Gene 12563 (Tetrahymena)

12563

Species: Tetrahymena
Alias: 12563, 19.m00355, PreTt12563, 838, TTHERM_00227530
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-E1,

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
12563.AA Protein None 1063 None Fasta, JSON
12563.NA RNA None 3192 None Fasta, JSON
12563.kin_dom Protein Kinase Domain None 188 None Fasta, JSON
12563.kin_dom2 Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of 12563.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12563.AA Ciliate-B2 333-520 42 1.5e-95 225.2 In-house 1-197 (197) Show / Hide 
Range on Protein: 333-520
Range on HMM: 1-197/197
Sequence Identity: 42% (83 aa)

YYLGKYIAEGGYGVIFDGK-IYQNNKIQEIIFKIQFA-DEQNINQSEEEYNIMKGFEKNIYLINAIDYKKIDENVSVILKEKCECDLNSKLKQLQQNN-Q
|||.|||..|| |.|..|     . . |...|||.|  .. . .. ..|..||| ||.||. .  ||. .|.|.. |.  |||||.| . |...|.   .
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKC

FSFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHYGIHVFSDFGTSYKNKNDQSIQVKGFTPYYAPQEVLKGE------NNINYQSDAFSIG
|    |.|.||.|||||| .| | |.||||||.|||.  .|  |..||| |   |..| |..|||| .||. | ..         ||..||| .|.|
FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 12563.AA Ciliate-E1 339-517 40 1.1e-63 205.82 In-house 1-202 (202) Show / Hide 
Range on Protein: 339-517
Range on HMM: 1-202/202
Sequence Identity: 40% (83 aa)

IAEGGYGVIFDGKIYQNN--KIQEIIFKIQFA-DEQNINQSEEEYN-IMKGFEKNIYLINAIDYKKIDEN-VSVILKEKCECDLNSKLK---------QL
|..|.....|..|...||  .....|....|. .......  .||. ||| |.|..|.|. |||.|||.| ...|..|.|.| |. .|.         |.
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

Q-QNNQFSFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHYGIHVFSDFGTSY--KNKNDQSIQVKGFTPYYAPQEVLK-------GENNINYQS
| ..|||.|.|..||||.|||||| |..|.|||.||||.|||||..|..|..|||.|   ||...|..|.||.| ||.|.|...        ...|||.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS

DAF
| .
DIY
Kinase 12563.AA Ciliate-E2-Unclassified 333-520 19 1.2e-13 43.69 In-house 1-257 (352) Show / Hide 
Range on Protein: 333-520
Range on HMM: 1-257/352
Sequence Identity: 19% (50 aa)

YYLGKYIAEGGYGVIFDGKIYQNN---------KIQEIIFKIQFADEQNINQSEEEYNIMK---------------GFEKNIYLINAIDYKKIDENVSVI
| ..| | .||.|...  .  ...         |||..  |..   . .|.....| |..|                  ....... ..... ..|.  .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LKE-------KCECDLNS-------KLKQLQQNNQFSFTQLL-----QIIFDLIDGL-ILLRAYKIIHLDIKPSNILINHYG---IHVFSDFGTSYKNKN
.         .. .. ..       . ....|...|.  | .     ...  ...||  | .  .||| ||||.|||..  |       .||| |.|...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

D----------------QSIQVKGFTPYYA----PQEVLKGENNIN---YQSDAFSIG
.                | .. .  ||.|     . |||.|.|. .   |..| .| |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
Kinase 12563.AA C8 337-523 25 3.2e-13 42.32 In-house 5-226 (226) Show / Hide 
Range on Protein: 337-523
Range on HMM: 5-226/226
Sequence Identity: 25% (57 aa)

KYIAEGGYGVIFDGKIYQNNKIQEIIFKIQFADEQNINQSEEEYNIMKGFEK----NIYLINAIDYKKIDENVSVILKEKCE-----------CDLNS--
.|.  |.||..  .|  ..|.  ||. |.|   ... .| .|.  ||| .|       |    ..|.   |  .|. .|||.           |....  
QYLSFGAYGMVLKAKNVKDNR--EIVLKFQKCQNKQDIQNIES--IMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

---------KLKQLQQNNQFSFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHYGIHV----FSDFGTSYKNKNDQS-IQVKGF----TPYYAPQ
          ... ... |||  . ..|   .|||.  .   .|.| ||||.|.|.   .  .     .||| . . . ..| || | .    |  |   
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVLKG----ENNINYQSDAFSIGKTL
|..|.        . ||| ||.|  |
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 12563.AA Ciliate-E2 333-520 18 6.5e-13 40.65 In-house 1-283 (365) Show / Hide 
Range on Protein: 333-520
Range on HMM: 1-283/365
Sequence Identity: 18% (54 aa)

YYLGKYIAEGGYGVIFDGKIYQNNK-------------------IQEIIFKIQFADEQNINQSEEEYNIMKGFE---------------KNIYLINAIDY
| . | | .|..|... .| ....|                    .  |. .    ...|.| . | .||.  .               .. ..|. ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KK-IDENVSVILKEKCEC-DLNSKLKQL---------------QQNNQFSFTQLLQ--------IIFDLIDGLILLRAYK-IIHLDIKPSNILINHYGIH
 . .|.|   .  | |.  || . .|.                 .  .. ..|.||        .|  .|..|  |   . ||| ||||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

VFSDFGTSYKNKND---------QSIQVKGF------------------------TPYYAPQEVLKGENN--------INYQSDAFSIG
  .|||.| |...|         . .    .                        ||.| . |.|.|...         .|..| .|.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG
Kinase 12563.AA S_TKc 333-610 17 1.5e-11 -7.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 333-610
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

YYLGKYIAEGGYGVIFDGKIYQNNKIQEIIFKIQFADEQNINQSEEEYNIMKGFEKNIYLINAIDYKKIDENVSVILKEKCEC---DLNSKLKQLQQ---
| ... | .|..|. .  | . ..  ..   ||        .. . | .|.|   .  .... .|.    ... ... | |.    || . .|. .    
YEILRKIGKGAFGKVY--KCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVM-EYCDGDLGDLFDYIKKRGRHGL

NNQFSFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHYGIHVFSDFGTSYKNKNDQSIQVKGFTPYYAPQEVLKGENNINY-QSDAFSIGKTLEI
. .|.  .   ..  ....|  .   .||| |.||.|||...      .||| . .            ||.| . |||      ..  .|  |.| .| .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

VFNHYEMLNKFNKNEKNMIEKFKQILKDYALREQVSERKTCLELHKAFYEAVIFEGYLEFSESYIDKIRLILSQ------SCGDRNK-------DIYF
 .  |           .| . ||.|.                                  |.. .| || .|        .. .  .       . .|
MLCGYPPFP-------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12563.AA STE 405-520 22 1.9e-10 33.26 In-house 124-255 (359) Show / Hide 
Range on Protein: 405-520
Range on HMM: 124-255/359
Sequence Identity: 22% (31 aa)

VSVILKEKCECDLNSKLKQLQQNNQFSFTQLLQIIFDLIDG-LILLRAYKIIHLDIKPSNILINHYGIHVFSDFGTSYKNKND-----------------
.. |.|.|..|  . .... . .  |. .|.  |..... | | .|   .||| ||||.|||.        .|||.. .  ..                 
LDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQ

-QSIQVKGFTPYYAPQEVLKG-----ENNINYQSDAFSIG
 ..  . |   . || ||...     ..  ....|  |.|
QKRNTFVGTP-WMAP-EVIQQNGQGRDKGYDTKCDIWSLG
Kinase 12563.AA Ciliate-E3 333-526 22 2.4e-10 28.78 In-house 1-202 (202) Show / Hide 
Range on Protein: 333-526
Range on HMM: 1-202/202
Sequence Identity: 22% (48 aa)

YYLGKYIAEGGYGVIFDGKIYQNNKIQEIIFKIQFADEQNI-------NQSEEEYNIMKGFE-KNIYLINAIDYKKIDENVSVILKEKCECDLNSKLKQL
|   . .. |..|. .  | .  .  |..  | .. ..|.        . .  | .  . .. .|.  .  . |..  ..  .. .     ||   .||.
YTVQQILGCGQFGRVY--KAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQ

QQNNQFSFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHYG---IHVFSDFGTS---YKNKNDQSIQVKGFTPYYAPQEVLKGENNINYQSDAFS
 .  .     ...|.  .| |.| . . .||| ||||.|||.       |  ..||| |   .|||   . |  |.||.||. |... ...|   ||  |
NKTQN----IIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQND-QQQISKESDYYS

IGKTL-EIV
.|  . ...
VGAVFCQLC
Kinase 12563.AA Ciliate-C8 342-523 20 4.1e-09 29.12 In-house 1-238 (238) Show / Hide 
Range on Protein: 342-523
Range on HMM: 1-238/238
Sequence Identity: 20% (48 aa)

GGYGVIFDGKIYQNNKIQEIIFKIQFADEQNIN--QSEEEYNIMKGFEKNIYLINAID-----YKKIDEN-----------------VSVILKEKCE--C
|..|..   .  ..|.. .. |.    ..|..   . ..||     | .  ....  |      .. .|                   .|.  |||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

DLNSKLKQLQQNN-QFSFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHY-----GIHVFS-----DFGTSYKNKNDQS-IQVKG--FTPYY---
.|.. ...... . ..|  . ..|    ||..  |    |.| ||||.|.| .        |         ||| . . ....| . .|    | .|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

---------APQEVLKG----ENNINY-QSDAFSIGKTL
         || ||.|.    .. |   .|| .| |  |
YFCGNWGYFAP-EVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 12563.AA CAMK 453-520 17 4.5e-08 21.36 In-house 199-321 (425) Show / Hide 
Range on Protein: 453-520
Range on HMM: 199-321/425
Sequence Identity: 17% (22 aa)

KIIHLDIKPSNILINHY-----------------GIHVFSDFGTS--YKNKN----------------------DQSIQVKGFTPYYAP-QEVLKG----
.|.|.|.|| |||...                  .    .||| .  .. ..                      .|  .    ||.|..  |||.|    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------ENNINYQSDAFSIG
         .  .....|  |.|
NMQNATDEEKPYYGPKCDMWSCG
Kinase 12563.AA TKL-Sp1 436-467 34 5.7e-08 20.55 In-house 101-132 (263) Show / Hide 
Range on Protein: 436-467
Range on HMM: 101-132/263
Sequence Identity: 34% (11 aa)

LQIIFDLIDGLILLRAYKIIHLDIKPSNILIN
.||  ..   .  . |..| ||||||.|....
MQISCEVLQAVTFMHACNILHLDIKPANVMVE
Kinase 12563.AA Pkinase 411-520 26 1.6e-05 20.64 Pfam 80-199 (293) Show / Hide 
Range on Protein: 411-520
Range on HMM: 80-199/293
Sequence Identity: 26% (33 aa)

EKCEC-----DLNSKLKQLQQNNQF--SFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHYGIH----VFSDFGTSYK--NKNDQSIQVKGFTPY
| ||.     || . ..  .... |  |  ..  ..  .. ||  . . .||| |.||.||||.. |        .||| . .  . |..  ..   ||.
EYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YAPQEVLKGENNINYQSDAFSIG
|.. ||..| . . . .| .|.|
YMAPEVIRGGQYYGPKVDMWSCG
Kinase 12563.AA TyrKc 333-573 15 3e-05 -137.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 333-573
Range on HMM: 1-280/280
Sequence Identity: 15% (44 aa)

YYLGKYIAEGGYGVIFDGKIYQNNKIQEIIFKIQFADEQNINQSEEEYNIMKGF-EKNIYLINAIDYKKID-------ENVSVILKEKCECDLNSKLKQL
  ||| . || .|... |. .     ..   |   .|   .    .| .||. .  ..  ... . .   .       | . ...   .  ||.. |.  
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

QQNNQFSFTQLLQIIFDLIDGLILLRAYKIIHLDIKPSNILINHYGIHVFSDFGTSYKNKND-------QSI------QVKG-FTPYYAPQEVLKGENNI
. .  ..  .||.. ..  .|   |   ..|| |.   |.|... ..   |||| | . ..|       . .      . |. .     . |..    ..
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGK

-NYQSDA----------FSIGKTLEIV-----FNHYEMLNKFNKNEKNMIEKF---------KQILKDYALR---EQVSERKTCLELHKAF
 . .||           |. |..          . .|....  . .  .. .           . . .  ..   |. ..| |  |.|. |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
TPR_2 12563.AA TPR_2 743-771 31 0.475112 7.8 Pfam 1-29 (34) Show / Hide 
Range on Protein: 743-771
Range on HMM: 1-29/34
Sequence Identity: 31% (9 aa)

AIYLNTLSWCYSSLNDHKQALKVQEETLK
| ... | .||  ..|...|..  |. ||
AEAWYNLGQCYYKQGDYDEAIEYYEKALK
TPR_2 12563.AA TPR_2 826-849 37 0.008855 13.92 Pfam 1-24 (34) Show / Hide 
Range on Protein: 826-849
Range on HMM: 1-24/34
Sequence Identity: 37% (9 aa)

AQSLDYIGQCYLKMGNLEQAKKYL
|  . ..||||.|.|....|..|.
AEAWYNLGQCYYKQGDYDEAIEYY
TPR_2 12563.AA TPR_2 868-901 17 9.538578 3.19 Pfam 1-34 (34) Show / Hide 
Range on Protein: 868-901
Range on HMM: 1-34/34
Sequence Identity: 17% (6 aa)

RVSLMNIARYHQQSGEFIKSIFFYKKYFQMVRNL
   ..|... . . |.. . | .|.|  .   | 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_2 12563.AA TPR_2 910-943 23 2.464759 5.27 Pfam 1-34 (34) Show / Hide 
Range on Protein: 910-943
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

YVFLYNIAQCLFFNRAFQQSIFILQYFLKIFSND
   .||..||.. .. ... |  ..  ||.. |.
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_2 12563.AA TPR_2 948-969 22 2.081142 5.53 Pfam 1-22 (34) Show / Hide 
Range on Protein: 948-969
Range on HMM: 1-22/34
Sequence Identity: 22% (5 aa)

SKAHIIIGLCQLNLGQFQKSLE
 .|.  .|.| ...|.... .|
AEAWYNLGQCYYKQGDYDEAIE