Gene 23531 (Tetrahymena)

23531

Species: Tetrahymena
Alias: 23531, PreTt23531, TTHERM_00393030, 219, 3813.m01486, 42.m00265
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
23531.AA Protein None 504 None Fasta, JSON
23531.kin_dom Protein Kinase Domain None 289 None Fasta, JSON
23531.NA RNA None 1515 None Fasta, JSON

Protein domain

Protein domains of 23531.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23531.AA AGC 155-443 31 6.2e-153 398.65 In-house 1-395 (395) Show / Hide 
Range on Protein: 155-443
Range on HMM: 1-395/395
Sequence Identity: 31% (134 aa)

FVFYKILGQGAFGVVFLSIDK------QTNEEVAVKMISKHE-IEIKK--QRDHTQTE------------KLILEHIK----------HPFLIN-VLGTF
| |.|..|.|.|| |.|  .|      .|..  |.|...| . | |||  . .||.||            . |||...          |||...    .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDCSV--NNFSNQNTIIICFINNQS--TEGG-ELFQHLK---TQRFFAEERVKFYAAQ-------MILALEHLHS-FNIIYRD-LKLENILLDEEGYLCL
|| .     |  .  ..  ..|  .    || |||.||.    .. | |||..||||.       ..||||.|||  .||.|| ||.|||||||.|...|
QDKDHTYLYFVMEYMPR--YVN--DLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKL

TDFGLAKILS---------------------------------------------------DTDTALTFCG--TPEYLSPETIKGFGSSKASDWWS--LG
|||||.|..                                                    ..|.. ||||  ||||..|| .     .|| ||||  ||
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLG

TLLYEMLFSMPPFYHK----------QHKQMFQKIV------FEELQFNPN--------MQVSSQAKDLIGRVKYLIIQSINKIYFVKLKFQLLCKDPRI
 |.||||.  ||||..          ....|||||       .....|...         ..|..||||| .                    ||||||. 
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKK--------------------LLCKDPEK

RLGSCE------GASELKNHPWF
|||. .      ||.|.||||||
RLGCGGNDFGDKGAEEIKNHPWF
Kinase 23531.AA AktR 155-443 44 1e-151 510.35 In-house 1-268 (268) Show / Hide 
Range on Protein: 155-443
Range on HMM: 1-268/268
Sequence Identity: 44% (132 aa)

FVFYKILGQGAFGVVFLSIDK-QTNEEVAVKMISKHEIEIKKQRDHTQTEKLILE-HIKHPFLINVLGTFQDCSVNNFSNQNTIIICFINNQSTEGGELF
|..||.||.|||| |.|  .| .... .| |||.|..|. ..|..||.||. |.| ...|||....  .||..      .....|....     .|||||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTK------EKLFFIMEYC-----PGGELF

QHLKTQRFFAEERVKFYAAQMILALEHLHSF-NIIYRDLKLENILLDEEGYLCLTDFGLAK---ILSDTDTALTFCGTPEYLSPETIKG-FGSSKASDWW
||||....| ||...||.||..||||.||.. |||||||| |||||||.|....|||||.|   . .....| .|||||||..||.|.  .|  |..|||
QHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWW

SLGTLLYEMLFSMPPFYHKQHKQMFQKIVFEE-LQFNPNMQVSSQAKDLIGRVKYLIIQSINKIYFVKLKFQLLCKDPRIRLG-SCEGASELKNHPWF
..|...|||.. .||||||...|||||| ... ..|......|||.|||| |                   .||||.|. ||| .|.|..|.|.||||
AFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQR-------------------KLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 23531.AA Akt 248-443 49 1e-107 345.44 In-house 84-264 (264) Show / Hide 
Range on Protein: 248-443
Range on HMM: 84-264/264
Sequence Identity: 49% (100 aa)

GGELFQHLKTQRFFAEERVKFYAAQMILALEHLHSFNIIYRD-LKLENILLDEEGYLCLTDFGLAK-I-LSDTDTALTFCGTPEYLSPETIKGFGSSKAS
|||||.||. .|.| |.| .||.|..|||.||||| |||||| ||.||||.|..|..|||||||.| . ..|.|.. |||||||||.|| ..| | .||.
GGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAV

DWWS-LGTLLYEMLFSMPPFYHKQHKQMFQKIVFEELQFNPNMQVSSQAKDLIGRVKYLIIQSINKIYFVKLKFQLLCKDPRIRLG-SCEGASELKNHPW
|||. || ..|||.. .||||...|.|||.||  ....|... ..| ..|||| .                    || |||  |||   ..| |.|.|||
DWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISG--------------------LLNKDPKKRLGGGPNDAQEIKRHPW

F
|
F
Kinase 23531.AA SGK 247-396 51 8e-84 258.67 In-house 108-256 (283) Show / Hide 
Range on Protein: 247-396
Range on HMM: 108-256/283
Sequence Identity: 51% (78 aa)

EGGELFQHLKTQRFFAEERVKFYAAQMILALEHLHSFNIIYRDLKLENILLDEEGYLCLTDFGLAK-ILSDTDTALTFCGTPEYLSPETIKGFGSSKASD
.|||.| ||.  . | | |..||||. ..|||.||| .||||||| |||||| .|..|||||||.|    ..||  ||||||||| || ... . ... |
NGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVD

WWSLGTLLYEMLFSMPPFYHKQHKQMFQKIVFEELQFNPNMQVSSQAKDLI
||.||..||||.. .||||.. ..||...|  ..||. |.|...  |.|||
WWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSND--AWDLI
Kinase 23531.AA S_TKc 155-443 31 9.8e-80 272.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 155-443
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

FVFYKILGQGAFGVVFLSIDKQTNEEVAVKMISKHEIEIKKQRDHTQTEKLILEHIKHPFLINVLGTFQDCSVNNFSNQNTIIICFINNQSTEGGELFQH
. . ...|.||||.|.. ..| |...||.|.|.          .|.. |  ||.. .||.... ...|||          . .  .    .. .|.||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDY

LKTQRF------FAEERVKFYAAQMILALEHLHSFNIIYRDLKLENILLDEEGYLCLTDFGLAKILSDTDTALTFCGTPEYLSPETIKGFGSSK-ASDWW
.| ..       | | ...||..|...|||..|| .||.|||| |||||||   . ..|||||..|       ||||||.|..|| .   | .| ..|||
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGTLLYEMLFSMPPFYHKQHKQMFQKIVFEELQFNPNMQVSSQAKDLIGRVKYLIIQSINKIYFVKLKFQLLCKDPRIRLGSCEGAS---ELKNHPWF
|.| .|||||   |||.  |...||.||.                                   .  .  ..|.|||. |..  |      . |.||||
SCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23531.AA Pkinase 155-398 30 4.3e-70 243.96 Pfam 1-272 (293) Show / Hide 
Range on Protein: 155-398
Range on HMM: 1-272/293
Sequence Identity: 30% (87 aa)

FVFYKILGQGAFGVVFLSIDKQTNEEVAVKMISKHEIEIKKQRDHTQ-TEKLILEHIKHPFLINVLGTFQDCSVNNFSNQNTIIICFINNQSTEGG----
... ...|.|.||.|.. ..| |...|||| |.|.... .|.. |.  .|  |. ...||. .  ...|.|         . | ...      |||    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVM---EYCEGGLYVM

ELFQHLK--TQRFF--AEERVKFYAAQMILALEHLHSFNIIYRDLKLENILLDEEGYL----CLTDFGLAKI--LSDTDTALTFCGTPEYLSPETIK-GF
.|| ...   .. |   |. .|||. |.. .||..|| .||.||||.||||.|..|..    ...||||||   .     . ||||||.|..|| |. | 
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

GSSKASDWWSLGTLLYEMLFSMPPFYHK------QHKQMFQKIVFEELQFNPNMQVS-------------------SQAKDLIGR
. ....|.||.| .|||||.  |||...       ..||...|   .| |.     |                   . .||.| .
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW
Kinase 23531.AA Ciliate-E2-Unclassified 155-443 26 8.4e-67 228.25 In-house 1-352 (352) Show / Hide 
Range on Protein: 155-443
Range on HMM: 1-352/352
Sequence Identity: 26% (97 aa)

FVFYKILGQGAFGVVFLSIDKQTNEEV-AVKMISKHEIEIKKQRDH--------TQTEKL--------------ILEHIKHPFLINVLGTFQDC----SV
. . |..|||.||.|.. ..|... .. | |...|. |  .||  .        .. ...              || ...|||... . .|||      |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

NNFSNQNTIIICFINNQSTE--GGELFQHLKTQRFFAEERVK-----FYAAQMILALEHLHSFN-IIYRDLKLENILLDEEG---YLCLTDFGLAKILSD
  . .... . .  .. .    |..||...|... | |. .|     ||.|| ...||.||. | ||.||.|.||||.|..|   |....|||..| . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------TDTALTFCGTPEYL----SPETIKGFGSS----KASDWWSLGTLLYEMLFSMPPFYHKQHKQ----------------MFQKIV
                 . . ||||||.|.    .|| ..| . .    ...|.|||| .||||||  .||| .. .|                ..|.| 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

FEELQFNP--N----MQVSSQAKDLIGRVKYLIIQSINKIYFVKLKFQLLCKDPRIRLGSCEGASELKNHPWF
  ..||..  .    ...| .|||.|                     .||.|..  ....  ......|||||
QKNIQFPKFPWQQIPKHWSPEAKDFIN--------------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 23531.AA RSK 247-398 42 1e-59 204.68 In-house 84-252 (278) Show / Hide 
Range on Protein: 247-398
Range on HMM: 84-252/278
Sequence Identity: 42% (72 aa)

EGGELFQHLKTQRF---FAEERVKFYAAQMILALEHLHSFNIIYRDLKLENILLDE---EGYLCLTDFGLAKI--LSDTDTALTFCGTPEYLSPETIK--
.||||| ||.....   | |....||.|. .||.||||.  ||.||||.||||.|.   || . |||||..|.  ....  . |||.| ||. || .|  
RGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRA

--GFGSSKASDWWSLGTLLYEMLFSMPPFYH---KQHKQMFQKIVFEE--LQFNPNMQVSSQAKDLIGR
  . | .|| |||||| |.||||.  |||..   ...|. ...|   .  | .  .  .|  ||||| .
NQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRK
Kinase 23531.AA Ciliate-E2 247-443 26 1.5e-57 196.08 In-house 117-365 (365) Show / Hide 
Range on Protein: 247-443
Range on HMM: 117-365/365
Sequence Identity: 26% (74 aa)

EGGELFQHLK-------------------TQRFFAEERVK-------FYAAQMILALEHLHSFN-IIYRDLKLENILLDEEGYLCLTDFGLAKILSDT--
.||.||...|                     ... .. ..       ||.|..|||||.||| | ||.||.|.||||.     ....||||.|...|   
QGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQ

------------------------------DTALTFCGTPEYLSPETIK---------GFGSSKASDWWSLGTLLYEMLFSMPPFYHKQHKQMFQKIVFE
                              ... |.||||.|..|| ..         . | ....|.|||| .||||||  |||        .|.|   
NRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQC

ELQFNPN----------------MQVSSQAKDLIGR--VKYLIIQSINKIYFVKLKFQLLCKDPRIRLGSCEGASELKNHPWF
...|...                 ..| ..|||| .                     ..|.|||  |..   |.....|||||
KIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK------------------RMLQKDPEKRIT---GWEQILNHPWF
Kinase 23531.AA RSK-Unclassified 248-396 39 2.3e-57 178.5 In-house 83-255 (283) Show / Hide 
Range on Protein: 248-396
Range on HMM: 83-255/283
Sequence Identity: 39% (68 aa)

GGELFQHLK--TQRFFAEERVKFYAAQMILALEHLHSFNIIYRDLKLENILLDEEGYLCLTDFGL---A-------------------KILSDTDTALTF
||..|.||    .. |.|..|.|||.  ..|||.||   .|||||| .||.|. ||   ||||.|   |                   ||...   .  |
GGDFFRHLQTRKEKCFCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSF

CGTPEYLSPETIKGFGSSKASDWWSLGTLLYEMLFSMPPFYHKQHKQMFQKIVFEELQFNPNMQVSSQAKDLI
||| ||| || |.. |  || ||| || ..||||| .||.|   .  .|. |  ....|  .  .| ...|||
CGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLI
Kinase 23531.AA PKA 247-396 49 9e-56 191.6 In-house 83-235 (263) Show / Hide 
Range on Protein: 247-396
Range on HMM: 83-235/263
Sequence Identity: 49% (77 aa)

EGGELFQHLKTQRFFAEERVKFYAA-QMILALEHLHSFNIIYRDLKLENILLDEEGYLCLTDFGLAKILSDTDTALTFCGTPEYLSPETIKGF-GSSKAS
.|||.| .|   . | .   ||||| | .|||| ||| |||||||| ||||.|..|.. .|||| || . |     | ||||||| || |..  |  |. 
PGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSV

DWWSLGTLLYEMLFSMPPFYHK--QHKQMFQKIVFEELQFNPNMQVSSQA---KDLI
|||.|| | ||||.  |||| .  .  |...||.  ...| ...  .|.|   ||||
DWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHF--DSDANYFKDLI
Kinase 23531.AA RSK 247-376 45 4.9e-50 172.54 In-house 84-218 (271) Show / Hide 
Range on Protein: 247-376
Range on HMM: 84-218/271
Sequence Identity: 45% (62 aa)

EGGELFQHLKTQRFFAEERVKFYAAQMILALEHLHSFNIIYRDLKLENILLDEE----GYLCLTDFGLAKILSDTDT-ALTFCGTPEYLSPETIKGFGSS
.||.|| .|  |..| |. ||||.|   ||.|.|||  |..|||| ||||.|.|    | . ..|||.|| | | .  ..|||.| .|. || .|  | .
RGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHD

KASDWWSLGTLLYEMLFSMPPFYHKQHKQMFQKIV
.|.||||.|.|.||||   .||..|  . ....|.
QACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQ
Kinase 23531.AA Akt 155-224 45 3.5e-18 54.64 In-house 1-71 (264) Show / Hide 
Range on Protein: 155-224
Range on HMM: 1-71/264
Sequence Identity: 45% (32 aa)

FVFYKILGQGAFGVVFLSIDKQTNEEV-AVKMISKHEIEIKKQRDHTQTEKLILEHIKHPFLINVLGTFQD
| | |.||.|.|| |||  .|.|..   | |...|  |. |.|  ||.||. ||.|..|||..|    ||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQT
Kinase 23531.AA Ciliate-E2 155-224 25 3e-17 55.75 In-house 1-105 (365) Show / Hide 
Range on Protein: 155-224
Range on HMM: 1-105/365
Sequence Identity: 25% (27 aa)

FVFYKILGQGAFGVVFLSIDKQTNE-----------------------EVAVKMISKHEIEIKKQRDHTQ----------TEKLILEHIKHPFLINVLGT
. | |..|||.||.|..  ......                       ..|.|...| .||..|| .|             || |||...||..|.   .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--D
||  |
FQEKD
Kinase 23531.AA PKA 155-224 43 4.2e-15 56.49 In-house 1-71 (263) Show / Hide 
Range on Protein: 155-224
Range on HMM: 1-71/263
Sequence Identity: 43% (31 aa)

FVFYKILGQGAFGVVFLSIDKQTNEEVAVKMISKHEIEIKKQRDHTQTEKLILEHIKHPFLIN-VLGTFQD
| ... ||.| || | |  .|.. . .| ||..|.||   || .|. .|| ||  |||||...   .||||
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQD
Kinase 23531.AA SGK 155-217 26 1.6e-14 40.77 In-house 1-89 (283) Show / Hide 
Range on Protein: 155-217
Range on HMM: 1-89/283
Sequence Identity: 26% (24 aa)

FVFYKILGQGAFGVVFLSIDKQT------------------NEEVAVKMISKHEIE-------IKKQRDHTQTEK-LILEHIKHPFLIN
| | |..|.| || |..   |..                      |.| ..|  |         ||.  |...|.  ||  .||||..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVN
Kinase 23531.AA RSK 155-224 30 2.1e-13 44.37 In-house 1-72 (271) Show / Hide 
Range on Protein: 155-224
Range on HMM: 1-72/271
Sequence Identity: 30% (22 aa)

FVFYKILGQGAFG---VVFLSIDKQTNEEVAVKMISKHEIEIKKQRDHTQTEKLILEHIKHPFLINVLGTFQD
. . . .|||.|.   |.   . |.|| . |.| | |  . .| . . . .|  ||... ||| .     |||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQD
Kinase 23531.AA TyrKc 155-419 20 3.8e-12 -26.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 155-419
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

FVFYKILGQGAFGVVFLSIDKQTNEEVAVKMISKHEIEIKKQRDHTQTEKLILEHI--KHPFLINVLGTFQDCSVN--NFSNQNTIIICFINNQSTEGGE
 .. |.|| ||||.|.. . |   ..|||||. ..       |     |  |. ..  .|| ... .|    |.    ||     . | .      ..| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYG---VCTQQGRNFMYIEPLMIVM---EYMPHGD

LFQHL-KTQRFFAEERVKFYAAQMILALEHLHSFNIIYRDLKLENILLDEEGYLCLTDFGLAKILSDTD-----TALTFC----GTPE-----YLSPETI
| ..| |... .  .    .. |     |.||| |.| |||   |.|..|..    .||||.. . | |     .         |.        ..||.|
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

KGFGSSKASDWWSLGTLLYEML-FSMPPFYH-----KQHKQMFQKIVFEELQFNPNMQVSSQAKDL----IGRVKYLIIQSINKI------YFVKLKFQL
.    . .|| || | ...|.. . ..| .      .  .......   .    |          .         | |...  .        |  .. ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 23531.AA RSK 158-224 36 3.2e-11 37.61 In-house 1-72 (278) Show / Hide 
Range on Protein: 158-224
Range on HMM: 1-72/278
Sequence Identity: 36% (26 aa)

YKILGQGAFGVVFLSIDK---QTNEEVAVKMISKHEIEIKKQ-RDHTQTEKLILEHIK-HPFLINVLGTFQD
 | ||||..| |||   .   .|. . |.| ..|..|  ..    || ||  |||... |||...   .||.
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQT
Kinase 23531.AA RSK-Unclassified 155-223 31 4.2e-11 30.58 In-house 1-69 (283) Show / Hide 
Range on Protein: 155-223
Range on HMM: 1-69/283
Sequence Identity: 31% (22 aa)

FVFYKILGQGAFGVVFLSIDKQTNEEVAVKMISKHEIEIKKQRDHTQTEKLILEHIKHPFLINVLGTFQ
|.  . .||| || |.|   |.|.   | |  .||..  ..      ||. |.   .||| .     ||
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQ
Kinase 23531.AA SGK 418-443 53 1e-10 28.86 In-house 258-283 (283) Show / Hide 
Range on Protein: 418-443
Range on HMM: 258-283/283
Sequence Identity: 53% (14 aa)

QLLCKDPRIRLGSCEGASELKNHPWF
.|| |||. |||. ... | ||||.|
GLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 23531.AA RSK 418-443 48 1.2e-07 24.4 In-house 252-278 (278) Show / Hide 
Range on Protein: 418-443
Range on HMM: 252-278/278
Sequence Identity: 48% (13 aa)

QLLCKDPRIRLGS-CEGASELKNHPWF
..|..||  |||.  ..|.|.|.||||
KMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 23531.AA Pkinase_Tyr 155-220 31 2.1e-07 25.68 Pfam 1-71 (270) Show / Hide 
Range on Protein: 155-220
Range on HMM: 1-71/270
Sequence Identity: 31% (23 aa)

FVFYKILGQGAFGVVFLSIDK----QTNEEVAVKMISKHEIEIKK--QRDHTQTEKLILEHI-KHPFLINVLG
 .| | ||.||||.|.. . |    .|. .|||||. |.    .   ..|  . |  |. .. .|| ... .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYG
Kinase 23531.AA RSK-Unclassified 419-443 46 4.2e-07 17.82 In-house 258-283 (283) Show / Hide 
Range on Protein: 419-443
Range on HMM: 258-283/283
Sequence Identity: 46% (12 aa)

LLCKDPRIRLGSCEG-ASELKNHPWF
|| . |  |||.  | | . | || |
LLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 23531.AA RSK 418-443 44 9e-06 16.89 In-house 245-271 (271) Show / Hide 
Range on Protein: 418-443
Range on HMM: 245-271/271
Sequence Identity: 44% (12 aa)

QLLCKDPRIRLGS-CEGASELKNHPWF
..|  ||  |||.  .|. . |.||||
MMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 23531.AA S_TK_X 444-493 18 4.5e-05 20.11 SMART 1-79 (79) Show / Hide 
Range on Protein: 444-493
Range on HMM: 1-79/79
Sequence Identity: 18% (15 aa)

EDVDWDALYK--RQVQAPFKPVTN----QECWLGYFDQEFVS-----KPINN------------------FFKQIYDFN
 ..|||.||.  .....||||  .     .  ...||.|| .     .|..                    | .   ..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 23531.AA PKA 411-443 41 5.8e-05 19.24 In-house 230-263 (263) Show / Hide 
Range on Protein: 411-443
Range on HMM: 230-263/263
Sequence Identity: 41% (14 aa)

YFVKLKFQLLCKDPRIRLGSCE-GASELKNHPWF
||  | ..|| .|.  |.|. . |.   |||.||
YFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 23531.AA Pkinase 419-443 44 0.000662 14.89 Pfam 273-293 (293) Show / Hide 
Range on Protein: 419-443
Range on HMM: 273-293/293
Sequence Identity: 44% (11 aa)

LLCKDPRIRLGSCEGASELKNHPWF
.|||||  |..    | ....||||
CLCKDPKKRPT----AEQILQHPWF
Kinase 23531.AA Pkinase_Tyr 276-357 32 0.002207 12.08 Pfam 123-208 (270) Show / Hide 
Range on Protein: 276-357
Range on HMM: 123-208/270
Sequence Identity: 32% (28 aa)

ALEHLHSFNIIYRDLKLENILLDEEGYLCLTDFGLAKILSDTDTA-LTFCGTPE---YLSPETIKGFGSSKASDWWSLGTLLYEML
..|.|.| |.| |||   |.|..|..    .|||||. . ..|.   .  |..     ..|| |.    . .|| || | |..|..
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF