Gene 20554 (Tetrahymena)

20554

Species: Tetrahymena
Alias: TTHERM_00899480, 20554, 881, PreTt20554, 160.m00090
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
20554.AA Protein None 551 None Fasta, JSON
20554.kin_dom Protein Kinase Domain None 272 None Fasta, JSON
20554.NA RNA None 1656 None Fasta, JSON

Protein domain

Protein domains of 20554.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH_Akt_basal 20554.AA PH_Akt_basal 40-123 53 7.8e-54 185.16 In-house 1-90 (90) Show / Hide 
Range on Protein: 40-123
Range on HMM: 1-90/90
Sequence Identity: 53% (48 aa)

IQKYNRKNKRQERNLMITSKGVYGMS---KKTLKRKIPVQKVGGLTVS-KMGSEFVLHVPDEYDYRYS--SYDRRDQILELICKAYQEFT
..||||.|||||||||||||.||...   |...|..||.||. |...| ..|.|||.||||||||||.  |.|.|..|....|.||....
VIKYNRYNKRQERNLMITSKHVYNCKPNKKHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC
Myosin_TH1 20554.AA Myosin_TH1 16-99 19 2.2e-08 29.72 Pfam 31-150 (234) Show / Hide 
Range on Protein: 16-99
Range on HMM: 31-150/234
Sequence Identity: 19% (23 aa)

LSFTKEKSILKLIDPDE-----------KILLTCM----IQKYNR--KNKRQERNLMITSKGVYGM-------------SKKTLKRKIPVQKVGGLTVSK
|....... ....   .           |.|  .     ..||||  ..| . | |  | | .| .              ....||.||.... ....| 
LGYEHNPKLQDCMGREHGINELRKHPFMKVLFADHCECLVNKYNRFWFGKPSPRDLLLTDKHIYLVGREKKKKGPEKDQKTYQVKRRIPLNEITSVSLSP

MG-SEFVLHV-----PDEYD
|    ||.|.      ...|
MQDDWFVIHCKESDNSQQHD
Kinase 20554.AA Akt 199-470 55 1.3e-193 624.38 In-house 1-264 (264) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-264/264
Sequence Identity: 55% (153 aa)

FNLLKVLGRGAFGKVMLVEEKSTKKIY-ALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTKTERVILEHCNHPFLVNLVYAFTTPEKIFFVTQFMKGGE
|..|||||.|.||||.||..|.|.|.| |.|...|                ||.|.|.||||||| ||.||||||.|||.|.| |..|..||.....|||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDY--------------IIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGE

LFQHLKHAKRFDENRARFYVAEIALALGHLHKKSIIYRD-LKPENILMDEHGHICLTDFGMAK-IVRKN-ELAMSFCGTPEYLSPEIISGVGHTISCDWW
||.||....||.|.|||||.||| ||..|||.|.||||| |||||||||..|||||||||..| .. |. . ...||||||||.|||..|.||| ..|||
LFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWW

A-LGIFTYEMLFALPPFYTQNQDQMFKAIKESQIRFPDKIAISPEAQNFILSCCKKDPHQRLG-THGDLEEIKSHPWL
. ||...|||.. .||||.|...|||| ||.....||||..||||....| ....|||..||| ...|..|||.|||.
GSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 20554.AA AGC 199-470 33 1.5e-184 482.32 In-house 1-395 (395) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-395/395
Sequence Identity: 33% (138 aa)

FNLLKVLGRGAFGKVMLVEEK------STKKIYALKSIRKLASFLVGSLNKQNQEDIIDKD--QIEHTKTE------------RVILEHCN---------
|..|||.|.|.||||.||..|      .|.|.||.| ..|                |..|.  ..|||.||            | |||.||         
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKH-------------KIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKS

-HPFLVN-LVYAFTTPEK--IFFVTQFMK---------GG-ELFQHLK---HAKRFDENRARFYVAE-------IALALGHLHK-KSIIYRD-LKPENIL
 |||.|. | |.| ....  ..|| ..|.         || |||.||.   . .||||.||||| ||       |.||| .||. . ||.|| |||||||
HHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL

MDEHGHICLTDFGMAKIVR---------------------------------------------------KNELAMSFCG--TPEYLSPEIISGVGHTIS
.||.|||.|||||..|...                                                   |.... .|||  ||||..|||.    .. .
LDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKA

CDWWA--LGIFTYEMLFALPPFYTQN----------QDQMFKAIK------ESQIRFPDK--------IAISPEAQNFILSCCKKDPHQRLGTHGD----
||||.  ||.. ||||. .|||| .|          ...||. |.      . ...||..          .||||...|  ...||| .|||..|.    
CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGD

--LEEIKSHPWL
   ||||.||| 
KGAEEIKNHPWF
Kinase 20554.AA AktR 199-470 50 1.1e-139 470.32 In-house 1-268 (268) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-268/268
Sequence Identity: 50% (142 aa)

FNLLKVLGRGAFGKVMLVEEK-STKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTKTERVILE-HCNHPFLVNLVYAFTTPEKIFFVTQFMKGG
| ..|.||.||||||.||..|  ..|.||.|.|.|               .||.. |..|| ||| |.| .|||||.|.|.|.| | ||.||. ....||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKK--------------KIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGG

ELFQHLKHAKRFDENRARFYVAEIALALGHLHKK-SIIYRDLKPENILMDEHGHICLTDFGMAK--IVR-KNELAMSFCGTPEYLSPEIISG-VGHTISC
|||||||. |.|.|..|||| |.| ||| .||..  ||||||||||||.||.||...||||..|  ... ..|.| ||||||||..||.|   .||. |.
ELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV

DWWALGIFTYEMLFALPPFYTQNQDQMFKAIKESQ-IRFPDKIAISPEAQNFIL-SCCKKDPHQRLG-THGDLEEIKSHPWL
||||.||| |||.. .|||| .|| |||. ||..| ..||. . .|......|   . .|.| .|||    . |||||||| 
DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 20554.AA SGK 199-470 42 8.49999999999e-127 393.77 In-house 1-283 (283) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-283/283
Sequence Identity: 42% (128 aa)

FNLLKVLGRGAFGKVMLVEEKST------------------KKIYALKSIRKLASFLVGSLNKQNQEDII-------DKDQIEHTKTER-VILEHCNHPF
| .|||.| | ||||..|. |..                  .|.||.| ..|              . ||        | .  |...|| |||   .|||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQK--------------QHIINEYRQDLKKKEQKHIMAERNVILKNMKHPF

LVNLVYAFTTPEKIFFVTQFMKGGELFQHLKHAKRFDENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDEHGHICLTDFGMAK-IVRKNELAMSFC
.||| ||| |..| .||  .. |||.| ||. .|.| | |||||.|||..||..||.. |||||||||||| |  ||.|||||| .|  . .|.   .||
IVNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFC

GTPEYLSPEIISGVGHTISCDWWALGIFTYEMLFALPPFYTQNQDQMFKAIKESQIRFPDKIAISPEAQNFILSCCKKDPHQRLGTHGDLEEIKSHPWL
|||||| ||.. . .|  . ||| ||.. |||.. ||||| .|  ||.  |  . ...|    .|..|   |    .||| .||||  | .|||.||. 
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ--MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 20554.AA RSK 202-470 42 5.1e-113 381.78 In-house 1-278 (278) Show / Hide 
Range on Protein: 202-470
Range on HMM: 1-278/278
Sequence Identity: 42% (124 aa)

LKVLGRGAFGKVMLVEEK---STKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTKTERVILEHCN-HPFLVNLVYAFTTPEKIFFVTQFMKGGE
|||||.|..||| |. ..    |..||| | ..| | . .                ..||.||| |||.|. |||.|.| ||| |..|.. ......|||
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKK-AKIVQRQKD------------TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGE

LFQHLKHAKR---FDENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDE---HGHICLTDFGMAKI--VRKNELAMSFCGTPEYLSPEIIS----GV
|| ||.. |.   |.|..|.|| |||.||. |||.. ||.||||||||| |.   .||| ||||| .|.   ..|...|.||.| ||. ||..     ..
LFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQG

GHTISCDWWALGIFTYEMLFALPPFYT---QNQDQMFKAIKESQ--IRFPDKIAISPEAQNFILSCCKKDPHQRLG-THGDLEEIKSHPWL
||. .|||| ||.  ||||.  |||.    .|... .| |.. .   ..|    .|.||...|  . ..|||.|||  ..|.||||.|||.
GHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 20554.AA S_TKc 199-470 35 1.2e-105 358.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-231/231
Sequence Identity: 35% (102 aa)

FNLLKVLGRGAFGKVMLVEEKSTKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTKTERVILEHCNHPFLVNLVYAFTTPEKIFFVTQFMKG--G
. .|...|.||||||... .|.|..|.|.| |.                        ||.. |. ||.. .||..|.| ..| . .....|. .. |  |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

ELFQHLKHAKR------FDENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDEHGHICLTDFGMAKIVRKNELAMSFCGTPEYLSPEIISGVGHTI-
.||...|. .|      |.| .||||...|..|| ..|.. ||.|||||||||.||  || ..|||.|...      ..|||||.|..||..   |..  
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKC

SCDWWALGIFTYEMLFALPPFYTQNQDQMFKAIKESQIRFPDKIAISPEAQNFILSCCKKDPHQRLGTHGDLE---EIKSHPWL
.||||..|.  ||||   |||.  ....||| |.            |||| .||  |..||| .|..    |.   .||.|||.
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20554.AA PKC 199-470 40 7.5e-100 324.36 In-house 1-262 (262) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-262/262
Sequence Identity: 40% (112 aa)

FNLLKVLGRGAFGKVMLVEEKSTKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTKTERVILEHC-NHPFLVNLVYAFTTPEKIFFVTQFMKGGE
||.|||||.| ||||||.| | |...|| | ..|              . ||. | .| | ||. .|.   .||||..|   | |....|||  . .|| 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKK--------------DVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGD

LFQHLKHAKRFDENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDEHGHICLTDFGMAKI-VRKNELAMSFCGTPEYLSPEIISGVGHTISCDWWAL
|  |   ..||.| .|||| |||..||  ||.| ||||||| .|.|.|. ||| ..||||.|  ... . . .|||||.|..|||...   . | ||||.
LMFHIQQQRRFKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAF

GIFTYEMLFALPPFYTQNQDQMFKAIKESQIRFPDKIAISPEAQNFILSCCKKDPHQRLGTHGDL----EEIKSHPWL
|.  |||.   .||  .. |..|..| . ....|  . .| || . . .  .|.|..||| | .     ..|..||  
GVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYP--RWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 20554.AA PKA 199-470 39 2.7e-96 326.22 In-house 1-263 (263) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-263/263
Sequence Identity: 39% (110 aa)

FNLLKVLGRGAFGKVMLVEEKSTKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTKTERVILEHCNHPFLVN-LVYAFTTPEKIFFVTQFMKGGE
|.....||.| ||.|||. .|.....||.| ..|              ..|..  |.||...|. ||  ..|||.|. . . | .. ....|  .  |||
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKK--------------QEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGE

LFQHLKHAKRFDENRARFYVA-EIALALGHLHKKSIIYRDLKPENILMDEHGHICLTDFGMAKIVRKNELAMSFCGTPEYLSPEIISGV-GHTISCDWWA
.| .| . .||..  |.||.| .| |||  ||.. ||||||||||||.|. ||| .|||| || |.     .. ||||||| ||||..  ||  | ||||
MFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWA

LGIFTYEMLFALPPFYTQ--NQDQMFKAIKESQIRFPDKIAISPEA---QNFILSCCKKDPHQRLGTHG-DLEEIKSHPWL
|||  ||||.  ||||    .. |... | . .|.||    ... |     .| .   .|. .|.|..  . . || |.| 
LGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRH--FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 20554.AA p70 199-470 36 7.1e-93 314.86 In-house 1-299 (299) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-299/299
Sequence Identity: 36% (112 aa)

FNLLKVLGRGAFGKVMLVEEKS---TKKIYALKSIRKLASFLVGSLNKQNQEDIIDKD-------------------QIEHTKTERVILEHCNHPFLVNL
| ||||||.|..|||..|       | |||| | .|| |. .       || |   .                    ..| |  || |||  .|||.. |
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRK-AKIVR------NQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDL

VYAFTTPEKIFFVTQFMKGGELFQHLKHAKRFDENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDEHGHICLTDFGMAK-IVRKNEL---------
.||| | .| . . ... ||||| ||.    ..|. |.|| .|| .||.|||.. ||||||||||.. .. ||. |||||  |  . . .          
HYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVN

-AMSFCGTPEYLSPEIISGVGHTISCDWWALGIFTYEMLFALPPFYTQNQDQMFKAIKESQ--IRFPDKIAISPEAQNFILSCCKKDPHQRLG-THGDLE
   .||||.||  |||....||   .|||.||.  | ||   |||   |  .  . |      .. | .   ..|.   |    |..| ||.|   .| .
ATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPY--LTHEMRDLIKKLLKRHPTQRWGAGPEDAA

EIKSHPWL
.|..||. 
DIQEHPFF
Kinase 20554.AA Ciliate-E2-Unclassified 199-470 28 7.4e-91 308.16 In-house 1-352 (352) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-352/352
Sequence Identity: 28% (104 aa)

FNLLKVLGRGAFGKVMLVEEKSTKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTK-----------TERVILEHCNHPFLVNLVYAFTTPEKIF
....|..|.|.|||| ....|..|..||.| . |  .. . . .... | .  .....  |            .  || ...|||.|...|.|.. ..|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIY

FVTQFMKGGELFQHLKH-----------------AKRFDENRAR-----FYVAEIALALGHLHKKS-IIYRDLKPENILMDEHG---HICLTDFGMAKIV
.|.....||.|.|..|.                  |.|.|. |.     || |.| ..| .||.|  ||.||.||||||.|. |   .|...||| .|  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

RKN----------------ELAMSFCGTPEYL----SPEIISGVGHT----ISCDWWALGIFTYEMLFALPPFYTQNQDQ----------------MFKA
 .|                ... .|||||.|.    .||.. | ..     ..||.|.||.  |||||  .||| .|..|                ... 
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IKESQIRFPDKIA------ISPEAQNFIL----SCCKKDPHQRLGTHGDLEEIKSHPWL
||. .| ||          .||||..||     .. ||.| .|.    ..|.|. |||.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI----TFEQILNHPWF
Kinase 20554.AA Pkinase 199-470 30 1.1e-88 305.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 199-470
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

FNLLKVLGRGAFGKVMLVEEKSTKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTK-TERVILEHCNHPFLVNLVYAFTTPEKIFFVTQFMKGG-
. .....|.|.||.| .  .|.| ||.|.| |.|              ... .. ...|.. .|  |. ..|||. | | ..|... .| .|. .. || 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK--------------RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGL

---ELFQHLK--HAKRF--DENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDEHGHI----CLTDFGMAKI--VRKNELAMSFCGTPEYLSPEIIS
   .|| ...    ..|  .|. ..||. .|. .| ..|...||.|||||||||.|..|||    ...||| ||     .|. ...|||||.|..||.| 
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR

-GVGHTISCDWWALGIFTYEMLFALPPFYTQ------NQDQMFKAIKESQIRFPDKIAIS-------------------PEAQNFILSCCKKDPHQRLGT
 | ... ..|.|..|.  ||||.  |||. .      .|.||.. |.. ...|.    .|                   .|.. || .|..|||..|.. 
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-

HGDLEEIKSHPWL
    |.|. |||.
---AEQILQHPWF
Kinase 20554.AA RSK 249-470 39 3e-83 282.86 In-house 34-271 (271) Show / Hide 
Range on Protein: 249-470
Range on HMM: 34-271/271
Sequence Identity: 39% (94 aa)

IIDKDQIEHT-----KTERVILEHCNHPFLVNLVYAFTTPEKIFFVTQFMKGGELFQHLKHAKRFDENRARFYVAEIALALGHLHKKSIIYRDLKPENIL
||.|...  .     ..|| ||.. .||| | | |.| . .|.. .. ||.||.|| .|   | | |. ..|| ||||||. .||.. |..|||||||||
IIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENIL

MDEH----GHICLTDFGMAKIVR-KNELAMSFCGTPEYLSPEIISGVGHTISCDWWALGIFTYEMLFALPPFYTQNQDQMFKAIKESQIRF-----PDKI
 |..    ||| ..||| || .| .|...|.||.| .|. ||...  ||. .|||| .|.  ||||   .||. .. | ..  |.  .        . . 
YDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWD

AISPEAQNFILSCCKKDPHQRLGT-HGDLEEIKSHPWL
 ||.||.  .    . |||.|||.   . |.||.|||.
FISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 20554.AA TyrKc 199-464 20 5.1e-14 4.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 199-464
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FNLLKVLGRGAFGKVMLVEEKSTKKIYALKSIRKLASFLVGSLNKQNQEDIIDKDQIEHTKTERVILEHC--NHPFLVNLVYAFTTP-------EKIFFV
  |.|.||.||||.|.. . |      | |.... |                    .|    |  |. .   .|| .|.|. . |..       | .. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

TQFMKGGELFQHL-KHAKRFDENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDEHGHICLTDFGMAKIVRKN--------ELAMSF--CGTP----
. .|..| | ..| || ...       .   ||    .||.| .| |||   |.| .| ...  .|||... .              ..   .|      
MEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

EYLSPEIISGVGH--TISCDWWALGIFTYEML-FALPPFYT-----QNQDQMFKAIKESQIRFPDKIA-------ISPEAQNFILSCCKKDPHQRLGTHG
  ..|| |    .  |.  | |. |.  .|.. .  .| .       . ..... .|.   . . . .        ..|  . ...|.. ||..|     
RWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

DLEEI
  |..
IHECF
Kinase 20554.AA S_TK_X 471-534 30 3.8e-11 44.26 SMART 1-79 (79) Show / Hide 
Range on Protein: 471-534
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

AGMDWEALLN--KTAEPPFKPKME----HWE--HYFDEEFTKEEPINSYVPETNKEIVDEYQ-------TEFDGFSYNP
.| ||..|.|  |. |||||||      . .   .||.|||.|.|  . ....  ..... .       ..| ||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 20554.AA RSK 199-232 32 1.6e-08 26.78 In-house 1-37 (271) Show / Hide 
Range on Protein: 199-232
Range on HMM: 1-37/271
Sequence Identity: 32% (12 aa)

FNLLKVLGRGAFGKVMLVEEK---STKKIYALKSIRK
..|....|.|.|.|| ..  .    |.. || | |.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKK
Kinase 20554.AA Pkinase_Tyr 268-361 26 2e-06 22.3 Pfam 61-161 (270) Show / Hide 
Range on Protein: 268-361
Range on HMM: 61-161/270
Sequence Identity: 26% (27 aa)

CNHPFLVNLVYAFT-TPEK--IFFVTQFMKGGELFQHLKH----AKRFDENRARFYVAEIALALGHLHKKSIIYRDLKPENILMDEHGHICLTDFGMAKI
..|| .|.|. . |   |   |. |. .|..| |  .|.      ....  .   . ..|| .. .|. | .| |||   |.| .| ...  .|||.|. 
GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD

V
.
I
Kinase 20554.AA Pkinase_C 497-536 30 1.4e-05 22.96 Pfam 10-46 (46) Show / Hide 
Range on Protein: 497-536
Range on HMM: 10-46/46
Sequence Identity: 30% (12 aa)

YFDEEFTKEEPINSYVPETNKEIVDEYQTEFDGFSYNPNA
.||.|||.| |  ..   ..  .  . | .| ||.| .  
NFDPEFTDEPPMDTP--PDWR-MSSGDQEPFRGFTYVNPD
Kinase 20554.AA Pkinase_Tyr 199-215 47 0.001418 12.73 Pfam 1-17 (270) Show / Hide 
Range on Protein: 199-215
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FNLLKVLGRGAFGKVML
  ..|.||.||||.|..
ITFGKKLGEGAFGEVYK