Gene 21909 (Tetrahymena)

21909

Species: Tetrahymena
Alias: 21909, 117.m00161, TTHERM_00726440, PreTt21909, 918
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
21909.AA Protein None 671 None Fasta, JSON
21909.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
21909.NA RNA None 2016 None Fasta, JSON

Protein domain

Protein domains of 21909.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 21909.AA Ank 171-203 27 1.7e-05 24.05 Pfam 1-33 (33) Show / Hide 
Range on Protein: 171-203
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DNYTALHFSVTDMHNQIVQILIDNGCNIEAETT
| .|.||  .   | ..|. |...|... | . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 21909.AA Ank 141-170 26 45.363277 0.9 Pfam 9-33 (33) Show / Hide 
Range on Protein: 141-170
Range on HMM: 9-33/33
Sequence Identity: 26% (8 aa)

AAEIGNVDKIKYLLDKSKNLYPVDLNYQSL
|.. |... .|.||.     .  |.| |  
ACRCGHTEVVKMLLQ-----HGADVNAQDD
Ank 21909.AA Ank 237-269 30 6.7e-07 29.15 Pfam 1-33 (33) Show / Hide 
Range on Protein: 237-269
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

NNNTPILLASQNRWHEIVEILLDNGGDPHIKNN
. .||  ||...  .|.|. ||..| |......
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 21909.AA Ank 208-236 41 0.000127 20.93 Pfam 5-33 (33) Show / Hide 
Range on Protein: 208-236
Range on HMM: 5-33/33
Sequence Identity: 41% (12 aa)

PLHLCCIIGNIDALKILIKHKAEINPLDN
|||| |. |... .| |..| |..|  |.
PLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase 21909.AA AktR 364-621 52 2e-166 559.17 In-house 1-268 (268) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-268/268
Sequence Identity: 52% (141 aa)

YEYYRILGSGAFGKVILVKDK-KNQKYYAMKIISKEKFQQLNLMKYALSEKNAMS-KMQHPFIVKLHYAFQTKRKLFLIQQYCGGGSLGRMLKIKQRFDE
...|..||.||||||.||..| .|||.||||.|.|.|....|.|.... |.| |  ...|||||||||.||||.|||.|..|| || | ..|| |..|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QTAKKYMCQIILAIEALHDN-LIIFRDLKPDNIVLDEEGNAYLVDFGLAK-LGV--YDEINKSFLGTPAYLPPEIIVK-DGHNRMADWYAVGIVLYELLM
..|..|..||.||.| ||.. .||.|||||.||.|||.|. ...||||.| ...  |||...||.|||.|..||.| | .|||...||.|.||..||...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GCTPFNQGNVSREVLYERIKQ-NSIKIPSNISSECQDIIQ-KLLCKNPKKRLG-YKNDGKEIRSHPWF
||.||...|  .......||| |....||..||.|.|.|| |||||||.|||| |.|. .||.|||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 21909.AA AGC 364-621 28 5.9e-164 427.81 In-house 1-395 (395) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-395/395
Sequence Identity: 28% (114 aa)

YEYYRILGSGAFGKVILVKDK------KNQKYYAMKIISKEK-FQQLN--LMKYALSE------------KNAMSKMQ----------HPFIVK-LHYAF
.| ....| |.||||.||..|       ..||||||...|..  ....   ......|            .| ..|..          |||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKRK--LFLIQQY---------CGGG-SLGRMLK---IKQRFDEQTAKKYMCQ-------IILAIEALHD-NLIIFRD-LKPDNIVLDEEGNAYLVDFG
|.|..  |... .|         ||||  |  .|.    ..||||..|. |...       |.||.| ||. . || || |||.||.|||.|.  |.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKLGVYDE---------------------------------------------------INKSFLG--TPAYLPPEIIVKDGHNRMADWYA--VGIVLY
|.| |. |.                                                    ...| |  || |..|||.    ... .||..  .|...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLMGCTPFNQGNVS--------REVLYERIK------QNSIKIP----------SNISSECQDIIQKLLCKNPKKRLGYKNDG------KEIRSHPWF
|.| |..||.  |.         .. ....|.      .. .|.|          ...|.|..|.|.|||||.|.||||.....      .||..||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 21909.AA Akt 364-621 45 8.4e-130 417.15 In-house 1-264 (264) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-264/264
Sequence Identity: 45% (121 aa)

YEYYRILGSGAFGKVILVKDKKNQKYY-AMKIISKEKFQQLNLMKYALSEKNAMSKMQHPFIVKLHYAFQTKRKLFLIQQYCGGGSLGRMLKIKQRFDEQ
 .. ..||.|.||||.|||.|..||.| |||...|.. .| |  .... |.|   ...|||||.|||.|||. ||... .||.|| |   |. |.||.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

TAKKYMCQIILAIEALHDNLIIFRD-LKPDNIVLDEEGNAYLVDFGLAKLG-VYD-EINKSFLGTPAYLPPEIIVKDGHNRMADWYA-VGIVLYELLMGC
.|. | ..||||||.|| . ||.|| ||| ||..|..|. .| ||||.| . . | .. |.| |||.||.|||. . || ...||.. .|.|.||.. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFNQGNVSREVLYERIKQNSIKIP--SNISSECQDIIQKLLCKNPKKRLG-YKNDGKEIRSHPWF
 ||   .  ...... ||.. .|.|  ..|| ||.|.| .|| |.||||||  .|| .||..||||
PPFYNQD--HHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 21909.AA SGK 364-621 38 2.9e-114 354.35 In-house 1-283 (283) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-283/283
Sequence Identity: 38% (111 aa)

YEYYRILGSGAFGKVILVKDKKN------------------QKYYAMKIISKEKFQ-------QLNLMKYALSEK-NAMSKMQHPFIVKLHYAFQTKRKL
 ..  ..| | |||| .|| |.                   .| ||||...|.          . .. |. ..|. .....| |||||.|||||||| ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLIQQYCGGGSLGRMLKIKQRFDEQTAKKYMCQIILAIEALHDNLIIFRDLKPDNIVLDEEGNAYLVDFGLAKLGVYDEIN-KSFLGTPAYLPPEIIVKD
..   |  || ..  |.  ..| |  |. |. .|..|.| ||.  ||.|||||.||.|| .|.. | ||||.|.|. ..   ..| |||.|| ||.. | 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHNRMADWYAVGIVLYELLMGCTPFNQGNVSREVLYERIKQNSIKIPSNISSECQDIIQKLLCKNPKKRLGYKNDGKEIRSHPWF
.| |  ||.  |.||||...|  ||   |.  . .|. |    ..|| ..|... |.|| || |.|||||| |.|. ||..||.|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNK--QQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 21909.AA RSK 367-621 38 2.3e-105 356.35 In-house 1-278 (278) Show / Hide 
Range on Protein: 367-621
Range on HMM: 1-278/278
Sequence Identity: 38% (108 aa)

YRILGSGAFGKVILVKDK---KNQKYYAMKIISKEKFQQLNL-MKYALSEKNAMSKMQ-HPFIVKLHYAFQTKRKLFLIQQYCGGGSLGRMLKIKQR---
 . || |..||| |.. .   .....||||...| |. | .   .... | | ..  | |||||.|||||||. ||.|| .|| || |.. |. ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEQTAKKYMCQIILAIEALHDNLIIFRDLKPDNIVLDE---EGNAYLVDFGLAKLGVYD--EINKSFLGTPAYLPPEIIV----KDGHNRMADWYAVGI
|.| .|. || .|.||.| ||.  ||.|||||.||..|.   ||   |.|||..|... |  .  ..| .| .|..||..     . ||.. .||.  |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VLYELLMGCTPFNQGNV-SREVLYERIKQNS--IKIP--SNISSECQDIIQKLLCKNPKKRLGY-KNDGKEIRSHPWF
..||.|.||.|| ..|  .|... .||...    ..|  ...| |..|.|.|.|...|.||||. ..| .||..||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 21909.AA RSK-Unclassified 364-621 39 1.9e-104 329.02 In-house 1-283 (283) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-283/283
Sequence Identity: 39% (112 aa)

YEYYRILGSGAFGKVILVKDKKNQKYYAMKIISKEKFQQLNLMKYALSEKNAMSKMQHPFIVKLHYAFQTKRKLFLIQQYCGGGSLGRMLK--IKQRFDE
..  | .| | |||| ||. |. |. ||||. .|.|  . |. ||.. |.| |.  .|||||.| ..|||. .|.|. .|| || ..| |    . .| |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

QTAKKYMCQIILAIEALHDNLIIFRDLKPDNIVLDEEGNAYLVDFGLAKLG--------------------VYDEIN--KSFLGTPAYLPPEIIVKDGHN
  .. |.  ...| | ||   .|.||||||||||. || . | ||.| . .                    . |.    .|| || .|| ||.|   || 
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

RMADWYAVGIVLYELLMGCTPFNQGNVSREVLYERIKQNSIKIP--SNISSECQDIIQKLLCKNPKKRLGYKND-GKEIRSHPWF
.  ||.  |||.||.|.||.|.   |  .. ... | .| .|.|  | || .|.| | ||| .|| |||| |     .|. || |
KAVDWWTLGIVMYEMLFGCPPYYGNN--KNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 21909.AA S_TKc 364-621 35 1.1e-93 318.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-231/231
Sequence Identity: 35% (95 aa)

YEYYRILGSGAFGKVILVKDKKNQKYYAMKIISKEKFQQLNLMKYALSEKNAMSKMQHPFIVKLHYAFQTKRKLFLIQQYCGG--GSLGRMLKIKQR---
||  |..|.|||||| ....|| ....|.|||.          . ...| . ..| .||.||||...||.  .|...  ||.|  |.| ...| ..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEQTAKKYMCQIILAIEALHDNLIIFRDLKPDNIVLDEEGNAYLVDFGLAKLGVYDEINKSFLGTPAYLPPEIIVKDGHNR-MADWYAVGIVLYEL
   |.| .|..||.||..|.| .|.. || |||||.|| |||  .  . |||||..       ..| ||| |..||..   |...  .||...|..|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LMGCTPFNQGNVSREVLYERIKQNSIKIPSNISSECQDIIQKLLCKNPKKRLGYKNDGK---EIRSHPWF
| |..||       ......|.          |.|. |.|.|.|.|.|.||..     .   .|..||||
LCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21909.AA Ciliate-E2 364-621 24 3.2e-83 282.79 In-house 1-365 (365) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-365/365
Sequence Identity: 24% (95 aa)

YEYYRILGSGAFGKVILVKDKKNQ-----------------------KYYAMKIISKEKFQQLNLMKYAL----------SEKNAMSKMQHPFIVKLHYA
|.  ...|.|.||.| ..|..|.|                       |.|||||..| . .|.. ... .           ||| .....||.|.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TKRKLFLIQQYCGGGSLGRMLKIK-----------QRFDEQTAKKYMCQIIL---------------AIEALHDNL-IIFRDLKPDNIVLDEEGNA
||  .. ...|.  || ||.|   .|..           ..|.|. .|..| ||.                |.| || .  || ||.||.||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

YLVDFGLAKLGVYDEINKS--------------------------------FLGTPAYLPPEIIVKDG---------HNRMADWYAVGIVLYELLMGCTP
 ..||||.|    |..|..                                ..||| |..|||. . .         .. ..|....|..|||.|.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNQGNVSREVLYERIKQNSIKIP------------------SNISSECQDIIQK----LLCKNPKKRLGYKNDGKEIRSHPWF
|          .. |||. |..|                   ..| ||.|.|.|    .|.|.|.||..   . ..|  ||||
F----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase 21909.AA Pkinase 364-621 30 8.8e-83 286.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

YEYYRILGSGAFGKVILVKDKKNQKYYAMKIISKEKFQQLNLMKYAL-SEKNAMSKMQHPFIVKLHYAFQTKRKLFLIQQYCGGG----SLGRMLK--IK
|.  |..|||.||.| . ..|...| .|.|||.|..     ..  .. ||   | ...||.||.|...|..|... ... ||.||    .| ....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QRF--DEQTAKKYMCQIILAIEALHDNLIIFRDLKPDNIVLDEEGNA----YLVDFGLAKL--GVYDEINKSFLGTPAYLPPEIIV-KDGHNRMADWYAV
 .|  .|...|.|| ||. ..| .|.. || |||||.|| .|..|.      . ||||||.     .. ...| ||| |..||.|    .. . .|....
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIVLYELLMGCTPFNQG----NVSREVLYERIKQNSIKIPSNIS---------------------SECQDIIQKLLCKNPKKRLGYKNDGKEIRSHPWF
|..|||.| | .|| .     |..  ....||..  .. ..  .                     .||.|.| ..|||.||||..     ..|  ||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 21909.AA Ciliate-E2-Unclassified 364-621 26 4.4e-81 275.67 In-house 1-352 (352) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

YEYYRILGSGAFGKVILVKDKKNQKYYAMKIISKEKFQQLNLMKY---------ALSEKN-------------AMSKMQHPFIVKLHYAFQTKRKLFLIQ
|.  ...|.|.|||| ....||...|||||...| . .  .....         .. .|.              .. ..||||||..|.||.| ..... 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

QYCGGGSLGRMLKIK-----------------QRFDEQTAK-----KYMCQIILAIEALHDNL-IIFRDLKPDNIVLDEEG---NAYLVDFGLAK-----
.|| ||.|  ..|..                 ..|.|| ||     .|. ||....| || .. || ||.||.||..|..|   .  . |||..|     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------LGVY-DEINKSFLGTPAYL----PPEIIVKDGHNRM----ADWYAVGIVLYELLMGCTPFNQGNVSREV--------------LYERIKQ
          .... ... ..| ||| |.    .||.. . ... .    .|....|..|||.|.|  ||.. |   .               ||. |||
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

NSIKIPS--------NISSECQDIIQKLLCKNPKKRLGYKNDGKEIRSHPWF
. |..|.        ..| |..|.|..||.|..||..... . ..|  ||||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 21909.AA PKA 364-621 40 7.5e-77 261.63 In-house 1-263 (263) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-263/263
Sequence Identity: 40% (107 aa)

YEYYRILGSGAFGKVILVKDKKNQKYYAMKIISKEKFQQLNLMKYALSEKNAMSKMQHPFIV-KLHYAFQTKRKLFLIQQYCGGGSLGRMLKIKQRFDEQ
.| .. ||.| ||.| |...|.. .|||||...|..  .|.     ..||| .. ..||||| |. . ||. |.|.... |..|| .   |  ..||...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TAKKYMC-QIILAIEALHDNLIIFRDLKPDNIVLDEEGNAYLVDFGLAKLGVYDEINKSFLGTPAYLPPEIIVKD-GHNRMADWYAVGIVLYELLMGCTP
.|| | . ||.||.| ||   || ||||| || .|..|.  . ||| ||  | |   ..  ||| ||.||||    ||..  || | ||. ||.| | .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD-RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FNQGNVSREVLYERIKQNSIKIPSNISSEC---QDIIQKLLCKNPKKRLG-YKNDGKEIRSHPWF
|.  | .   .||.| .  || |....|      | | ||| ....||.|  ||..  |. |.||
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 21909.AA RSK 364-621 35 3.3e-76 259.49 In-house 1-271 (271) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-271/271
Sequence Identity: 35% (96 aa)

YEYYRILGSGAFGKVILVKDK---KNQKYYAMKIISKEKFQQLNLMKYALSEKNAMSKMQHPFIVKLHYAFQTKRKLFLIQQYCGGGSLGRMLKIKQRFD
||  . .| |.|.|| ..| .    ....|||||| | ..       ..  | . ..  .|||||||||.||. .|...|   . || |.  |  .  | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EQTAKKYMCQIILAIEALHDNLIIFRDLKPDNIVLDEE----GNAYLVDFGLAK-LGVYDEINKSFLGTPAYLPPEIIVKDGHNRMADWYAVGIVLYELL
|. .| ||. | || | ||   |..|||||.||..|.|    | . ..|||.|| |  .... ..| .| .|. ||.. . || . .||.  |...|| |
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

MGCTPFNQGNVSREVLYERIKQNSIKI-------PSNISSECQDIIQKLLCKNPKKRLGY-KNDGKEIRSHPWF
 |||||  ..  |. . . |.     .       ...|| |..| . ..|  .| .|||   |. ..|..||||
TGCTPFQNKP--RDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 21909.AA TyrKc 364-615 20 2.2e-14 9.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 364-615
Range on HMM: 1-280/280
Sequence Identity: 20% (58 aa)

YEYYRILGSGAFGKVILVKDKKNQKYYAMKIISKEKFQQLNLMKYALSEKNAMSKM--QHPFIVKLHYAFQTK-------RKLFLIQQYCGGGSLGRMLK
 .  ..||.||||.| . . |      | | . ...      ..  ..| . |.|   .|| ||.|. .  ..         |...  |. .|.|   |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

IKQR-FDEQTAKKYMCQIILAIEALHDNLIIFRDLKPDNIVLDEEGNAYLVDFGLAKLGVYD--------EINKSF--LGTP----AYLPPEIIVKDGHN
 ... .  ..  ... ||    | ||.. .| |||   |. ..|.. .   ||||.. .  |         . |.    |        ..|| | .   .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RMADWYAVGIVLYELLMGCTPFNQGN----VSREVLYERIKQN-SIKIPSN--------ISSECQDIIQKLLCKNPKKRLGYKNDGKEI
   | .. |....|..  . .   |     .| . ..|..||    ..| |         ..|  .|...    .|..|   ..  ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 21909.AA Pkinase_Tyr 410-471 21 9e-06 20.21 Pfam 51-120 (270) Show / Hide 
Range on Protein: 410-471
Range on HMM: 51-120/270
Sequence Identity: 21% (15 aa)

LSEKNAMSKM-QHPFIVKLHYAFQ-TKRK--LFLIQQYCGGGSLGRMLKI----KQRFDEQTAKKYMCQI
..| . |... .|| ||.|. .    ..   ....  |. .|.|   |.     ||... ..  ..  ||
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQI
Kinase 21909.AA Pkinase_Tyr 364-378 46 0.029423 8.27 Pfam 1-15 (270) Show / Hide 
Range on Protein: 364-378
Range on HMM: 1-15/270
Sequence Identity: 46% (7 aa)

YEYYRILGSGAFGKV
 .  . ||.||||.|
ITFGKKLGEGAFGEV