHGKAVDYYHLGVLLYEMLTGSP
 |..|   .| ||.  ||...||||||||||| || .||  .|||| .|  | |   | . ||   |||||....  ||||.||   ||.| ||||.| |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFFSD--SKDEICHNIEFQEIRFPSYVSDNA---RNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
||. .  .. .|   |   .|.||.... .|   . ||..||.... ||.|  ||. . ||.|..|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 9468.AA PKC 1215-1472 40 5.69999999999e-101 328.03 In-house 1-262 (262) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-262/262
Sequence Identity: 40% (107 aa)

FRIVNQIGRGSFGEVYLVEKKGSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLSIMS-HPFIVKLMYAFQTSKDLFLIMEYMPGGDLSHALQRDKRFSEQ
|. .  .|.|||| | |.|.||.|.|||.| | |  ..       .|||. ||.  . ||| ..|   |||   || .|||  |||| .  |. .||.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDGVYDHYSTHSFCGSLAYLAPEMLKRCGHGKAVDYYHLGVLLYEMLTGSPPF
.|| |  ||..| . ||...||||||| .|. .| |||  ..|||..|.....   | .|||   |.||| |.    ||.||.  .|||.|||. | .||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

FSDSKDEICHNIEFQEIRFPSYVSDNARNLISRLLVKNPQKRLGFGKND---FEEIKKHPFF
  .  ||. ..|  .....| . |  | .... .. |||.|||| .. .   ...|..||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 9468.AA S_TKc 1215-1472 33 7.8e-99 335.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

FRIVNQIGRGSFGEVYLVEKKGSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLSIMSHPFIVKLMYAFQTSKDLFLIMEYMPG--GDLSHALQRDKR---
..|...||.|.||.||.. .|......|.|...          . .. |...|.   ||.|||| ..||. ..|...|||..|  ||| . ... .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDGVYDHYSTHSFCGSLAYLAPEMLKRCGHGK-AVDYYHLGVLLYE
   |.| .|| |. .| .|....|.| ||.|||||||| .|   | ...||||..         ..|||.. |.|||.|   |.|| ..| . .|..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLTGSPPFFSDSKDEICHNIEFQEIRFPSYVSDNARNLISRLLVKNPQKRLGFGKNDF--EEIKKHPFF
||.| |||     ... ..|           |. |...|...|.|.|.||..  .     ..||.||.|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 9468.AA Pkinase 1215-1472 28 1.9e-86 298.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

FRIVNQIGRGSFGEVYLVEKKGSDQYYAMKMLHKSKVLGQNLTKYAM-TERNVLSIMSHPFIVKLMYAFQTSKDLFLIMEYMPGG----DLSHALQ--RD
..|. .||.||||.||.  .||. . .|.| . |..   . .   .  .|  ..  ..||.||.| ..|...... ..|||..||    ||.. ..  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRF--SEQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHA----MLTDFGLSKDG-VYDHYSTHSFCGSLAYLAPEMLK-RCGHGKAVDYYHL
..|  ||. .. |. .|  .....|.. ||.|||||||| || .||      ..||||.|         ...|||.. |.||| .. . ..|..|| . .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLLYEMLTGSPPFFSD------SKDEICHNIEFQEIRFPSYVS---------------------DNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
|..|||||.| ||| ..      .....  .|   ...|... .                     .... .|...| |.|.||..     .|.|..||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase 9468.AA TyrKc 1215-1472 22 4e-15 21.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 1215-1472
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FRIVNQIGRGSFGEVYLVEKKGSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLSIM--SHPFIVKLMYAFQTS-------KDLFLIMEYMPGGDLSHALQ
 .   ..|.| |||||. . |   .  | |||....       .  | | ....    .|| ||.|  .  ..       . |...|||||.||| . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RDKR-FSEQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDGVYD--------HYST----HS-FCGSLAYLAPEMLKRCGHG
. .. .. .    .   |     .||.. .| |||   |. .. ....  .|||||.|.  |         |..    .. .   .  .||| .. .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KAVDYYHLGVLLYEMLT-GSPPFFS-----DSKDEICHNIEFQ-EIRFPSY--------VSDNARNLISRLLVKNPQKRLGFGKNDFEEIKKHPFF
 . | .  ||...|..| | .|         | .|. ....     . | .         .|   .....    .| .|       |.||  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase 9468.AA Pkinase_Tyr 1215-1372 24 1.5e-08 29.6 Pfam 1-173 (270) Show / Hide 
Range on Protein: 1215-1372
Range on HMM: 1-173/270
Sequence Identity: 24% (43 aa)

FRIVNQIGRGSFGEVYLVEKK----GSDQYYAMKMLHKSKVLGQNLTKYAMTERNVLSIM-SHPFIVKLMYAFQ-TSKD--LFLIMEYMPGGDLSHALQR
 ..  ..|.|.|||||. . |    . ..  | |||  .    ||. .  | | .... . .|| ||.|. .    ..   ....|||||.||| . |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----DKRFSEQRARIYLSEIMLAIKHLHKHDIIYRDLKPENIVIDGEGHAMLTDFGLSKDG----VYDHYSTHS
    ..... ..   .  .|  .  .|. . .| |||   |. .. ....  .||||..|      | ......
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGG