Gene 23592 (Tetrahymena)

23592

Species: Tetrahymena
Alias: 42.m00326, 217, 23592, PreTt23592, 3813.m01545, TTHERM_00394690
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
23592.AA Protein None 604 None Fasta, JSON
23592.kin_dom Protein Kinase Domain None 311 None Fasta, JSON
23592.NA RNA None 1815 None Fasta, JSON

Protein domain

Protein domains of 23592.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH_Akt_basal 23592.AA PH_Akt_basal 34-117 51 1.3e-52 181.1 In-house 1-90 (90) Show / Hide 
Range on Protein: 34-117
Range on HMM: 1-90/90
Sequence Identity: 51% (46 aa)

VGKYNRKDVRQDRFIMITDKAFYNLK---KTSIKRRIDLNFIKGITTS-TCGTEFVLHVPSEYDYRYS--STLYREKIIQLLRRYCGCLA
| ||||...||.|..|||.|..||.|   |.|||..|.|..|.||..| |.|.|||.|||.||||||.  |. .|..||..|.|...|..
VIKYNRYNKRQERNLMITSKHVYNCKPNKKHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC
Myosin_TH1 23592.AA Myosin_TH1 5-79 24 1.5e-11 40.41 Pfam 27-130 (234) Show / Hide 
Range on Protein: 5-79
Range on HMM: 27-130/234
Sequence Identity: 24% (25 aa)

TEDYLNLLEVSSIKKHLQKT---KE-------ELLFSCP----VGKYNR--KDVRQDRFIMITDKAFYNL-------------KKTSIKRRIDLNFIKGI
. |||.. .  . .......   .|        .||...    | ||||  .   ..|..  |||..| .             |.  .||||.|| |...
VGDYLGYEHNPKLQDCMGREHGINELRKHPFMKVLFADHCECLVNKYNRFWFGKPSPRDLLLTDKHIYLVGREKKKKGPEKDQKTYQVKRRIPLNEITSV

TTST
. |.
SLSP
Kinase 23592.AA AGC 220-530 33 1.4e-174 455.96 In-house 1-395 (395) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-395/395
Sequence Identity: 33% (139 aa)

FDIIKVLGRGTFGKVMMVQKK------DTGVYYALKSIRKLK-IQDEK--QAEHLRME------------RYILESIN----------NNFLVK-LKYTF
|...||.|.|.||||. |.||      ||| |||.| ..| . |.. |  . ||   |            | ||| .|          . |.|| |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTDDK--IFFIMDFMK---------GG-ELFQHLK---LNRRFNEQTAKFFAAE-------VLLALEYLHS-RKIIYRD-LKPENILLDEHGHIRITDFG
|..|.  ..|.|..|.         || |||.||.    ..||.|..|.|.|||       ..|||||||| ..||.|| ||||||||||.|||..||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MAKQFSTINEIPSLLKLVKVNSCISDGATNDSESWSSPKISQRSNQSNLSSATSSPELQPANANRER--------------TNSFVG--TPQYISPEIIG
..|.. . .|...     .           .. .|...|. | ..  |..  | .  . |.|..|..              |..|.|  ||.|..|||. 
LCKEGMNDGEKGQQ-SQSN-----------MKFHWHNKKY-Q-KS--NMD--T-NK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-

RKSYTYSSDVWQ--FGLFIYELIYGYPPFFHQQTQ----------IVFQLID------ECRIFFPQH--------IKISNECKDIITKILQRDPEKRLT-
   |... | |   .| ..||...|||||.....|           .||.|       .... || .         ..|.|.||.|.| |..||||||. 
---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC

---------LQQAKMHPWF
          .. | ||||
GGNDFGDKGAEEIKNHPWF
Kinase 23592.AA AktR 220-530 41 8.20000000001e-170 570.44 In-house 1-268 (268) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-268/268
Sequence Identity: 41% (134 aa)

FDIIKVLGRGTFGKVMMVQKK-DTGVYYALKSIRKLKIQDEKQAEHLRMERYILE-SINNNFLVKLKYTFQTDDKIFFIMDFMKGGELFQHLKLNRRFNE
|...|.||.|.||||..|||| |.. .||.|.|.| ||....|..|...||.|.|  .|..|.|||.|.|||..|.||||....||||||||| ...|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QTAKFFAAEVLLALEYLHSR-KIIYRDLKPENILLDEHGHIRITDFGMAKQFSTINEIPSLLKLVKVNSCISDGATNDSESWSSPKISQRSNQSNLSSAT
..|.|..|..||||||||.. .|||||||||||||||.||..|||||..|                                                  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

SSPELQPANANRERTNSFVGTPQYISPEIIGR-KSYTYSSDVWQFGLFIYELIYGYPPFFHQQTQIVFQLIDECR-IFFPQHIKISNECKDIIT-KILQR
    ||. ....|...||.|||.|..||.| . | ...|.| |.|| ||||...|.|||.|..... ||.|.... ..||.....|..|||.|. |.|..
----LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCK

DPEKRLT-----LQQAKMHPWF
.|.|||.      .. |.||||
NPNKRLGYYCNGWEEIKSHPWF
Kinase 23592.AA S_TKc 220-530 32 1.8e-104 354.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-231/231
Sequence Identity: 32% (105 aa)

FDIIKVLGRGTFGKVMMVQKKDTGVYYALKSIRKLKIQDEKQAEHLRMERYILESINNNFLVKLKYTFQTDDKIFFIMDFMKG--GELFQHLKLNRR---
..|....|.|.||||. ...|.|| ..|.| |.          ||.| |. ||.. .  ..|||...||. |.....|... |  |.||...| ..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FNEQTAKFFAAEVLLALEYLHSRKIIYRDLKPENILLDEHGHIRITDFGMAKQFSTINEIPSLLKLVKVNSCISDGATNDSESWSSPKISQRSNQSN
   |.| .|.|.......||||.||..||.||||||||||||  || |.|||.|.|.                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

LSSATSSPELQPANANRERTNSFVGTPQYISPEIIGRKSYTY-SSDVWQFGLFIYELIYGYPPFFHQQTQIVFQLIDECRIFFPQHIKISNECKDIITKI
                    ..|.||| |..||..   .|.. ..|.| .|  .||...|||||   | | .|..|             | |.||.| |.
--------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKC

LQRDPEKRLTLQQAKM-------HPWF
||.|||||.|  .|         ||||
LQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23592.AA RSK 223-530 33 1.9e-100 340.03 In-house 1-278 (278) Show / Hide 
Range on Protein: 223-530
Range on HMM: 1-278/278
Sequence Identity: 33% (110 aa)

IKVLGRGTFGKVMMVQKK---DTGVYYALKSIRKLKIQD-EKQAEHLRMERYILESIN-NNFLVKLKYTFQTDDKIFFIMDFMKGGELFQHLKLNRR---
.||||.| .|||  ..|.   ||| .|| | ..| ||   .| ..| . || ||| ..   |.|.|.|.|||..|.. ||....||||| ||.  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FNEQTAKFFAAEVLLALEYLHSRKIIYRDLKPENILLDE---HGHIRITDFGMAKQFSTINEIPSLLKLVKVNSCISDGATNDSESWSSPKISQRSNQSN
| | .|.| .||. ||.|.||...||.|||||||||.|.   .|||..|||| .|||                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

LSSATSSPELQPANANRERTNSFVGTPQYISPEIIG---RKS-YTYSSDVWQFGLFIYELIYGYPPFFH---QQTQIVFQLIDECR--IFFPQHIKISNE
             . . ..|..|..| .|. ||..    ... .. . |.| .|  .||.  |.||| .   .. . ... | ...    .|   ..|.|
------------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQE

CKDIITKILQRDPEKRLT-----LQQAKMHPWF
.||.|.| |.|||.|||.     ... | ||||
AKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 23592.AA Ciliate-E2 220-530 25 1.2e-97 330.65 In-house 1-365 (365) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-365/365
Sequence Identity: 25% (108 aa)

FDIIKVLGRGTFGKVMMVQKKDTGV-----------------------YYALKSIRKLKIQDEKQAEHLR----------MERYILESINNNFLVKLKYT
...||..|.|.||.|  .... ..                        .||.|...| .|.  || .|.           .|. |||..|.....|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TDDKIFFIMDFMKGGELFQHLKLN-------------------RRFNEQTAK-------FFAAEVLLALEYLHSRK-IIYRDLKPENILLDEHGHI
||  .|..|...|.. .||.||...| |                   ... .| ..       |..|...||||||||.. ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RITDFGMAKQFSTINE-------------------IPSLLKLVKVNSCISDGATNDSESWSSPKISQRSNQSNLSSATSSPELQPANANRERTNSFVGTP
 |.|||..|.... |.                    |. ...                                                . .|...|||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQ--------------------------------------------IIQQNMFNTICGTP

QYISPEIIGRKS---------YTYSSDVWQFGLFIYELIYGYPPFFHQQTQIVFQLIDECRIFFP----------------QHIKISNECKDIITK----
 | .|||...|.         |.|..|.| .|  .||...|.|||        .| | .| | ||                 . |.|.||||.| |    
GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKR

ILQRDPEKRLT-LQQAKMHPWF
.||.|||||.|  .|.. ||||
MLQKDPEKRITGWEQILNHPWF
Kinase 23592.AA Akt 220-367 55 4.1e-94 301.25 In-house 1-150 (264) Show / Hide 
Range on Protein: 220-367
Range on HMM: 1-150/264
Sequence Identity: 55% (83 aa)

FDIIKVLGRGTFGKVMMVQKKDTGVYY-ALKSIRKLKIQDEKQAEHLRMERYILESINNNFLVKLKYTFQTDDKIFFIMDFMKGGELFQHLKLNRRFNEQ
||..||||.|.||||. |.||||. .| |.|...| .|.. .| ||   ||.||. .|..|.|.|.| ||| ||..|.||...|||||.||.  |||.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

TAKFFAAEVLLALEYLHSRKIIYRD-LKPENILLDEHGHIRITDFGMAKQ
.|.|..||. ||.|.|||. ||||| |||||||.|..|||..||||..|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKE
Kinase 23592.AA Ciliate-E2-Unclassified 220-530 27 1.2e-92 314.14 In-house 1-352 (352) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-352/352
Sequence Identity: 27% (107 aa)

FDIIKVLGRGTFGKVMMVQKKDTGVYYALKSIRKLKIQDEKQAEHL---------RMERY-------------ILESINNNFLVKLKYTFQTDDKIFFIM
. |||..|.| |||| ..|.|... |||.| . | .|.. || ..           ...              || .... |.||. |.||....|...|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DFMKGGELFQHLKLN-----------------RRFNEQTAK-----FFAAEVLLALEYLHSRK-IIYRDLKPENILLDEHG---HIRITDFGMAKQFSTI
....||.|.|..| .                 ..| || ||     |..|..|..|||||. . ||.||.||||||.|. |   .|.|.||| .|.  . 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

NEIPSLLKLVKVNSCISDGATNDSESWSSPKISQRSNQSNLSSATSSPELQPANANRE---RTNSFVGTPQYI----SPEIIGRKSYT----YSSDVWQF
|..                                               | .. ..    ....|.|||.|.    .||..... |     |..|.| .
NNCD-TNQ------------------------------------------Q-QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSL

GLFIYELIYGYPPFFH-QQTQ---------------IVFQLIDECRIFFPQHI------KISNECKDIIT----KILQRDPEKRLTLQQAKMHPWF
|  .||...||.||.  ...|               ...| | .. |.|| .       ..|.|.||.|.    |.|. .|.||.|..|.. ||||
GVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 23592.AA MAST 220-530 30 2.5e-88 284.83 In-house 1-334 (334) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-334/334
Sequence Identity: 30% (105 aa)

FDIIKVLGRGTFGKVMMVQKKDTGVYYALKSIRKLKIQDEKQAEHLRMERYILESINNNFLVKLKYTFQTDDKIFFIMDFMKGGELFQHLKLNRRFNEQT
|..||....| .|||  | .|.|.  .|.| |.|    . .. .... || ||. . |.| ||. |.|||.......|..| || ....|.   .| | .
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKFFAAEVLLALEYLHSRKIIYRDLKPENILLDEHGHIRITDFGMAKQ--FSTINEIPSL-----LKLVKVNSCISDGATNDSESWSSP--------KIS
||.  ||. |.||||||  |. |||||.|.|.|  ||| .|||| .|    . .| ....     .    .|. ... ..|. .  . |        .  
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI----FNNSTDPMNKNQQDYSQFPGDFGINGNTNK

QRSNQSNLSSATSSPELQPANANRERTNSFVGTPQYISPEIIGRKS-YTYSSDVWQFGLFIYELIYGYPPFFHQQTQIVFQLIDECR---IFFPQH----
  ..| ...      . .. . | .. .. .|||.||.||.| ... .  ..| |  |  .||.. |.|||.   ....|| |   .   | .|      
NQIQQQQEQPQCQQQN-MRPH-NIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDIN

--IKISNECKDIITKILQRDPEKRLTLQ----QAKMHPWF
  ...| | .|.| | || ||.|||. .    . | || |
DDEAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 23592.AA Pkinase 220-530 28 4.5e-88 303.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-293/293
Sequence Identity: 28% (100 aa)

FDIIKVLGRGTFGKVMMVQKKDTGVYYALKSIRKLKIQDEKQAEHLR-MERYILESINNNFLVKLKYTFQTDDKIFFIMDFMKGG----ELFQHLK--LN
. |....|.|.||.|   ..|.||  .|.| |.| .. ..|. .|.| .| .|. ..|  . |.|...|...|.| ..|... ||    .|| ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RRF--NEQTAKFFAAEVLLALEYLHSRKIIYRDLKPENILLDEHGHI----RITDFGMAKQFSTINEIPSLLKLVKVNSCISDGATNDSESWSSPKISQR
..|   |...||.. ..| .|||.||..||.|||||||||.|..|||    .|.||| ||||.                                     
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------------------------

SNQSNLSSATSSPELQPANANRERTNSFVGTPQYISPEIIG-RKSYTYSSDVWQFGLFIYELIYGYPPFFHQ------QTQIVFQLIDECRIFFPQHIKI
                  . | . ...|.||| |..||.|  .. |....|.| .|. .||.. |.||| ..        . ....| .... |.   ..
------------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWC

S-------------------NECKDIITKILQRDPEKRLTLQQAKMHPWF
|                    ||||.|...|..||.||.| .|.. ||||
SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 23592.AA SGK 220-367 43 1.3e-78 242.26 In-house 1-174 (283) Show / Hide 
Range on Protein: 220-367
Range on HMM: 1-174/283
Sequence Identity: 43% (76 aa)

FDIIKVLGRGTFGKVMMVQKKDT------------------GVYYALKSIRKLKIQ-------DEKQAEHLRMER-YILESINNNFLVKLKYTFQTDDKI
||..||.| | ||||..|..||.                  .  ||.| ..|  |          |.. |   ||  ||  ..  |.|.|.| |||..| 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFIMDFMKGGELFQHLKLNRRFNEQTAKFFAAEVLLALEYLHSRKIIYRDLKPENILLDEHGHIRITDFGMAKQ
.| ||.. |||.| ||.  ..| |  |.| |||. .||||||| .||||||||||||||  ||...|||| .|.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKE
Kinase 23592.AA PKA 220-366 51 1.8e-75 257.02 In-house 1-149 (263) Show / Hide 
Range on Protein: 220-366
Range on HMM: 1-149/263
Sequence Identity: 51% (77 aa)

FDIIKVLGRGTFGKVMMVQKKDTGVYYALKSIRKLKIQDEKQAEHLRMERYILESINNNFLV-KLKYTFQTDDKIFFIMDFMKGGELFQHLKLNRRFNEQ
|.||..||.|.||.|| ...|..| |||.| ..| .| ..|| ||   |. || .|.. |.| |...|||.|......|..  |||.| .|  ..||...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TAKFFAA-EVLLALEYLHSRKIIYRDLKPENILLDEHGHIRITDFGMAK
.||| || .. ||||||||  ||||||||||||.|. ||| ||||| ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase 23592.AA RSK 220-367 44 5.5e-62 212.24 In-house 1-154 (271) Show / Hide 
Range on Protein: 220-367
Range on HMM: 1-154/271
Sequence Identity: 44% (69 aa)

FDIIKVLGRGTFGKVMMVQKK---DTGVYYALKSIRKLKIQDEKQAEHLRMERYILESINNNFLVKLKYTFQTDDKIFFIMDFMKGGELFQHLKLNRRFN
.......|.|.|.||  ..|.   ||. .|| | |.| ..    .     .||.||. ..  | |||.| ||.  |.. |||||.||.|| .|   . | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EQTAKFFAAEVLLALEYLHSRKIIYRDLKPENILLDEH----GHIRITDFGMAKQ
|. .|| .||..||.||||| .|..|||||||||.|..    |||.|.||| |||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ
Kinase 23592.AA Akt 429-530 39 1.8e-37 117.32 In-house 157-264 (264) Show / Hide 
Range on Protein: 429-530
Range on HMM: 157-264/264
Sequence Identity: 39% (43 aa)

ERTNSFVGTPQYISPEIIGRKSYTYSSDVWQ-FGLFIYELIYGYPPFFHQQTQIVFQLIDECRIFFPQHIKISNECKDIITKILQRDPEKRL-----TLQ
..|..| ||| |..|||.  . .| ..| |  .| ..||...| |||..|. .  |..| .. . ||  ..||.||||.|.. |..||.|||     ..|
DKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQ

QAKMHPWF
. | ||||
EIKRHPWF
Kinase 23592.AA SGK 431-530 34 3.4e-26 77.51 In-house 182-283 (283) Show / Hide 
Range on Protein: 431-530
Range on HMM: 182-283/283
Sequence Identity: 34% (36 aa)

TNSFVGTPQYISPEIIGRKSYTYSSDVWQFGLFIYELIYGYPPFFHQQTQIVFQLIDECRIFFPQHIKISNECKDIITKILQRDPEKRLTLQ----QAKM
| .| ||| |  ||..  . .  . | |  | . ||..|| |||... .|. .. |    . .|.   .||...|.|.  ||.||.|||       . | 
TFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPP--QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKN

HPWF
||.|
HPFF
Kinase 23592.AA PKA 436-530 36 4.2e-22 79.75 In-house 160-263 (263) Show / Hide 
Range on Protein: 436-530
Range on HMM: 160-263/263
Sequence Identity: 36% (39 aa)

GTPQYISPEIIGRK-SYTYSSDVWQFGLFIYELIYGYPPFFHQ--QTQIVFQLIDECRIFFPQHIKISNEC---KDIITKILQRDPEKRL-TLQQ----A
|||.|. |||| .|  .  | | | .|  |||.  |||||.    ..   .. | ...|.||.|  ...     || | | ||.|..||. ....     
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRH--FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDI

KMHPWF
| |.||
KNHKWF
Kinase 23592.AA RSK 426-530 29 3.2e-20 69.01 In-house 157-271 (271) Show / Hide 
Range on Protein: 426-530
Range on HMM: 157-271/271
Sequence Identity: 29% (35 aa)

ANRERTNSFVGTPQYISPEIIGRKSYTYSSDVWQFGLFIYELIYGYPPFFHQQTQIVFQLIDECRIFFPQ-------HIKISNECKDIITKILQRDPEKR
.  . . .| .| .|. ||.. |. .. ..|.| ||   ||   |..|| ..  .  ...|   ||   .         .|| |.|| ... | |||..|
DENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNII--QRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNR

LTL-----QQAKMHPWF
|.      .|.| ||||
LGAGPNGVEQIKQHPWF
Kinase 23592.AA TyrKc 220-530 19 6.3e-14 2.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 220-530
Range on HMM: 1-280/280
Sequence Identity: 19% (66 aa)

FDIIKVLGRGTFGKVMMVQKKDTGVYYALKSIRKLKIQDEKQAEHLRMERYILESI--NNNFLVKLKYTFQTD-------DKIFFIMDFMKGGELFQHLK
   .|.||.| ||.|.  . |   .  | |.... .       | .. |  |. ..  ..  .|.|     ..       . .. .| .|..| | ..|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

LNRR-FNEQTAKFFAAEVLLALEYLHSRKIIYRDLKPENILLDEHGHIRITDFGMAKQFSTI-NEIPSLLKLVKVNSCISDGATNDSESWSSPKISQRSN
 .|. .. ..   |.  .    |||||...| |||   |.|..| ....|.|||...      ..                                  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--------------------------------ES

QSNLSSAT--SSPELQPANANRERTNSFVGTPQYISPEIIGRKSYTYSSDVWQFGLFIYELI-YGYPPFFH-----QQTQIVFQLIDEC-RIFFPQHIK-
..  ....  ..  . |                  .|| |  . .|  |||| ||  ..|.  || .|           | |......  |   |...  
KDYYRKKEHKGGKTMLPIR--------------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP

-----ISNECKDIITKILQRDPEKRLTLQQAKMHPWF
      . |  .|...  ..|||.| | ..   |  |
MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 23592.AA Pkinase_Tyr 220-366 24 2.4e-09 32.28 Pfam 1-159 (270) Show / Hide 
Range on Protein: 220-366
Range on HMM: 1-159/270
Sequence Identity: 24% (39 aa)

FDIIKVLGRGTFGKVMMVQKK----DTGVYYALKSIRKLKIQDEKQ--AEHLRMERYILESI-NNNFLVKLKYTFQ-TDDK--IFFIMDFMKGGELFQHL
  ..|.||.| ||.|..   |    .|..  | |...     ...|   | .  |  |. .. ..  .|.|       ..   |. .| .|..| |  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KL----NRRFNEQTAKFFAAEVLLALEYLHSRKIIYRDLKPENILLDEHGHIRITDFGMAK
.     ..... ..   .....  ..|||.|...| |||   |.|..| ....|.|||.|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 23592.AA S_TK_X 531-592 20 1.3e-05 25.19 SMART 1-79 (79) Show / Hide 
Range on Protein: 531-592
Range on HMM: 1-79/79
Sequence Identity: 20% (16 aa)

KDMDWEKLAK--KQISSPYIPCTQ----GEEWIKGFDSDFTSEAPINSYEPEKISMIKQN-----------LINFNDLK
.. ||.|| .  |.|  |..|  .    ... .. || .||.|.|  .  .. .|.. ..            ..|.   
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 23592.AA Pkinase_Tyr 442-474 37 2.561849 1.7 Pfam 182-216 (270) Show / Hide 
Range on Protein: 442-474
Range on HMM: 182-216/270
Sequence Identity: 37% (13 aa)

SPEIIGRKSYTYSSDVWQFGLFIYELIY-GYPP-F
.|| |  . .|  |||| ||  ..|..  |  | .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY