Gene 5269 (Tetrahymena)

5269

Species: Tetrahymena
Alias: 36.m00233, TTHERM_00348570, 5269, 3703.m00095, PreTt05269, 483
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
5269.AA Protein None 339 None Fasta, JSON
5269.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
5269.NA RNA None 1020 None Fasta, JSON

Protein domain

Protein domains of 5269.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5269.AA Akt 11-267 55 2.3e-188 607.32 In-house 1-264 (264) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-264/264
Sequence Identity: 55% (147 aa)

FDLKYVLGKGSFAKVVLVKKKDTKKLY-AMKILKKDYIQRRRQDQNVMVERNLLVEMNHPFIIKVKHTFQSEKKLYFCLEYCPGGELFNLLYKKERFNED
||...|||||||.||.|||||||.|.| |||.||||||. ..| .... |||.|. .|||||.. .. ||...||||...||.|||||..|..|.||.||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

QTRFYVSQMILAIEFLHEKNVIYRD-LKPENVLIDKQGYIRVTDFGLSKQN-VKGNYEAKSVVGTPEYLAPEILEGKGYGKTVDWWT-LGCIIYELLTGR
..|||....|||||.||.||.|||| |||||.|.||.|.|..|||||.|.| .| ....|.. |||||||||||.|.|..|.||||. |||..||...||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFYKDEGKEDLFQQIQQNKVEIE--KNWISDCKDLVLSLLQKDPKLRLG--FNGAHEIKDHPWF
||||. . .. .|..|....|..   ...  .||||. .||.||||.|||  .|.|.|||.||||
PPFYN-QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 5269.AA AGC 11-267 33 2.8e-182 476.3 In-house 1-395 (395) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-395/395
Sequence Identity: 33% (133 aa)

FDLKYVLGKGSFAKVVLVKKK------DTKKLYAMKILKKDY-IQRRR--QDQNVMVE------------RNLLVEMN----------HPFIIK-VKHTF
|... |.||||| || ||.||      ||.|.||||.|||.. |....  . ...|.|            || |...|          ||||.|  ...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSEKK--LYFCLEYCP---------GG-ELFNLLY---KKERFNEDQTRFYVSQ-------MILAIEFLHE-KNVIYRD-LKPENVLIDKQGYIRVTDFG
|....  |||..||.|         || |||  |.   |. ||.|...||| ..       ..||.|.||. ...|.|| |||||.|.|..|.|. ||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKQNVKGN--------------------------------------------------YEAKSVVG--TPEYLAPEILEGKGYGKTVDWWT--LGCIIY
|.|......                                                    ... .|  ||||.|||||    |||..|||.  |||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLTGRPPFYKDE---------GKEDLFQQIQ------QNKVEIE----------KNWISDCKDLVLSLLQKDPKLRLGFN-------GAHEIKDHPWF
|.|||.|||| |.          ....||.|.      ..||..           ... ...|||.  ||.|||. ||| .       || |||.||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 5269.AA SGK 11-267 42 8e-139 431.58 In-house 1-283 (283) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-283/283
Sequence Identity: 42% (121 aa)

FDLKYVLGKGSFAKVVLVKKKDT------------------KKLYAMKILKKDYIQ-------RRRQDQNVMVER-NLLVEMNHPFIIKVKHTFQSEKKL
||.. |.||||| || .||.||.                  .|.||||.|.|. |        .. .  ..| || ..|. |.||||.. .  || ..||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YFCLEYCPGGELFNLLYKKERFNEDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQGYIRVTDFGLSKQNVKGNYEAKSVVGTPEYLAPEILEGK
|| ..|  |||.|. | .  .| ||. |||... ..|.| ||....|||||||||.| | ||... |||||.|...| | . ..  |||||||||.| ..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GYGKTVDWWTLGCIIYELLTGRPPFYKDEGKEDLFQQIQQNKVEIEKNWISDCKDLVLSLLQKDPKLRLGFN-GAHEIKDHPWF
....||||| |||. ||...| |||| .  |. ....|   .  | ..  .|..||   ||||||| ||| . .. |||.||.|
PHDRTVDWWCLGCVLYEMMYGLPPFY-SRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 5269.AA AktR 11-267 48 2.4e-133 449.3 In-house 1-268 (268) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-268/268
Sequence Identity: 48% (131 aa)

FDLKYVLGKGSFAKVVLVKKK-DTKKLYAMKILKKDYIQRRRQDQNVMVERNLLV-EMNHPFIIKVKHTFQSEKKLYFCLEYCPGGELFNLLYKKERFNE
|..  .|||| |.||.||.|| |..|.||||..||  |..|.| . .  ||| .  ..|||||.|....||...||.|..|||||||||. | ||..|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DQTRFYVSQMILAIEFLHEK-NVIYRDLKPENVLIDKQGYIRVTDFGLSK-QNVK-GNYEAKSVVGTPEYLAPEILEG-KGYGKTVDWWTLGCIIYELLT
.|.||| .|..||.|.||.. |.||||||||| |.|. |... ||||||| |...  . .|.|..|||||.|||..   ||..|.||||..|. |||..|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRPPFYKDEGKEDLFQQIQQN--KVEIEKNWISDCKDLVL-SLLQKDPKLRLG--FNGAHEIKDHPWF
| |||| .  ..... .. ..  |... ..  | ||||.   ||.|.|. |||   ||. |||.||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 5269.AA PKA 11-267 46 1.8e-118 399.9 In-house 1-263 (263) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-263/263
Sequence Identity: 46% (123 aa)

FDLKYVLGKGSFAKVVLVKKKDTKKLYAMKILKKDYIQRRRQDQNVMVERNLLVEMNHPFII-KVKHTFQSEKKLYFCLEYCPGGELFNLLYKKERFNED
|... .||.|||..| |...|.... ||||.|||..| |..| . |. |.| | ...||||. | . ||| ...||. .||.||||.|  | |. ||...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

QTRFYVS-QMILAIEFLHEKNVIYRDLKPENVLIDKQGYIRVTDFGLSKQNVKGNYEAKSVVGTPEYLAPEILEGK-GYGKTVDWWTLGCIIYELLTGRP
...||.  | .||.|.|| .| ||||||||| ||||.|.| .|||| .| .|..  . ... ||||||||||. .| |.|| ||||.||..|||.|.| |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK-KVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYKDE-GKEDLFQQIQQNKVEIEKNWISDC---KDLVLSLLQKDPKLRLG--FNGAHEIKDHPWF
||| .   . .... |.. |.. . .  ||    |||. .|||.|.. |.|   ||.  ||.|.||
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 5269.AA RSK 14-267 42 5.6e-112 378.31 In-house 1-278 (278) Show / Hide 
Range on Protein: 14-267
Range on HMM: 1-278/278
Sequence Identity: 42% (117 aa)

KYVLGKGSFAKVVLVKKK---DTKKLYAMKILKKDYIQRRRQD-QNVMVERNLLVEMN-HPFIIKVKHTFQSEKKLYFCLEYCPGGELFNLLYKKER---
  |||.|.. || |..|.   ||...||||.|||  | .|  |   .| ||| | . . ||||.. ...|| |.||| ..|||.|||||  |.|...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FNEDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDK---QGYIRVTDFGLSKQ-NVKGNYEAKSVVGTPEYLAPEILE----GKGYGKTVDWWTLGC
| ||  .|| .. .||.|.||.. .|.|||||||.| |    .| |..||||..|| . . |  ... ..| ||.|||.|     ..|..| .|||.||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

IIYELLTGRPPFYK--DEGKEDLFQQIQQNK--VEIE--KNWISDCKDLVLSLLQKDPKLRLG--FNGAHEIKDHPWF
..||.|||.|||.   |. .......||..|  ....  ..   ..|||.  .|..||. |||   ..| |||.||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 5269.AA RSK-Unclassified 11-267 41 3.3e-111 350.65 In-house 1-283 (283) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-283/283
Sequence Identity: 41% (118 aa)

FDLKYVLGKGSFAKVVLVKKKDTKKLYAMKILKKDYIQRRRQDQNVMVERNLLVEMNHPFIIKVKHTFQSEKKLYFCLEYCPGGELFNLLY--KKERFNE
|     .|.|.| || ||.||||...||||.|.|. . |..  . || |.| .   |||||..  | ||.. .|| |.|||.||..|  |   |. .| |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQGYIRVTDFGLSKQN-------VK--------------GNYEAKSVVGTPEYLAPEILEGKGYG
|. |||.|  ..| | || . .|||||||.|.. .. | .. |||.||.|        .|                  ..| .|| ||||||.. . | .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KTVDWWTLGCIIYELLTGRPPFYKDEGKEDLFQQIQQNKVEIE-KNWIS-DCKDLVLSLLQKDPKLRLGF-NG-AHEIKDHPWF
| ||||||| ..||.| | ||.| .  |. .|. | .|.| .   . || .|.||.  |||. |  |||   | | .|| || |
KAVDWWTLGIVMYEMLFGCPPYYGNN-KNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 5269.AA S_TKc 11-267 36 2.8e-107 363.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

FDLKYVLGKGSFAKVVLVKKKDTKKLYAMKILKKDYIQRRRQDQNVMVERNLLVEMNHPFIIKVKHTFQSEKKLYFCLEYCPG--GELFNLLYKKER---
...  ..|||.|.|| ....|.|....|.||.|          .... |...| . .||.|.| . .||. ..||...|||.|  |.|| .. |. |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FNEDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQGYIRVTDFGLSKQNVKGNYEAKSVVGTPEYLAPEILEGKGYGK-TVDWWTLGCIIYE
   |.| ..|||. |...|.|..|....|.|||||||.|.|.   | ..||||..|        ....|||.|.|||.|   ||||  .||| .|||.||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLTGRPPFYKDEGKEDLFQQIQQNKVEIEKNWISDCKDLVLSLLQKDPKLRLGFNGAHE----IKDHPWF
.|.|.|||.     . .|..|            ...||..  .|||||. |..   | .    || ||||
MLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5269.AA Pkinase 11-267 31 2.5e-98 337.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

FDLKYVLGKGSFAKVVLVKKKDTKKLYAMKILKKDYIQRRRQDQNVM-VERNLLVEMNHPFIIKVKHTFQSEKKLYFCLEYCPGG----ELFNLLY--KK
. .. ..|.|||..| . ..|.| |..|.||.||. .    . ...   |  .. ..|||.|.. ...|......|...|||.||    .|| ..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ERF--NEDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQGYI----RVTDFGLSKQN-VKGNYEAKSVVGTPEYLAPEILE-GKGYGKTVDWWTL
 .|   |.. .||. |.. ..|..|....|.|||||||.|||..|.|    ...||||.||     |  .....|||.|.|||..  |..||. ||.| .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIIYELLTGRPPFYKDE------GKEDLFQQIQQNKVEIEKNWI---------------------SDCKDLVLSLLQKDPKLRLGFNGAHEIKDHPWF
|||.||.|.|||||. ..       .  ....| . ... .  |                      ..|||.. ..|.|||| |..   |..|. ||||
GCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 5269.AA Ciliate-E2 11-267 29 8.6e-97 327.87 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-365/365
Sequence Identity: 29% (113 aa)

FDLKYVLGKGSFA-----KVVLVKK------------------KDTKKLYAMKILKKDYIQRRRQDQNVM----------VERNLLVEMNHPFIIKVKHT
...  ..|.|.|.     || .|.|                  |...|.|||||.||. |.   | ...|           |.|.| ..|||.||| . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--SEKKLYFCLEYCPGGELFNLLYKK-----------ERFNEDQTR---------------FYVSQMILAIEFLHEKN-VIYRDLKPENVLIDKQGYI
||  .....|. .||| ||.|| .....           ..|.| . .               ||. ..|||.|.||.|| .|.||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RVTDFGLSKQNVKGNYE-------------------------------AKSVVGTPEYLAPEILEGKG---------YGKTVDWWTLGCIIYELLTGRPP
 ..||||||.. . |..                               .....|||.|.|||||.||.         |.. .|.| ||.|.||.|.|.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYKDEGKEDLFQQIQQNKVEIE------------------KNWISDCKDLVLS----LLQKDPKLRLGFNGAHEIKDHPWF
|         .|||.|.|...                   |.|  .||||       .|||||. |..  |. .|..||||
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 5269.AA RSK 11-267 38 5.5e-94 318.55 In-house 1-271 (271) Show / Hide 
Range on Protein: 11-267
Range on HMM: 1-271/271
Sequence Identity: 38% (104 aa)

FDLKYVLGKGSFAKVVLVKKK---DTKKLYAMKILKKDYIQRRRQDQNVMVERNLLVEMNHPFIIKVKHTFQSEKKLYFCLEYCPGGELFNLLYKKERFN
..|. ..|.||| || ..||.   ||...|||||.||. .  . . .    ||..| . .||||.| .  ||.|.|.|  .. . ||.||  | |.  | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQ----GYIRVTDFGLSKQNVKGNYEAKSVVGTPEYLAPEILEGKGYGKTVDWWTLGCIIYELL
|.  .|| .   || |.||.. ...|||||||.|.| .    | |...|||..||    |  ...  .| .|.|||.|  .|... .||| .| . || |
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

TGRPPFYKDEGKEDLFQQIQQNKVEI------EKNWISD-CKDLVLSLLQKDPKLRLGF--NGAHEIKDHPWF
||..||.    .......||  |. .       .. ||| .|||.  .|  ||  |||   ||. .|| ||||
TGCTPFQNKP-RDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 5269.AA MAST 11-157 37 2.7e-56 170.17 In-house 1-150 (337) Show / Hide 
Range on Protein: 11-157
Range on HMM: 1-150/337
Sequence Identity: 37% (56 aa)

FDLKYVLGKGSFAKVVLVKKKDTKKLYAMKILKKDYIQRRRQDQNVMVERNLLVEMNHPFIIKVKHTFQS--EKKLYFCLEYCPGGELFNLLYKKE-RFN
|. . ...|| . .| |||.|.|....|||....... .. | ..|.|||| |..   ||. |  ..||.  .|.|.. .||  ||  . ||     .. 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQGYIRVTDFGLSK
|. ...|. . .|..|.||..  . |||||.|.|||. | |  |||||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSK
Kinase 5269.AA MAST 167-267 46 9.2e-50 149.84 In-house 226-337 (337) Show / Hide 
Range on Protein: 167-267
Range on HMM: 226-337/337
Sequence Identity: 46% (53 aa)

KSVVGTPEYLAPEILEGKG-YGKTVDWWTLGCIIYELLTGRPPFYKDEGKED-LFQQIQQNKVEIEKNWISD------------CKDLVLSLLQKDPKLR
|...|||.|.|||.. |.| |||.|||| .| |.||.|.| |||  ..  |  .||.| . . |||  |...             .||.  |||..|| |
KQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFN-GDTPEEMIFQNIINHDREIE--WPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKR

LGFNGAHEIKDHPWF
||.|||.||| || |
LGANGADEIKQHPFF
Kinase 5269.AA TyrKc 11-262 21 2.1e-14 10.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-262
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FDLKYVLGKGSFAKVVLVKKKDTKKLYAMKILKKDYIQRRRQDQNVMVERNLLVEM--NHPFIIKVKHTFQSE-------KKLYFCLEYCPGGELFNLL-
  |. .|| | | .|.. . |      | | ||.|        .  | | ... .   .|| |..      ..       . |.  .||.|.| | . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YKKERFNEDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQGYIRVTDFGLSKQNVKG--------NYEAKSVVGTPE-----YLAPEILEGKGYG
....... ..   .  |     |.||.||.| |||   |.|..... ....|||||.    .         | .|.  |.        .||| .  . . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KTVDWWTLGCIIYELLT-GRPPFYKD----EGKEDLFQQIQQN-KVEIEKN--------WISDCKDLVLSLLQKDPKLRLGFNGAHEIK
   | |  |  ..|..| | .| . .       ........|    .. .|          ..  .. ..  . ||. |  |.  ||. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 5269.AA S_TK_X 268-328 24 3e-07 31.35 SMART 1-79 (79) Show / Hide 
Range on Protein: 268-328
Range on HMM: 1-79/79
Sequence Identity: 24% (21 aa)

MSLDWDVLKN--KKYTPPFVPDIK----NEDTPGYVDKYFLNMNIQSVEQNSLKNDYK------------------DFKGFTYDS
 ..||| | |  |...|||.|.||    ..   .. |. | .. .       |..| .                  .| ||||. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 5269.AA Pkinase_Tyr 11-157 25 0.000119 16.37 Pfam 1-159 (270) Show / Hide 
Range on Protein: 11-157
Range on HMM: 1-159/270
Sequence Identity: 25% (41 aa)

FDLKYVLGKGSFAKVVLVKKK----DTKKLYAMKILKKDYIQR-RRQDQNVMVERNLLVEM-NHPFIIKVKHTFQ-SEKK--LYFCLEYCPGGELFNLLY
  .  .||.|.| .|.. . |    .||   | |.|| .. ..     .  | | ... .. .|| |..        ..   .|  .||.|.| | . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----KERFNEDQTRFYVSQMILAIEFLHEKNVIYRDLKPENVLIDKQGYIRVTDFGLSK
|    |....  .   .  |   . |.|..|| | |||   |.|..... ....||||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR