Gene 14057 (Tetrahymena)

14057

Species: Tetrahymena
Alias: 47.m00252, 57, 14057, PreTt14057, TTHERM_00426220
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: NAK,

Classification

Group: TKL
Family: TKL-ciliate1

Sequence

Name Sequence Type Origin Length Description Download
14057.AA Protein None 1926 None Fasta, JSON
14057.kin_dom Protein Kinase Domain None 267 None Fasta, JSON
14057.kin_dom2 Protein Kinase Domain None 211 None Fasta, JSON
14057.NA RNA None 5781 None Fasta, JSON

Protein domain

Protein domains of 14057.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Tet_res_leader 14057.AA Tet_res_leader 1-20 43 2.2e-10 39.96 Pfam 1-23 (23) Show / Hide 
Range on Protein: 1-20
Range on HMM: 1-23/23
Sequence Identity: 43% (10 aa)

MKTNKFRR-VQVKNG--DYGINL
||.||..| ||.|..  ...|.|
MKCNKCNRPVQCKHCLVQVSITL
Kinase 14057.AA TKL-ciliate1 220-437 39 1.2e-137 463.53 In-house 23-279 (279) Show / Hide 
Range on Protein: 220-437
Range on HMM: 23-279/279
Sequence Identity: 39% (101 aa)

YVCLLRKINIFQGSK--IDTKAAFRMI--------------LKDTEFG----IFVMEHCPKGSLDSICIRLPS--YALKEIQIMRIIRDILQGVQYLHMR
|.  ....|.|....  |..|...|.|              |....|.    ...||||.||....||.|..|  |..|....||...||.||.||||||
YDVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMR

QNPLIHRNLTMQNILLGEDNNYKITNFSYVTT---HRIQNDDFASLQNEIKKNTTEGYRAPEQI--HLQSGYPINEKVDIFAVGVILYILCFNKKPFQNQ
|||||||.|.|||||..|...|||.||..|..   |||.|..|...|||...|||....||||.  |....||||||.||.|.|...|||||.|.|||..
QNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQK

ISVLNEQVDIPDFP------------KYSANVNTVLQRMLCRDPNQRANSSELLSFV
.||.|.......||            ....|......|..|..||.|.|..|..  .
MSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase 14057.AA Ciliate-E2 253-434 21 8.8e-35 116.82 In-house 111-360 (365) Show / Hide 
Range on Protein: 253-434
Range on HMM: 111-360/365
Sequence Identity: 21% (55 aa)

FVMEHCPKGSLDSICI--RLPS-------YALKEIQIMRIIRDILQ---------------GVQYLHMRQNPLIHRNLTMQNILLGEDNNYKITNFSYVT
.||| |  |.| ....  .. .         ..| .| .|.. |||               ...||| . |  |||..  .|||.      ||. | . .
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----IKIIDFGLSK

THRIQNDDFA--SLQNEIKKNT------------------------TEGYRAPEQIHLQS------GYPINEKVDIFAVGVILYILCFNKKPFQNQISVL
   ..|..    .......                           | || ||| .  ..      . . ..|.||...|||||...|.| ||  |.  .
KYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--QQQIK

NEQVDIP----------------DFPKYSANVNTVLQR----MLCRDPNQRAN-SSELL
. ..|.|                .. | | ..   ...    ||..||..| .  ...|
QCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 14057.AA TKL 253-437 18 2e-31 110.4 In-house 115-364 (364) Show / Hide 
Range on Protein: 253-437
Range on HMM: 115-364/364
Sequence Identity: 18% (48 aa)

FVMEHCPKGS-LDSICIRLPSYALKEIQIMRIIRDILQGVQYLHMRQ------NPLIHRNLTMQNILLGEDNN--------------YKITNFSYVTTHR
.||| ||.|| |. .            |..|...|| .|..|||...       |.|||.|. .|||. |...               ||. |   ... 
IVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMS

IQNDDFASLQN-------------EIKKNTTEGYRAPEQIHLQ-------------SGYPINEKVDIFAVGVILYILCFNKKPFQ---------------
  ... ..  .              ...  | .. ||| .  |              |.. .||.|... |..|. ..  ..|..               
QSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEE

--NQISVLNEQVDIPDFPK----------YSANVNTVLQRMLCRDPNQRANSSELLSFV
   .... ...  ||. ..              .   .|.    ||..| . .|.|.  
MFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 14057.AA STE 254-437 19 1.6e-18 62.13 In-house 115-359 (359) Show / Hide 
Range on Protein: 254-437
Range on HMM: 115-359/359
Sequence Identity: 19% (51 aa)

VMEHCPKGSLDSICIRLPSYALK------------EIQIMRIIRDILQG-VQYLHMRQNPLIHRNLTMQNILLGEDNNYKITNFSYVT------------
.||... ||||.|  .  .                | || .|.|.||.|  .|||  .   ||| .  .||||      |...|   .            
CMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSN

-------THRIQNDDFASLQNEIKKNTTEGYRAPEQIHLQSGY---PINEKVDIFAVGVIL------YILCFNKKPFQNQISVLNEQ-------------
       |   ... |.  .          . ||| |  ...    . ..|.||  .|  .         ... .|...    ....             
NIIDCIETMQQKRNTFVGTP----------WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVN

VDIPDFP--------------------KYSANVNTVLQRMLCRDPNQRANSSELLS----FV
 ..| .|                    |.| . .  ... | .|||.|...|.||.    |.
GPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
S_TKc 14057.AA S_TKc 184-437 19 8.7e-15 39.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 184-437
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

RNPIDFLGNIQ--NVYKFEYNK--NKVCIYYSANNSSILQYVCLLRKINIFQGSKIDTKAAFRMILKDTEFGIFVMEHCPK--GSLDSICIRLPS----Y
   .. .|      |||   .|   .| |              ..| |.| .  . .    .  .  | ..  .|||.|.   |.| ..  . ..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

ALKEIQIMRIIRDILQGVQYLHMRQNPLIHRNLTMQNILLGEDNNYKITNFSYVTTHRIQNDDFASLQNEIKKNTTEGYRAPEQIHLQSGYPINE-KVDI
 . | .. .... |.....|.| .    ||| |  .|||| |  . ||. |   .                    |  |.||| .      . .  |.|.
PFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------GYGKCKCDW

FAVGVILYILCFNKKPFQNQISVLNEQVDIPDFPKYSANVNTVLQRMLCRDPNQRANSSELLS---------FV
 ..|.|||...  . ||. |. .. ...        |  .   ....|..||..|    |.|          ..
WSCGCILYEMLCGYPPFP-QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14057.AA TKL-Unique 252-380 26 6.1e-14 45.72 In-house 76-219 (290) Show / Hide 
Range on Protein: 252-380
Range on HMM: 76-219/290
Sequence Identity: 26% (38 aa)

IFVMEHCPKGSLDSICIR--------LPSYALKEIQIMRIIRDILQGVQYLHMRQNPLIHRNLTMQNILLGED-----NNYKITNFSYVTTHRIQNDDFA
..||| || |||..   .         ... |   |......|| ||  ||| .. | |||.|. .|.|. ..     .| ||  |. ...    |. ..
CIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN

SLQNEIKKNTTE---GYRAPEQIHLQSGYPINEKVDIFAVGVILY
.  .  .. | .    ..||| .     . ..||.|... |..|.
NEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSEKSDVYSFGIVLW
Kinase 14057.AA Pkinase 349-437 18 1.3e-13 49.27 Pfam 174-293 (293) Show / Hide 
Range on Protein: 349-437
Range on HMM: 174-293/293
Sequence Identity: 18% (22 aa)

TEGYRAPEQIHLQSGYPINEKVDIFAVGVILYILCFNKKPFQNQ------------ISVLNEQVDIPDFPKYS-------------------ANVNTVLQ
| .|.|||   ...| ..  |||....|.|||.... . ||...              ..  ... . . ..|                    .   .. 
TPWYMAPEV--IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

RMLCRDPNQRANSSELLSF--V
..||.||..| .  ..|    .
WCLCKDPKKRPTAEQILQHPWF
Kinase 14057.AA MLK 254-324 27 1.6e-09 29.36 In-house 88-177 (291) Show / Hide 
Range on Protein: 254-324
Range on HMM: 88-177/291
Sequence Identity: 27% (25 aa)

VMEHCPKGSLDSICIRLPS------------YALKEIQIMRIIRDILQGVQYLHM-RQNPLIHRNLTMQNILLGE------DNNYKITNF
||| |..||| ...   .|               .  ..|..  .. .|..|||.  . |.||| |  .|||. |      . . ||. |
VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF
Kinase 14057.AA TK 254-324 14 3e-06 16.3 In-house 133-295 (486) Show / Hide 
Range on Protein: 254-324
Range on HMM: 133-295/486
Sequence Identity: 14% (24 aa)

VMEHCPKGS----LDSICIRLPSY--------------------------------------------------------------------------AL
|||..|.|.    |..   . . .                                                                           |
VMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQL

KEIQIMRIIRDILQGVQYLHMRQN----PLIHRNLTMQNILLGEDNN-----------YKITNF
   | . . ..| .| .||| ..      ..||.|   |.|.||.|.            ||. |
TMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADF
Kinase 14057.AA Dicty4 254-324 30 8e-06 15.54 In-house 80-158 (277) Show / Hide 
Range on Protein: 254-324
Range on HMM: 80-158/277
Sequence Identity: 30% (24 aa)

VMEHCPKGSLDSICIRLPSYALKEIQIM--RIIR------DILQGVQYLHMRQNPLIHRNLTMQNILLGEDNNYKITNF
|.| .|||.| |.    ||   ..|..   .|.|      |. .|...|| .    ||| |   |.|  .... |.. |
VTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF
Kinase 14057.AA Pkinase 253-322 27 3.4e-05 19.43 Pfam 77-154 (293) Show / Hide 
Range on Protein: 253-322
Range on HMM: 77-154/293
Sequence Identity: 27% (22 aa)

FVMEHCPKG----SLDSICI--RLPSYALKEIQIMRIIRDILQGVQYLHMRQNPLIHRNLTMQNILLGEDNNY----KIT
.|||.|..|    .| ..    |  .. . | .. .... ||.|..|.| .    ||| |  .|||. ....     ||.
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKIC
Kinase 14057.AA Pkinase_Tyr 254-322 29 0.000899 13.4 Pfam 85-153 (270) Show / Hide 
Range on Protein: 254-322
Range on HMM: 85-153/270
Sequence Identity: 29% (21 aa)

VMEHCPKGSLDSICIRL--PSYALKEIQIMRIIRDILQGVQYLHMRQNPLIHRNLTMQNILLGEDNNYKIT
|||..|.|.|..   .   .  .|.  ..  . ..| .| .||. ..  .||| |   |.|..|.|  ||.
VMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKIC
Kinase 14057.AA DRK 254-321 29 0.069494 2.21 In-house 75-139 (258) Show / Hide 
Range on Protein: 254-321
Range on HMM: 75-139/258
Sequence Identity: 29% (20 aa)

VMEHCPKGSLDSICIRLPSYALKEIQIMRIIRDILQGVQYLHMRQNPLIHRNLTMQNILLGEDNNYKI
.||  |.||| .|    .|  .    ....  |.  |. ||| .    ||| |   | |   | ....
CMEYMPRGSLYNI-LHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLV--DEHWQV
Kinase 14057.AA Dicty5 279-324 34 0.187524 0.76 In-house 105-148 (260) Show / Hide 
Range on Protein: 279-324
Range on HMM: 105-148/260
Sequence Identity: 34% (16 aa)

QIMRIIRDILQGVQYLHMRQNPLIHRNLTMQNILLGEDNNYKITNF
|.. .  || |. ..||      ||| |   |.|. |.   ||  |
QQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITENWKIKIIDF
Kinase 14057.AA TKL-ciliate1 1552-1815 50 2.3e-191 642.05 In-house 1-279 (279) Show / Hide 
Range on Protein: 1552-1815
Range on HMM: 1-279/279
Sequence Identity: 50% (142 aa)

ITFGKKIGSGHSGKVFSGVFNSVEVAIKEMEVNNLNE--RNQKEFQREIETLVKISPQINLVSLIGVAQKKDNFYIITELCHGGTMFDLLHRKHS--VPI
||.|.||||||...|..|..||..|||..|...|..|  .|||||||||....||...|||..|.|......|||||.|.||.|||||..|||||  ..|
ITMGQKIGSGHFCNVYKGRCNSYDVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMI

PWLHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDY-HVKIADFGLARTESKDEM---TQVLGTFHWMAPEVFD-----NKQYTIKA
.|.||...|||||.||.|||....|.||||||..|.|.|.|||...... |||||||...|..|...|   .|...||||||||..|     |.....|.
KWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKI

DVYSYAIVLWEFISRKTPY-QKMSTVDIMKNVCEGK-RPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERL
|.|.|.||......||||. ||||...||...||.. ||.|||.||..|||.....||..||.|.|||||.|.|....|
DIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase 14057.AA TKL 1558-1815 28 5.1e-100 338.58 In-house 1-364 (364) Show / Hide 
Range on Protein: 1558-1815
Range on HMM: 1-364/364
Sequence Identity: 28% (107 aa)

IGSGHSGKVFSGVFNS----------VEVAIKEMEVNNLNERNQKE-----------------------FQREIETLVKISP-QINLVSLIGVAQKKDN-
||||..|.|. |...            .||.| . ..| .|.. ..                       |..| |......    |.|...|...  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FYIITELCHGGTMFDLLHRKHSVPIPWLHRVKMCKDIATGMIYLHSLE------PPIIHRDLKSLNLLLDVPYQEDSFDYH-------
            ..|..|.|.||. ...||        | .|.....||| || |||| .      |||||||||| |.|.|  .. .| .|        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADW

-VKIADFGLARTESKDE---------------------MTQVLGTFHWMAPEVFDNK----------------QYTIKADVYSYAIVLWEFISRKTPYQ-
 .||.||||.|. |...                        . ||. ||||||....                .|. |.||||..||||| ..|..||. 
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

-KMSTVDIM-------KNVC-EGKRPGLGPE-------FIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERL
 ........       . || .|.|| . |.         ..|||||...||.|||..||.||| | |.|.||
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 14057.AA TKL-Unique 1554-1815 36 8.6e-89 301.29 In-house 1-290 (290) Show / Hide 
Range on Protein: 1554-1815
Range on HMM: 1-290/290
Sequence Identity: 36% (109 aa)

FGKKIGSGHSGKVFSGVFNSVEVAIKEMEV-NNLNERNQKEFQREIETLVKISPQINLVSLIGVAQ----KKDNFYIITELCHGGTMFDLLHR-------
|..|||.| .|.|. |.... .||||  .. . .. .  .|| .|. .. |. . .|.| ..|.      .  |..|..| | ||.  |.||.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-KHSVPIPWLHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQE-DSFDYHVKIADFGLARTESKD-EMTQV----------LGTFHWMAPEV
 . . ..... |||| .||| ||.|||..|||||||||||.|.|.|   ..  .  . .||.||||... ||. .||            .|.| ||||||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD---NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

FDN--KQYTIKADVYSYAIVLWEFISRKT------PYQKMSTVDIMKNVCE---GKRPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERL
. .  .||..|.||||..||||| ..||       |||.|.   . . | .   ..||      || .||... ||...|| .|| .|| | |...||
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRP-----PIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 14057.AA MLK 1552-1815 32 1.6e-84 287.11 In-house 1-291 (291) Show / Hide 
Range on Protein: 1552-1815
Range on HMM: 1-291/291
Sequence Identity: 32% (98 aa)

ITFGKKIGSGHSGKVFSGVFNSVE-----VAIKEMEVNN----LNERNQKEFQREIETLVKISPQIN----LVSLIGVAQKKDN-FYIITELCHGGTMFD
|.| ..||||..|||..|..   .     ||.|. . .       .  |..|..|.. | ..| . |     . . || ..  . |.|..| | || ...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILS-HPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHRKHS------------VPIPWLHRVKMCKDIATGMIYLHSLEP-PIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLARTESKD-E-MTQVLGTFH
.|| . |            . ..  | .. ....| || ||||..| ||||||||| |.|.|    .|  . ..||.|||..|  ..  . |.   ||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA

WMAPEVF---DNKQYTIKADVYSYAIVLWEFISRKTPYQ-KMS-TVDIMKNVCEGKRPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERL
||||||.    . .|..|.||.|...|||| ..|..||.  ..    ..... .|.|| ....     ||...  |||.||.|||.|||.||.... |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 14057.AA Dicty4 1552-1817 36 1.4e-79 265.06 In-house 1-277 (277) Show / Hide 
Range on Protein: 1552-1817
Range on HMM: 1-277/277
Sequence Identity: 36% (106 aa)

ITFGKKIGSGHSGKVFSGVFNSVEVAIKEMEVNNLN--ERNQKEFQREIETLVKIS-PQINLVSLIGVAQ----KKDNFYIITELCHGGTMFDLLHR---
|.....||.|. |.|. |     |||.| .  .| |  |   .|| .|.. . ||. |  |.. . |       ..  . | ||... |. . |||    
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHP--NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

--KHSVPIPWLHRVK---MCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLAR-----TESKDEMTQVLGTFHWMAPEVFDN
  . |....|  . .   |..|.| ||..||.  | |||||||| ||| |        .. ||..||||..     .. || .. . ||  ||||||  .
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDK-------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH

KQYTIKADVYSYAIVLWEFISRKTPYQ--KMSTVDIMKNVCE-GKRPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLER--LEY
. |. ||||||..|||||   |. |||   |... .   ||. . ||      ||..||||...|...||. ||..|| | |...|  || 
QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRP-----PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 14057.AA Dicty5 1552-1819 37 3.4e-76 259.44 In-house 1-260 (260) Show / Hide 
Range on Protein: 1552-1819
Range on HMM: 1-260/260
Sequence Identity: 37% (103 aa)

ITFGKKIGSGHSGKVFSGVFNSVEVAIKEMEVNNLNERNQKEFQREIETLVKISP--QINLVSLIGVAQKKDNF-YIITELCHGGTMFDLLHRKHS---V
. |.. | || ||.|..|...   ||||.    |    .  ||.||. |.. |.     |..   |  |. |.  ...||.|| |..|..|  .      
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREV-TIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQ

PIPWLHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLAR-TESKDEMTQVLGTFHWMAPEVFDNKQYTIKADVYSYA
|| .  .. |  ||| .| .|||    ||||||||.| |.         .. .|| |||  |  . . .||  .||  |||.|.|  . |. |.||||..
PIAYFQQLHMAIDIAQSMRHLHSMN--IIHRDLKSMNFLITE-------NWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFG

IVLWEFISRKTPYQKMSTVDIMKNVCEGKRPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERLEYIE
||||| . ||.||  .   .|   |  | ||      |||||| .   | | || | | .|| | |... .| | 
IVLWEMFTRKEPYDNINNWNIPVMVMKGERPT-----IPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 14057.AA Pkinase_Tyr 1552-1815 31 3.2e-69 235.06 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1552-1815
Range on HMM: 1-270/270
Sequence Identity: 31% (91 aa)

ITFGKKIGSGHSGKVFSGVFN------SVEVAIKEMEVNNLNERN--QKEFQREIETLVKISPQINLVSLIGVAQ-KKDN--FYIITELCHGGTMFDLLH
||||||.|.|. |.|. |. .       ..||.| .  ..  ...  ...| ||.... ..    |.|.|.||   ...    ||..|.. .| . | |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RK--HSVPIPWLHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLARTESKDEMT-QVLG----TFHWMAPEVFDNKQ
..     |..  . ..|| .|| || ||.|    .|||||   | |..        . .|||.||||||.  .|.   .. |       |||||.. .. 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

YTIKADVYSYAIVLWEFIS-RKTP-YQKMSTVDIMKNV-CEGKRPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERL
.|.| ||.|. ...|| ..  ..| |. ||  .... .  .| |     .  |..||. . ||||.||..||..|| |.|..|.|
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR----MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 14057.AA TyrKc 1552-1815 29 3.2e-67 230.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 1552-1815
Range on HMM: 1-280/280
Sequence Identity: 29% (87 aa)

ITFGKKIGSGHSGKVFSGVFNSVEVAIKEMEVNNLNERNQKEFQREIETLVKI-SPQINLVSLIGVAQKK-------DNFYIITELCHGGTMFDLLHRKH
||.|||.|.|. |.|. |. . ..||.| .  .      ...| ||.. . |.     |.| |.||. ..       .  .|..|.. .|   | |....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

SVPIPWLHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLARTESKD-------EMTQV----LGT----FHWMAPEV
   ... . ...| .|| || ||||   ..|||||   | |.. ..       .|||.||||.|    |       ..  .     |       |||||.
PK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

FDNKQYTIKADVYSYAIVLWEFISR-KTPYQK-----MSTVDIMKNVCEGKRPGLGPE-----FIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERL
.. . .|.| ||.|. ...||  .. ..||       ||  .....| .|.|.   |.     |    ||. . ..||.||. ||..|| |.|. |..
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 14057.AA DRK 1552-1817 40 5.6e-66 222.44 In-house 1-258 (258) Show / Hide 
Range on Protein: 1552-1817
Range on HMM: 1-258/258
Sequence Identity: 40% (111 aa)

ITFGKKIGSGHSGKVFSGVFNSVEVAIKEMEVNNLN-ERNQKEFQREIETLVKIS-PQINLVSLIGVAQKKDNFYIITELCHGGTMFDLLHRKHSVPIPW
|  |  || |  | || |     .||.| .   | | |   .||.|||. . .   |  | .  .|         |..|    |     ||   |. . |
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHP--NICQFMGTCNNPPDICICMEYMPRGSLYNILH-DESIEMDW

LHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLAR----TESKDEMTQVLGTFHWMAPEVFDNKQYTIKADVYSYAI
  . .|  |.| ||||||. .| |||||||| ||| |  .|       ||.|||||.      ...       ||  | ||||  |  || ||||||.||
PLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQ-------VKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAI

VLWEFISRKTPYQKMSTVDIMKNVCE-GKRPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLERLEY
|||| . |. ||. | |  .   |   | ||      .|. |||  | ||.|||. ||  || . |.||||| 
VLWECVTRQDPYFGMPTFQVVFSVGRHGMRP-----PMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 14057.AA Pkinase 1552-1815 26 9.9e-65 226.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1552-1815
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

ITFGKKIGSGHSGKVFSGVFNSVE--VAIKEMEVNNLNERNQKEFQR--EIETLVKI-SPQINLVSLIGVAQKKDNFYIITELCHGG----TMFDLLHRK
...|.||||| .|.|. ..  . .  ||.|.... . ..  ...  |  ||. . .. .| |  | |... . ||. |...|.| ||      ||.....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNI--VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

HSVPI--PWLHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLAR---TESKDEMTQVLGTFHWMAPEVFD-NKQYTI
 . ..  .. .  .... |. |. |.||    |||||||. |.|.|  .. |.   .|||.|||||.   . ..  || . || ..|||||   .. |. 
RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KADVYSYAIVLWEFISRKTPYQKM----STVDIMKNVCEGKRPGLGPEFIPKDC------------------PPSLIDLMKDCWEQDPNKRPDFREVLER
|.|..|. ..|.|......|..      . .| |. .|. ..| |  ..  ...                  .....|..|.|...||.||| ....|. 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase 14057.AA TK 1552-1815 17 2.2e-64 214.49 In-house 1-486 (486) Show / Hide 
Range on Protein: 1552-1815
Range on HMM: 1-486/486
Sequence Identity: 17% (85 aa)

ITFGKKIGSGHSG---KVFSGVFNS---------------------------VEVAIKEMEVN-NLNERNQKE--------------FQREIETLVK-IS
||.|||.|.|. |   .|. |  ..                           ..||.| .    . ... ...              . .|.. .   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PQINLVSLIGVAQKKDN------------FYIITELCHGGT----MFDLLH--RKHSVP-----------------------------------------
   |.|.|.||  ....            ..|..|....|       | |.  |..  .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPWLHRVKMCKDIATGMIYLHSLEP----PIIHRDLKSLNLLLDVPYQE----DSFDYHVKIADFG---
                               ..  ... || .|| || ||||.       ..||||   | |..  ..     | . ...||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARTESKDEMTQVLGTFH----------------------------WMAPEVFD---------NKQYTIKADVYSYAIVLWEFIS--RKTPYQKM
     |||   .|.   . ..                              |||||...         .. .|.| ||.|. ...||  .  ....|  |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

ST---------VDIMKNVCEGKRP--------GLGPEFIP-KDCPP-------------SLI-DLMKDCWEQDPNKRPDFREVLERL
|           ..|.....| |.        | . .  . ..||.              .. |||..||. ||..||.|....|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 14057.AA S_TKc 1552-1818 29 1.9e-62 214.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 1552-1818
Range on HMM: 1-231/231
Sequence Identity: 29% (82 aa)

ITFGKKIGSGHSGKVFSGVFNS--VEVAIKEMEVNNLNERNQKEFQREIETLVKISPQINLVSLIGVAQKKDNFYIITELCHG--GTMFDLLHRKHS---
 ....|||.|  |||. .. ..   .||||..          . ..|||. | |     |.| |..| |  |..|...|.| |  |..||..... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-VPIPWLHRVKMCKDIATGMIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHVKIADFGLARTESKDEMTQVLGTFHWMAPEVFDNKQYTI-KADVYS
 .|.|  |  .... |. .. |.||.   |||||||  |.|||          |.||.||||||       | . || ..|||||.   .|.  |.|..|
RFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWS

YAIVLWEFISRKTPYQKMSTVDIMKNVCEGKRPGLGPEFIPKDCPPSLIDLMKDCWEQDPNKRPDFREVLE------RLEYI
  ..|.|......|..      ..|...                .|...|... |.. ||.|||   |.|.        ...
CGCILYEMLCGYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14057.AA STE 1552-1818 22 6.7e-51 175.42 In-house 1-359 (359) Show / Hide 
Range on Protein: 1552-1818
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

ITFGKKIGSGHSGKVFSG---------VFNSV--------EVAIKEMEVNNLN---------------ERNQKEFQREIETLVKISP-QINLVSLIGVAQ
 .. .|||.| .|.|. .           . |         .|||.|...| |               . .......||... | ..   | |  .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KK-------DNFYIITELCHGGTMFDLLHRKHSV------------PIPWLHRVKMCKDIATG-MIYLHSLEPPIIHRDLKSLNLLLDVPYQEDSFDYHV
|.       |. .|. |.. ||.  |....|...            ..|     ..|..|  | . ||||.   |||||.|. | ||            |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------------V

KIADFGLAR--TESKD----------------EMTQVLGTFHWMAPEVFDN------KQYTIKADVYSYAIVLWEFISRKTPY---QKM---STVDIMKN
|..|||..   |.| .                . . . ||  |||||| ..      |.|..|.|..|  ....| .  | |.   . |       ... 
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

VCE---------GKRPGLGPEFI--------------PKDCPPSLIDLMKDCWEQDPNKRPDFREVLER-LEYI
...         |. | | ...               |. . |...| .. | . ||||||.  . |.   . |
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 14057.AA Ciliate-E2 1552-1813 19 2e-40 136.5 In-house 1-361 (365) Show / Hide 
Range on Protein: 1552-1813
Range on HMM: 1-361/365
Sequence Identity: 19% (74 aa)

ITFGKKIGSGHSGKVFSGVFNSV--------------------EVAIKEMEVNNLNERNQKEFQREIETLVKISP---------------QINLVSLIGV
. | ||||.|  |.|. .   .|                    .|.||. ......... ... .||  . .| .                 |.. .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

AQ--KKDNFYIITELCHGGTMFDLL-HRKHS--------VPIPWLHRVKMCKDIAT---------------GMIYLHSLEPPIIHRDLKSLNLLLDVPYQ
 |  ...|.|...|.| ||..||.. ..|..         .. . .. .. | |.                .. ||||  . |||||.|  |.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

EDSFDYHVKIADFGLARTESKD-----------EMTQVL-----------------------GTFHWMAPEVFDNKQ---------YTIKADVYSYAIVL
       .||.||||..  ..|           ....                         || . ||||.. .|.         |. |.|..|  ..|
-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

WEFISRKTPYQKMSTVDIMKNVCEGKRPGLGPEF------------IPKDCPPSLIDLMKD----CWEQDPNKRPD-FREVLE
 |... |.|.        ... ...|     ||.            ..|..... .||.|     . . ||.||.. . ..|.
YEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN