Gene 21147 (Tetrahymena)

21147

Species: Tetrahymena
Alias: TTHERM_00777360, PreTt21147, 21147, 129.m00118, 908
External Links: Tetrahymena Genome Database (TGD) ,
Annotation: Secondary Group: Other, Secondary Family: Ciliate-C8,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
21147.AA Protein None 782 None Fasta, JSON
21147.kin_dom Protein Kinase Domain None 201 None Fasta, JSON
21147.kin_dom2 Protein Kinase Domain None 270 None Fasta, JSON
21147.NA RNA None 2349 None Fasta, JSON

Protein domain

Protein domains of 21147.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21147.AA Ciliate-E1 68-268 16 1.3e-42 136.42 In-house 1-202 (202) Show / Hide 
Range on Protein: 68-268
Range on HMM: 1-202/202
Sequence Identity: 16% (33 aa)

LKVNDQFVVKIKKINRHNEKEIKDLDILVNAVRSLGKENYIHQVDDSYFLQSDFQESKIDLFYIQEMEFANGKLFQFNSFNKCLFKNTKGN--FEDLFLQ
.. .....|...|.. .|....... |...  ..  ....... .....    .... |... ............ |.. ...|.......  . ... |
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRL-EYWQQ

LRTKSIELKDWQKERMAIQLFDALNIFHQCGSCHRNIKPSNILY--FYENGNFT-VKLADLQANNTEDFSQEFNQITNPVSSYKYIDVYQPLEAYLNQYH
.... ......||.....||.|.|...||.. .||.|||.|||.  . .|....   ..... ||... .|.......  ....| ...|  . . ....
CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKIN

KKSDLF
.|||..
YKSDIY
Kinase 21147.AA Ciliate-C8 62-274 20 5.1e-24 83.12 In-house 1-238 (238) Show / Hide 
Range on Protein: 62-274
Range on HMM: 1-238/238
Sequence Identity: 20% (53 aa)

GKQSLVLK-----VNDQFVVKIKKI-NRHNEKEIKDLDILVNAVRSLGKENYIHQVDDSYFLQ-SDFQES---------------KIDLFYIQEMEFANG
|  ..|||      | .   |.... |  . .... . .     .   .. .. || |...|.  . .|                |  .|.  |||.   
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK--SFFVMEMEKCQQ

KLFQFNSFNKCLFKNTKGNFEDLFLQLRTKSIELKDWQKERMAIQLFDALNIFHQCGSCHRNIKPSNIL-YFYENGNFTVKLAD------LQANNTEDFS
.                .| ...| ..| | ..... .|| .|||  | .|  |.    || |||.|.| .| .....|.||.|      .        .
N----------------CNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKN

QEFNQITNPVSSYKYIDV-------YQPLEAYLNQYHKKSDLFR-------LGLVL
..   . . . .. ||..       | . | . .|. ..||.|        .||||
KSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 21147.AA C2 122-288 26 1.1e-18 60.54 In-house 86-245 (245) Show / Hide 
Range on Protein: 122-288
Range on HMM: 86-245/245
Sequence Identity: 26% (48 aa)

QESKIDLFYIQEMEFANGKLFQFNSFNKCLFKNTKGNFEDLFLQLRTKSIELKDWQKERMAIQLFDALNIFHQCGSCHRNIKPSNILY-FYENGNFTVKL
|...  .|.  |.||  |.                   .  | ..| . ... . .|. ||||  |. |  |. .  || |||||.|| | ..|. |.||
QKNEKKIFVVYEQEFCQGN------------------LKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKL

AD----------LQANNTEDFSQEFNQITNPVSSYKYIDVYQPLEAYLNQYHKKSDLFR-LGLVLAQLDTPSFQFTNIS
.|          ..       ...   . . .... |.     .| | | | |.||||  .|.||  ||   .|.|  .
CDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDN-MQQYTICC
Kinase 21147.AA C8 53-274 22 2.5e-18 60.29 In-house 1-226 (226) Show / Hide 
Range on Protein: 53-274
Range on HMM: 1-226/226
Sequence Identity: 22% (52 aa)

YVQFKYIGTGKQSLVL---KVNDQFVVKIKKINRHNEKEIKDLDILVNAVRSLGKENYIHQVDDSYFLQSDFQESKIDLFYIQEMEFANGKLFQFNSFNK
  .|.|.  |  ..||   .|.|.  . .|     |...|. .  .   .    ..  . |  |.| .. | .. .   |  .. .     . .  |.  
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEY----EMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFV

CLFKNTKGNFEDLFLQLRTKSIELKDWQKERMAIQLFDALNIFHQCGSCHRNIKPSNIL-YFYENGNFTVKLADLQANNTEDFSQE-FNQIT-NPVSSYK
   . .. |...|....|.|  .... .|| .|||. | .|  |.    || |||.|.| .. .| .|..||.|.    .   ... . ..  | .   .
MEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWA

YI--DVYQPLEAYLNQYHKKSDLFRLGLVL
|.   . .  .  . || ..|||| .||||
YFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 21147.AA Ciliate-E2 181-331 16 1.7e-07 21.8 In-house 165-352 (365) Show / Hide 
Range on Protein: 181-331
Range on HMM: 165-352/365
Sequence Identity: 16% (33 aa)

MAIQLFDALNIFHQCG-SCHRNIKPSNILYFYENGNFTVKLADLQA--NNTED-----------FSQEFNQITNPVSSYK-------------YIDVYQP
.. .. .||.  |. .  .||.|||.|||.        .|..|.    ....|             .. .. |.  ..|              .   |..
YIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMA

LEAYLNQ----------YHKKSDLFRLGLVLAQLDTPSFQFTNISFEKYLQFQANFS--ENIFPISDNIKKDTFLY-----------KIIQR----CLHK
 | . ..          | .|.|.. || .| .. .  . |    ... .| . .|.  |.. . .. ..   . .            .|..    .| |
PEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQK

NPSQR
.|..|
DPEKR
Kinase 21147.AA CAMK 193-222 25 5e-06 14.65 In-house 196-239 (425) Show / Hide 
Range on Protein: 193-222
Range on HMM: 196-239/425
Sequence Identity: 25% (11 aa)

HQCGSCHRNIKPSNILYFYENGN--------------FTVKLAD
|... .|| .|| |||. . |..              ...|..|
HSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIID
Kinase 21147.AA CMGC 168-222 14 3.9e-05 11.81 In-house 155-247 (513) Show / Hide 
Range on Protein: 168-222
Range on HMM: 155-247/513
Sequence Identity: 14% (14 aa)

TKSIELKDWQ------------KERMA------IQLFDALN--IFHQCG--SCHRNIKPSNILYFYEN-----------------GNFTVKLAD
.. ..|.. .            .  .        |.. .|.    |. .   .|| .||.|||   ..                  |...|..|
KRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICD
Kinase 21147.AA STE 199-222 50 9.9e-05 12.78 In-house 175-190 (359) Show / Hide 
Range on Protein: 199-222
Range on HMM: 175-190/359
Sequence Identity: 50% (12 aa)

HRNIKPSNILYFYENGNFTVKLAD
|| |||.|||         |||.|
HRDIKPANILL--------VKLCD
Kinase 21147.AA ULK 199-208 80 0.046604 3.17 In-house 149-158 (324) Show / Hide 
Range on Protein: 199-208
Range on HMM: 149-158/324
Sequence Identity: 80% (8 aa)

HRNIKPSNIL
|| |||.|||
HRDIKPQNIL
Kinase 21147.AA ULK 199-208 80 0.047583 3.05 In-house 153-162 (329) Show / Hide 
Range on Protein: 199-208
Range on HMM: 153-162/329
Sequence Identity: 80% (8 aa)

HRNIKPSNIL
|| |||.|||
HRDIKPQNIL
Kinase 21147.AA Pkinase_Tyr 316-331 31 0.949495 3.16 Pfam 245-260 (270) Show / Hide 
Range on Protein: 316-331
Range on HMM: 245-260/270
Sequence Identity: 31% (5 aa)

LYKIIQRCLHKNPSQR
.|.....| |..|..|
IYDLMKQCWHYDPEDR
Kinase 21147.AA Pkinase 184-222 39 2.587921 2.19 Pfam 116-155 (293) Show / Hide 
Range on Protein: 184-222
Range on HMM: 116-155/293
Sequence Identity: 39% (16 aa)

QLFDALNIFHQCGSCHRNIKPSNILYFYENGNF--TVKLAD
|.. .|.  |..| .|| .||.|||.  .||.   .||..|
QILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICD
Kinase 21147.AA Ciliate-E1 393-584 29 1.2e-48 156.31 In-house 1-202 (202) Show / Hide 
Range on Protein: 393-584
Range on HMM: 1-202/202
Sequence Identity: 29% (60 aa)

LGAGSQGIVIEALNRESN-RIVALKIQLIEDQQSKEQLETEVQVVQSLQSQYIVKIYEVEMLKIGKKEFY---IIQMEKCDCSLFQYLK----------A
.|.||..||..| ....| . ||.||............. | .  ..... .. ..| ...... |....   || .|.|.|||..||.           
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

NQTQFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIADFGFAKEVNKQTQQASYEILNSLFYNKKGTPMYSAPEFSKNIIT
.|.|.. ... |.||..|.| ||..||..|||||||||||||.. | .| |  ...   | |. ..|..| .... .   .... .|.. ... ... |.
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQK-IN

MKSDIF
.||||.
YKSDIY
Kinase 21147.AA Ciliate-C8 396-590 29 5.9e-45 155.66 In-house 1-238 (238) Show / Hide 
Range on Protein: 396-590
Range on HMM: 1-238/238
Sequence Identity: 29% (71 aa)

GSQGIVIEALNRESNRIVALKIQLI----EDQQSKEQLETEVQVVQSLQSQYIVKIYEVEMLK--IGKKE-----------------FYIIQMEKCD--C
|. |.|. | |  .||.||||.  .    .  |.... . ..   | .|....|. |   .|   . |..                 |. . ||||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLFQYLKA-NQTQFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIAD------FGFAKEVNKQTQ-QASYEILNSLFYNKK
.| ||..   ..|   ..  |..|| |.| ..| || .||.||||||.|.||| . ..  .||..|      ||||  . |.     | .. ..  |.. 
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

---GTPMYSAPEFSKNIITMKSDIFS-------LGIIL
   |.  |.|||  |..   .|||||       .|..|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 21147.AA C8 387-590 28 1.3e-43 149.26 In-house 1-226 (226) Show / Hide 
Range on Protein: 387-590
Range on HMM: 1-226/226
Sequence Identity: 28% (66 aa)

YACFNALGAGSQGIVIEALNRESNRIVALKIQLIEDQQSKEQLETEVQVVQSLQSQYIVKIYEVEMLK--IGKKEFYIIQMEKCD-----------CSLF
   |. |  |. |.|..| | ..|| ..||.| ....| ....|   .. .... . ... |.  ...  ......  .. |||.           |.. 
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIE---SIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVM

Q-----------YLKANQTQFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIADFGFAKEVNKQTQQASYEILNSLFYNKK
.           |..  ..|  ...  | .|| |.| |.| .|.|||.||||||.|.||| ....  .||..|||||  | |     . .   | ..|. 
EMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSK-----NKSHIQSKKMNTC

GTPMYSAPEFSKN------IITMKSDIFSLGIIL
||  |.|||  |       . . .||.||.|..|
GTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 21147.AA C2 396-603 26 2.2e-42 142.66 In-house 1-245 (245) Show / Hide 
Range on Protein: 396-603
Range on HMM: 1-245/245
Sequence Identity: 26% (66 aa)

GSQGIVIEALNRESNRIVALKIQLIED--QQSKEQLETEVQVVQSLQ-SQYIVKIYE-----VEMLKI----------GKKE----------FYIIQMEK
|. |.|. | |...||.|||||| ...   . ..... |..  . .| . ||.|.|      |.   .          ....          |. . .|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CDCSLFQYLKANQTQF-SIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIAD----FGFAKEVNKQTQQASYEILNSLFYNKK
|.. | ||.. .. |    ..  |...| |.. . | || ..|.||||||.|.|.  . ..   ||..|    .   |   .. .  .|.  .  | . |
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QKKCDFDFASKLKYNKSRIHFSKFK

GTPMY----SAPEFSKNIITMKSDIFS-LGIILLEIDNYEDFSYSF
.|  |    .|||  .||   .||.|| .|..|||.|| . .. . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 21147.AA S_TKc 387-654 25 2.7e-42 147.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 387-654
Range on HMM: 1-231/231
Sequence Identity: 25% (73 aa)

YACFNALGAGSQGIVIEALNRESNRIVALKIQLIEDQQSKEQLETEVQVVQSLQSQYIVKIYEVEMLKIGKKEFYIIQMEKCDC---SLFQYLKANQTQ-
|   . .| |. | |  . .....||||.||         |... |.|. .. .  .|||.|.|        ... . || ||    .||.|.| .... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--FSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIADFGFAKEVNKQTQQASYEILNSLFYNKKGTPMYSAPEFSKNIITM-
  | ..|     ..|||. .|. .||..|||||.||.|||..       .|||.|||.|...                .   ||| | |||      .  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------------TTFCGTPWYMAPEVL--GYGKC

KSDIFSLGIILLEIDN----YEDFSYSFQNFLQLMIPFTVPLEGINQIRRNSFLYQVASQCLKYSEKQRPQLNTLIQ---------LF
|.|. |.|.|| |       ..      |  ....                ...    ..||..  ..||    . |          |
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21147.AA Pkinase 387-592 31 1.2e-41 148.37 Pfam 1-204 (293) Show / Hide 
Range on Protein: 387-592
Range on HMM: 1-204/293
Sequence Identity: 31% (70 aa)

YACFNALGAGSQGIVIEALNRESNRIVALKIQLIEDQQSKEQ-----LETEVQVVQSLQSQYIVKIYEVEMLKIGKKEFYIIQMEKCDC-----SLFQYL
| .   .|.|| | | .. .. ...|||.||   ... |...     | .|.|. ..|.. .||..|.. .    |.. | . || |..     .|| |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED---KDHIY-MVMEYCEGGLYVMDLFDYI

K-ANQTQFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIADFGFAKEVNKQTQQASYEILNSLFYNKKGTPMYSAPEFSK-
.  ... |. .|   . ..|||. ||. .||..|||||.||.|||.  .| ..  .||.|||.|| ..        .  || ..   ||| | |||  . 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRG

-NIITMKSDIFSLGIILLE
 . .. |.|..|.|.|| |
GQYYGPKVDMWSCGCILYE
Kinase 21147.AA CAMK 392-590 19 2.1e-40 127.43 In-house 1-324 (425) Show / Hide 
Range on Protein: 392-590
Range on HMM: 1-324/425
Sequence Identity: 19% (63 aa)

ALGAGSQGIVIEALNRESN------------RIVALKI----QLIED------------------------QQSKEQLETEVQVVQSLQ-------SQYI
 || || |.| .. .....            . || ||    .| ..                        ........ |... ..||          |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKIYEVEM----------------LKIGKKEFYIIQM---EKCDC-----SLFQYLKANQT------------QFSIDETLKIQIAYQIIVGLNILHSKN
.|.|||                      |...... |   | |.       ||.|....               . ..|    ..  ||. ... .||.|
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPQNILVCIQGSNSV-------------QIKIADFGFAKEVNKQTQQA--------------SYEILNSLFYNKKGTPMYSA-PEFSKNI----
|.|||.|| |||..  ...|              .|||.|||||.....  ..               . .. . ...   ||| | | ||  .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------ITMKSDIFSLGIIL
           .. |.|. |.|.||
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 21147.AA ULK 387-590 31 2.5e-40 140.28 In-house 1-242 (324) Show / Hide 
Range on Protein: 387-590
Range on HMM: 1-242/324
Sequence Identity: 31% (79 aa)

YACFNALGAGSQG-IVIEALNRES---NRIVALKIQL---IEDQQSK-------EQLETEVQVVQSLQ---SQY--IVKIYEVEMLKIGKKEFYIIQMEK
|   . || || |  | .. | ..   | .|| |.     . .....       ..|. |.|... |    ...  ||| |.. . .   . .||| || 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH-NNIYII-MEY

CDC-SLFQYLKANQT------QFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQG---------SNSVQIKIADFGFAKEVNK--QTQQA
|..  |.||.| |..      .  . |   ||. .||. |.  ||..|||||||||||||.             . ....||||||||| |..  . || 
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQM

SYEILNSLFYNKK---GTPMYSAPE-FS----KNIIT-MKSDIFSLGIIL
 ....|      |   |||.| ||. ..    .   .  |.||.|||.|.
CQTCVNE-----KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 21147.AA ULK 387-590 30 3.9e-39 134.27 In-house 1-246 (329) Show / Hide 
Range on Protein: 387-590
Range on HMM: 1-246/329
Sequence Identity: 30% (79 aa)

YACFNALGAGSQGIVIEALNRES----NRIVALKIQLIE--DQQSKE--------QLETEVQVVQSL----QSQY----IVKIYEVEMLKIGKKEFYIIQ
|   . || || | | .. | ..    | .|| |. ...  .|...|        .|. |... . |    ....    ||| |.. . .   . .||| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYII-

MEKCDC-SLFQYLKANQT-------QFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQG---------SNSVQIKIADFGFAKEVNKQ--
|| |.   |.||.| |..       .  . |   ||. .||. |.  ||..|||||||||||||.             . ....||||||||| |..   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNM

TQQASYEIL-NSLFYNKK---GTPMYSAPE-FS----KNIIT-MKSDIFSLGIIL
 ||  .  .        |   |||.| ||. ..    .   .  |.||.|||.|.
EQQMMMTCVNE------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 21147.AA STE 387-592 22 1e-35 123.61 In-house 1-260 (359) Show / Hide 
Range on Protein: 387-592
Range on HMM: 1-260/359
Sequence Identity: 22% (62 aa)

YACFNALGAGSQGIVIEALNR------ESNRI---------VALKIQLIEDQ-----------------QSKEQLETEVQVVQSLQ--SQYIVKIYEVEM
. .   .| |. | |  |.|.      .....         .| |.  .|..                 . ..|.. |... . ..  ...||| |  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LK---IGKKEFYIIQMEKCDC-SLFQYLKAN-QTQFSID----------ETLKIQIAYQIIVG-LNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIADF
 .    . ..   | || .|  || . .| .  .... .          |.. . |..||. | |. |||..||||||||.|||.         .|..||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF

GFAKEVNK---QTQQASYEILN--------SLFYNKKGTPMYSAPEF-SKNI------ITMKSDIFSLGIILLE
|... ...      | |  . .        .  .   ||| . |||  ..|        . |.|| |||. ..|
GVCGQLTDSMANI-Q-S-NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE
Kinase 21147.AA Ciliate-E2 387-590 22 4.8e-35 117.74 In-house 1-286 (365) Show / Hide 
Range on Protein: 387-590
Range on HMM: 1-286/365
Sequence Identity: 22% (69 aa)

YACFNALGAGSQGIVIEALNRESNRIVALKI--------------------QLIEDQQSKEQLETEVQVVQ----------------SLQSQYIVKIYEV
|   . .| |..|.| .. ... .. .|.||                      |  .. .||.. | .. .                .|.. .|.|.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

EMLKIG--KKEFYIIQMEKCDC-SLFQYLKANQTQF--------SIDETLKIQIAYQIIV---------------GLNILHSKN-IIHRDIKPQNILVCI
        ... . . || |.  .||.|.| |....        ...|   ..| .||.                .|. ||||| ||||||||.|||.  
----FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

QGSNSVQIKIADFGFAKEVNKQTQQASYEILNSLFYNKKG------------------------TPMYSAPEFSKNI----------ITMKSDIFSLGII
       |||.|||..|..... |. ..    .  |   .                        ||.| |||  ..            . |.||.|||.|
-------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

L
|
L
Kinase 21147.AA CMGC 387-559 17 1.9e-33 106.61 In-house 1-291 (513) Show / Hide 
Range on Protein: 387-559
Range on HMM: 1-291/513
Sequence Identity: 17% (52 aa)

YACFNALGAGSQGIVIEALN--------------RESNRIVALKIQLIEDQQSKEQL------------ETEVQVVQSLQ-----------------SQY
| . . .| |. |.| .. .              .|.|.|||.|.   .     ...              |..  . |.                   .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKIYEVEMLKIGK--------------KEFYIIQMEKCDCSLFQYLKANQT--------QFSIDE----------TLKIQIA------YQIIVGLN--I
|||.|.. . |  .              ...|.. .| .|..|.||.| ||.         .|  .           ..  .       |||. ||.   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLV-FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSKN--IIHRDIKPQNILVCIQGSN----------------SVQIKIADFGFAKEVNKQ--------------------TQQASYEILNSLFY
.||..  |||||.||.|||.. .. .                . ..||.|||.|. ...                     .... ..   ...|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWY
TyrKc 21147.AA TyrKc 382-654 23 2.8e-12 -24.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 382-654
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

IQLKKYACFNALGAGSQGIVIEALNRESNRIVALKIQLIEDQQSKEQLETEVQVVQSL--QSQYIVKIYEVEMLKIGK----KEFYIIQ--MEKCDCSLF
|.|.|      || |  |.| ..  .   . || |    .    .| .  | ..  .|  . . ||..| | . . ..    .  .|.   |..   .| 
ITLGKK-----LGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLK

QYLKANQTQFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIADFGFAKEVNKQ-TQQASYEILNSLFYNKK---GTPM---
.||.... .  .    ......||  | . |||||.||||.   |.||  ..    ..||.||| ....    .|       ..  | ||   |. .   
DYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLP

--YSAPE-FSKNIITMKSDIFSLGIILLEIDNYEDFSYSFQ----NFLQLMIPFTVPLEGINQIRR---------NSFLYQVASQCLKYSEKQRPQLNTL
    ||| . ... | |||..| |. . ||  | .  |. .       | .| .    .   |             . .||. .|| ..  ..||  ...
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IQLF
...|
HECF
Pkinase_Tyr 21147.AA Pkinase_Tyr 381-542 27 0.000161 15.93 Pfam 1-161 (270) Show / Hide 
Range on Protein: 381-542
Range on HMM: 1-161/270
Sequence Identity: 27% (47 aa)

IIQLKKYACFNALGAGSQGIVIEALNR----ESNRIVALKIQLIEDQQS---KEQLETEVQVVQSL-QSQYIVKIYEVEM-LKIGKKEFYIIQMEKCDC-
|. .||      ||.|. | | ..  .    . .  || |.      ..   .| .  |...  .| . . ||. | | .  .  . . ||. || . . 
ITFGKK------LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIV-MEYMPHG

SLFQYLKAN-QTQFSIDETLKIQIAYQIIVGLNILHSKNIIHRDIKPQNILVCIQGSNSVQIKIADFGFAKEV
.|  ||...   . ...   ..|...||  |.. |.|||.||||.   |.||     |  ..||.||| |. .
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NN-VVKICDFGLARDI
Kinase 21147.AA Pkinase_Tyr 629-654 23 0.48438 4.15 Pfam 245-270 (270) Show / Hide 
Range on Protein: 629-654
Range on HMM: 245-270/270
Sequence Identity: 23% (6 aa)

LYQVASQCLKYSEKQRPQLNTLIQLF
.|..  || .|  ..||    ... .
IYDLMKQCWHYDPEDRPTFSEIHEQL