Gene 14484 (Tetrahymena)

14484

Species: Tetrahymena
Alias: 14484, 982, 3825.m02853, TTHERM_00037490, 2.m02172, PreTt14484
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-E6,

Classification

Group: Other
Family: Ciliate-E6

Sequence

Name Sequence Type Origin Length Description Download
14484.AA Protein None 1766 None Fasta, JSON
14484.kin_dom Protein Kinase Domain None 95 None Fasta, JSON
14484.kin_dom2 Protein Kinase Domain None 207 None Fasta, JSON
14484.NA RNA None 5301 None Fasta, JSON

Protein domain

Protein domains of 14484.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14484.AA Ciliate-E6 66-218 53 9.5e-100 317.5 In-house 1-154 (154) Show / Hide 
Range on Protein: 66-218
Range on HMM: 1-154/154
Sequence Identity: 53% (82 aa)

ALSLKSCNHENIAKYLGEFQIQENYFILLESFEMNLIDWQVQNKLNKKINRK-TFIQFALQLFHALEHIHSKNYVLQKLALRNIYLDKDYNIKLSDFGFP
. .||.|||.||.||...|||...|||..|..||||.||. |.|..|.||.. .|..|..|||||.|..||||||||...|.||.|||..|||..||||.
IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ

QEVIPSQLSRQFMDQKADNIQFYLPPELLDISKDKIAKQKKVLQENEGDIWVVS
|..||.|....||.||..|...|.|||..|.|||...|..||....|||||.|.
QCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC
Kinase 14484.AA Ciliate-A2 33-256 37 1.1e-44 152.99 In-house 16-249 (272) Show / Hide 
Range on Protein: 33-256
Range on HMM: 16-249/272
Sequence Identity: 37% (89 aa)

NDNQNQYSIKVISLHQNDGEQMSQQKLEYAKQLALSLKSCNHENIAKYLGEFQIQENYFILLESF-EMNLIDWQVQNKLN--KKINRKTFIQFALQLFHA
|.|  .| ||..|.    .   |||||  .|  |..|| |||.|| || .||||  .|||  |   |..| || .. . |  |.|... |. ||.|.  |
NHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDW-IDKFQNQQKFIPDHQFVHFACQILDA

LEHIHSKNYVLQKLALRNIYLDKDYN-IKLSDFGFPQEVIPSQLSRQFMDQKADNIQFYLPPELLDI---SKDKIAKQKKVLQENEGDIWVVSICLYALT
.|..|.|||||  | |||| .|.|.. ||| |||.  .. |.. | .| ..      || |||..     . . . |.... |  .||||.  ||||.| 
IEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFMGDIWAFGICLYQLG

GPTLQFIKKFT----EGSAFYIFYEEIDQDINKVL
|...|. .|.|    ..   |  |   |. .|. .
GADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQII
Kinase 14484.AA TK 43-162 12 9.6e-09 24.64 In-house 57-296 (486) Show / Hide 
Range on Protein: 43-162
Range on HMM: 57-296/486
Sequence Identity: 12% (29 aa)

VISLHQNDGEQMSQQKL-------------EYAKQLALSLK-SCNHENIAKYLGEFQIQEN------------YFILLESFE-MN----LIDWQVQNKLN
|  |.  |.... ....             | |  ... .   ..|.|| . .|    .|.            . |..|  .  .    | |.  ... .
VKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPK

KK-------------------------------------------------------------------------INRKTFIQFALQLFHALEHIHSK--
..                                                                         .. .. . ...|.  ..|..|||  
FQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNC

----NYVLQKLALRNIYLDKDYN-----------IKLSDFG
    |.|   || ||. ......           .|..|||
EFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase 14484.AA Ciliate-E2-Unclassified 33-194 19 3.2e-07 21.1 In-house 20-239 (352) Show / Hide 
Range on Protein: 33-194
Range on HMM: 20-239/352
Sequence Identity: 19% (43 aa)

NDNQNQY-----SIKVISLH-----QNDGEQMSQQKLEYAKQ---------LAL-SLKSCNHENIAKYLGEFQIQENYFILLESFEM-NLIDWQV-----
...|.||      .|... .     ..| | | ..| .  |.         ..  .|....|..| |.. .|| ..| .| .| .|  .|...       
HKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQ

--------QNKLNKKINRKTFIQ------FALQLFHALEHIHSKNYVLQK-LALRNIYLDKDY---NIKLSDFGFPQEVIPS------------QLSRQF
        .|....||     ..      .. |.  .||..|.|| ..   . . || .|..    .||..|||.  . . .            ....| 
KQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQM

MDQKADNIQF---YLPPELLD
|.... ....   |..||.|.
MWTFCGTPNYMPQYTAPEVLQ
Kinase 14484.AA TKL-Unique 108-193 19 2.1e-05 15.2 In-house 101-198 (290) Show / Hide 
Range on Protein: 108-193
Range on HMM: 101-198/290
Sequence Identity: 19% (19 aa)

NKLNKKINRKTFIQFALQLFHALEHIHSKN--YVLQKLALRNIYLDKD-----YNIKLSDFGFPQEVIPSQLSRQFMDQK-----ADNI--QFYLPPELL
|. |.|.| . ....|..   .....|...      .|  .|...| .     .|||..|||..   . |. .. .   .     ....   ....||.|
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK--FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL
Kinase 14484.AA C8 121-221 26 4e-05 13.86 In-house 127-226 (226) Show / Hide 
Range on Protein: 121-221
Range on HMM: 127-226/226
Sequence Identity: 26% (28 aa)

QFALQLFHALEHIHSKNYVLQKLALRNIY--LDKDYN--IKLSDFGFPQEVIPSQLSRQFMDQKADNIQFYLPPELLDISKDKIAKQKKVLQENEGDIWV
. |.|.   .. ||.|| . ... . |.   ||. |.  |||.||||   |  .. . |  . ..   . |. || .   .|.  || .     . |.. 
IIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKK-QDNQYKQYRI----QSDLFS

VSICL
| . |
VGLVL
Kinase 14484.AA TKL 41-163 12 4.9e-05 14.09 In-house 31-200 (364) Show / Hide 
Range on Protein: 41-163
Range on HMM: 31-200/364
Sequence Identity: 12% (23 aa)

IKVISLHQNDG--------------------EQMSQQKLEYAKQLALSLKSCNHENIAKYLGEFQIQEN-------------YFILLE-----SFEMNLI
.|... |..|                     ......  .  .. ........|.|| ...|  .  ..             ..|  |     | . .|.
VKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH

DWQVQNKLNKKINRKTFIQFALQLFHALEHIHS--------KNYVLQKLALRNIYLDKDYN--------------IKLSDFGF
                ....||.   .... ||        .. .   |  .|| .|....              .|..|||.
-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL
Kinase 14484.AA Dicty4-Unclassified 120-162 34 7.8e-05 12.44 In-house 112-154 (263) Show / Hide 
Range on Protein: 120-162
Range on HMM: 112-154/263
Sequence Identity: 34% (15 aa)

IQFALQLFHALEHIHSKNYVLQKLALRNIYLDKDYNIKLSDFG
| .|.     . | |..| .   .   || .||..|||  |||
IKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFG
Kinase 14484.AA TBCK 69-164 25 0.00035 10.75 In-house 28-131 (346) Show / Hide 
Range on Protein: 69-164
Range on HMM: 28-131/346
Sequence Identity: 25% (27 aa)

LKSCNHENIAKYLGEFQIQ---ENYFILLESFEMNLID-WQVQNKLNKKINRKTFIQFALQLFHALEHIHSKNYVLQKLALRNIYLDKDY----NIKLSD
|||  |.| . ||     .   |   .  |  .||| |   .. |  . .   .   .. |   .|   |... |   | . ||||| .      .||. 
LKSLQHPNLCQYLDFSRGKIHHERMIVVMEHYKMNLEDQIEIYAKRHTPKDCSQILCIYYQILCGLSYMHKHHIVHRFLHPHNIYLDDNGNQKLHVKLAN

FGFP
.| .
YGLY
Kinase 14484.AA Ciliate-E2 52-193 19 0.031695 3.42 In-house 53-259 (365) Show / Hide 
Range on Protein: 52-193
Range on HMM: 53-259/365
Sequence Identity: 19% (42 aa)

EQMSQQKLEYAKQLALSLK----------------SCNHENIAKYLGEFQ--IQENYFILLESFEM-NLIDWQVQNKLN--------KKINRKTFIQFAL
..|.....|. ||    ..                . || || |.   ||   ..|... .| ..  .| |.  .||..        |... |  ...  
KIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMK

QLFH---------------ALEHIHSKN-YVLQKLALRNIYLDKDYNIKLSDFGFPQEVIPS-------QLSRQFMDQKADN------------------
|..                |||..||||  .   . . || .     ||..|||. ... ..       |..  .|. | |.                  
QILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNT

---IQFYLPPELL
      |..|| |
ICGTPGYMAPEIL
TPR_1 14484.AA TPR_1 365-398 38 8.6e-10 38.16 Pfam 1-34 (34) Show / Hide 
Range on Protein: 365-398
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

AIVYKQLGHCYFNLKQYEIAIENLKKSIEYNPEY
| ....||.||.....|. ||| ..| .| ||..
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR 14484.AA TPR 365-398 35 4.6e-09 37.36 SMART 1-34 (34) Show / Hide 
Range on Protein: 365-398
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

AIVYKQLGHCYFNLKQYEIAIENLKKSIEYNPEY
| ....||.||.....|. ||| ..|..| .|..
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 14484.AA TPR_2 331-364 32 3.3e-08 33.14 Pfam 1-34 (34) Show / Hide 
Range on Protein: 331-364
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

YYCLNLIGNNYLENKQYEEAIDYYKKSINIFPEN
 ......|. |.....|.|||.||.|.. ..|.|
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 331-364 32 7.9e-08 33.26 SMART 1-34 (34) Show / Hide 
Range on Protein: 331-364
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

YYCLNLIGNNYLENKQYEEAIDYYKKSINIFPEN
. ... .|| |. ...|.|||..|.|.. . |.|
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 331-364 32 2.2e-07 29.77 Pfam 1-34 (34) Show / Hide 
Range on Protein: 331-364
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

YYCLNLIGNNYLENKQYEEAIDYYKKSINIFPEN
.  .. .|| |.. ..|.|||..|.| . . |.|
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_1 14484.AA TPR_1 436-466 51 3.8e-07 28.95 Pfam 4-34 (34) Show / Hide 
Range on Protein: 436-466
Range on HMM: 4-34/34
Sequence Identity: 51% (16 aa)

FFNLGTIYFKEMYYEKSIKCYQKCIELNPNK
..||| .|.|   |.. |.||||..||||| 
WYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 365-398 32 5.2e-07 28.89 Pfam 1-34 (34) Show / Hide 
Range on Protein: 365-398
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

AIVYKQLGHCYFNLKQYEIAIENLKKSIEYNPEY
| .. .|| ||.....|. ||| ..|.....|..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 433-466 44 1e-06 29.45 SMART 1-34 (34) Show / Hide 
Range on Protein: 433-466
Range on HMM: 1-34/34
Sequence Identity: 44% (15 aa)

CLPFFNLGTIYFKEMYYEKSIKCYQKCIELNPNK
   ..||| .|.|   |.. |.||||..||.|| 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 14484.AA TPR 467-500 32 1.5e-05 25.64 SMART 1-34 (34) Show / Hide 
Range on Protein: 467-500
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

TNAYINLGANYCRQNLFKQALIYFEKASEVDPLS
  |. |||  | ... ...|. ...|| |.||  
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 14484.AA TPR_2 433-466 35 2.4e-05 23.0 Pfam 1-34 (34) Show / Hide 
Range on Protein: 433-466
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

CLPFFNLGTIYFKEMYYEKSIKCYQKCIELNPNK
    .||| .|.|   |.. |..|.|...|.|| 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_2 14484.AA TPR_2 467-500 38 6.1e-05 21.58 Pfam 1-34 (34) Show / Hide 
Range on Protein: 467-500
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

TNAYINLGANYCRQNLFKQALIYFEKASEVDPLS
  |. |||  | .|. ...|. |.||| . ||  
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 14484.AA TPR_1 467-500 29 0.000115 20.27 Pfam 1-34 (34) Show / Hide 
Range on Protein: 467-500
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

TNAYINLGANYCRQNLFKQALIYFEKASEVDPLS
 .|. |||. | ... ...|. ...|| |..|  
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 297-330 29 0.000591 18.08 Pfam 1-34 (34) Show / Hide 
Range on Protein: 297-330
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

FIDKYNKARNLYSDGRFQESIQLLKEAFKIDPSS
.   || .. .|  |...| |.....| |.||  
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 399-432 32 0.029989 13.97 SMART 1-34 (34) Show / Hide 
Range on Protein: 399-432
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

SHAFYLLGVGYEILSDIENSVVNYFKASTLCPQQ
. |.| ||. |. . |..  .  | || .| |. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 14484.AA TPR 297-330 26 0.035003 13.38 SMART 1-34 (34) Show / Hide 
Range on Protein: 297-330
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

FIDKYNKARNLYSDGRFQESIQLLKEAFKIDPSS
    ||..  .|. |...| |. ...| ..||. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 301-330 26 0.082249 10.31 Pfam 5-34 (34) Show / Hide 
Range on Protein: 301-330
Range on HMM: 5-34/34
Sequence Identity: 26% (8 aa)

YNKARNLYSDGRFQESIQLLKEAFKIDPSS
||..  .|. |...| |. ...| ...|. 
YNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_1 14484.AA TPR_1 399-432 29 0.303655 8.33 Pfam 1-34 (34) Show / Hide 
Range on Protein: 399-432
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

SHAFYLLGVGYEILSDIENSVVNYFKASTLCPQQ
. |.| ||. |. . . .  .  | ||  | |. 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_1 14484.AA TPR_1 510-525 25 49.01663 0.62 Pfam 10-25 (34) Show / Hide 
Range on Protein: 510-525
Range on HMM: 10-25/34
Sequence Identity: 25% (4 aa)

ACMKLQRHDHAISYFK
...|....| || ...
CYYKMGNYDEAIECYQ
Kinase 14484.AA Ciliate-E6 638-777 51 5.7e-94 298.89 In-house 1-154 (154) Show / Hide 
Range on Protein: 638-777
Range on HMM: 1-154/154
Sequence Identity: 51% (79 aa)

AQNLRECNHQSILKYIEEFQIDKYYLVVMER-------------LKKKINRN-QFLKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQNVKICDFNIS
.|||..|||..||||...|||..||..||||             .||.||.| ||.|....||.|.|||||||..|||.|||||.||...|.|||||...
IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ

QEIIPSIATQEFFASKTYNLEFYLPPELYDSSKNQSAKQSKIFQEKEGDIWSAG
|.|||...|.||.|.|..|...|.|||..|.||.|..|..|.....||||||..
QCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC
Kinase 14484.AA Ciliate-A2 606-837 32 1.5e-38 131.47 In-house 17-272 (272) Show / Hide 
Range on Protein: 606-837
Range on HMM: 17-272/272
Sequence Identity: 32% (83 aa)

DKDRQFSIRAFCLASDQNSDISDDKLKSAKQFAQNLRECNHQSILKYIEEFQIDKYYLVVMERL---------------KKKINRNQFLKIALDLFKALE
..  .. | .. .    .. ||  ||...|  || |..|||. | || .||||. ||  .||                 .|.|.. ||...|. . .|.|
HNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIE

YLHSKNLLLQNLTLKNIYLDQDQN-VKICDFNISQEIIPSIATQEFFASKTYNLEFYLPPELYDS---SKNQSAKQSKIFQEKEGDIWSAGMCLYALTGV
|||.||  | .| |.|| .|||.. .| ||| .  .. |.|..| | .|      || |||..     .     |. .| | ..||||  | |||.| |.
YLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFMGDIWAFGICLYQLGGA

TLLFIKRLT----KGTGFFLFQEKLDKDISQFLMNIFWQNPKLRP-SISDLIDSIQ
.. . . ||    |.   .    .||. ..| . .|  . ||.|| ||  ... ..
DQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH
Kinase 14484.AA Ciliate-E2-Unclassified 641-783 20 9.9e-18 58.09 In-house 75-263 (352) Show / Hide 
Range on Protein: 641-783
Range on HMM: 75-263/352
Sequence Identity: 20% (40 aa)

LRECNHQSILKYIEEFQIDKYYLVVMERL----------------------------KKKINRNQFL-----KIALDLFKALEYLHSKN-LLLQNLTLKN
|. ..|  |.|....|| ...   ||| .                            .|..  .| .     ...  . ..|||||.||  .  .... |
LLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPEN

IYLDQDQ---NVKICDFNISQEIIPS------------IATQEFFASKTYNLEF---YLPPELYDSSKNQSAKQSKIFQEKEGDIWSAGMCLYAL
| .|...   ..||.|| || ... .            |  |. . ... ....   |..||.... ..   |       .. |||| |..||..
ILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEM
Kinase 14484.AA Ciliate-E2 639-834 17 1.1e-12 39.84 In-house 84-361 (365) Show / Hide 
Range on Protein: 639-834
Range on HMM: 84-361/365
Sequence Identity: 17% (52 aa)

QNLRECNHQSILKYIEEFQ--IDKYYLVVMERLKK----------KINR------------NQFLKIALDLFK---------------ALEYLHSKN-LL
..|.. ||  |.|..| ||   |...  ||| ..           |..|            .. ..|   ...               |||||||||  .
NILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNII

LQNLTLKNIYLDQDQNVKICDFNISQEIIPS-------IATQEFFASK-------TYN--------------LEFYLPPELYDSSK--NQSAKQSKIFQE
  .. . || .     .||.|| .|... ..          ...   |       .|.                 |..|| . . |  ||   | .    
HRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYD

KEGDIWSAGMCLYALTGVTLLFIKRLTKGTGFFLFQEKLDKDIS----------------------------QFLMN----IFWQNPKLRPS-ISDLID
.. ||||.|..|| .    . |            .|......|.                            ... .    ..  .|. |.. ......
YKCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 14484.AA TKL 676-726 26 1.1e-09 31.1 In-house 132-204 (364) Show / Hide 
Range on Protein: 676-726
Range on HMM: 132-204/364
Sequence Identity: 26% (19 aa)

NQFLKIALDLFKALEYLHS--------KNLLLQNLTLKNIYLDQDQN--------------VKICDFNISQEI
.|....|||  ....||||        ....  .|. ||| .|.. .              .||||| .|...
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM
S_TKc 14484.AA S_TKc 600-842 17 1.6e-09 -37.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 600-842
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)

YT-------------FLAFDKD--RQFSIRAFCLASDQNSDISDDKLKSAKQFAQNLRECNHQSILKYIEEFQIDKYYLVVMERLKK-------KINRNQ
|.             ... .|.  |.. |                  .....  | |.. .|  | |... ||  ... .||| .          | ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

F-----------LKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQNVKICDFNISQEIIPSIATQEFFASKTYNLEFYLPPELYDSSKNQSAKQSKIF
             ...  ...||||.||.. .   |   || ||.  ..||||| .. ..        |  .      .|..||.              .
RHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTP-----WYMAPEVL------------GY

QEKEGDIWSAGMCLYALTGVTLLFIKRLTKGTGFFLFQEKLDKDISQFLMNIFWQNPKLRPSISDLID---SIQQLQHI
  .. |.|| | .|| .     .|       . . .|.  ....  .|.....  .|. ||.. ..      | . . .
GKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14484.AA TKL-Unique 670-723 31 7.6e-09 27.52 In-house 104-164 (290) Show / Hide 
Range on Protein: 670-723
Range on HMM: 104-164/290
Sequence Identity: 31% (19 aa)

KKKINRNQFLKIALDLFKALEYLHSKN--LLLQNLTLKNIYLDQD-----QNVKICDFNIS
..|.| .|..|.|.|  ....|||...   .  .|. .|...|..      |.|||||..|
NCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS
Kinase 14484.AA Dicty4-Unclassified 679-726 35 1e-07 22.5 In-house 112-159 (263) Show / Hide 
Range on Protein: 679-726
Range on HMM: 112-159/263
Sequence Identity: 35% (17 aa)

LKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQNVKICDFNISQEI
.|.|.|  . . .||..|.    .   || .| . |.|| || || .|
IKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVI
Kinase 14484.AA C8 679-780 23 4.9e-07 20.58 In-house 126-226 (226) Show / Hide 
Range on Protein: 679-780
Range on HMM: 126-226/226
Sequence Identity: 23% (25 aa)

LKIALDLFKALEYLHSKNLLLQNLTLKNIY--LDQDQN--VKICDFNISQEIIPSIATQEFFASKTYNLEFYLPPELYDSSKNQSAKQSKIFQEKEGDIW
..||. .   ..|.|.|| . . . ..|.   ||| ..  .|.||| ..  .  .    .   ..|     |. ||     ...  ||..|    . |..
EIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKK-QDNQYKQYRI----QSDLF

SAGMCL
| |. |
SVGLVL
Kinase 14484.AA TK 670-720 23 1e-06 17.45 In-house 229-295 (486) Show / Hide 
Range on Protein: 670-720
Range on HMM: 229-295/486
Sequence Identity: 23% (16 aa)

KKKINRNQFLKIALDLFKALEYLHSK------NLLLQNLTLKNIYLDQDQN-----------VKICDF
| ...  | | ..... ...||||||      |.   .|   |. .... .           .||.||
KHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADF
Kinase 14484.AA TBCK 673-716 29 1.1e-05 16.26 In-house 77-124 (346) Show / Hide 
Range on Protein: 673-716
Range on HMM: 77-124/346
Sequence Identity: 29% (14 aa)

INRNQFLKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQ----NVK
.  .| | |.    ..| |.|....   .| ..||||| .      ||
KDCSQILCIYYQILCGLSYMHKHHIVHRFLHPHNIYLDDNGNQKLHVK
TyrKc 14484.AA TyrKc 580-836 14 1.2e-05 -131.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 580-836
Range on HMM: 1-280/280
Sequence Identity: 14% (48 aa)

LEIQKQI------QVTQSYVDKEDNKYTFLAFDKDRQFSIRAF--CLASDQNSDISDDKLKSAKQF---AQNLREC--NHQSILKYIEEFQID-------
..  |..      .| .   .                  |     .| .|             . |   |. ...   .|. |.. .     .       
ITLGKKLGEGAFGEVYKGTWK------------------IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYI

KYYLVVME------------RLKKKINRNQFLKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQNVKICDFNISQEIIPS----IATQEFFASKTYNL
. ...|||            . ..|..  ..|.....  .  |||||||.    |   |. .. .. |||.||  | .|        ...   .... . 
EPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

E-----FYLPPELYDSSKNQSAKQSKIFQEKEGDIWS----------AGMCLYA------LTGVTLLFIKRLTKGTGFFLFQEKL--------DKDISQF
        ..||           . ..| .|  |.||           |.  |       ..   ..   .    .|. . | .           |    
KTMLPIRWMAPECI---------NYGKFTTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK----QGYRMPQPPNDYPMSFVCCPDEMYQ

LMNIFWQN-PKLRPSISDLIDSI
.|   |.  |. ||. |.... .
IMKQCWHEDPEDRPTFSEIHECF
Kinase 14484.AA TK 800-836 21 0.060148 1.45 In-house 451-486 (486) Show / Hide 
Range on Protein: 800-836
Range on HMM: 451-486/486
Sequence Identity: 21% (8 aa)

FFLFQEKLDKDISQFLMNIFWQ-NPKLRPSISDLIDSI
. . ..  . .. . ||   |. .|. ||. |.| . .
M-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 14484.AA TKL 821-836 25 0.065038 2.69 In-house 349-364 (364) Show / Hide 
Range on Protein: 821-836
Range on HMM: 349-364/364
Sequence Identity: 25% (4 aa)

QNPKLRPSISDLIDSI
..|. ||| ..... .
HDPEKRPSFQEILKRL
TPR_1 14484.AA TPR_1 925-958 32 2e-07 29.93 Pfam 1-34 (34) Show / Hide 
Range on Protein: 925-958
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

SFAYKCLGHSFLNLKKLDEAVNNIQKSIEINPEY
. |.. ||. .......|||.   || .|.||..
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR 14484.AA TPR 925-958 29 2.2e-07 31.79 SMART 1-34 (34) Show / Hide 
Range on Protein: 925-958
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

SFAYKCLGHSFLNLKKLDEAVNNIQKSIEINPEY
. |...||.........|||..  ||..|..|..
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 14484.AA TPR 1061-1094 32 2e-06 28.35 SMART 1-34 (34) Show / Hide 
Range on Protein: 1061-1094
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

EEPIQNIGRIYIHLEQYDEAINSLKKAIQINEKM
 |   |.| .| ....|||||. ..||...... 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 1066-1094 37 3e-06 25.72 Pfam 6-34 (34) Show / Hide 
Range on Protein: 1066-1094
Range on HMM: 6-34/34
Sequence Identity: 37% (11 aa)

NIGRIYIHLEQYDEAINSLKKAIQINEKM
|.| .| ....|||||  ..||...|.. 
NLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 925-958 23 2.5e-05 22.97 Pfam 1-34 (34) Show / Hide 
Range on Protein: 925-958
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

SFAYKCLGHSFLNLKKLDEAVNNIQKSIEINPEY
  |. .|| . ......|||..  .|.....|..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 14484.AA TPR_1 1036-1060 40 2.9e-05 22.36 Pfam 10-34 (34) Show / Hide 
Range on Protein: 1036-1060
Range on HMM: 10-34/34
Sequence Identity: 40% (10 aa)

LYYNQSKYEEALVYCKKALEIDPLQ
.||.. .|.||. ...||||..|  
CYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 1061-1094 32 4.5e-05 22.05 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1061-1094
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

EEPIQNIGRIYIHLEQYDEAINSLKKAIQINEKM
 |   |.|..|.....|||||. ..||...... 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 1027-1060 35 9.3e-05 23.05 SMART 1-34 (34) Show / Hide 
Range on Protein: 1027-1060
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

YDSVIELSFLYYNQSKYEEALVYCKKALEIDPLQ
..    |  .||.. .|.||. ...||||.||  
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 14484.AA TPR_2 1027-1060 38 0.000116 20.58 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1027-1060
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

YDSVIELSFLYYNQSKYEEALVYCKKALEIDPLQ
 .    |  .||.| .|.||. |..|||..||  
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 14484.AA TPR_1 891-924 26 0.000318 18.73 Pfam 1-34 (34) Show / Hide 
Range on Protein: 891-924
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

HSLLTLIGSLYFEIKSYEECNEYFLKAIQIHPQN
   .. .| .|.. . |.|  |.. ||... |.|
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 891-924 29 0.000375 18.78 Pfam 1-34 (34) Show / Hide 
Range on Protein: 891-924
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

HSLLTLIGSLYFEIKSYEECNEYFLKAIQIHPQN
  .. ..| .|.. . |.|  ||. ||... |.|
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 993-1026 26 0.001178 19.39 SMART 1-34 (34) Show / Hide 
Range on Protein: 993-1026
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

SLPSCNLGYLYVRKQNFQESESWLKKSMNINPNN
.   .||| .| .. ...| .  ..|.. ..|||
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 14484.AA TPR_2 993-1026 26 0.00135 16.81 Pfam 1-34 (34) Show / Hide 
Range on Protein: 993-1026
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

SLPSCNLGYLYVRKQNFQESESWLKKSMNINPNN
    .||| .| ......| . ...|.  ..|||
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 891-924 26 0.0014 19.14 SMART 1-34 (34) Show / Hide 
Range on Protein: 891-924
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

HSLLTLIGSLYFEIKSYEECNEYFLKAIQIHPQN
   .  .| .|.  . |.|. |.. ||... |.|
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 997-1026 36 0.002698 15.49 Pfam 5-34 (34) Show / Hide 
Range on Protein: 997-1026
Range on HMM: 5-34/34
Sequence Identity: 36% (11 aa)

CNLGYLYVRKQNFQESESWLKKSMNINPNN
.|||..| ...|..| .  ..|   .||||
YNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 857-890 26 0.003492 15.35 Pfam 1-34 (34) Show / Hide 
Range on Protein: 857-890
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

FIDIYNKGRDLYSNEQFQESIDLLKTALNIEPLH
.   || |. .| .....| |.... || ..| .
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 857-890 26 0.028984 14.1 SMART 1-34 (34) Show / Hide 
Range on Protein: 857-890
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

FIDIYNKGRDLYSNEQFQESIDLLKTALNIEPLH
    ||.|  .|......| |. .. || ..| .
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 14484.AA TPR 959-992 35 0.043053 12.59 SMART 1-34 (34) Show / Hide 
Range on Protein: 959-992
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

SHAHNVLGVCYERMLLEDKAEQQYKIAHNLHPQQ
. |.. ||.||..|   |.|.. |. |  | |. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 959-992 35 0.145048 9.45 Pfam 1-34 (34) Show / Hide 
Range on Protein: 959-992
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

SHAHNVLGVCYERMLLEDKAEQQYKIAHNLHPQQ
. |.. ||.||..|   |.|.. |. |  | |. 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 959-992 32 0.166645 9.41 Pfam 1-34 (34) Show / Hide 
Range on Protein: 959-992
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

SHAHNVLGVCYERMLLEDKAEQQYKIAHNLHPQQ
  |.. ||.||...   |.|.. |. |  | |. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 1095-1128 23 0.19578 6.81 SMART 1-34 (34) Show / Hide 
Range on Protein: 1095-1128
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

EYMYFTLAYAYLQKFKYYQGIYCLKKQIKLDSID
   .. |. .|... .| . | |..| ..||  .
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 861-890 30 0.250783 8.62 Pfam 5-34 (34) Show / Hide 
Range on Protein: 861-890
Range on HMM: 5-34/34
Sequence Identity: 30% (9 aa)

YNKGRDLYSNEQFQESIDLLKTALNIEPLH
||.|  .|. ....| |. .. || ..| .
YNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_1 14484.AA TPR_1 1129-1151 26 2.097823 5.4 Pfam 1-23 (34) Show / Hide 
Range on Protein: 1129-1151
Range on HMM: 1-23/34
Sequence Identity: 26% (6 aa)

IESFGMLGDQYIQQKKYEKVIKY
 | .  ||  | ....|.. |..
AEAWYNLGNCYYKMGNYDEAIEC
TPR_2 14484.AA TPR_2 1129-1151 34 11.822376 2.86 Pfam 1-23 (34) Show / Hide 
Range on Protein: 1129-1151
Range on HMM: 1-23/34
Sequence Identity: 34% (8 aa)

IESFGMLGDQYIQQKKYEKVIKY
 |   .||. |..|..|.. |.|
AEAWYNLGQCYYKQGDYDEAIEY
TPR_2 14484.AA TPR_2 1095-1128 23 12.133991 2.82 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1095-1128
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

EYMYFTLAYAYLQKFKYYQGIYCLKKQIKLDSID
 . .. |. .|... .| . | ...| .|||  .
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 14484.AA TPR_1 1095-1128 20 13.562256 2.57 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1095-1128
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

EYMYFTLAYAYLQKFKYYQGIYCLKKQIKLDSID
   .. |...|... .| . | |..| ..|.  .
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
Kinase 14484.AA Ciliate-E6 1234-1369 55 1.3e-85 271.93 In-house 17-154 (154) Show / Hide 
Range on Protein: 1234-1369
Range on HMM: 17-154/154
Sequence Identity: 55% (76 aa)

D-FQIDKYYLVVMERFEMNLIDWQYKNRLKKKINRN-QFLKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQNLKICDFNFPQEIVPSIATREFIASK
| |||..||..||||.||||.||. .. .||.||.| ||.|....||.|.|||||||..|||.|||||.||...|.|||||.|.|.|.|...|.|| |.|
DSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIPNQQTKEFMAQK

TYNLELYLPPELYDSSKNQLAKQSKIFQEKEGDIWSAG
..|.. |.|||..|.||.| .|..|.....||||||..
NQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC
Kinase 14484.AA Ciliate-A2 1234-1429 34 2.8e-33 112.95 In-house 66-272 (272) Show / Hide 
Range on Protein: 1234-1429
Range on HMM: 66-272/272
Sequence Identity: 34% (71 aa)

DFQIDKYYLVVMERF-EMNLIDWQYK-NRLKKKINRNQFLKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQN-LKICDFNFPQEIVPSIATREFIAS
.|||. ||  .||   |..| ||  | .  .|.|.. ||...|. . .|.||||.||  | .| |.|| .|||.. .| ||| .  .. |.|..  | .|
EFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTS

KTYNLELYLPPELYDS---SKNQLAKQSKIFQEKEGDIWSAGICLYGLIGGTLLLIKKLT----NGSAFFQFQEQLDKDISQFLMNIFWQNPKLRP-QIS
      .| |||..     .     |. .| | ..||||  ||||| | |...   .|||    ..   .|   .||. ..| . .|  . ||.||  | 
CPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFMGDIWAFGICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQ

DLIDSIQ
 ... ..
QIRHHWH
Kinase 14484.AA Ciliate-E2-Unclassified 1235-1445 17 2.5e-09 28.54 In-house 90-352 (352) Show / Hide 
Range on Protein: 1235-1445
Range on HMM: 90-352/352
Sequence Identity: 17% (50 aa)

FQIDKYYLVVMERFEM-NLIDWQY-------------KNRLKKK-INRNQFL-----KIALDLFKALEYLHSKN-LLLQNLTLKNIYLDQDQ---NLKIC
|| ...   ||| .|  .|...               .|....| .  .| .     ...  . ..|||||.||  .  .... || .|...   ..||.
FQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII

DFNF---------------------PQEIVPSIA-TREFIASKTYNLELYLPPELYDSSKNQLAKQSKIFQEKEGDIWSAGICLYGLIGGTLLLIKKLTN
|| .                     .|..  ... | ...  .      |..||.... ..   |       .. |||| |..|| .. |. .  .  . 
DFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------YTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEMLFGY-YPFYDNNC

GS-------------AFFQFQEQLDKDISQFLMNIFWQN--PKLRPQISDLID-------SIQQLQNIQIEQIQEEEDF
 .              . ..|....|.|... ..   |.   .. |.  |.|          .. ..|..||| .   |
EQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPW--QQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 14484.AA TKL 1268-1312 26 1.4e-08 27.04 In-house 132-198 (364) Show / Hide 
Range on Protein: 1268-1312
Range on HMM: 132-198/364
Sequence Identity: 26% (18 aa)

NQFLKIALDLFKALEYLHS--------KNLLLQNLTLKNIYLDQDQN--------------LKICDF
.|....|||  ....||||        ....  .|. ||| .|.. .              .|||||
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDF
Kinase 14484.AA TKL-Unique 1259-1315 29 3.6e-08 25.09 In-house 101-164 (290) Show / Hide 
Range on Protein: 1259-1315
Range on HMM: 101-164/290
Sequence Identity: 29% (19 aa)

NRLKKKINRNQFLKIALDLFKALEYLHSKN--LLLQNLTLKNIYLDQD-----QNLKICDFNFP
|. ..|.| .|..|.|.|  ....|||...   .  .|. .|...|..      | |||||...
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS
Kinase 14484.AA TBCK 1242-1309 31 1.8e-07 22.7 In-house 53-121 (346) Show / Hide 
Range on Protein: 1242-1309
Range on HMM: 53-121/346
Sequence Identity: 31% (22 aa)

LVVMERFEMNLID-WQYKNRLKKKINRNQFLKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQNLKI
.||||  .||| |      . .. .  .| | |.    ..| |.|....   .| ..||||| . | |.
IVVMEHYKMNLEDQIEIYAKRHTPKDCSQILCIYYQILCGLSYMHKHHIVHRFLHPHNIYLDDNGNQKL
Kinase 14484.AA Ciliate-E2 1235-1426 17 6.6e-07 19.72 In-house 101-361 (365) Show / Hide 
Range on Protein: 1235-1426
Range on HMM: 101-361/365
Sequence Identity: 17% (47 aa)

FQ--IDKYYLVVMERFEM-NLIDWQYKNRLK--------KKINRNQFLKIALDLFK---------------ALEYLHSKN-LLLQNLTLKNIYLDQDQNL
||   |...  ||| ..  .| |. ..|..|        |... .. ..|   ...               |||||||||  .  .. . || .     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KICDFNFPQEIVPS-------IATREFIASK-------TYN--------------LELYLPPELYDSSK--NQLAKQSKIFQEKEGDIWSAGICLYGLIG
||.|| . ... ..           ...  |       .|.                 |..|| . . |  ||   | .    .. ||||.|..|| .. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLF

GTLLLIKKLTNGSAFFQFQ----------------EQLDKDISQFLMN----IFWQNPKLRPQ-ISDLID
| .  ...  ..   |...                ......  ... .    ..  .|. |.. ......
GKPPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 14484.AA C8 1245-1372 26 7.2e-07 20.0 In-house 99-226 (226) Show / Hide 
Range on Protein: 1245-1372
Range on HMM: 99-226/226
Sequence Identity: 26% (35 aa)

MERFEMNLIDWQYKNRLKKKI-NRNQFLKIALDLFKALEYLHSKNLLLQNLTLKNIY--LDQDQN--LKICDFNFPQEIVPSIATREFIASKTYNLELYL
||  | || .   . | |..  . .. ..||. .   ..|.|.|| . . . ..|.   ||| ..   |.||| |   .  .    . . ..|     |.
MELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYF

PPELYDSSKNQLAKQSKIFQEKEGDIWSAGICL
 ||    ..||. ||..|    . |..| |. |
APEIEKKQDNQY-KQYRI----QSDLFSVGLVL
Kinase 14484.AA TK 1262-1312 23 1.1e-05 14.23 In-house 229-295 (486) Show / Hide 
Range on Protein: 1262-1312
Range on HMM: 229-295/486
Sequence Identity: 23% (16 aa)

KKKINRNQFLKIALDLFKALEYLHSK------NLLLQNLTLKNIYLDQDQN-----------LKICDF
| ...  | | ..... ...||||||      |.   .|   |. .... .            ||.||
KHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADF
Kinase 14484.AA Dicty4-Unclassified 1271-1312 33 1.9e-05 14.56 In-house 112-153 (263) Show / Hide 
Range on Protein: 1271-1312
Range on HMM: 112-153/263
Sequence Identity: 33% (14 aa)

LKIALDLFKALEYLHSKNLLLQNLTLKNIYLDQDQNLKICDF
.|.|.|  . . .||..|.    .   || .| . | || ||
IKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADF
TPR 14484.AA TPR 1517-1550 26 1e-06 29.46 SMART 1-34 (34) Show / Hide 
Range on Protein: 1517-1550
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

SFAYKCLGHSFLNLKKLDEAVIHLHKSIEINPEI
. |...||.........|||. .. |..|..|. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 1517-1550 29 2e-06 26.38 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1517-1550
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

SFAYKCLGHSFLNLKKLDEAVIHLHKSIEINPEI
. |.. ||. .......|||. .. | .|.||. 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_1 14484.AA TPR_1 1628-1650 39 2.1e-05 22.84 Pfam 10-32 (34) Show / Hide 
Range on Protein: 1628-1650
Range on HMM: 10-32/34
Sequence Identity: 39% (9 aa)

LYFNQSKYEEALVYCKKALEIDP
.|... .|.||. ...||||..|
CYYKMGNYDEAIECYQKALELNP
TPR_2 14484.AA TPR_2 1517-1550 23 3.6e-05 22.36 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1517-1550
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

SFAYKCLGHSFLNLKKLDEAVIHLHKSIEINPEI
  |. .|| . ......|||. .. |.....|. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_2 14484.AA TPR_2 1619-1652 35 6.1e-05 21.58 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1619-1652
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

QDPLIKLSFLYFNQSKYEEALVYCKKALEIDPLK
 . .  |  .|..| .|.||. |..|||..||  
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_2 14484.AA TPR_2 1449-1482 29 0.000241 19.46 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1449-1482
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

FIDIYNKGRDLYSNEQFQESIDLLKTALKIQPQH
.   || |. .| .....| |.... |||. |..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 1653-1686 38 0.00029 21.41 SMART 1-34 (34) Show / Hide 
Range on Protein: 1653-1686
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

EEPIQNIAKIYYHLGQYDEAINRQKKAIQMNENM
 |   |.. .||..|.|||||.  .||.....| 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 14484.AA TPR_2 1653-1686 38 0.000392 18.71 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1653-1686
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

EEPIQNIAKIYYHLGQYDEAINRQKKAIQMNENM
 |   |....||..|.|||||.  .||.. ..| 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_2 14484.AA TPR_2 1483-1516 29 0.000438 18.54 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1483-1516
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

HLLLNLIGSQYLEIKSYEECNEYFLKAIQIHPQN
  .....|  |.. . |.|  ||. ||... |.|
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_2 14484.AA TPR_2 1585-1618 23 0.000908 17.42 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1585-1618
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

WLPLRNLGLLYLRKKNFQESEYWLKKSMNIIPNK
.  ..|||..|.......| . ...|.  . || 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 14484.AA TPR 1449-1482 26 0.001061 19.54 SMART 1-34 (34) Show / Hide 
Range on Protein: 1449-1482
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

FIDIYNKGRDLYSNEQFQESIDLLKTALKIQPQH
    ||.|  .|......| |. .. ||...|..
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 1453-1482 30 0.001602 16.28 Pfam 5-34 (34) Show / Hide 
Range on Protein: 1453-1482
Range on HMM: 5-34/34
Sequence Identity: 30% (9 aa)

YNKGRDLYSNEQFQESIDLLKTALKIQPQH
||.|  .|. ....| |. .. ||...|..
YNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_1 14484.AA TPR_1 1483-1516 26 0.002349 15.7 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1483-1516
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

HLLLNLIGSQYLEIKSYEECNEYFLKAIQIHPQN
   .. .|  |.. . |.|  |.. ||... |.|
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_1 14484.AA TPR_1 1658-1686 44 0.003778 14.98 Pfam 6-34 (34) Show / Hide 
Range on Protein: 1658-1686
Range on HMM: 6-34/34
Sequence Identity: 44% (13 aa)

NIAKIYYHLGQYDEAINRQKKAIQMNENM
|.. .||..|.|||||   .||...|.| 
NLGNCYYKMGNYDEAIECYQKALELNPNN
TPR 14484.AA TPR 1619-1652 32 0.007139 16.79 SMART 1-34 (34) Show / Hide 
Range on Protein: 1619-1652
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

QDPLIKLSFLYFNQSKYEEALVYCKKALEIDPLK
 . .  |  .|... .|.||. ...||||.||  
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 14484.AA TPR 1483-1516 26 0.008258 16.58 SMART 1-34 (34) Show / Hide 
Range on Protein: 1483-1516
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

HLLLNLIGSQYLEIKSYEECNEYFLKAIQIHPQN
   .. .|  |.  . |.|. |.. ||... |.|
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 14484.AA TPR 1585-1618 23 0.01964 15.33 SMART 1-34 (34) Show / Hide 
Range on Protein: 1585-1618
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

WLPLRNLGLLYLRKKNFQESEYWLKKSMNIIPNK
.  . |||..|.......| .  ..|.. . || 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 14484.AA TPR 1551-1584 35 0.026723 14.41 SMART 1-34 (34) Show / Hide 
Range on Protein: 1551-1584
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

SHAHNLLGVCYERMLLEDKAEQQYKIAHNLHPQQ
. |.. ||.||..|   |.|.. |. |  | |. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 1551-1584 35 0.056845 10.87 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1551-1584
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

SHAHNLLGVCYERMLLEDKAEQQYKIAHNLHPQQ
. |.. ||.||..|   |.|.. |. |  | |. 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 14484.AA TPR_2 1551-1584 32 0.071982 10.7 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1551-1584
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

SHAHNLLGVCYERMLLEDKAEQQYKIAHNLHPQQ
  |...||.||...   |.|.. |. |  | |. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 14484.AA TPR_1 1585-1618 26 0.089024 10.19 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1585-1618
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

WLPLRNLGLLYLRKKNFQESEYWLKKSMNIIPNK
.  . |||..|....|..| .  ..|   . || 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR 14484.AA TPR 1688-1721 20 0.69212 1.99 SMART 1-34 (34) Show / Hide 
Range on Protein: 1688-1721
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

KNMYFTLAYAYLKKFKYYQVIYCLKKQIKINSID
   .. |. .|.|. .| . | |..| ....  .
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 14484.AA TPR_1 1688-1721 23 12.204444 2.73 Pfam 1-34 (34) Show / Hide 
Range on Protein: 1688-1721
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

KNMYFTLAYAYLKKFKYYQVIYCLKKQIKINSID
 . .. |...|.|. .| . | |..| ...|  .
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN