Gene 23086 (Tetrahymena)

23086

Species: Tetrahymena
Alias: TTHERM_00106920, 32, PreTt23086, 23086, 7.m00535
External Links: Tetrahymena Genome Database (TGD) ,
Annotation: Secondary Group: Other, Secondary Family: Ciliate-C8, Secondary Subfamily: C8,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
23086.AA Protein None 997 None Fasta, JSON
23086.kin_dom Protein Kinase Domain None 206 None Fasta, JSON
23086.kin_dom2 Protein Kinase Domain None 138 None Fasta, JSON
23086.NA RNA None 2994 None Fasta, JSON

Protein domain

Protein domains of 23086.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23086.AA Ciliate-E1 134-254 21 1.8e-25 80.05 In-house 71-202 (202) Show / Hide 
Range on Protein: 134-254
Range on HMM: 71-202/202
Sequence Identity: 21% (28 aa)

FFVLAMEYNEFNLKEYIQ---------KLKLEKKNLSQQQKENLAIQLLDAVNSLHQKDIIIGCLNPFNLLLSVNHAEGENQ-QIVLKVLNFGQTYYYFK
.... .|. . .||.|.|         ... .......|||.....||.|... |||. ||.....|.|.| . .  .. .. . . |.|.  |.... .
ICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQY

FQEKSNLSCNQKYKEITQ--YHNEKWGKQLDIF
............|....|  ..|.|.....||.
KGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 23086.AA C2 114-273 25 1.2e-20 67.38 In-house 74-245 (245) Show / Hide 
Range on Protein: 114-273
Range on HMM: 74-245/245
Sequence Identity: 25% (47 aa)

DESNNETQNINNQNGFNEKVFFVLAMEYNEFNLKEYIQKLKLEKKNLSQQQKENLAIQLLDAVNSLHQKDIIIGCLNPFNLLLSVNHAEGENQQI-VLKV
||.  | .|| .|.    |.|.|. .|  . ||| |..... ... ..||.|. .||| .|..| ||..||. .   | |.|.. .     .|.| ..| 
DEEEKEQENIKKQKN-EKKIFVVYEQEFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFD-----QQGIPTIKL

LN----FGQTYYYFKFQEKSNLSCNQKYKEITQYHNEKWG---------------KQLDIFC-IGLIILELDNLIAFDIDS
 .    . |     .|.. | |..|. .  . .   .                  |..|.|. .|.. |||||   ..| .
CDYHIQY-QK--KCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 23086.AA C8 39-260 26 3.1e-17 56.45 In-house 1-226 (226) Show / Hide 
Range on Protein: 39-260
Range on HMM: 1-226/226
Sequence Identity: 26% (61 aa)

FKDFSYLRSCNNTITLKVYNSKQEQFQVIKIAYLKNKNKVNTLSLETLLKEEYQLGQIFYQNQCFVKKPCKFYLFDESNNETQNINNQN-GFNEKVFFVL
|..| || . .  . || .|.|...  |.|..  .||.. .    .. .. ||.. |.| | ...| .   ||.  |  .| .. |..    .|| .|| 
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQN---IESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVM

AMEYNEFNLKEYIQKLKLEKKNLSQQQKENLAIQLLDAVNSLHQKDIIIGCLNPFNLLLSVNHAEGENQQIVLKVLNFGQTYYYFKFQEKSNLSC-----
 ||  | |||.. .... ... .|...||..|||..| || .|.| |..  . | |.|.  .    .|.    |   ||   .  | ...          
EMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLD----QNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCG

NQKYK--EITQY---HNEKWGKQLDIFCIGLII
...|   || .    .. .. .| |.| .||. 
TWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 23086.AA Ciliate-C8 48-260 25 1e-12 42.22 In-house 1-238 (238) Show / Hide 
Range on Protein: 48-260
Range on HMM: 1-238/238
Sequence Identity: 25% (63 aa)

CNNTITLKVYNSKQEQFQVIKIAYLKNKNKVNTLSLETLLKEEYQLGQIFYQNQCFVKKPCKFYLFDESNNETQNINNQNGFNEKV----FFVLAMEYNE
 .  . || .|.||...  .|.    ||.  |    | . ||.  . . | | .. |.    |||  | . | .. |..   ...     |||. ||. .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQ--MEHEIKEYEMI-MQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQ

--FNLKEYIQKLKLEKKNLSQQQKENLAIQLLDAVNSLHQKDIIIGCLNPFNLLLSVNHAEGENQQIVLKVLNFGQTYYYFKFQEKSNLSCNQK------
   |||.|..... ... .|||.||..||| .| || ||...|.     | |.|.. .    ...|   |  .|        |   | |..|.       
QNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFD----QQYQPTIKLCDF--K-KQCDFGFASQLPKNKSHYHSKK

YKEITQY----------------HNEKWGKQLDIFC-------IGLII
.|   ||                 .... .|.|||.        ||. 
FKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23086.AA CDC2 140-185 28 2.8e-05 11.6 In-house 80-125 (301) Show / Hide 
Range on Protein: 140-185
Range on HMM: 80-125/301
Sequence Identity: 28% (13 aa)

EYNEFNLKEYIQKLKLEKKNLSQQQKENLAIQLLDAVNSLHQKDII
|| ...||.|  ...  .|....|   ....|.|..|. .||. |.
EYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIM
Kinase 23086.AA Ciliate-A2 139-185 33 0.000125 12.33 In-house 77-124 (272) Show / Hide 
Range on Protein: 139-185
Range on HMM: 77-124/272
Sequence Identity: 33% (16 aa)

MEYN-EFNLKEYIQKLKLEKKNLSQQQKENLAIQLLDAVNSLHQKDII
||.  |..| . |.| .  .| ....|  ..| |.|||.. ||.|...
MEKCPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYV
Kinase 23086.AA Ciliate-E3 139-216 27 0.000367 9.21 In-house 83-151 (202) Show / Hide 
Range on Protein: 139-216
Range on HMM: 83-151/202
Sequence Identity: 27% (22 aa)

MEYNEF-NLKEYIQKLKLEKKNLSQQQKENLAIQLLDAVNSLHQKDIIIGCLNPFNLLLSVNHAEGENQQIVLKVLNFG
.|| .. .|..||...     |..|.    ..||..  .  .|.| || . ..| | |.. |     | |...|   ||
QEYCSNGDLYHYIKQQ-----NKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKN-----NNQLIIKICDFG
Kinase 23086.AA Ciliate-A1 246-263 44 0.008247 5.32 In-house 204-221 (301) Show / Hide 
Range on Protein: 246-263
Range on HMM: 204-221/301
Sequence Identity: 44% (8 aa)

KWGKQLDIFCIGLIILEL
| .|| |.. .|.||..|
KIYKQSDMYSLGCIICFL
Kinase 23086.AA Ciliate-E1 358-577 17 1.4e-31 100.14 In-house 1-202 (202) Show / Hide 
Range on Protein: 358-577
Range on HMM: 1-202/202
Sequence Identity: 17% (38 aa)

RENISSDDFKLIVQELYKKNEYRGYLELINFNETKLTFGCRNYKQFLVFEFERIGCNLVDFLNVQKVENSLNKDIKFNLVCQLLDAVNFVHQQNIILRNL
 .| |. ... ..|. ...|..  ......||... .| . .........  .  |.........|........|.|...|. |   ...|      . |
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH------NRL

SIKSFCIQEDNNQFYPTLKLCDFRHAVKQEDEVDFQNITLKDYENSFQAPEVTIQENQINKYSKESDIFSVGLIICLIDNYLTLTSNFQQYYRYLQKPFM
 ......|...|||. . |.... .....  |.  .||.  |.      |.  ...|| ..| ..   |........ .|. .  .....||.. .. ..
-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIK-----PQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNC

EPLLIEEINPDPINRKSELY
. .. |......|| ||..|
P-EQ-EHNKNQKINYKSDIY
Kinase 23086.AA C8 399-532 28 1.2e-19 64.91 In-house 90-226 (226) Show / Hide 
Range on Protein: 399-532
Range on HMM: 90-226/226
Sequence Identity: 28% (39 aa)

NYKQFLVFEFERIGCNLVD-FLNVQKVENSLNKDIKFNLVCQLLDAVNFVHQQNIILRNLSIKSFCIQEDNNQFYPTLKLCDFRHAVKQEDEVD-FQNIT
..| . | | |    || . ..  .. .  ..|..|...  |..| ||..|. ||. | .  . | ...|.|.  .. |||||  | . ... . .| . 
EEKSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYG-FEIKLCDFGFASQVSKNKSHIQSKK

LKD-YENSFQAPEVTIQ-ENQINKYSKESDIFSVGLII
 .      . |||.  . .||  .|...||.|||||. 
MNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 23086.AA Ciliate-C8 403-532 26 1.8e-19 66.63 In-house 88-238 (238) Show / Hide 
Range on Protein: 403-532
Range on HMM: 88-238/238
Sequence Identity: 26% (41 aa)

FLVFEFERIG--CNLVDFLNV-QKVENSLNKDIKFNLVCQLLDAVNFVHQQNIILRNLSIKSFCIQEDNNQFYPTLKLCD--------FRHAVKQEDE-V
| |.| |     ||| ....  .| .  .....|.... | .| ||. |. ||. |      |  ..| .| .|| ||||        |  ..... . .
FFVMEMEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFD-QQYQPTIKLCDFKKQCDFGFASQLPKNKSHY

DFQNITLKDYENSF--------QAPEVTIQ--ENQINKYSKESDIFSVGLII
 ....  .|. . .         ||||  .  ..|   .||.||..||||. 
HSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23086.AA C2 401-547 24 5.1e-12 37.47 In-house 91-245 (245) Show / Hide 
Range on Protein: 401-547
Range on HMM: 91-245/245
Sequence Identity: 24% (39 aa)

KQFLVFEFERIGCNLVDFLNVQKVEN-SLNKDIKFNLVCQLLDAVNFVHQQNIILRNLSIKSFCIQEDNNQFYPTLKLCD--------FRHAVKQEDEVD
| |.|.| |   .||  ..|... .|  .....|  .. | .|..|. |. .|. |      |  |.|... .||.||||           .  .  . .
KIFVVYEQEFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQG-IPTIKLCDYHIQYQKKCDFDFASKLKYN

FQNITLKDYENSFQA-PEVTIQENQINKYSKESDIFS-VGLIICLIDNYLTLTSNFQQ
. .|. .    . |    ... |.. | | |.||.|| ||..   .||  . ......
KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDN--MQQYTICC
Kinase 23086.AA Ciliate-A2 413-480 33 4.9e-08 24.31 In-house 83-147 (272) Show / Hide 
Range on Protein: 413-480
Range on HMM: 83-147/272
Sequence Identity: 33% (23 aa)

CNLVDFLN-VQKVENSLNKDIKFNLVCQLLDAVNFVHQQNIILRNLSIKSFCIQEDNNQFYPTLKLCDF
|.| |.    |. ...... .  ...||.|||..  |..|..||.||...  |  ||.     .|||||
CSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQ-I---IKLCDF
Kinase 23086.AA Ciliate-E6 408-529 23 2.3e-07 19.89 In-house 29-154 (154) Show / Hide 
Range on Protein: 408-529
Range on HMM: 29-154/154
Sequence Identity: 23% (31 aa)

FERIGCNLVDFLNVQKVENSLNKD-IKFNLVCQLLDAVNFVHQQNIILRNLSIKSFCIQEDNNQFYPTLKLCDFR---HAVKQEDEVDFQNITLKDYENS
.|| . || | ..  |   ..| . . |.  |||. ||. .|..|..| |.. |.  . .. |     .|.|||      .. .    |. .  ....  
MERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMN-----IKICDFGFQQCIIPNQQTKEFM-AQKNQNKYH

FQAPEVTI---QENQINKYSK---ESDIFSVG
. .||  .      ..... .   |.||.||.
YCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC
Kinase 23086.AA S_TKc 317-607 13 2e-06 -83.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 317-607
Range on HMM: 1-231/231
Sequence Identity: 13% (44 aa)

SEILQEL---------------LKMQTYQKQIPPIHSLVLENQVDTFLNIFKIQLQRENISSDDFKLIVQE--LYKKNEYRGYLELINFNETKLTFGCRN
 |||...                . .   |.|.                                . | .|  . ||        |. . ..        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD--------

YKQFLVFEFERI-GCNLVDFLNVQKVENS---LNKDIKFNLVCQLLDAVNFVHQQNII-----LRNLSIKSFCIQEDNNQFYPTLKLCDFRHAVKQEDEV
 . ..|.|.    . .| |..  .. .     ..      ...|...|... |...||       |. . .            ..|.|||  | .     
DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL----

DFQNITLKDYENSFQ------APEVTIQENQINKYSK-ESDIFSVG-LIICLIDNYLTLTSNFQQYYRYLQKPFMEPLLIEEINPDPINRKSELYNIIKL
           ..|       ||||        .|.| ..|. |.| ... ..  |     . |. .. .                     .|. ..|. 
-----------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------------SPEAKDFIRK

MLLYEPQQRKSLEQIVN---IIPSYQFF
.| ..|..| .  .. .    | . ..|
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23086.AA Ciliate-E3 504-536 39 4e-06 15.36 In-house 174-202 (202) Show / Hide 
Range on Protein: 504-536
Range on HMM: 174-202/202
Sequence Identity: 39% (13 aa)

FQAPEVTIQENQINKYSKESDIFSVGLIICLID
. |||. .| .     |||||. ||| ..|.. 
YAAPEQNDQQQ----ISKESDYYSVGAVFCQLC
Kinase 23086.AA TKL 301-323 47 7e-06 17.24 In-house 342-364 (364) Show / Hide 
Range on Protein: 301-323
Range on HMM: 342-364/364
Sequence Identity: 47% (11 aa)

LAQLCLLPDHSQRPSASEILQEL
|.| |  .| ..|||..|||..|
LMQDCWDHDPEKRPSFQEILKRL
Kinase 23086.AA Ciliate-A1 517-533 58 9.2e-05 12.07 In-house 203-219 (301) Show / Hide 
Range on Protein: 517-533
Range on HMM: 203-219/301
Sequence Identity: 58% (10 aa)

NKYSKESDIFSVGLIIC
|| .| ||..|.|.|||
NKIYKQSDMYSLGCIIC
Kinase 23086.AA Ciliate-A1 571-606 41 0.000152 11.31 In-house 268-301 (301) Show / Hide 
Range on Protein: 571-606
Range on HMM: 268-301/301
Sequence Identity: 41% (15 aa)

NRKSELYNIIKLMLLYEPQQRKSLEQIVNIIPSYQF
.|  || |.|. |. |||..| ||.|..     |.|
PRFEELQNLIFKMMQYEPNNRCSLQQCIDCL--YIF
Kinase 23086.AA CDC2 408-457 23 0.000372 8.09 In-house 79-129 (301) Show / Hide 
Range on Protein: 408-457
Range on HMM: 79-129/301
Sequence Identity: 23% (12 aa)

FERIGCNLVDFLN-VQKVENSLNKDIKFNLVCQLLDAVNFVHQQNIILRNL
||.. ..|  ..   .. . ..  ..  ..  |.|..|.| ||. |. |.|
FEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDL
Kinase 23086.AA TKL 506-601 15 0.002432 7.9 In-house 241-364 (364) Show / Hide 
Range on Protein: 506-601
Range on HMM: 241-364/364
Sequence Identity: 15% (20 aa)

APEVTIQENQIN------------KYSKESDIFSVGLIICLIDNYLTLTSNFQQYYRYLQKPF-----MEPLLIEEINPDPIN-----------RKSE--
||||  .... .            .||. .|..| |.... |   ||    ...|  . ....     |  . ... .. ||             ..   
APEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI---LTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPP

-LYNIIKLMLLYEPQQRKSLEQIVNII
 . ....    ..|..| | ..|. ..
SMKKLMQDCWDHDPEKRPSFQEILKRL