Gene 29341 (Tetrahymena)

29341

Species: Tetrahymena
Alias: 799, PreTt29341, TTHERM_00260780, 29341, 23.m00237
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: NEK,

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
29341.AA Protein None 2236 None Fasta, JSON
29341.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
29341.kin_dom2 Protein Kinase Domain None 257 None Fasta, JSON
29341.NA RNA None 6711 None Fasta, JSON

Protein domain

Protein domains of 29341.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29341.AA NEK 14-274 44 1.3e-137 463.48 In-house 1-286 (286) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-286/286
Sequence Identity: 44% (130 aa)

YVLKKKIGQGNYGQVYLVQSQRDGSI-----LAIKNISTQNMIFEDLEKCL-KECTILQKLDNPHIVKFKKAINQPNKQMIYIMMEYAE-GGDLRKK---
| . ||||||..|.||.|....||..     ...|.|...||  .. .... .|. ||..|..|.|||.. ..   ......| |||.| |||| .|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKEQKQTGKLFEEDQILDWFIQICLGLKYIHKN-----KIIHRDIKPENIFLTADNR----VKIGDFGISKELEYTNQQLYS-RIGTPYYLAPEMIKGEL
||.||| ||.|||.||.|||||.||.|||.|..     ||.|||||| |||||..|.    ||||||||||.|..|.. .|.  .|||||..||..... 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNSSVDIWSLGVVLYELCCL--KPPFNSW--NEYIIYYKTYKK-PYPPITQAQ-YSPQLKTLISKLLIKSPEGERGRYTLEK--QSPYE
||. .||||||.||||.|.|  |.||..|  | .  |.|  |   |||| . . ||..|. |||..| |.||    |.. ..  . |. 
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQ---RPSCNQILEMPFI
Kinase 29341.AA NEK1 14-259 43 7.3e-92 311.5 In-house 1-262 (276) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-262/276
Sequence Identity: 43% (114 aa)

YVLKKKIGQGNYGQVYLVQSQRDGSILAIKNISTQNMIFEDLEKCLKECTILQKLDNPHIVKFKKAINQPNKQMIYIMMEYAEGGDLRKKIKEQKQTGKL
|. .|.||.|..| ..||..  ||. ..|| |.  .| ... |. ..|  ||.|.. | |||.| .     . . || |||..|||| .||..||  |||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLT--ADN---------------RVKIGDFGISKELEYTNQQLYSRIGTPYYLAPEMIKGELYNS
| ||||..||.||||.|..||. ||.|||||. |||||   .                 ||.|||||.. |  |       ||||||| ||..    || 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

SVDIWSLGVVLYELCCLKPPFNSWNEYIIYYKTYKKPYPPITQAQYSPQLKTLISKLLIKSPE
  ||||||.|||||| || ||.. |.     |  . .||||  . ||  |. |.|... ..|.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIP-PHYSYELQSLVSQMFKRNPR
Kinase 29341.AA S_TKc 14-274 32 5.6e-83 282.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-231/231
Sequence Identity: 32% (90 aa)

YVLKKKIGQGNYGQVYLVQSQRDGSILAIKNISTQNMIFEDLEKCLKECTILQKLDNPHIVKFKKAINQPNKQMIYIMMEYAEG--GDLRKKIKEQKQ--
| . .|||.| .|.||...  ..| | ||| |.         |. ..|  ||.| . |.|||.. ..     . .|. |||..|  |||.. ||...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TGKLFEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADNRVKIGDFGISKELEYTNQQLYSRIGTPYYLAPEMIKGELYNS-SVDIWSLGVVLY
... | | ..  .. |||..|.|.|...|||||.|||||.|.   ..||.|||....|       .. .|||.|.|||..    |.  ..|.||.|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELCCLKPPFNSWNEYIIYYKTYKKPYPPITQAQYSPQLKTLISKLLIKSPEGERGRYTLEKQ-------SPYE
|..| .|||   ... .. |              ||..| .|.|.| | || .|       |        |. 
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPE-KRPTA-EALQDEWDIKCHPWF
Kinase 29341.AA ULK 14-259 30 1.1e-75 257.71 In-house 1-310 (324) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-310/324
Sequence Identity: 30% (96 aa)

YVLKKKIGQGNYG-QVYLVQSQRD---GSILAIKNISTQNMIFEDLE-------KCLK-ECTILQKLD---NPH--IVKFKKAINQPNKQMIYIMMEYAE
|.|....|.| .| .||    ...   . . |.| |. ..|.   .|       . || |  |..||.   .|.  |||...  . .|   |||.||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLRKKIKEQKQ-----TGKLFEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADN------------RVKIGDFGISKELEYTN---QQLYS
||||.. ||..|      ..| ..|....  |.||| |.|..||..||||||||.|| .. ..            ..||.||| .| ... |   |....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

RI------GTPYYLAPEMIKGEL----YNSS-VDIWSLGVVLYELCCLKPPFNSW-NEYI----------------IYYKTYKKPYPPITQAQYSPQLKT
        |||.| ||. ..|..    |... .||||||...||.   |.||.|| |...                |...  ..| ||  . . ||..| 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKD

LISKLLIKSPE
||...|.. ..
LIRRMLQYDEK
Kinase 29341.AA ULK 14-259 30 7e-74 251.75 In-house 1-315 (329) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-315/329
Sequence Identity: 30% (95 aa)

YVLKKKIGQGNYGQVYLVQSQRD----GSILAIKNISTQNMIF-------EDLEKCLK-ECTILQKLD--------NPHIVKFKKAINQPNKQMIYIMME
|.|....|.| .|.||    ...    . . |.| |. | |.        . . ..|| |. |..||.        .|.|||...  . .|   |||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAEGGDLRKKIKEQKQ------TGKLFEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADN------------RVKIGDFGISKELEYT---NQ
| .||||.. ||..|       ..| ..|....  |.||. |.|..||..||||||||.|| .. ..            ..||.||| .| ...    .|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

QLYSRI------GTPYYLAPEMIKGEL----YNSS-VDIWSLGVVLYELCCLKPPFNSW-NEYI--IYYKTYKKPYPP-----ITQAQ---------YSP
....        |||.| ||. ..|..    |... .||||||...||.   ||||..| |...  |..| ...|.|.      .. |          ||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

QLKTLISKLLIKSPE
..| ||...|.. ..
ECKDLIRRMLQYDEK
Kinase 29341.AA Pkinase 14-259 29 2.2e-70 244.95 Pfam 1-279 (293) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-279/293
Sequence Identity: 29% (85 aa)

YVLKKKIGQGNYGQVYLVQSQRDGSILAIKNISTQNMIFEDLEKCLK--ECTILQKLDNPHIVKFKKAINQPNKQMIYIMMEYAEGG----DLRKKIKEQ
|....|||.|..|.||. . . .| | |.| |. ..   . ..  ..  |. |...|. |.||... .     |. ||. |||.|||    ||   |.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

KQTGKLF--EEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADNRV----KIGDFGISKEL-EYTNQQLYSRIGTPYYLAPEMIK-GELYNSSVD
 . .. |  .|... ... ||. ||.|.|...|||||.|||||..  .. .    ||.|||..| . .  |. .... |||.|.||| |. |. | ..||
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSLGVVLYELCCLKPPFNSW------NEYIIYYKTYKKPYPPITQAQYS-------------------PQLKTLISKLLIKSPE
.||.|..|||..| .||| .       ... ..... ..|..   .  .|                   . .| .|...| | |.
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK
Kinase 29341.AA Ciliate-E2 14-259 25 4.8e-70 239.03 In-house 1-350 (365) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-350/365
Sequence Identity: 25% (94 aa)

YVLKKKIGQGNYG-----QVYLVQSQR------------------DGSILAIKNISTQN-MIFEDLEKCLKECT----------ILQKLDNPHIVKFKKA
| . |||||||.|     .|..|| |                   ...| |.|... ..  ...  .. ..|            ||..|..|.|.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

INQPNKQMIYIMMEYAEGGDLRKKIKEQ-KQTGKLFE------EDQILDWFIQICL---------------GLKYIHKNK-IIHRDIKPENIFLTADNRV
    ... ||. |||..||||.. ||.. |. .. .|      | .|.. . ||.                .|.|.|... |||||||||||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGISK----------------ELEYTN----------------QQLYSRIGTPYYLAPEMIKGEL---------YNSSVDIWSLGVVLYELCCLKP
|| |||.||                .. . .                .. .. .|||.|.|||...|.          |. ..|||||||.|||... ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFNSWNEYIIYYKTYKKPYPPITQA-----------------QYSPQLKTLISK----LLIKSPE
||         ..  |.    . ..                 . |.. | ||.|    .| | ||
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPE
Kinase 29341.AA Ciliate-E2-Unclassified 14-259 28 2.5e-69 236.65 In-house 1-338 (352) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-338/352
Sequence Identity: 28% (96 aa)

YVLKKKIGQGNYGQVYLVQSQRDGSIL-------AIKNISTQNMIFEDLEKCLKECTILQK------------------LDNPHIVKFKKAINQPNKQMI
| . |.||||..|.||..|   ..  .        |.... ... ..| |. ... .. .|                  ...|.|||.  . .. ..  |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--I

YIMMEYAEGGDLRKKIK-------------EQKQTGKLFEEDQIL-----DWFIQICLGLKYIHKNK-IIHRDIKPENIFLTADN---RVKIGDFGISKE
|| |||.|||||.. ||             ......| |.| |..     ..| ||..||.|.|... |||||||||||... ..   ..|| ||||||.
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

LEYTNQQ---------------LYSRIGTPYYL----APEMIKGELYNSS----VDIWSLGVVLYELCCLKPPFNSWNEYI---------------IYYK
... |..               .....|||.|.    |||...|. |. |    .|||||||.|||..  ..||.. |...               ..|.
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

TYK---KPYPPITQ----AQYSPQLKTLIS----KLLIKSPE
  |     .|.  .     . ||. | .|.    |.| | |.
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPN
Kinase 29341.AA CAMK 19-259 21 3.7e-69 221.76 In-house 1-411 (425) Show / Hide 
Range on Protein: 19-259
Range on HMM: 1-411/425
Sequence Identity: 21% (90 aa)

KIGQGNYGQVYLVQSQRDG------------SILAIKNISTQNMIF--------------------------EDLEKCLKECTILQK-------LDNPHI
..|.|..|.|.|..  ...               ||| |... .                            .|... ..|  |..|       || |.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFKKAINQPN-----------------KQMIYIMM---EYAEGG----DLRKKIKEQKQTG-----------KLFEEDQILDWFIQICLGLKYIHKNKI
.|.  ..  |.                 ....|. |   ||..||    ||  .|.|... |           . |.|..   .| ||| ...|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENIFLTAD-----------------NRVKIGDFGISKELEY-----------------------TNQQLYSRIGTPYYLA-PEMIKGEL----
.|||.||||| |. .                 | .|| ||| .....                        ..| .. . |||.| | ||...|.     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNSSVDIWSLGVVLYELCCLKPPFNSW-------------NEYIIYYKTYKKPYP-P------------------ITQA---QYSPQLKT
          |. ..|.||.||.|| . | .|||..              |.| .. |  |  |  |                  |..    . |.. | 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISKLLIKSPE
||.|.| . ||
LIRKMLQVDPE
Kinase 29341.AA CAMKL 14-259 28 1.4e-67 214.69 In-house 1-283 (297) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-283/297
Sequence Identity: 28% (83 aa)

YVLKKKIGQGNYGQVYLVQS-QRDGSILAIKNISTQNMIF--------------EDLEKCLKECTILQKLD---NPHIVKFKKAINQPNK----QMIYIM
| . | .|.|..|.| | .  .  |   ||| |  . .                 |. .  .|  |...|.    |.|.|.   |  |..    . ||. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MEYAEGGD--LRKKIKEQKQTGKLFEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADN--RVKIGDFGISKELE-Y---TNQQLYSRIGTPYY
|||..||.  |  .|....  .. ..|..    | ||. ...|.|...|.||||||||| |. ..   .|| ||| | . . .   ..| |  . |.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

LAPEMIKG--ELYN-SSVDIWSLGVVLYELCCLKPPFNSWN-------EYIIYYKTYKKPYPPITQA-QYSPQLKTLISKLLIKSPE
 |||...|  . |.   |||||.||.|| . | . ||.  .        .  .|.  ..    ..   . | ... ||.|.| . ||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPE
Kinase 29341.AA NEK4 14-274 37 1.3e-66 227.6 In-house 1-257 (257) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-257/257
Sequence Identity: 37% (98 aa)

YVLKKKIGQGNYGQVYLVQSQRDGSILAIKNISTQNMIFEDLEKCLKECTILQKLDNPHIVKFKKAINQPNKQMIYIMMEYAEGGDLRKKIKEQKQTGKL
|   | .|.| || |.||...||.    .| .  .|   ..    ..|  .| .|  | ||..|      | |. || | . ||||| .| |.||  ...
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQK--NQF

FEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADNRVKIGDFGISKELEYTNQQLYSRIGTPYYLAPEMIKGELYNSSVDIWSLGVVLYELCCL
 || |...||.|| ..| |.|. .|.||| |  |||||  | .||||||||. |.   .     ||||||. ||.     |.   ||||||  .||.  |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KPPFNSWNEYIIYYKTYKKPYPPITQAQYSPQLKTLISKLLIKSPEGERGRYTLEKQSPYE
|  |.  .   . |.  .   ||. . .||..|. |. ..| | |. .|       | || 
KHAFDAKDMNSLIYQIIQGQPPPMPP-NYSQDLQNLVYQMLEKQPT-KRPSIFDIFQMPYI
Kinase 29341.AA STE 14-259 26 1.6e-63 217.33 In-house 1-343 (359) Show / Hide 
Range on Protein: 14-259
Range on HMM: 1-343/359
Sequence Identity: 26% (93 aa)

YVLKKKIGQGNYGQVYLVQSQR---------------DGSILAIKNIS---------------TQNMIFEDLEKCLKECTILQKLD--NPHIVKFKKAIN
. . .|||.|..|.||.                     | | ||| ..               ..|.  |.... |||  |..|..   |.|||.  .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----QPNKQMIYIMMEYAEGGDLRKKIKEQKQTGKL----------FEEDQILDWFIQICLG-LKYIHKNKIIHRDIKPENIFLTADNRVKIGDFGISK
     . |.. ..| ||| .|| |.. ||. . .||           |.|.||     ||. | |.|.|...|||||||| ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ELEY---------------TNQ-QLYSRIGTPYYLAPEMIKGEL------YNSSVDIWSLGVVLYELCCLKPPFNS-WNEYIIYYKTYK-----------
 |.                |.| . .. .||| . |||.|...       |. ..|||||| .. |... |||.    . . ..... .           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---KPYPPITQ------------------AQYSPQLKTLISKLLIKSPE
   .| ||. .                   ..|| .|  |.| |.| |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPN
Kinase 29341.AA Pkinase_Tyr 14-213 26 5.5e-30 102.17 Pfam 1-210 (270) Show / Hide 
Range on Protein: 14-213
Range on HMM: 1-210/270
Sequence Identity: 26% (57 aa)

YVLKKKIGQGNYGQVYLVQSQ----RDGSILAIKNISTQNMIFED--LEKCLKECTILQKL-DNPHIVKFKKAIN---QPNKQMIYIMMEYAEGGDLRKK
 .. ||.|.|..|.||.         ..   |.| .  ..   |.  .|. ..|  |. .| ..|.||..  ..    .||   ||| |||...|||.. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

IKEQKQTGKLFEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADNRVKIGDFGISKEL---EYT-NQQLYSRIGTPYYLAPEMIKGELYNSSVD
 ....  .. .   ..|.. .||. |. | . ...||||.   |. .| .| |||.||| .. .   .|   ..  ...  . . ||| |.   ...  |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGKFTTKSD

IWSLGVVLYELCCL
.|| ||...|.. .
VWSFGVLMWEIFTY
Kinase 29341.AA TyrKc 14-253 21 7.2e-20 73.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-253
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YVLKKKIGQGNYGQVYLVQSQRDGSILAIKNISTQNMIFEDLEKCLKECTILQKL--DNPHIVKFKKAINQPNK-----QMIYIMMEYAEGGDLRKKIKE
 .|.||.| |..|.||. .        |.| .         .|  ..|  |. ||  ..|.||..  .. |.       . ..| |||...|||.. ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QKQTGKLFEEDQILDWFIQICLGLKYIHKNKIIHRDIKPENIFLTADNRVKIGDFGISKELEYT-----NQQLYSR---IGTP-----YYLAPEMIKGEL
 . .   .  .. |.. .||. |  |.|....||||.   |. ......|||.||| |....       ... |.     |.        .||| |.   
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNSSVDIWSLGVVLYELC--CLKPPFN------SWNEYIIYYKTYKKPYPPIT---------------------QAQYS--PQLKTLISKL
...  |.|| ||...|..  . .|. .      |. | | | |. . . .|                       ... .  |  .......
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 29341.AA NEK 1187-1443 43 3.8e-134 451.96 In-house 1-286 (286) Show / Hide 
Range on Protein: 1187-1443
Range on HMM: 1-286/286
Sequence Identity: 43% (123 aa)

KRLKNELCYGSQGQVHLIESKEDSSK-----LAIKNISTKNMSQQQKRKHQ-DEYRCLQKLD--HIVKFKKAIHCINNQMIQIIMEYTE-GGDLQKA---
 ..  ..  ||.|.|.....|.|...     ...|.|...|||...|.. |  | | |..|.  .|||.. ..   .|... |.||| | ||||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IEKQIQIGKPFEEEQILDWFAQICQGLKYIHEN-----KIIHRDIKPANLFLTAQNT----VKIGDFGVAKEQKYTNEQLSS-QIGTPYYLAPEIIDGKP
|.|| | ||.||||||.|||.|.| .|||.|..     ||.||||||.|.|||..|.    |||||||..|....|.. ... |.|||||..||.. .||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNSSVDIWSLGVVLYELCCL--KPPFNSW--CEAGLYYKSKNL-PYPPIQAK--YSKKLKELISKLLRKSPDDRYTLQEILDEPFI
||. .||||||.||||.|.|  |.||..|     .||.| ..   ||||. .  ||..|..|||..|.|.|..|.. ..||  |||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 29341.AA NEK1 1188-1443 40 9.7e-86 291.16 In-house 2-276 (276) Show / Hide 
Range on Protein: 1188-1443
Range on HMM: 2-276/276
Sequence Identity: 40% (111 aa)

RLKNELCYGSQGQVHLIESKEDSSKLAIKNISTKNMSQQQKRKHQDEYRCLQKLDH--IVKFKKAIHCINNQMIQIIMEYTEGGDLQKAIEKQIQIGKPF
  .  .  || | . |  .|||.. ..|| |.  .|... . .   |   |.|..|  |||.| .     . .  |.||| .|||| ..|..|   ||.|
HYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKLF

EEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLT--AQN---------------TVKIGDFGVAKEQKYTNEQLSSQIGTPYYLAPEIIDGKPYNSS
 | ||..|| ||| .|..||  ||.|||||. |.|||                    .||.||||.|.    | |  .  ||||||| |||.  ||||  
SEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNK

VDIWSLGVVLYELCCLKPPFNSWCEAGLYYKSKNLPYPPIQAKYSKKLKELISKLLRKSPDDRYTLQEILDEPFI
 ||||||.|||||| || ||..  .  |  |    .|||| . ||..|..|.|......| .|   . ||  |||
SDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 29341.AA S_TKc 1187-1443 28 2.1e-74 254.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 1187-1443
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

KRLKNELCYGSQGQVHLIESKEDSSKLAIKNISTKNMSQQQKRKHQDEYRCLQ-KLDHIVKFKKAIHCINNQMIQIIMEYTEG--GDLQKAIEKQIQIGK
 .. ...  |. |.|..   |..  . ||| |.         .. . | ..|. . ..|||.. ...    . . ..||| .|  ||| . |.|.   |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

P--FEEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTAQNTVKIGDFGVAKEQKYTNEQLSSQIGTPYYLAPEIIDGKPYNS-SVDIWSLGVVLYE
.  | | ..  ...|||..|.|.|...|||||.||.|..|.   ..||.|||.|..        ....|||.|.|||..   .|.  ..|.||.|..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCCLKPPFNSWCEAGLYYKSKNLPYPPIQAKYSKKLKELISKLLRKSPDDRYTLQEILD-------EPFI
..| .|||    .. .. | .           |. .|..|.|.|.| |..|.|  |.|         |..
MLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29341.AA CAMK 1192-1443 19 1.2e-65 210.25 In-house 1-425 (425) Show / Hide 
Range on Protein: 1192-1443
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

ELCYGSQGQVHLIESKEDS------------SKLAIKNISTKNMS--------------------------QQQKRKHQDEYRCLQKL---------DHI
.|  || |.|.| . |..              | ||| |..| ..                          .. ... . |.....||          .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFKKAIHCIN-----------------NQMIQIIM---EYTEGG----DLQKAIEKQ------------IQIGKPFEEEQILDWFAQICQGLKYIHENK
.|.  ..   .                 .... ..|   || .||    ||   | ..            .   . |.|..   .| |||....|.|...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPANLFLTAQ-----------------NTVKIGDFGVAKEQKY-----------------------TNEQLSSQIGTPYYLA-PEIIDG-----
|.|||.|| |. |.                   |..|| ||| |.. .                        ... .. . |||.| | ||.. |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYNSSVDIWSLGVVLYELCCLKPPFNSWCE---------------------AGLYY-KSKNLP------YPPIQAKYSKK--------LK
         ..|. ..|.||.||.|| . | .|||.. |.                     .| |.  .. ..      .|..  . |.          |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELISKLLRKSPDDRYTLQEILDEPFI
 ||.|.|.. |..|.|....|. |..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 29341.AA ULK 1187-1443 28 1.7e-65 223.94 In-house 1-324 (324) Show / Hide 
Range on Protein: 1187-1443
Range on HMM: 1-324/324
Sequence Identity: 28% (93 aa)

KRLKNELCYGSQG-QVHLIESKED---SSKLAIKNISTKNMSQQQKR--------KHQDEYRCLQKLD-----H--IVKFKKAIHCINNQMIQIIMEYTE
  |...|. || | .|.  . |..     . |.| |. |.|......        . . | . ..||.     .  |||...   . |.  | ||||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLQKAIEKQIQ-----IGKPFEEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTA------------QNTVKIGDFGVAKE-QKYT--NEQLSS
||||.. |.|.        .| ..|....  | |||.|.|..|...||||||||.|. ..             ....||.||| ||  ....    .. .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QI------GTPYYLAPEIID----GKPYNSS-VDIWSLGVVLYELCCLKPPFNSWCEAGLY----------------YKSKNLPYPP--IQAKYSKKLKE
.       |||.| ||.|.     .|||... .||||||...||.   |.||.||    .|                 | .....|.   . | |...|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LISKLLRKSPDDRYTLQEILDEPFI
||...| . ..|| . .||.. |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 29341.AA Ciliate-E2 1186-1443 23 2.6e-65 223.16 In-house 1-365 (365) Show / Hide 
Range on Protein: 1186-1443
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FKRLKNELCYGSQGQVHLIESKEDSSKLAIKNISTKNMSQQQ-------------KRKHQDEYRCLQKLDH-------------------------IVKF
.| .|  .. |..|.| . . ...  . ||| |  ... |.|             |...... . . . .|                         |.|.
YKFIK-KIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM

KKAIHCINNQMIQIIMEYTEGGDLQKAIEKQIQIG-------KPFEEEQILDWFAQICQ---------------GLKYIHENK-IIHRDIKPANLFLTAQ
. .   .... | ..||| .||||.. |... .         |.| |..|.. ..||.|               .|.|.|... |||||||| |...   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

NTVKIGDFGVAK----------------EQKYTN----------------EQLSSQIGTPYYLAPEIIDGKP---------YNSSVDIWSLGVVLYELCC
  .|| ||| .|                . .. .                ..  ...|||.|.||||. ||.         |. ..|||||||.|||...
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

LKPPFNSWCEAGLYYKSK--NLPYPPIQ---------------AKYSKKLKELISK----LLRKSPDDRYT-LQEILDEPFI
 ||||        . . |  .. .|. .                | |.. | ||.|    .| | |. |.|  ..||. |..
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 29341.AA Ciliate-E2-Unclassified 1188-1443 25 7.4e-65 221.79 In-house 2-352 (352) Show / Hide 
Range on Protein: 1188-1443
Range on HMM: 2-352/352
Sequence Identity: 25% (91 aa)

RLKNELCYGSQGQVHLIESKEDSSKL-------AIKNISTKNMSQ----------QQKRKHQDEYR--------CLQKLDHIVKFKKAIHCINNQMIQII
..   .. |..|.|.. . |..  ..        |.... |.. .           ...|. .  |         |. ..|... |.  .  . | | |.
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYTEGGDLQKAIE-------------KQIQIGKPFEEEQIL-----DWFAQICQGLKYIHENK-IIHRDIKPANLFLTAQN---TVKIGDFGVAKEQKY
||| |||||.. |.             .... .| |.|.|..     ..||||.|||.|.|... |||||||| |.... ..    .|| ||| .|....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

TNEQ---------------LSSQIGTPYYL----APEIIDGKPYNSS----VDIWSLGVVLYELCCLKPPFNSWCEAG----------------LYYKSK
 |..               .....|||.|.    |||...|. |. |    .|||||||.|||..  ..||.. ..                  || . |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

N-----LPYPP--IQAKYSKKLKELIS----KLLRKSPDDRYTLQEILDEPFI
.      ..|.  |  . |.. |..|.    |.| | |. |.|...||  |..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 29341.AA ULK 1187-1443 27 2e-64 220.37 In-house 1-329 (329) Show / Hide 
Range on Protein: 1187-1443
Range on HMM: 1-329/329
Sequence Identity: 27% (92 aa)

KRLKNELCYGSQGQVHLIESKED----SSKLAIKNISTKNMSQQQKR--------KHQDEYRCLQKLD----------HIVKFKKAIHCINNQMIQIIME
  |...|. || |.|.  . |..      | |.| |. . |.|...           . | . ..||.          .|||...   . |.  | ||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YTEGGDLQKAIEKQIQ------IGKPFEEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTA------------QNTVKIGDFGVAKE-QKY--TNE
| .||||.. |.|.         .| ..|....  | ||..|.|..|...||||||||.|  ..             ....||.||| ||  ..    ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

QLSSQI------GTPYYLAPEIID----GKPYNSS-VDIWSLGVVLYELCCLKPPFNSW-CEAGLYYKSKNLPY----------PPIQAK-------YSK
.. ..       |||.| ||.|.     .|||... .||||||...||.   ||||..| ..  |... |.. .           |.| .        |.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

KLKELISKLLRKSPDDRYTLQEILDEPFI
..|.||...| . ..|| . .|... |..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 29341.AA NEK4 1186-1443 35 9.4e-64 218.12 In-house 1-257 (257) Show / Hide 
Range on Protein: 1186-1443
Range on HMM: 1-257/257
Sequence Identity: 35% (91 aa)

FKRLKNELCYGSQGQVHLIESKEDSSKLAIKNISTKNMSQQQKRKHQDEYRCLQKLDH--IVKFKKAIHCINNQMIQIIMEYTEGGDLQKAIEKQIQIGK
.  .|     || | | |. .. |  .  .| .  || |.....    | . | .| |  ||..|      |.|.  |.| . ||||| .   .  | ..
YCHMK-VVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQ

PFEEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTAQNTVKIGDFGVAKEQKYTNEQLSSQIGTPYYLAPEIIDGKPYNSSVDIWSLGVVLYELCC
  ||.|...|| ||  .| |.|| .|.||| |  |.||| .| .||||||...      .  .  ||||||. ||.   .||.   ||||||  .||.  
FLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMIT

LKPPFNSWCEAGLYYKSKNLPYPPIQAKYSKKLKELISKLLRKSPDDRYTLQEILDEPFI
||  |.      | |.  .   ||.  .||. |..|. ..| | |..|  . .|.  |.|
LKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 29341.AA CAMKL 1186-1443 28 2e-62 197.95 In-house 1-297 (297) Show / Hide 
Range on Protein: 1186-1443
Range on HMM: 1-297/297
Sequence Identity: 28% (88 aa)

FKRLKNELCYGSQGQVHLIES-KEDSSKLAIKNISTKNMS-QQQKRKH------------QDEYRCLQKLD-----HIVKFKKAIHCI-NNQM------I
.. .| .|  || |.| | .  .    | ||| |  | ..  ....|.            . |......|.     .|.|.    ..| . ..      |
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL---YEVIETPEHDIETKKI

QIIMEYTEGGD--LQKAIEKQIQIGKPFEEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTAQN--TVKIGDFGVAKEQK-Y---TNEQLSSQIGT
...||| .||.  |.  |.|.   .....|..    | ||. ...|.|...|.|||||| |. |. ..  ..|| ||| . ... .   ... |. . |.
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PYYLAPEIIDG--KPYN-SSVDIWSLGVVLYELCCLKPPFNSW--------CEAGLYYKSKNLPYPP-IQAKYSKKLKELISKLLRKSPDDRYTLQEILD
| | ||||. |  |||.   |||||.||.|| . | . ||.          .   || | . . | | |  . |  .. ||.|.| . |..|.|...|. 
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN

EPFI
 |. 
HPWM
Kinase 29341.AA Pkinase 1196-1443 27 3.8e-61 214.24 Pfam 10-293 (293) Show / Hide 
Range on Protein: 1196-1443
Range on HMM: 10-293/293
Sequence Identity: 27% (80 aa)

GSQGQVHLIESKEDSSKLAIKNISTKNMSQQQKRKHQD--EYRCLQKL--DHIVKFKKAIHCINNQMIQIIMEYTEGG----DLQKAIEKQIQIGKPF--
|| |.| .   | .. . |.| |. .. . .... |    | . ...|  ..||... . .  .. .  ..||| |||    ||   |.   . ...|  
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIY-MVMEYCEGGLYVMDLFDYIST--WRHGCFYF

EEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTAQNTV----KIGDFGVAKEQ-KYTNEQLSSQIGTPYYLAPEIID-GKPYNSSVDIWSLGVVLY
.|... ... ||..||.|.|...|||||.||.|...  ....    ||.|||.||      |. ...  |||.|.|||.|  |..| ..||.||.|..||
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY

ELCCLKPPFNSW----CEAGLYYKSKNLPYPPIQAKYS-----------------------KKLKELISKLLRKSPDDRYTLQEILDEPFI
|..| .||| .       .  ... ..  .||.   ..                       . .|..|...|.| | .|.| ..||  |..
EMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 29341.AA STE 400-1443 8 7e-50 172.03 In-house 25-359 (359) Show / Hide 
Range on Protein: 400-1443
Range on HMM: 25-359/359
Sequence Identity: 8% (92 aa)

NIHLNRNQLKNNQQQGLNQLKQDNKQNTQFQKQILPNQKDLYTDIQLDQSPRQILKNKKKQGDVQYDLNKVEVANQNNNNKEEEEQNSKTKQDYEQTTQS
|||   ... |                                                                                         
NIH-KTGEVEN-----------------------------------------------------------------------------------------

QKQILPNQKDLYTDIQLDQSPRQILKNKKKQGDVQYDLNKVEVANQNNNNDNNNNKEEEEQNSKTKQDYEQSTQSQKQILHNQKDLHTNTQLYQRPLQIL
                                                                                                    
----------------------------------------------------------------------------------------------------

KNKKKQGDVQDLNKVQVTNLNNNNNKEEEEEQNSKTKQDYEQSTQSQKQILPNQKDLHTDIQLDQSPLEILQNEKKQVDMQDLNKVEVTNQNNNKEEQNN
                                                                                                    
----------------------------------------------------------------------------------------------------

KTQSNLSIKSQKTFETNNSTYFFQQSNETYESDTIPAIQKNNLQNINLIDQVQNKTRLTYRKKNKDSNEEDQKNKEPIFYQPNNQQQKLKNNESNDQDFK
                                                                                                    
----------------------------------------------------------------------------------------------------

LEPKIQSTTDQSSQKLQKQTQIDEVFQSPNNSTQITQKGKDDQNYPVRITAKVVSKCKNQISEPEKQNTEFEIKTKSNPKQADEIPITPIKPGQKDLNTE
                                                                                                    
----------------------------------------------------------------------------------------------------

LNDNSQEQKNLSKTKRNISKEQEFSTAASCKLITLNKEQSLEKNSQDPYELKTHNQSLGQVIEEMEAKSNYQYINQLSQKYKKDNEQQLSPNLIQKELLD
                                                                                                    
----------------------------------------------------------------------------------------------------

DTSQNKQEKIDNYFFEEIEEDICPYEQPEEESQNDMNTRLTQLEVLYSENNYTQFLLYSISKTDPSNLKDTNKDNQKNKLQDNYHQLIDDKSMHCDDKES
                                                                                                    
----------------------------------------------------------------------------------------------------

DVEDSFYEEDQEEEEEDDEEEDNIYIIPSKQSESFKKLKVSLLQDMDQEQFQLFSNIVKKEADRFQEKFLLKQFQPIKEINLVYNPFKRLKNELCYGSQG
                                                                                                    
----------------------------------------------------------------------------------------------------

QVHLIESKEDSSKLAIKNISTKNMSQ---------------QQKRKHQDEYRCLQKLD--H--IVKFKKAIHCI-----NNQMIQIIMEYTEGGDLQKAI
       .|     ||| .. .| ..               ... . . | . ..|..  |  |||.  .         |.. . |.||| .|| | . |
------NGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDII

EKQIQIGKP----------FEEEQILDWFAQICQG-LKYIHENKIIHRDIKPANLFLTAQNTVKIGDFGVAKEQKY---------------TNE-QLSSQ
..   .|||          |.|.||     ||..| |.|.|...|||||||||| .|     ||. ||||..                   |.  .  . 
KHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTF

IGTPYYLAPEIIDG------KPYNSSVDIWSLGVVLYELCCLKPPF---NSW---CEAGLYYKSKN---------LPYPPIQ------------------
.||| . |||.|..      |.|. ..|||||| .. |... |||.   .      ..   |.. .          | ||..                  
VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTY

-AKYSKKLKELISKLLRKSPDDRYTLQEILD--EPFI
  |.|...|. |.| |.| |..| | .. |    |||
PHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 29341.AA Pkinase_Tyr 1259-1384 30 2.5e-18 62.72 Pfam 82-210 (270) Show / Hide 
Range on Protein: 1259-1384
Range on HMM: 82-210/270
Sequence Identity: 30% (40 aa)

IQIIMEYTEGGDLQKAIEKQIQIGKPFEEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTAQNTVKIGDFGVAKEQKYTNEQLSSQIGT-----PY
| |.||| ..||| .   |.   ..|.  ...|.. .||..|. | .....||||.   |  .| .|.|||.||| |.   |  ..  .. ..       
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIK

YLAPEIIDGKPYNSSVDIWSLGVVLYELCCL
 .||| |  . ...  |.|| ||...|.. .
WMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase 29341.AA TyrKc 1187-1447 21 6.8e-15 18.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 1187-1447
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

KRLKNELCYGSQGQVHLIESKEDSSKLAIKNISTKNMSQQQKRKHQDEYRCLQKL----DHIVKFKKAIHCINN-------QMIQIIMEYTEGGDLQKAI
 .|. .|  |  |.|.. . |    . |.| .         ..   .| | . ||    ..||..  .  |.         . . |.||| ..|||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

EKQIQIGKPFEEEQILDWFAQICQGLKYIHENKIIHRDIKPANLFLTAQNTVKIGDFGVAKEQKYT-------NEQLSSQ-IGTP-----YYLAPEIIDG
 |       .  .. |..  ||..|  |.|....||||.   |  .....||||.||| ... .             ...  |.        .||| |. 
RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

KPYNSSVDIWSLGVVLYELC--CLKPPFN------SWCEAGLYYKSKNLPYPPIQAK------YSKKLKELISKLLRKSPDDRYTLQEILDEPFIKNRL
. ...  |.|| ||...|..  . .|. .      |. |.  | |. . . .|  .        .... .....  .  |.|| | .||      . ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF