Gene 8818 (Tetrahymena)

8818

Species: Tetrahymena
Alias: 15.m00529, PreTt08818, 553, TTHERM_00191680, 3697.m00240, 8818
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-B3,

Classification

Group: Other
Family: Ciliate-B3

Sequence

Name Sequence Type Origin Length Description Download
8818.AA Protein None 963 None Fasta, JSON
8818.kin_dom Protein Kinase Domain None 68 None Fasta, JSON
8818.kin_dom2 Protein Kinase Domain None 116 None Fasta, JSON
8818.NA RNA None 2892 None Fasta, JSON

Protein domain

Protein domains of 8818.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8818.AA Ciliate-B3 98-165 68 1.3e-41 144.54 In-house 1-69 (69) Show / Hide 
Range on Protein: 98-165
Range on HMM: 1-69/69
Sequence Identity: 68% (47 aa)

LALYHFTQVVNTIKKLHSLNLCHCDIKVDNILVEQQSN-GLKDILIDFGHCQSKKQNEKSEAVCGTLTY
.||.||.|||..||.||..|.||||||||||||.||.. ..|.|.|||||||.|.||.|||..||||||
FALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFGHCQRKCQNCKSEMICGTLTY
Kinase 8818.AA Ciliate-E1 6-190 21 9.2e-15 44.85 In-house 1-202 (202) Show / Hide 
Range on Protein: 6-190
Range on HMM: 1-202/202
Sequence Identity: 21% (44 aa)

IAQGGQSVCYRVKTQKGNIYLLKEFLTKTEYNHE--------KKIYQHLNEITKEI-DLSILKMIDHDDH-KCQIVFPFINFQLALICS--------KVK
|..|..|. .. | |. |..  .. . ....| .        |..|. .. . ||.  . |...|..|.   | |.| . . .|    .        . .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

ENNARGMKWILALYHFTQVVNTIKKLHSLNLCHCDIKVDNILVEQQSNGLKDILIDFGHCQ--SKKQNEKSEAVCGTLTYNPLEL---NEGIAKQQIKEY
..|   ..    .. . | .  .  ||..|..|.||| .|||...|.|...    ||| ..   ..||. .   . |  | | |    .|  . .. ...
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC---DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKI

SPYMLDLF
. |..|..
N-YKSDIY
Kinase 8818.AA Ciliate-C8 105-196 22 8.9e-12 38.78 In-house 127-238 (238) Show / Hide 
Range on Protein: 105-196
Range on HMM: 127-238/238
Sequence Identity: 22% (25 aa)

QVVNTIKKLHSLNLCHCDIKVDNILVEQQ-SNGLKDILID------FGHCQSKKQNEK---------SEAV-----CGTLTYNPLELNEGIAKQQIKEYS
|.   .  ||  |  | ||| .|.||  . ....   | |      ||     ..|.          ....     ||...| . |. ... ..| . .|
QMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFS

PYMLDLFQLGMLL
    |....| .|
KK-SDSYSVGLVL
Kinase 8818.AA C8 105-196 30 4.7e-10 31.2 In-house 131-226 (226) Show / Hide 
Range on Protein: 105-196
Range on HMM: 131-226/226
Sequence Identity: 30% (30 aa)

QVVNTIKKLHSLNLCHCDIKVDNILVEQQSNGL-KDILIDFGHCQSKKQNEK---SEAV--CGTLTYNPLELNEGIAKQQIKEYSPYMLDLFQLGMLL
|..  .  .|. |  | ||| .|.||  . | . .  | |||     ..|..   |  .  |||..|   |  ..  ..| |.|.    |||..|..|
QMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKK-QDNQYKQYR-IQSDLFSVGLVL
Kinase 8818.AA Ciliate-E8 105-147 41 6.4e-10 27.2 In-house 97-138 (138) Show / Hide 
Range on Protein: 105-147
Range on HMM: 97-138/138
Sequence Identity: 41% (18 aa)

QVVNTIKKLHSLNLCHCDIKVDNILVEQQSNGLKDILIDFGHC
|. . .  ||..|  |||.| .|||| |    .|  .||||  
QIMDAFCYLHNNNIIHCDFKLNNILV-QRNDDTKIKIIDFGFS
Kinase 8818.AA Ciliate-E2-Unclassified 99-165 25 8.1e-10 30.26 In-house 140-228 (352) Show / Hide 
Range on Protein: 99-165
Range on HMM: 140-228/352
Sequence Identity: 25% (23 aa)

AL-----YHFTQVVNTIKKLHSLN-LCHCDIKVDNILVEQQSNGLKDILIDFGHCQSKKQN----------------EKSEAVCGTLTY
|.     . | |... ...||. |  .| ||| .|||. .. . ..  .|||| .   .||                ...  .|||. |
AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNY
Kinase 8818.AA CAMK 103-165 19 1.9e-09 25.83 In-house 185-285 (425) Show / Hide 
Range on Protein: 103-165
Range on HMM: 185-285/425
Sequence Identity: 19% (20 aa)

FTQVVNTIKKLHSLNLCHCDIKVDNILVEQQSNG--------------LKDILIDFGHCQSKKQ------------------------NEKSEAVCGTLT
| |..  .. .||.| .|.|.| .|||. . ...               .  .||||  . ...                        ..| . .|||. 
FRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPE

Y
|
Y
Kinase 8818.AA S_TKc 4-267 17 2.4e-09 -39.93 SMART 5-231 (231) Show / Hide 
Range on Protein: 4-267
Range on HMM: 5-231/231
Sequence Identity: 17% (48 aa)

QQIAQGGQSVCYRVKTQK-GNIYLLKEFLTKTEYNHEKKIYQHLNEITKEIDLSILKMIDHDDHKCQIVFPFINFQLALICSKVKENNARG----MKWIL
..| .|. ...|...  | | |. .|.         | .| ..     .   .  |. . .| ..  .|. ...  |    .  |... .|    .    
RKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

ALYHFTQVVNTIKKLHSLNLCHCDIKVDNILVEQQSNGLKDILIDFGHCQSKKQNEKSEAVCGTLTYNPLELNEGIAKQQIKEYSPYMLDLFQLGMLLLT
| . . |... .. .||.. .|.|.| .|||. .        ..||| .           .|||. | . |.           |..   |   .| .|  
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYE

LIV-YFPISEQNKKLISLKKKNKFLECITLKYKKTYNTNLQMKSEVYDLIWDLLTGKIE---DAASILD-------HEVY
... | | . | .... . .                       .|. |.|  .|.   |    |  .|        |.  
MLCGYPPFP-QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 8818.AA MARK 103-165 37 2.5e-09 26.85 In-house 110-171 (262) Show / Hide 
Range on Protein: 103-165
Range on HMM: 110-171/262
Sequence Identity: 37% (24 aa)

FTQVVNTIKKLHSLNLCHCDIKVDNILVEQQSN-GLKDILIDFGHCQSKKQNEKSEAVCGTLTY
|.|.|  .. .|| | .|.||| .|||. .. |   |  .|||| .   . ..| .  |||. |
FRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIK--IIDFGFSICIPPGQKLNTFCGTPPY
Kinase 8818.AA CAMK-Unique 103-165 22 6.7e-08 21.94 In-house 163-241 (363) Show / Hide 
Range on Protein: 103-165
Range on HMM: 163-241/363
Sequence Identity: 22% (18 aa)

FTQVVNTIKKLHSLNLCHCDIKVDNILVEQQSN-------------GLKDILIDFGHCQSKKQNEKSE---AVCGTLTY
.....  .. .||..  | |.| .||.|    .              ..  |.||| |  . .|....   ..|||. |
MQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCY
Kinase 8818.AA Pkinase 103-165 26 5.5e-07 25.77 Pfam 114-177 (293) Show / Hide 
Range on Protein: 103-165
Range on HMM: 114-177/293
Sequence Identity: 26% (18 aa)

FTQVVNTIKKLHSLNLCHCDIKVDNILVEQQSNGL----KDILIDFGHCQS--KKQNEKSEAVCGTLTY
..|..  .. .|| . .|.|.| .|||.  . . .    |  ..||| .       |.    .|||. |
MYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVK--ICDFGLAKQFDY-NNS-MTTFCGTPWY
Kinase 8818.AA Ciliate-E2 4-221 16 0.000426 9.94 In-house 5-305 (365) Show / Hide 
Range on Protein: 4-221
Range on HMM: 5-305/365
Sequence Identity: 16% (51 aa)

QQIAQGGQS-VCYRVKTQKGNIYLLKEFLTKT-------------EYNHEKKIYQHLNEITKEIDLS-----------------------ILKMI----D
..| ||... |..  . .... . .| .  .              .|. . .. . ...| .||..                        |.||.    .
KKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQE

HDDHKCQIVFPFINFQ--LALICSK-VKENNARG----MKWILALYHFTQVVN---------------TIKKLHSLN-LCHCDIKVDNILVEQQSNGLKD
 ||... .|. ... .  . .| ..  |.|. .     ...  ..| ..|...                .. ||| |  .| ||| .|||.         
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------I

ILIDFGHCQSKKQNEKSEA--------------------------------VCGTLTYNPLELNEGIA--KQQIKEYSPYMLDLFQLGMLLLTLIVY-FP
 .|||| ..  ..... .                                 .|||. | . |  .|    .|| ...  |. |.. ||..|  ..   .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

ISEQNKKLISLKKKNKF
        .  .|..|.
F-------QQQIKQCKI
Kinase 8818.AA Ciliate-E2-Unclassified 4-71 16 0.008605 5.54 In-house 5-83 (352) Show / Hide 
Range on Protein: 4-71
Range on HMM: 5-83/352
Sequence Identity: 16% (13 aa)

QQIAQGGQSVCYRVKTQKGN-IYLLKEFLTKTEYNHEKKIYQHLNEITKEIDLSILKMIDHDD------------HKCQIV
.|| |||... |...  | . .| .|.   . .|.  .. ... ... ... . ..|. .|..            |.. ..
KQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFI
Kinase 8818.AA Ciliate-B3 605-671 75 2.7e-40 139.94 In-house 1-69 (69) Show / Hide 
Range on Protein: 605-671
Range on HMM: 1-69/69
Sequence Identity: 75% (52 aa)

FALKLFHLVVEKIKILHEINICHCDIKFDNILINGQGKENYKVIIIDFGQYQ--ELNIKSTMICGTELY
||||.||.||||||||||.||||||||.||||.|.|.||||||||||||..|  . |.||.|||||..|
FALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFGHCQRKCQNCKSEMICGTLTY
Kinase 8818.AA Ciliate-E2 617-712 25 2e-11 35.45 In-house 173-291 (365) Show / Hide 
Range on Protein: 617-712
Range on HMM: 173-291/365
Sequence Identity: 25% (33 aa)

IKILHEIN-ICHCDIKFDNILINGQGKENYKVIIIDFG---QYQELNIKSTM-------------------------------ICGTELYNPPKLIQGQK
.. ||. | |.| ||| .|||.         . |||||   .|.. |.. |.                               ||||  | .|  ..|.|
LEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

LFENFGKQIEEYSPQEFDVYQLGMLLFRILT
   .   | ...   . |.. ||..|.. |.
YDNQ---QKQKGYDYKCDIWSLGVILYEMLF
Kinase 8818.AA CAMK 620-674 21 4.3e-11 31.25 In-house 195-289 (425) Show / Hide 
Range on Protein: 620-674
Range on HMM: 195-289/425
Sequence Identity: 21% (20 aa)

LHEINICHCDIKFDNILINGQGKEN-------------YKVIIIDFGQYQELNI--------------------------KSTMICGTELYNP-P
.|. ||.|.|.| .|||..  ....             ... |||||  ....                           | .  |||  | . |
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP
Kinase 8818.AA CAMK-Unique 620-681 21 4e-09 26.06 In-house 173-265 (363) Show / Hide 
Range on Protein: 620-681
Range on HMM: 173-265/363
Sequence Identity: 21% (20 aa)

LHEINICHCDIKFDNILINGQGKE------------NYKVIIIDFG--QYQELNIKST---MICGTELYNPP--------------KLIQGQK
.|...| | |.| .||...  .|.            |... ..|||   . . |....    .|||..|  |               .| .|.
MHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQC
Kinase 8818.AA Ciliate-E8 617-655 46 2.1e-08 22.4 In-house 102-138 (138) Show / Hide 
Range on Protein: 617-655
Range on HMM: 102-138/138
Sequence Identity: 46% (18 aa)

IKILHEINICHCDIKFDNILINGQGKENYKVIIIDFGQY
. .||  || |||.| .|||.  |     |. |||||  
FCYLHNNNIIHCDFKLNNILV--QRNDDTKIKIIDFGFS
Kinase 8818.AA C8 613-707 25 1.1e-07 22.81 In-house 132-226 (226) Show / Hide 
Range on Protein: 613-707
Range on HMM: 132-226/226
Sequence Identity: 25% (26 aa)

VVEKIKILHEINICHCDIKFDNILINGQGKENYKVIIIDFG-------QYQELNIKSTMICGTELYNPPKLIQGQKLFENFGKQIEEYSPQEFDVYQLGM
... .  .|  || | |||..|.|.  ........ . |||         ..  .|  . |||  |  |  ...|   .|  || .  |    |....|.
MIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQ---DNQYKQYRIQS----DLFSVGL

LL
.|
VL
Kinase 8818.AA Ciliate-E2-Unclassified 617-713 27 6.1e-07 20.15 In-house 156-266 (352) Show / Hide 
Range on Protein: 617-713
Range on HMM: 156-266/352
Sequence Identity: 27% (33 aa)

IKILHEIN-ICHCDIKFDNILINGQGKENYKVIIIDFGQYQELN------------------IKSTMICGTELYN----PPKLIQGQKLFEN-FGKQIEE
.. ||. | |.| ||| .|||.. .|| ||.. |||||   ...                   ... .|||  |     .| ..|||.  .  .      
LEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------

YSPQEFDVYQLGMLLFRILTQ
    . |.. ||..|. .|..
---YKCDIWSLGVILYEMLFG
Kinase 8818.AA Ciliate-C8 620-707 22 1e-06 20.25 In-house 135-238 (238) Show / Hide 
Range on Protein: 620-707
Range on HMM: 135-238/238
Sequence Identity: 22% (25 aa)

LHEINICHCDIKFDNILINGQGKENYKVIIID------FGQYQELNIKST-----------MI-----CGTELYNPPKLIQGQKLFENFGKQIEEYSPQE
||  || | ||| .|.| . . ...  . . |      ||.   |    .            .     ||.  | .| ....|.      .|   .| . 
LHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSR-----IQSDIFSKK-

FDVYQLGMLL
 |.|..| .|
SDSYSVGLVL
Kinase 8818.AA MARK 606-653 45 2e-06 17.04 In-house 106-151 (262) Show / Hide 
Range on Protein: 606-653
Range on HMM: 106-151/262
Sequence Identity: 45% (22 aa)

ALKLFHLVVEKIKILHEINICHCDIKFDNILINGQGKENYKVIIIDFG
| ..|. .|. .. .|..||.|.||| .||||  .|. | |  |||||
ARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIK--IIDFG
Kinase 8818.AA Pkinase 620-681 36 7e-06 21.88 Pfam 124-187 (293) Show / Hide 
Range on Protein: 620-681
Range on HMM: 124-187/293
Sequence Identity: 36% (24 aa)

LHEINICHCDIKFDNILINGQGKENYKVIIIDFGQ---Y-QELNIKSTMICGTELYNPPKLIQGQK
.|. .|.|.|.| .||||. .|  . .| |.|||    .    |   | .|||  | .| .|.|..
CHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ
Kinase 8818.AA Ciliate-E1 515-701 19 0.031357 3.63 In-house 1-202 (202) Show / Hide 
Range on Protein: 515-701
Range on HMM: 1-202/202
Sequence Identity: 19% (40 aa)

IIEGGQSTGLIFTDQSTQ-----QICFKKIFN-NEQDYDREKTFYQKVLMEIAPSDRS-SFLELLHFNDYNKE-LIFPFIKQRFLEVCT----------I
| .|..|  ..   |...     |. .. .|| |..... |.  |.|... .   . .  ... .   ... . .|| . ......  .          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

QKGIKSRYFA--LKLFHLVVEKIKILHEINICHCDIKFDNILINGQGKENYKVIIIDFGQYQELNIKSTMICGTELYNPPKLIQGQKLFENFGKQIEEYS
|.  .. .|   ....   .. . .||  ||.|.||| .||||| ||. .|     |||. . |. ...  |  . |      . |.  ..  . .... 
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQK

P-QEFDVY
  .. |.|
INYKSDIY