Gene 15295 (Tetrahymena)

15295

Species: Tetrahymena
Alias: 3809.m00209, 215.m00038, 252, TTHERM_01055410, 15295, PreTt15295
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
15295.AA Protein None 529 None Fasta, JSON
15295.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
15295.NA RNA None 1590 None Fasta, JSON

Protein domain

Protein domains of 15295.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH_Akt_basal 15295.AA PH_Akt_basal 33-129 46 3.1e-50 173.19 In-house 1-90 (90) Show / Hide 
Range on Protein: 33-129
Range on HMM: 1-90/90
Sequence Identity: 46% (46 aa)

VQKYNHVNKKQERILCITDKAVYNISPSKFLSKLISKVVQVRIKRRIPLNKIFAVTIS-RFATQFIIHVPDEHDYLLQ--SDDFRQKIIEVLCYSYCTLL
|.|||..||.|||.|.||.|.|||..|.|          ...||..|||.||.....| .....|.||||||.||...  |.|.||.||.|||..||...
VIKYNRYNKRQERNLMITSKHVYNCKPNK----------KHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC
Myosin_TH1 15295.AA Myosin_TH1 25-111 31 2.4e-10 36.34 Pfam 51-156 (234) Show / Hide 
Range on Protein: 25-111
Range on HMM: 51-156/234
Sequence Identity: 31% (33 aa)

E-------KVLLSSL----VQKYNH--VNKKQERILCITDKAVYNISPSKFLSKLISKVVQVRIKRRIPLNKIFAVTISRFATQ-FIIHV-----PDEHD
|       ||| ..     |.|||.   .| . |.|. |||..| . ..|   .   ....  .|||||||.|  |..| .. . |.||.      ..||
ELRKHPFMKVLFADHCECLVNKYNRFWFGKPSPRDLLLTDKHIYLVGREKKKKGPEKDQKTYQVKRRIPLNEITSVSLSPMQDDWFVIHCKESDNSQQHD

YLLQSD
 .|..|
FVLCCD
Kinase 15295.AA AGC 201-458 33 8.3e-191 498.86 In-house 1-395 (395) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-395/395
Sequence Identity: 33% (133 aa)

FHLIKVLGRGAFGKVMLCQKK------DTQDLFAIKSIRKED-IIERE--QIEHTKTE------------RKILEQVN----------FPFLVN-LEYAF
|...||.|.|.||||.|..||      ||....|.| ..|.. |....  ..|||.||            |.|||..|           ||.|. | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKEK--LFFAMK----FVR-----GG-ELFFHLK---KDKKFKESRALFYASQ-------ILLALEYLHN-QDIIYRD-LKPENILLDQDGYVKITDFG
|.|..  |.| |     .|.     || |||.||.   | ..| |.|| |||..       |.|||||||. ..||.|| |||||||||.||..|.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKVLE---------------------------------------------------KGKLTNSLVG--TPDYLSPEIINQKGHNRTADYWA--FGILIY
|.|..                                                    |...|....|  ||.|..|||.    .....|.|.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMVIGIPPFFNNN----------QNVMFQLIS------EKDVKFPTS--------TPLSKECMDIILRLLKKDPNERLGSVN------GTKDIKEHPWF
||..|.|||...|          .. |||.|       ...||||            .|.|..|.| .||.|||..|||. .      |...||.||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 15295.AA AktR 201-458 58 2.9e-175 588.56 In-house 1-268 (268) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-268/268
Sequence Identity: 58% (158 aa)

FHLIKVLGRGAFGKVMLCQKK-DTQDLFAIKSIRKEDIIEREQIEHTKTERKILE-QVNFPFLVNLEYAFQTKEKLFFAMKFVRGGELFFHLKKDKKFKE
||..|.||.||||||.|.||| |.|...|.|.|.|..||||.|..|| |||.|.| ..|.||.|.|.|.|||||||||.|....|||||.||||.|||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SRALFYASQILLALEYLHNQ-DIIYRDLKPENILLDQDGYVKITDFGLAK---VLEKGKLTNSLVGTPDYLSPEIINQ-KGHNRTADYWAFGILIYEMVI
..|.||..||||||||||.. .||||||||||||||.||.||||||||.|   . ..  ...|..||| |..||.|.. ||||...|.|||||.|||||.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GIPPFFNNNQNVMFQLISEKD-VKFPTSTPLSKECMDIIL-RLLKKDPNERLG-SVNGTKDIKEHPWF
|.|||...||| |||.| .|. .|||.....|..|.|.|  .||.|.||.||| . ||...||.||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 15295.AA Akt 201-458 51 2.9e-164 529.08 In-house 1-264 (264) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-264/264
Sequence Identity: 51% (135 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLF-AIKSIRKEDIIEREQIEHTKTERKILEQVNFPFLVNLEYAFQTKEKLFFAMKFVRGGELFFHLKKDKKFKES
| ..||||.|.||||.|..|||||... |.|...|. ||.. |.|||||||.||. .|.||.||| |.|||..||.| | .. |||||.||.....|.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RALFYASQILLALEYLHNQDIIYRD-LKPENILLDQDGYVKITDFGLAK--VLEKGKLTNSLVGTPDYLSPEIINQKGHNRTADYWA-FGILIYEMVIGI
|| ||...| ||.|.||...||||| |||||||.|.||....|||||.|  ..  .  |... ||| ||.|||.|..|| ...| |. .|...|||  | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFFNNNQNVMFQLISEKDVKFPTSTPLSKECMDIILRLLKKDPNERLG-SVNGTKDIKEHPWF
|||.| .. .||..| ...||||    .|.|| |.| .||.|||..|||   |....||.||||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 15295.AA SGK 201-458 42 2.3e-141 439.54 In-house 1-283 (283) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-283/283
Sequence Identity: 42% (122 aa)

FHLIKVLGRGAFGKVMLCQKKDT------------------QDLFAIKSIRKEDII-------EREQIEHTKTER-KILEQVNFPFLVNLEYAFQTKEKL
|...||.| | ||||.. ..||.                  ....|.| ..|. ||        ...  |...|| .||  .. ||.||| ||||||.||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFAMKFVRGGELFFHLKKDKKFKESRALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAK-VLEKGKLTNSLVGTPDYLSPEIINQK
.| | .| |||.|.||.. |.|.|.|| |||..| .|||||| |||||||||||||||| .|....|||||.|   .. . | .  ||| || ||... .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHNRTADYWAFGILIYEMVIGIPPFFNNNQNVMFQLISEKDVKFPTSTPLSKECMDIILRLLKKDPNERLGSVNGTKDIKEHPWF
.| || | |  |.. ||| .|.|||...| . |.. |  .. ..|..   | .. |.|  ||.||| .|||. ..  .||.||.|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ--MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 15295.AA PKA 201-458 44 2.6e-128 432.58 In-house 1-263 (263) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-263/263
Sequence Identity: 44% (119 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTKTERKILEQVNFPFLVN-LEYAFQTKEKLFFAMKFVRGGELFFHLKKDKKFKES
| .|..||.| ||.||||..|.. . .|.| ..|..|. . |.||...|..|| ....||.|. ... ||.  .|.. | .| |||.| .| | ..| ..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RALFYAS-QILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAKVLEKGKLTNSLVGTPDYLSPEIINQK-GHNRTADYWAFGILIYEMVIGIPP
 |.|||  || |||||||.|.||||||||||||.|..|..|||||| || ..    | .| |||.|| ||||. | ||..  | ||.|||||||. |.||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FFNN--NQNVMFQLISEKDVKFPTSTPLSKEC---MDIILRLLKKDPNERLGSVN-GTKDIKEHPWF
|...  ... ... | . ..||| .  ...      | | .|| .|...|.|.   |. |||.|.||
FYDHNRDPMQIYEKICNGKIKFPRH--FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 15295.AA RSK 204-458 42 3e-114 385.87 In-house 1-278 (278) Show / Hide 
Range on Protein: 204-458
Range on HMM: 1-278/278
Sequence Identity: 42% (119 aa)

IKVLGRGAFGKVMLCQKK---DTQDLFAIKSIRKEDIIEREQ-IEHTKTERKILEQVN-FPFLVNLEYAFQTKEKLFFAMKFVRGGELFFHLKKDKK---
.||||.|..||| ||.|.   ||. ..| | ..|  |. |.  ..||.|||.||| ..  ||.|.| |||||..||.  | ..|||||| ||.| |    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FKESRALFYASQILLALEYLHNQDIIYRDLKPENILLDQ---DGYVKITDFGLAKV--LEKGKLTNSLVGTPDYLSPEIIN----QKGHNRTADYWAFGI
| |..| ||...| ||.|.|| |.||.|||||||||.|.   .| .|.||||..|   ......|.. ..| .|. ||...    |.||.. .|.| .|.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMVIGIPPFFN---NNQNVMFQLISEKD--VKFPTSTPLSKECMDIILRLLKKDPNERLGS-VNGTKDIKEHPWF
|.|||  | ||| .   ||... .. | ...  ...|    ||.|. |.| ..|..||. |||.  .....||.||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 15295.AA PKC 201-458 43 6.9e-114 370.58 In-house 1-262 (262) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-262/262
Sequence Identity: 43% (115 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTKTERKILEQ-VNFPFLVNLEYAFQTKEKLFFAMKFVRGGELFFHLKKDKKFKES
|...||||.| ||||||  .|.|. ..||| ..|. ||. . .| | ||...|..  . |||..|   |||...|||.| .|.|| | ||  . ..|||.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAKV-LEKGKLTNSLVGTPDYLSPEIINQKGHNRTADYWAFGILIYEMVIGIPPF
.| |||  |..|| .||...||||||| .|.|||..| .||.|||..|  . .|. |..  |||||..|||.  .  .   |.||||.| ||| .| .||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

FNNNQNVMFQLISEKDVKFPTSTPLSKECMDIILRLLKKDPNERLGS----VNGTKDIKEHPWF
   .   .|| | .... .| .  |||| ..|.  ...|.|..|||.     .|..||.||| |
HGEDEDELFQSIMHDNPHYPRW--LSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 15295.AA RSK-Unclassified 201-458 42 1.7e-112 354.82 In-house 1-283 (283) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-283/283
Sequence Identity: 42% (119 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTKTERKILEQVNFPFLVNLEYAFQTKEKLFFAMKFVRGGELFFHLK--KDKKFKE
|  .. .|.| |||| | .||||| ..|.|   |. .| .  |    ||. |.   | || | | ..|||. .|.  |..  ||..| ||   |.|.| |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

SRALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGL---A-------------------KVLEKGKLTNSLVGTPDYLSPEIINQKGHN
 .. |||| . .|||||| .|.|||||||.||.|.|.| |. |||.|   |                   |... |  ||| .|| .|| ||.|   || 
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

RTADYWAFGILIYEMVIGIPPFFNNNQNVMFQLISEKDVKFPTSTPLSKECMDIILRLLKKDPNERLGSVNG-TKDIKEHPWF
.  | |  ||..||| .|.||.  ||.| .|. |  ..||||    .|..| | | .||.. |  |||.  |   ||| || |
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 15295.AA S_TKc 201-458 37 5.5e-105 356.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-231/231
Sequence Identity: 37% (101 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTKTERKILEQVNFPFLVNLEYAFQTKEKLFFAMKFVRG--GELFFHLKKDKK---
.......|.||||||..|..|.|. ..||| |.          ||.. |..||.. . |..|.| ..||. ..|.. | .. |  |.|| ..|| ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FKESRALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAKVLEKGKLTNSLVGTPDYLSPEIINQKGHNR-TADYWAFGILIYEM
   | | .| ||. ||..||||.|.. ||.|||||||||||.   .||.|||||..|      ....|||.|..||..   |...  .| |..|...|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

VIGIPPFFNNNQNVMFQLISEKDVKFPTSTPLSKECMDIILRLLKKDPNERLGSVNGTK---DIKEHPWF
. | |||   ....||..|             |.|. |.| ..|.|||..|..     .   ||| ||||
LCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15295.AA MAST 201-458 31 2.6e-104 337.2 In-house 1-334 (334) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-334/334
Sequence Identity: 31% (106 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTKTERKILEQVNFPFLVNLEYAFQTKEKLFFAMKFVRGGELFFHLKKDKKFKESR
|  ||....||.||| |  .|.| |.||.| |.| | | . .... ..|| ||...  || |.. |.||||..|.. | .. || ....|.    | |. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAKV--------LEKG----------------------KLT---------------
| .| ... |.|||||...|. |||||.|.|.| .| .|.|||||.||        ...|                      ...               
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

---------------------NSLVGTPDYLSPEIINQKG-HNRTADYWAFGILIYEMVIGIPPFFNNNQNVMFQLISEKD---VKFPTS------TPLS
                     ....|||||..||.|...| |. . |.|. || .||  .|.|||.  ...  || |  ..   ...|          .|
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

KECMDIILRLLKKDPNERLGSVNGTKDIKEHPWF
.| .|.| .||  ||..|||. || ...|.|| |
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 15295.AA Pkinase 201-458 31 6e-98 336.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 201-458
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTK-TERKILEQVNFPFLVNLEYAFQTKEKLFFAMKFVRGG----ELFFHLK--KD
.|.....|.|.||.| .|..|.|....|.| |.|... . ....|.. .| .|.  .| |. | | ..|..| .. . | ...||    .|| ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKF--KESRALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYV----KITDFGLAKV--LEKGKLTNSLVGTPDYLSPEIIN-QKGHNRTADYWAF
..|   |  . ||. ||| .|||.|.. ||.|||||||||.|..|..    ||.||||||.  . ..  .....|||.|..||.|. .... . .| |..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILIYEMVIGIPPFFNN------NQNVMFQLISEKDVKFPTSTPLS-------------------KECMDIILRLLKKDPNERLGSVNGTKDIKEHPWF
|...|||. | ||| .       .|..|...| .....|. ... |                   .|| |.| ..|.|||..|..     ..|..||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 15295.AA MAST 201-348 41 1.3e-64 196.02 In-house 1-151 (337) Show / Hide 
Range on Protein: 201-348
Range on HMM: 1-151/337
Sequence Identity: 41% (62 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTKTERKILEQVNFPFLVNLEYAFQT--KEKLFFAMKFVRGGELFFHLKKDK-KFK
|  ||....||.|.| | ..|.| |.||.|.|.. |.| . |... . || ||...  || |.. |.|||  |..|.. | .. ||  ...|.     . 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ESRALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAKV
|. | .|  .. |.|||||...|. |||||.|.|.| .| .|.|||||.||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKV
Kinase 15295.AA MAST 356-458 34 2.6e-47 142.18 In-house 226-337 (337) Show / Hide 
Range on Protein: 356-458
Range on HMM: 226-337/337
Sequence Identity: 34% (39 aa)

NSLVGTPDYLSPEIINQKG-HNRTADYWAFGILIYEMVIGIPPFFNNNQNV-MFQLISE--KDVKFPTS------TPLSKECMDIILRLLKKDPNERLGS
.. .|||||..||.|. .| .. ..|.|. || .||  .|.|||.  ...   || |    ... .|         ..|.| .|.| .|| ..| .|||.
KQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGA

VNGTKDIKEHPWF
  | ..||.|| |
N-GADEIKQHPFF
Kinase 15295.AA TyrKc 201-452 21 7.8e-17 49.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 201-452
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FHLIKVLGRGAFGKVMLCQKKDTQDLFAIKSIRKEDIIEREQIEHTKTERKILEQV--NFPFLVNLEYAFQTK-------EKLFFAMKFVRGGELFFHLK
 .|.|.||.||||.|.... |      |.|.....       .|    | .|. ..  . | .|.|  .  ..       | |.  | .. .| |  .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KDKK-FKESRALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAKVLEKG-------KLTNSLV--GTPD-----YLSPEIINQKGHN
| .. .. .  | .. ||    |||| . .| |||   |.|.. .. |||.||||.. .. .       .   .    |. .      ..|| || .  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RTADYWAFGILIYEMV-IGIPPFFN-----NNQNVMFQLISEKDVKFPTSTP-------LSKECMDIILRLLKKDPNERLGSVNGTKDI
   | |.||....|.   | .|  .      .   ..... . .   .   .        ..|  .|...  . ||..|    .  ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 15295.AA Pkinase_Tyr 201-392 27 9.2e-17 57.39 Pfam 1-208 (270) Show / Hide 
Range on Protein: 201-392
Range on HMM: 1-208/270
Sequence Identity: 27% (57 aa)

FHLIKVLGRGAFGKVMLCQKK----DTQDLFAIKSIRKEDIIERE--QIEHTKTERKILEQV-NFPFLVNLEYAFQ-TKEK--LFFAMKFVRGGELFFHL
 ...|.||.||||.|...  |    .|.   |.|.. ||.  ...  . .  . | ||. |  . | .|.|  .    .|   ..  | .. .| |  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KK----DKKFKESRALFYASQILLALEYLHNQDIIYRDLKPENILLDQDGYVKITDFGLAKVL-EKG---KLTNSLVGTPDYLSPEIINQKGHNRTADYW
.|    ..... .. | .. ||  ..|||... .| |||   |.|.. .. |||.|||||. . ...   . . .       ..|| || .  .   | |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

AFGILIYEMV
.||.|..|..
SFGVLMWEIF
Kinase 15295.AA S_TK_X 459-521 26 5.2e-15 57.11 SMART 1-79 (79) Show / Hide 
Range on Protein: 459-521
Range on HMM: 1-79/79
Sequence Identity: 26% (21 aa)

AKINFDEILN--RKVPAPFVPQLK----SDTDVSCFDEEFISENPIDSFVQPSNLKNYNDQ----------FNGMSFVP
..|..| ..|  .....||.|..|    |.||.| ||.|| .| | .. ..|  ... . .          | | ..| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 15295.AA Pkinase_C 478-523 34 2e-08 32.94 Pfam 1-46 (46) Show / Hide 
Range on Protein: 478-523
Range on HMM: 1-46/46
Sequence Identity: 34% (16 aa)

QLKSDTDVSCFDEEFISENPIDS-FVQPSNLKNYNDQFNGMSFVPGM
|.||.||.| ||.|| .| | |.   ..   .. ...| | ..|. .
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD