Gene 5142 (Tetrahymena)

5142

Species: Tetrahymena
Alias: 24, TTHERM_00621450, 5142, 86.m00174, PreTt05142
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-E3,

Classification

Group: Other
Family: Ciliate-E3

Sequence

Name Sequence Type Origin Length Description Download
5142.AA Protein None 870 None Fasta, JSON
5142.kin_dom Protein Kinase Domain None 193 None Fasta, JSON
5142.kin_dom2 Protein Kinase Domain None 164 None Fasta, JSON
5142.NA RNA None 2613 None Fasta, JSON

Protein domain

Protein domains of 5142.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5142.AA Ciliate-E3 17-180 55 2.5e-102 319.63 In-house 1-186 (202) Show / Hide 
Range on Protein: 17-180
Range on HMM: 1-186/202
Sequence Identity: 55% (104 aa)

FTVQQLLGQGGFGRVYKAFDFNNKQDVAIKAILPSQTYN--VGEQFQKTIKEFQNCGKPNSKHVVQVKDVLVDLDNKLIFIVQAQQNT---Q---KNFKK
.||||.||.|.||||||||||.|.||||||||......|  ||||||||..|||||...||..||...|...| .||.|||||        .   |   |
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQNK

QK-----------IGVIAIHEQNIIHSDLKPDNILVDKNG---VVKIGDFGEAKQLRFENGHTHTQGQGWTPFFAAPELVQYSAFS
..            |.|||||.||||||.||||||||||    ..||.||||.||||...||||||.||||||.||||.......|
TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQIS
Kinase 5142.AA Ciliate-A1 17-173 26 4.8e-25 82.18 In-house 1-190 (301) Show / Hide 
Range on Protein: 17-173
Range on HMM: 1-190/301
Sequence Identity: 26% (52 aa)

FTVQQLLGQGGFGRVYKAFDFNNKQ-DVAIKAILPSQTYNVGEQFQKTIKEFQNCGKPNSKHVVQVKDVLVDLDN--KLIFIVQ--AQQNTQKNFKKQKI
..| ||.. |.|| | .|.|  |..  ...| |  . .    ||..  | |.. |   |.  |. . . | . .|     ||.    | . . |. .|. 
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNF----EQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQND

----------------GVIAIHEQNIIHSDLKPDNILVDKNGVVKIGDFGEAKQLRFEN----------------GHTHTQGQGWTPFFAAPEL
                |...||..||.|.||||.|||.      || |.|  ||| . .                 | ||  .| .  . .||.
YMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQ
Kinase 5142.AA Ciliate-E2-Unclassified 17-175 23 1.1e-19 64.96 In-house 1-239 (352) Show / Hide 
Range on Protein: 17-175
Range on HMM: 1-239/352
Sequence Identity: 23% (56 aa)

FTVQQLLGQGGFGRVYKAFDFNNKQDVAIKAILPSQTYNVGEQ-FQKTIKEFQ----NCGK---------------PNSKHVVQVKDVLVDLDNKLIFIV
..... .|||||| |||. . ..||  |.| .  .| |..  . ... .. ..    |. |                |..| . ||.. .. | . |.||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

QAQ--------------------------QNTQKNFKKQKI--------------GV-IAIHEQNIIHSDLKPDNILVDKNG---VVKIGDFGEAKQLRF
  .                          ....| |  |..              |    .|..|||| |.||.|||.|.||    .|| ||| .|..  
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

ENG-------------HTHTQGQGWTPFFA----APELVQ
 |.             . ... . .|| .     |||. |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
Kinase 5142.AA Pkinase 112-183 36 7e-19 67.85 Pfam 120-193 (293) Show / Hide 
Range on Protein: 112-183
Range on HMM: 120-193/293
Sequence Identity: 36% (28 aa)

GVIAIHEQNIIHSDLKPDNILVDKNGVV----KIGDFGEAKQLRFENGHTHTQGQGWTPFFAAPELVQ-YSAFSVTC
|.  .|...||| ||||.|||.|.||..    ||.||| |||.. .   . ...   ||...|||... ..  .  .
GLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV
Kinase 5142.AA CAMKL 116-175 40 2.3e-16 48.56 In-house 143-206 (297) Show / Hide 
Range on Protein: 116-175
Range on HMM: 143-206/297
Sequence Identity: 40% (26 aa)

IHEQNIIHSDLKPDNILVDKNG--VVKIGDFGEAKQLR---FENGHTHTQGQGWTPFFAAPELVQ
.|...|.| |.||.|||.|.||  ..|| ||| . . |   | .|.. .   | .| ..|||..|
CHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG-SPPYMAPEIFQ
Kinase 5142.AA STE11 117-174 34 9.6e-16 53.64 In-house 133-207 (303) Show / Hide 
Range on Protein: 117-174
Range on HMM: 133-207/303
Sequence Identity: 34% (26 aa)

HEQNIIHSDLKPDNILVDKNGV-VKIGDFGEAKQLRFENGHTHT---------QGQGWTPF--------FAAPELV
|...||| |.|..|||.|..|. .|..||| ||.|  .. .||.         . .| ||.        . ||| .
HSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTG-TPYNSMMGTPMWMAPEVI
Kinase 5142.AA S_TKc 17-231 20 1e-15 53.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-231
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)

FTVQQLLGQGGFGRVYKAFDFNNKQDVAIKAILPSQTYNVGEQFQKTIKEFQNCGKPNSKHVVQVKDVLVDLDNKLIFIVQAQQN----TQKNFKKQKI-
... ...|.|.||.|||. . . .. |||| |            .....| | . | . ...|. .|| .|  ..| ..     .      .  ||..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-------------------GVIAIHEQNIIHSDLKPDNILVDKNGVVKIGDFGEAKQLRFENGHTHTQGQGWTPFFAAPELVQYSA--------------
                   ..  .|...||| ||||.|||.|.  ..||.||| |.||           .  ||.. |||...|.               
GLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYE

-------FSVTCLMRICQEFKQKNTQPFN-----MMTYEPKKRASCQTVLN--LLQNLGGSKNHEII
       |.   .... .  .   ....      .....|.|| ..  .|.  ..      |.|. .
MLCGYPPFP--QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD-----IKCHPWF
Kinase 5142.AA CAMK 116-176 25 5.1e-15 44.15 In-house 195-294 (425) Show / Hide 
Range on Protein: 116-176
Range on HMM: 195-294/425
Sequence Identity: 25% (26 aa)

IHEQNIIHSDLKPDNILVDKN-----------------GVVKIGDFGEAKQLRFEN----------------------GHTHTQGQGWTPFFAA-PELVQ
.|..||.| ||||.|||.|.|                 . .|| ||| |....  .                      |.  .   | || ..| ||...
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG-TPEYMAAPEVLN

Y
.
G
Kinase 5142.AA Ciliate-E2 111-177 22 6.6e-14 44.11 In-house 158-274 (365) Show / Hide 
Range on Protein: 111-177
Range on HMM: 158-274/365
Sequence Identity: 22% (27 aa)

I-------------GVIAIHEQN-IIHSDLKPDNILVDKNGVVKIGDFGEAKQLRFENG-HTHTQGQG----------------------------WTPF
.             ..  .|..| ||| |.||.|||.     .|| ||| .|..  .|  .|| |...                            .|| 
FKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPG

FAAPELVQ------------YS
. ||| ..            |.
YMAPEILNGKKYDNQQKQKGYD
Kinase 5142.AA ULK 112-177 31 3.3e-13 42.54 In-house 142-233 (329) Show / Hide 
Range on Protein: 112-177
Range on HMM: 142-233/329
Sequence Identity: 31% (30 aa)

GVIAIHEQNIIHSDLKPDNILVDKN------------GVVKIGDFGEAKQLRFEN-----GHTHT-QGQ---GWTPFFAAPELVQ-------YS
|  ..|..|||| |.||.|||....            ||.||.||| ||..  .|      .| . . .   | || . ||...|       |.
GFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE-KRLCG-TPLYMAPQILQGQGEQKPYY
Kinase 5142.AA ULK 112-177 30 1.7e-12 40.67 In-house 138-229 (324) Show / Hide 
Range on Protein: 112-177
Range on HMM: 138-229/324
Sequence Identity: 30% (29 aa)

GVIAIHEQNIIHSDLKPDNILVDKN------------GVVKIGDFGEAKQLRF-ENGHTHTQ---------GQGWTPFFAAPELVQ-------YS
|  ..|..|||| |.||.|||. ..            ||.||.||| ||..   .   . .|         |   || . ||...|       |.
GFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKG---TPLYMAPQILQGQGEQKPYY
Kinase 5142.AA ULK 17-96 24 3.3e-10 31.91 In-house 1-99 (329) Show / Hide 
Range on Protein: 17-96
Range on HMM: 1-99/329
Sequence Identity: 24% (24 aa)

FTVQQLLGQGGFGRVYKAFDFNNK----QDVAIKAIL---PSQTYNVGE---QFQKTIKEFQNCGKPN----SKH----VVQVKDVLVDLD-NKLIFIV
. . . ||.| ||.|||... ..|    ..||.| |.    .| .|  |   . |  ..| ..  | .    .|.    .|. .|.. . . | . .|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM
Kinase 5142.AA STE 116-150 48 3.3e-10 32.38 In-house 168-197 (359) Show / Hide 
Range on Protein: 116-150
Range on HMM: 168-197/359
Sequence Identity: 48% (17 aa)

IHEQNIIHSDLKPDNILVDKNGVVKIGDFGEAKQL
.|...||| |.||.|||.     ||. ||| ..||
LHSHHIIHRDIKPANILL-----VKLCDFGVCGQL
Kinase 5142.AA ULK 17-96 23 6.5e-10 31.42 In-house 1-96 (324) Show / Hide 
Range on Protein: 17-96
Range on HMM: 1-96/324
Sequence Identity: 23% (23 aa)

FTVQQLLGQGGFG-RVYKAFDFNN---KQDVAIKAIL---PSQTYNVGE---QFQKTIKEFQNCGKPN---SKH--VVQVKDVLVDLD-NKLIFIV
. . . ||.| ||  |||... ..   .|.||.| |     .. .|  |   . |. ..| |.  | .   ...  .|. .|.. . . | . .|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM
Kinase 5142.AA STE 17-80 18 2.1e-08 25.88 In-house 1-94 (359) Show / Hide 
Range on Protein: 17-80
Range on HMM: 1-94/359
Sequence Identity: 18% (18 aa)

FTVQQLLGQGGFGRVYKAFDFN---------------NKQDVAIKAIL--PSQTYNVG------------EQFQKTIKEFQNCGKPN--SKHVVQ
.. .. .|.|.|| |||| . .               ... .||| .   ......              |..|. .|| . . | |  ....|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK
Kinase 5142.AA STE11 17-48 31 2.3e-07 22.97 In-house 1-32 (303) Show / Hide 
Range on Protein: 17-48
Range on HMM: 1-32/303
Sequence Identity: 31% (10 aa)

FTVQQLLGQGGFGRVYKAFDFNNKQDVAIKAI
..  ...|.| ||.|||... .. . .|.| |
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQI
Kinase 5142.AA Pkinase 17-97 24 6.9e-07 25.44 Pfam 1-79 (293) Show / Hide 
Range on Protein: 17-97
Range on HMM: 1-79/293
Sequence Identity: 24% (20 aa)

FTVQQLLGQGGFGRVYKAFDFNNKQDVAIKAILPSQTYNVGEQFQKTIK--EFQNCGKPNSKHVVQVKDVLVDLDNKLIFIVQ
... . .|.|.||.|||. . .. . ||.| |  .   .  .. |  ..  | |   . |....|. .|.  |  .. | .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVM
Kinase 5142.AA Ciliate-E2 17-46 36 1e-06 18.67 In-house 1-30 (365) Show / Hide 
Range on Protein: 17-46
Range on HMM: 1-30/365
Sequence Identity: 36% (11 aa)

FTVQQLLGQGGFGRVYKAFDFNNKQDVAIK
. .....|||.|| |||. . ......|||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIK
Kinase 5142.AA CAMK 22-48 30 3e-06 15.45 In-house 1-39 (425) Show / Hide 
Range on Protein: 22-48
Range on HMM: 1-39/425
Sequence Identity: 30% (12 aa)

LLGQGGFGRVYKAFD-FNNK-----------QDVAIKAI
 ||.|.|| |.....  ...           | |||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKII
Kinase 5142.AA CAMKL 17-48 36 4e-06 15.49 In-house 1-33 (297) Show / Hide 
Range on Protein: 17-48
Range on HMM: 1-33/297
Sequence Identity: 36% (12 aa)

FTVQQLLGQGGFGRVYKAFD-FNNKQDVAIKAI
... . ||.|.|| |  | .  .... |||| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKII
Kinase 5142.AA Pkinase_Tyr 117-145 55 0.000131 16.23 Pfam 128-156 (270) Show / Hide 
Range on Protein: 117-145
Range on HMM: 128-156/270
Sequence Identity: 55% (16 aa)

HEQNIIHSDLKPDNILVDKNGVVKIGDFG
...|.|| ||   |.||..|.||||.|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 5142.AA Pkinase_Tyr 17-51 35 0.000299 15.02 Pfam 1-39 (270) Show / Hide 
Range on Protein: 17-51
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

FTVQQLLGQGGFGRVYKAFDF----NNKQDVAIKAILPS
 |  . ||.| ||.|||.  .    |.|..||.| . ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase 5142.AA Ciliate-A1 199-222 41 0.017277 4.21 In-house 278-301 (301) Show / Hide 
Range on Protein: 199-222
Range on HMM: 278-301/301
Sequence Identity: 41% (10 aa)

FNMMTYEPKKRASCQTVLNLLQNL
| || |||. | | | ..  |  .
FKMMQYEPNNRCSLQQCIDCLYIF
Kinase 5142.AA CAMK 200-217 33 0.129542 0.16 In-house 404-421 (425) Show / Hide 
Range on Protein: 200-217
Range on HMM: 404-421/425
Sequence Identity: 33% (6 aa)

NMMTYEPKKRASCQTVLN
.|....|.||.... .||
KMLQVDPEKRMTIEQCLN
Kinase 5142.AA Ciliate-E3 379-575 65 5e-144 451.52 In-house 1-202 (202) Show / Hide 
Range on Protein: 379-575
Range on HMM: 1-202/202
Sequence Identity: 65% (133 aa)

FTVQQQLGQGSFGRVYKAFNFNQNQVVAIKAILPCIGND--VSEQFQKTFQEFQNCMKLKSQYIVKVEDVLVDFDNKLLFIVQEYCSNGSLTEYIKKLEK
.||||.||.|.||||||||.|..||.||||||...  ..  |.||||||.||||||....||..||..|...|..||..||||||||||.|..|||...|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQNK

TENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNR---VIKIADFGEAKQLRQEKGHTHTQGQGCTPFFAAPEVNFNNQISKESDYYSVGAIFCL
|.||...|.|||..|.|||||..|||||.||||||||||.   .|||.||||.||||..|||||||.||.|||.||||.|...|||||||||||||.||.
TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQ

LC
||
LC
Kinase 5142.AA Pkinase 379-571 32 7.1e-50 176.81 Pfam 1-202 (293) Show / Hide 
Range on Protein: 379-571
Range on HMM: 1-202/293
Sequence Identity: 32% (67 aa)

FTVQQQLGQGSFGRVYKAFNFNQNQVVAIKAILPCIGNDVSEQFQKTFQ--EFQNCMKLKSQYIVKVEDVLVDFDNKLLFIVQEYCSNG----SLTEYIK
... ...|.||||.|||. . . ...||.| |  .  .. |.. |  .   | |   .|.. .||.  |.  |  .. . .|.||| .|    .| .||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

---KLEK--TENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNRVI----KIADFGEAKQLRQEKGHTHTQGQGCTPFFAAPEVNF-NNQISKES
   .     .|. .| .. |||.|.  .|...||| ||||.|||.|.| .|    ||.||| |||.. .   . ...  .||...||||   .. .....
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DYYSVGAIF
| .|.| |.
DMWSCGCIL
Kinase 5142.AA S_TKc 379-626 26 1.2e-48 168.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 379-626
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

FTVQQQLGQGSFGRVYKAFNFNQNQVVAIKAILPCIGNDVSEQFQKTFQEFQNCMKLKSQYIVKVEDVLVDFDNKLLFIVQEYCSN--GSLTEYIKKLEK
... ...|.|.||.|||. . . ...|||| |            ... .| | ..| .  .|||  || .|   . |..| |||..  |.| .||||  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

-------TENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNRVIKIADFGEAKQLRQEKGHTHTQGQGCTPFFAAPEVNFNNQISK-ESDYYSVG
       .|   . .. ||....  .|...||| ||||.|||.|.  .|||.||| |.||           .  ||.. ||||    . .| ..| .|.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

AIFCLLCD----LSLQDMLGIQAGKFPKITNHKYKNLLILAFNMMKYEPKQRACCQAVLN---------LL
 |.  ..      . |... ..  .         . .. .  ......|..|  .  .|.          .
CILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5142.AA Ciliate-A1 379-629 28 1.4e-48 163.5 In-house 1-301 (301) Show / Hide 
Range on Protein: 379-629
Range on HMM: 1-301/301
Sequence Identity: 28% (86 aa)

FTVQQQLGQGSFGRVYKAFNFNQNQ-VVAIKAILPCIGNDVSEQFQKTFQEFQNCMKLKSQYIVKVEDVLVDFDN--KLLFIVQEYCSNGSLTEYIKKLE
..| | .. |||| | .|..   ..  ...| |. |  .   ||..   ||.. |  . . . .|. . | . .|     ||. |||  | | .|..  .
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCK-IIICTNF---EQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQND

--KTENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNRVIKIADFGEAKQLRQEK----------------GHTHTQGQGCTPFFAAPEV-----
  | | |   |  || .|...||.. |.|.||||.|||.     .||.|.|  ||| | .                 | ||  .| .  . .||      
YMKKEEIY-EICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHY

----NFNNQISKESDYYSVGAIFCLLCD-----------LSL--QDMLG------------IQAGKFPKITNHKYKNLLILAFNMMKYEPKQRACCQAVL
       | |.| || ||.| |.| ||             ..    | .            |  . || . . ... | .|.| || |||..|   | ..
RDQMFIENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCI

NLLQDL
  |  .
DCLYIF
Kinase 5142.AA ULK 379-571 30 2.1e-43 150.52 In-house 1-242 (324) Show / Hide 
Range on Protein: 379-571
Range on HMM: 1-242/324
Sequence Identity: 30% (73 aa)

FTVQQQLGQGSFG-RVYKAFNFNQ---NQVVAIKAILPCIGNDVSEQ------FQKTFQEFQNCMKLK---SQY--IVKVEDVLVDFDNKLLFIVQEYCS
. . ..||.||||  |||..| ..   ||.||.| |  .  |. . .       |.  .| |.  |||   ...  |||  |.. . ... ..|..||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGSLTEYIKKLEK----------TENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNR------------VIKIADFGEAKQLRQ-EKGHTHTQG
 | | .||||  |          .|.. .|.|.||. |  ..|...||| |.||.|||. ..             |.|||||| ||..   ..  . .| 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QG------CTPFFAAPEVNF----NNQIS-KESDYYSVGAIF
.       .|| . ||..      . . . ...| .|.| ||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 5142.AA ULK 379-571 29 7.4e-43 147.46 In-house 1-246 (329) Show / Hide 
Range on Protein: 379-571
Range on HMM: 1-246/329
Sequence Identity: 29% (74 aa)

FTVQQQLGQGSFGRVYKAFNFNQ----NQVVAIKAIL---PCIGNDVSE---QFQKTFQEFQNCMKLK----SQY----IVKVEDVLVDFDNKLLFIVQE
. . ..||.||||.|||..| ..    |..||.| |.     . |. .|   . |   .| ..  |||    ...    |||  |.. . ... ..|..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSNGSLTEYIKKLEK-----------TENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNR------------VIKIADFGEAKQLR-----QE
||  | | .||||  |           .|.. .|.|.||| |  ..|...||| |.||.|||....             |.|||||| ||..      |.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KGHTHT-QGQG---CTPFFAAPEVNF----NNQIS-KESDYYSVGAIF
  .| . .      .|| . ||..      . . . ...| .|.| ||
MMMTCVNE--KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 5142.AA Ciliate-E2 379-571 21 4.1e-41 138.88 In-house 1-286 (365) Show / Hide 
Range on Protein: 379-571
Range on HMM: 1-286/365
Sequence Identity: 21% (63 aa)

FTVQQQLGQGSFGRVYKA------FNF-----------------NQNQVVAIKAI----LPCIGNDVSEQ------FQKTFQEFQNCMKLKSQYIVKVED
. .....|||.|| |||.       .|                 .... .|.| .    .  | .  ..       . |  .| ... .|.. .|.|  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

VLVDFDNKLLFIVQEYCSNGSLTEYIKKLEK------------TENILKQIFIQILK---------------GVIAIHEQK-IIHSDLKPDNILVDKNRV
.  . |.. ...| |||. |.| .|||.  |            ||.  |.|. |||.               ..  .|... ||| |.||.|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKIADFGEAKQLRQEKGHTHTQGQGC------------------------------TPFFAAPEVNFNNQ---------ISKESDYYSVGAIF
|||.||| .|.. ..   .   .|.|                              || . |||.  . .          ....|..|.| |.
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 5142.AA Ciliate-E2-Unclassified 379-571 25 6e-41 139.77 In-house 1-260 (352) Show / Hide 
Range on Protein: 379-571
Range on HMM: 1-260/352
Sequence Identity: 25% (68 aa)

FTVQQQLGQGSFGRVYKAFNFNQNQVVAIKAILPCIGNDVSEQFQKTFQEFQNC----MKLKSQYIVK------------------VEDVLVDFDNKLLF
.....|.|||.|| |||. . .|.  .... ..  | .. . | ..   |. |.    ...|. |...                  | .. .. | . ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

IVQEYCSNGSLTEYIKKLEK------------------TENILK-----QIFIQILKGVIAIHEQK-IIHSDLKPDNILVDKNR---VIKIADFGEAK--
|| ||| .|.| .|||| .|                  ||.  |     ..| |||.|   .|... ||| |.||.|||.|.|     |||.||| .|  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

-QLRQEKGHTH-----------TQGQGCTPFFA----APEVNFNNQIS----KESDYYSVGAIF
 | .... ..            .. . .|| .     ||||  ... .    ...|..|.| |.
QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase 5142.AA CAMK 384-570 20 1.1e-39 125.02 In-house 1-323 (425) Show / Hide 
Range on Protein: 384-570
Range on HMM: 1-323/425
Sequence Identity: 20% (65 aa)

QLGQGSFGRVYKAFN-FNQN-----------QVVAIKAIL-PCIGNDV-----------------------SEQFQKTFQEFQNCMK-------LKSQYI
.||.|||| |.....  ...           | |||| |    . ...                        .  .. ..| . ..|       |.   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKVEDVLVD-----------FDNK-------LLFIVQ---EYCSNG----SLTEYIKKLEK----------------TENILKQIFIQILKGVIAIHEQK
.|  .|  |           . .|        ...|    ||||.|     | .||.. ..                ||   ...| ||. .|  .|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHSDLKPDNILVDKN-----------------RVIKIADFGEAKQLRQEKGHT---------------------HTQGQGCTPFFAA-PEVNFNNQ---
|.| ||||.|||.|.|                   |||.||| |..... .. .                       . .  || ..| |||   ..   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------ISKESDYYSVGAI
           .....|  |.| |
MQNATDEEKPYYGPKCDMWSCGVI
Kinase 5142.AA STE 379-552 25 2.9e-36 125.58 In-house 1-233 (359) Show / Hide 
Range on Protein: 379-552
Range on HMM: 1-233/359
Sequence Identity: 25% (61 aa)

FTVQQQLGQGSFGRVYKAFNFN---------------QNQVVAIKAILPCIGN-------------DVSEQFQKTFQEFQNCMKLK--SQYIVKVEDVLV
.. ....|.|.|| |||| | .               .....||| .  .  |             . .|..|.  .| . ..|..  ...|||  .  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DFD-----NKLLFIVQEYCSNGSLTEYIK---KLEKT------------ENILKQIFIQILKG-VIAIHEQKIIHSDLKPDNILVDKNRVIKIADFGEAK
. .     .  |.|. ||...|||.. ||   .  |.            |.... |  |||||    .|...||| |.||.|||.     .|..||| ..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLRQ---EKGHTH--------TQGQGC-----TPFFAAPEV
|| .   ..            |..| .     || . ||||
QLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEV
Kinase 5142.AA CAMKL 379-552 28 1.4e-35 110.91 In-house 1-204 (297) Show / Hide 
Range on Protein: 379-552
Range on HMM: 1-204/297
Sequence Identity: 28% (59 aa)

FTVQQQLGQGSFGRVYKAFN-FNQNQVVAIKAIL------PCIGNDV------SEQFQKTFQEFQNCMKLK---SQYIVKVEDVLVDFDN----KLLFIV
... ..||.|||| |  | .  .... |||| |        .. ..       .    . ..| |  ..|.    . |.|  .|. . ..    | ...|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

QEYCSNGS--LTEYIKKLE-----KTENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNR--VIKIADFGEAKQLR---QEKGHTHTQGQGCTPF
 ||||.|.  | .||.| .      .|.  ...| ||. .|  .|...|.| |.||.|||.|.|   .|||.||| . . |     .|.. .   | .| 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG-SPP

FAAPEV
..|||.
YMAPEI
Kinase 5142.AA STE11 379-552 28 2.8e-28 99.48 In-house 1-206 (303) Show / Hide 
Range on Protein: 379-552
Range on HMM: 1-206/303
Sequence Identity: 28% (60 aa)

FTVQQQLGQGSFGRVYKAFNFNQNQVVAIKAILPCIGN----DVSEQFQK------TFQEFQNCMKLKSQYIVKVEDVLVDF-DNKLLFIVQEYCSNGSL
..  . .|.|.||.|||..| . ....|.| |  .  |    | ... |.        .| .   .|. . ||.  .. ..  .|. . |  |||..|||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TEYIK-K---LEKTENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDK-NRVIKIADFGEAKQLRQEKGHTHT---------QGQGCTPF-------
 . .. |   .  .|.  ..   |||.|.   |...||| |.|..|||.|. . |.|.|||| ||.| ..  .||.         . .| ||.       
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTG-TPYNSMMGTP

-FAAPEV
 . ||||
MWMAPEV
Kinase 5142.AA Pkinase_Tyr 379-524 31 4e-14 48.47 Pfam 1-156 (270) Show / Hide 
Range on Protein: 379-524
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

FTVQQQLGQGSFGRVYKAFNF----NQNQVVAIKAILPCIGNDVSEQ--FQKTFQEFQNCMKL-KSQYIVKVEDVLV-DFD-NKLLFIVQEYCSNGSLTE
 |  ..||.|.||.|||.  .    |... ||.| . .   .  .||   .. ..| .  ..| . . ||.   | . . . |  ..|| ||. .|.| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLD

YIKKL-----EKTENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNRVIKIADFG
| .|        |   | |. .|| ||    .....|| ||   |.||..|.|.||.|||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 5142.AA TyrKc 379-626 20 4.9e-14 4.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 379-626
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FTVQQQLGQGSFGRVYKAFNFNQNQVVAIKAILPCIGNDVSEQFQKTFQEFQNCMKL--KSQYIVKVEDVLVDF-----DNKLLFIVQEYCSNGSLTEYI
 |  ..|| | ||.|||.      . ||.| . ..         .   .| .  .||  . . ||.   | ..        . |.|| ||...|.| .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKLEK--TENILKQIFIQILKGVIAIHEQKIIHSDLKPDNILVDKNRVIKIADFGEAKQLRQE------KGHTHT----QGQG-CTPFFAAPEVNFNNQI
.| ..  .   | .. .|| .|   .|....|| ||   |.||..|...||.||| .. .  .      |   ..    .| .       |||. . .  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SKESDYYSVG--------AIFCLLCD-----LSLQDMLG-IQAGKFPKITNH--------KYKNLLILAFNMMKYEPKQRACCQAVLNLL
. .|| .| |               .     .| |...  ...|. ...  .          . .  .     ...|..| . ...  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF