Gene 18101 (Tetrahymena)

18101

Species: Tetrahymena
Alias: PreTt18101, 709, 3671.m00050, 116.m00126, TTHERM_00723410, 18101
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
18101.AA Protein None 535 None Fasta, JSON
18101.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
18101.NA RNA None 1608 None Fasta, JSON

Protein domain

Protein domains of 18101.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH_Akt_basal 18101.AA PH_Akt_basal 35-118 50 4.9e-49 169.23 In-house 1-90 (90) Show / Hide 
Range on Protein: 35-118
Range on HMM: 1-90/90
Sequence Identity: 50% (45 aa)

VFKYNEYLNRQERTLMITNKCVYNLK---NHSIKRVIPFPKIEAITVA-YFGSEFVIHVPSEYDYRYY--SLDKIESILLFITQEYVKSQ
|.|||.| .||||.||||.|.|||.|   .||||..||..||..|... ..|.|||||||.||||||.  | |....|. .....|....
VIKYNRYNKRQERNLMITSKHVYNCKPNKKHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC
Kinase 18101.AA Akt 216-474 53 7.1e-187 602.5 In-house 1-264 (264) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-264/264
Sequence Identity: 53% (142 aa)

FQLLKVLGGGAFGKVLLVEDKQTQEWF-AMKVIKKQVIIQNGKFEHTKTEKAILEHVNFPFLVNLVYAFQDNQHIFFVMQFLKGGELYQYLKRDGRFTES
|..||||| |.||||.||..|.||.|. ||||.||..|||....||||||. ||.|.|.||.|||.|.||......|||.. .||||...|.|..||.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RTKFYIAQLILALGHLHSKNIIYRD-LKLENIVMDSTGYICLTDFGLAKKI-IHQQQIATTFCGTAEYLSPEILKGDGQDFTADWWA-LGIICYELLYGN
|..||.|..|||..||||||||||| ||.|||.||..|.||||||||.|.. | ......|||||.|||.||||.| |.. ..|||. ||...||...|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFHNKNAHQMFEQIKYAKLEFKNTVAISNEAKDFIEKCLTKDKTKRLG-AINGQSDVQAHPWF
 ||.|.. ||||..||.....|... .||.|.||.|...|.||..|||| ..|.. ....||||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 18101.AA AGC 216-474 31 9.1e-179 467.0 In-house 1-395 (395) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-395/395
Sequence Identity: 31% (127 aa)

FQLLKVLGGGAFGKVLLVEDK------QTQEWFAMKVIKKQV-IIQNG--KFEHTKTE------------KAILEHVN----------FPFLVN-LVYAF
|..|||.| |.|||| ||..|      .|.. .||||.||.. |...   . |||.||            . |||..|           ||.|. | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDNQH--IFFVMQFLK---------GG-ELYQYLK---RDGRFTESRTKFYIAQ-------LILALGHLHS-KNIIYRD-LKLENIVMDSTGYICLTDFG
||..|  ..|||....         || ||...|.   . |||.|.|..||.|.       ..||| .||| ..||.|| ||.|||..|. |.|.|||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKKIIH--------------------------------------------------QQQIATTFCG--TAEYLSPEILKGDGQDFTADWWA--LGIICY
|.|...                                                   ... ..||||  |.||..||||     ....|||.  ||.. |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLYGNTPFHNKN----------AHQMFEQIK------YAKLEFKNT--------VAISNEAKDFIEKCLTKDKTKRLGAIN------GQSDVQAHPWF
|.|.| .||...|           ..||..|.        |..| .         . .|.||||.|.|.|.|| .||||. .      | .....||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 18101.AA AktR 216-474 45 6.5e-136 457.83 In-house 1-268 (268) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-268/268
Sequence Identity: 45% (123 aa)

FQLLKVLGGGAFGKVLLVEDK-QTQEWFAMKVIKKQVIIQNGKFEHTKTEKAILE-HVNFPFLVNLVYAFQDNQHIFFVMQFLKGGELYQYLKRDGRFTE
|...|.|| |||||| ||..| ..|. .|||.|||. ||.. ...|| ||. |.| ..|.||.|.|.|.||.. ..||.|.. .||||.|.||....|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SRTKFYIAQLILALGHLHSK-NIIYRDLKLENIVMDSTGYICLTDFGLAK--KIIHQQQIATTFCGTAEYLSPEILKG-DGQDFTADWWALGIICYELLY
....||.|| .||| .||.. |||||||| |||..|. |....|||||.|  ...|  ..|..|||| ||..||...  .| ....||||.||  ||...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GNTPFHNKNAHQMFEQIKYAK-LEFKNTVAISNEAKDFIE-KCLTKDKTKRLG-AINGQSDVQAHPWF
|..|| .||  |||. ||.   ..|. .. .|...||.|. |.| |. .|||| . || ...  ||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 18101.AA SGK 216-474 41 8.70000000001e-127 393.73 In-house 1-283 (283) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-283/283
Sequence Identity: 41% (117 aa)

FQLLKVLGGGAFGKVLLVEDKQT------------------QEWFAMKVIKKQVII-------QNGKFEHTKTEK-AILEHVNFPFLVNLVYAFQDNQHI
|..|||.| | ||||..|. |..                  .  .||||..|| ||       .. .  |...|.  ||  .. ||.||| ||||  .  
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMQFLKGGELYQYLKRDGRFTESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDSTGYICLTDFGLAKKIIHQQQIATTFCGTAEYLSPEILKGD
.||| .. |||.  .|.| ..| |.| .|| |....||..|||..||||||| |||. |. |..|||||||.|  | ...  .||||| ||| ||.|.. 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GQDFTADWWALGIICYELLYGNTPFHNKNAHQMFEQIKYAKLEFKNTVAISNEAKDFIEKCLTKDKTKRLGAINGQSDVQAHPWF
. | | ||| ||.. ||..||  || ..|  ||...|   .| ..    .||.|.| |.  |.||..||||. ..  ... ||.|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPP--QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 18101.AA RSK 219-474 41 1.1e-113 383.99 In-house 1-278 (278) Show / Hide 
Range on Protein: 219-474
Range on HMM: 1-278/278
Sequence Identity: 41% (115 aa)

LKVLGGGAFGKVLLVEDK---QTQEWFAMKVIKKQVIIQNGK-FEHTKTEKAILEHVN-FPFLVNLVYAFQDNQHIFFVMQFLKGGELYQYLKRDGR---
||||| |..||| |.  .   .|.  .||||.|| .|.|. |  .||.||  |||...  ||.|.| ||||...... .|....||||.  |.. ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDS---TGYICLTDFGLAKK-IIHQQQIATTFCGTAEYLSPEILK----GDGQDFTADWWALGI
|.|.. .||.|...||. |||.. ||.||||.|||. |.    | | |||||..|.  ... | . |||.|.||. ||.||    . | |  .||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

ICYELLYGNTPFHN---KNAHQMFEQIKYAK--LEFKNTVAISNEAKDFIEKCLTKDKTKRLGA-INGQSDVQAHPWF
. ||.| |..||..   .|... ...|. .|  |...|   .|.||||.| |.|..|  ||||.  .. .....||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 18101.AA S_TKc 216-474 38 1.4e-102 347.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-231/231
Sequence Identity: 38% (105 aa)

FQLLKVLGGGAFGKVLLVEDKQTQEWFAMKVIKKQVIIQNGKFEHTKTEKAILEHVNFPFLVNLVYAFQDNQHIFFVMQFLKG--GELYQYLKRDGR---
...|...| |||||| .. .| |.. .|.|.||          ||.. | .||.. . |..|.| ..||| .|...|| .. |  |.|..|.|. ||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDSTGYICLTDFGLAKKIIHQQQIATTFCGTAEYLSPEILKGDGQDF-TADWWALGIICYE
   |.| ...||..|...|| ..||..||.|||| ||| .|.   | ..|||||...       |||||| .|..||.|   | ..  .|||..|.| ||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLYGNTPFHNKNAHQMFEQIKYAKLEFKNTVAISNEAKDFIEKCLTKDKTKRLGAINGQS---DVQAHPWF
.|.| .||.  . ..||..|.            | ||||||.|||.|| .||..|        |. .||||
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18101.AA PKA 216-474 42 1.4e-99 337.08 In-house 1-263 (263) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-263/263
Sequence Identity: 42% (115 aa)

FQLLKVLGGGAFGKVLLVEDKQTQEWFAMKVIKKQVIIQNGKFEHTKTEKAILEHVNFPFLVN-LVYAFQDNQHIFFVMQFLKGGELYQYLKRDGRFTES
|.....|| | ||.| |. .|.. . .|||..||| |..    ||...|| ||  ...||.|. . . |||......|| .  |||.  || . |||...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RTKFYIA-QLILALGHLHSKNIIYRDLKLENIVMDSTGYICLTDFGLAKKIIHQQQIATTFCGTAEYLSPEILKGD-GQDFTADWWALGIICYELLYGNT
 .|||.| | .|||  |||.|||||||| ||| .|. |.| .|||| |||.        | ||| ||| |||...  |     |||||||. ||.| | .
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFHNK--NAHQMFEQIKYAKLEFKNTVAISNEA---KDFIEKCLTKDKTKRLGAIN-GQSDVQAHPWF
|| ..  .  |..| |  .|..| .   ... |   ||.|.| |..| |||.|    |  |.  |.||
PFYDHNRDPMQIYEKICNGKIKFPR--HFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 18101.AA PKC 216-474 41 7.7e-98 317.73 In-house 1-262 (262) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-262/262
Sequence Identity: 41% (109 aa)

FQLLKVLGGGAFGKVLLVEDKQTQEWFAMKVIKKQVIIQNGKFEHTKTEKAILEH-VNFPFLVNLVYAFQDNQHIFFVMQFLKGGELYQYLKRDGRFTES
|..||||| | ||||.|.| |.|.| .|.||.|| ||||.   | | ||| .|.   . |||..|   || . ..|||| ...|| |     . .|| |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDSTGYICLTDFGLAKKIIHQQQIATTFCGTAEYLSPEILKGDGQDFTADWWALGIICYELLYGNTPF
...|| |  |.||  ||.|.||||||||.|. .|. | | ..|||..|  . . . ..||||| .|..||||...   .  ||||.|.  ||.. |  ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

HNKNAHQMFEQIKYAKLEFKNTVAISNEAKDFIEKCLTKDKTKRLGA---I-NGQSDVQAHPWF
| ..  ..|. |   .  .   . .| ||.. ... .||. .||||.     .|. |...|| |
HGEDEDELFQSIMHDNPHY--PRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 18101.AA p70 216-474 37 1.2e-92 314.15 In-house 1-299 (299) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-299/299
Sequence Identity: 37% (111 aa)

FQLLKVLGGGAFGKVLLVEDKQ---TQEWFAMKVIKKQVIIQNGK-FEHTK-------------------------TEKAILEHVNFPFLVNLVYAFQDN
|.|||||| |..|||..| . .   |   .||||..|  |. | |  .||.                          |  ||| |. ||.. |.||||.|
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

QHIFFVMQFLKGGELYQYLKRDGRFTESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDSTGYICLTDFGLAKKIIHQQQI----------ATTFCG
   . . ..| ||||.  |.| | . |  ..|| .  |.||.|||.. ||||||| ||.  .. | . |||||| |. ||  ..            ||||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TAEYLSPEILKGDGQDFTADWWALGIICYELLYGNTPFHNKNAHQMFEQIKYAKLEFKNTVAISNEAKDFIEKCLTKDKTKRLG-AINGQSDVQAHPWF
| ||  |||| . | .   |||.||.  |  | |  ||   |  .  . |  .|   |     ..|..| | | | .. |.|.|   .   |.|.||.|
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 18101.AA RSK 216-474 38 1.1e-91 310.91 In-house 1-271 (271) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-271/271
Sequence Identity: 38% (104 aa)

FQLLKVLGGGAFGKVLLVEDK---QTQEWFAMKVIKKQVIIQNGKFEHTKTEKAILEHVNFPFLVNLVYAFQDNQHIFFVMQFLKGGELYQYLKRDGRFT
. |....| |.|.|| ..  .   .|.  .|||.||| ..    .   ...|  ||.... || | | |.||| .... .| |..||.|   | . . |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

ESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDST----GYICLTDFGLAKKIIHQQQIATTFCGTAEYLSPEILKGDGQDFTADWWALGIICYELL
|.  ||| | . ||. .|||. |..|||| |||. |..    | | ..|||.||. . .  .. |||.||.|. ||.||  | |  .||| .|.. || |
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

YGNTPFHNKNAHQMFEQIKYAKLEF-----KNTVAISNEAKDFIEKCLTKDKTKRLGA-INGQSDVQAHPWF
 |.|||.||.   ....|. .||        |   || |||| . . |. |...||||  ||  ..  ||||
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 18101.AA Pkinase 216-474 33 3e-90 310.94 Pfam 1-293 (293) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

FQLLKVLGGGAFGKVLLVEDKQTQEWFAMKVIKKQVIIQNGKFEHTK-TEKAILEHVNFPFLVNLVYAFQDNQHIFFVMQFLKGG----ELYQYLK--RD
.......| |.||.| .  .| |.. .|.|.|||. .  . . .|.. .| .|. ..| |. | | ..|.|..|| .|| .. ||    .|. |..  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--TESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDSTGYI----CLTDFGLAKKI-IHQQQIATTFCGTAEYLSPEILK-GDGQDFTADWWAL
|.|  .|   |||. |.. .| ..||..||.||||.||| .|..|.|    ...||||||.. .  .. .|||||| .|..||... | . .  .|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIICYELLYGNTPFHNK------NAHQMFEQIKYAKLEFKNTVAIS-------------------NEAKDFIEKCLTKDKTKRLGAINGQSDVQAHPWF
|.|.||.| |..|| ..      .  ||...|....|.|     .|                    |.||||..||.|| .||..      ..  ||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 18101.AA Ciliate-E2 216-474 29 1.9e-89 303.47 In-house 1-365 (365) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-365/365
Sequence Identity: 29% (112 aa)

FQLLKVLGGGAFGKVLLVEDKQTQEWFA-----------------------MKVIKKQVIIQNGKFEHTK----------TEKAILEHVNFPFLVNLVYA
. ..|..| |.||.| .......|. ||                       ||..||. |.|  . .|             || |||..|.|........
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DNQHIFFVMQFLKGGELYQYLK------------RDGRFTESRTK---------------FYIAQLILALGHLHSKN-IIYRDLKLENIVMDSTGY
||  |...|..|| ...||.|..|.|              ..|||   |               ||||..|||| .||||| ||.||.|.|||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

ICLTDFGLAKKI-------------------------------IHQQQIATTFCGTAEYLSPEILKGDG---------QDFTADWWALGIICYELLYGNT
|...||||.||.                               | ||... |.|||..|..||||.| .          |. .|.|.||.| ||.|.|..
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFHNKNAHQMFEQIKYAKLEFK----------------NTVAISNEAKDFIEK----CLTKDKTKRLGAINGQSDVQAHPWF
||        ..|||  |..|                 ..  .|.|.||.| |    .| ||  ||..   | ...  ||||
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase 18101.AA TyrKc 216-468 20 3e-13 -8.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 216-468
Range on HMM: 1-280/280
Sequence Identity: 20% (58 aa)

FQLLKVLGGGAFGKVLLVEDKQTQEWFAMKVIKKQVIIQNGKFEHTKTEKAILEHV--NFPFLVNLVYAFQDN-------QHIFFVMQFLKGGELYQYLK
 .|.|.|| ||||.| . . |   .  | |..|.         |    |  |. ..  . | .|.|. .  .        . .. || . ..| | .||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RDGR-FTESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDSTGYICLTDFGLAKKIIHQ-------QQIATTF--CGT----AEYLSPEILKGDGQD
. .. .. .    .  |      .|||||.| |||   |.  .. . .  .||||...| .        . . ..   .|        ..|| ..     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FTADWWALGIICYELL-YGNTPFHN-----KNAHQMFEQIKYA-KLEFKNT------VAISNEAKDFIEKCLTKDKTKRLGAINGQSDV
.  | |. |. ..|.. || .|  .     ... ...|..|    ..          |  . |  . ...|   |  .|    .  .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 18101.AA Pkinase_Tyr 266-364 26 6.1e-07 24.14 Pfam 55-161 (270) Show / Hide 
Range on Protein: 266-364
Range on HMM: 55-161/270
Sequence Identity: 26% (28 aa)

AILEHV-NFPFLVNLVYAFQ-DNQH--IFFVMQFLKGGELYQYLKR----DGRFTESRTKFYIAQLILALGHLHSKNIIYRDLKLENIVMDSTGYICLTD
.|. .  . | .|.|. .   . ..  |. || . ..| |. ||..    ....| ..   . .|   .. .|.|||.| |||   |.  .... .  .|
KIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD

FGLAKKI
||||. |
FGLARDI
Kinase 18101.AA S_TK_X 475-535 25 1.9e-05 23.49 SMART 1-79 (79) Show / Hide 
Range on Protein: 475-535
Range on HMM: 1-79/79
Sequence Identity: 25% (20 aa)

NDIDFNKLLK--KEYSPEFVPVTE----GMSWISNFDKDFTKLSARITNNPN------DQF------STDSFNDIFKDF
 .||..||..  ||. | |.|       .   .||||..||. ... |. .       .|       ..| | . ...|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 18101.AA Pkinase_Tyr 216-230 53 0.017196 9.06 Pfam 1-15 (270) Show / Hide 
Range on Protein: 216-230
Range on HMM: 1-15/270
Sequence Identity: 53% (8 aa)

FQLLKVLGGGAFGKV
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ITFGKKLGEGAFGEV
Kinase 18101.AA Pkinase_Tyr 398-427 21 4.353407 0.92 Pfam 198-230 (270) Show / Hide 
Range on Protein: 398-427
Range on HMM: 198-230/270
Sequence Identity: 21% (7 aa)

WALGIICYELLY-GNTP-FHNKNAHQMFEQI-K
|. |. ..|..  | .| . .   ....|.| .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE