Gene 5185 (Tetrahymena)

5185

Species: Tetrahymena
Alias: 227.m00041, PreTt05185, 803.7, TTHERM_01087840, 5185
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-A8,

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
5185.AA Protein None 289 None Fasta, JSON
5185.NA RNA None 864 None Fasta, JSON
5185.kin_dom Protein Kinase Domain None 113 None Fasta, JSON
5185.kin_dom2 Protein Kinase Domain None 171 None Fasta, JSON

Protein domain

Protein domains of 5185.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5185.AA Ciliate-A8 6-150 33 4.9e-31 104.53 In-house 16-151 (151) Show / Hide 
Range on Protein: 6-150
Range on HMM: 16-151/151
Sequence Identity: 33% (53 aa)

VLAFSQKLSIQVAIKIYQN-DNQFEIQN-----QLKMIELVKKKKYILQAIEVVKDDQIGITALVLELCDC---NKNHIFFHSLFIKIFIYLTIYLSXGS
|.| |...  |||||| .. ..| .|       . . ... |..||||| ||   |...| .| | |.|||   .|                      ..
VQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYK--------------------KKEN

LKEIFE--DNKMNFQQVCALACQLLKGFAALKDKSIIYGNIKPEKILYSSIRNEFL
| .|.|   || .|.|. ||. ||||.   .. |.||...|||. ||||.  | |.
LASILENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI
Kinase 5185.AA Ciliate-E1 81-195 18 5e-26 81.91 In-house 68-202 (202) Show / Hide 
Range on Protein: 81-195
Range on HMM: 68-202/202
Sequence Identity: 18% (25 aa)

FIKIFIYLTIYLSXGSLKEIF-------------EDNKMNFQQVCALACQLLKGFAALKDKSIIYGNIKPEKILYSSIRNEFLINDFSIAR--LLNDINS
...|.| .. ...   .....             ..|...|||......||..|...|... ||...|||..||...  ......||.|..   .|....
QNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQ

GKEELEGNMMYVAPEVN------EKIKPLTINVDMF
 ... . ...|  ...|      .| .. ....|..
CQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 5185.AA Ciliate-E2-Unclassified 109-262 21 1.1e-13 43.89 In-house 138-347 (352) Show / Hide 
Range on Protein: 109-262
Range on HMM: 138-347/352
Sequence Identity: 21% (46 aa)

QQVC-----ALACQLLKGFAALKDKS-IIYGNIKPEKILYSSIRN--EFLINDFSIARLLNDINSG-----------KEELE----GNMMYV----APEV
||..      .. |.|.|.  |  |  ||. .|||| ||...  .  .  | ||.|.. ... |             |...     |. .|     ||||
QQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV

NEKIKPLT---INVDMFGVGQILLEALIQQHPLN----------------------MMQWISLKERNLFDVMP----QLLQSQYKQFAQKILLNMIVVNP
 .. .. .   . .|....| || | | ...| .                      . |.|  |. . .   .    . .. ..| | ...|  |...||
LQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNP

NSRSNADELL
|.| .....|
NKRITFEQIL
Kinase 5185.AA Ciliate-E2 91-262 15 3.2e-12 38.24 In-house 115-360 (365) Show / Hide 
Range on Protein: 91-262
Range on HMM: 115-360/365
Sequence Identity: 15% (41 aa)

YLSXGSLKEIFEDN------------KMNFQQVCALACQLLK---------------GFAALKDKS-IIYGNIKPEKILYSSIRNEFLINDFSIARLLND
|.. |.|... ..|            ... .... .  |.|.               ..  |. |  ||. .|||| ||.        | || ... ..|
YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDD

INS---------GKEELE-----------------------GNMMYVAPEVNEKIKP--------LTINVDMFGVGQILLEALIQQHPLNMMQWISLKER
 |           . .                         |. .|.|||. .. |          .  .|.. .| || | |  ..|      .  .. 
DNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQ

NLFDVMPQLLQ-------------SQYKQFAQKILLN----MIVVNPNSRSN-ADELL
. .|  ..  |              .  | .. .. .    |....|. | . ....|
CKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 5185.AA Ciliate-C5 110-277 24 3.9e-10 29.32 In-house 97-260 (260) Show / Hide 
Range on Protein: 110-277
Range on HMM: 97-260/260
Sequence Identity: 24% (41 aa)

QVCALACQLLKGFAALKDKSIIYGNIKPEKILYSSIRNEFLINDFSIARLLNDINSGKEELEGNMMYVAPEVNEKIKPLTINVDMFGVGQILLEALIQQH
|.  .| |.   | ..... .|   .||| ||| |    | . |.  .. . |     .       | |||. ..     |  |..|.| ||||  . . 
QIIGFAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKF

PLNMMQWISLKERNLFDVMPQLLQSQYKQFAQKILLNMIVVNPNSRSNADELLINLNEFNIDENSLKQ
 |.      ... .| . . .  .. |.   | |.. |. . |. | .. ||  .|||. .  .|   
-LEDEDCTFIRNGKLPNYISK--NALYQDINQ-IIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 5185.AA S_TKc 28-269 16 4.7e-10 -29.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-269
Range on HMM: 1-231/231
Sequence Identity: 16% (45 aa)

FEIQNQL---------KMIELVKKKKYILQAIEVVKDDQIGITALVLELCDCNKNHIFFHSLFIKIFIYLTI---YLSX--GSLKEIFEDNK-------M
.|| ...         | ..   .... .  |     ..|     .|.     .| . ..  |     .| .   |..   |.|... ....       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NFQQVCALACQLLKGFAALKDKSIIYGNIKPEKILYSSIRNEFLINDFSIARLLNDINSGKEELEGNMMYVAPEVNEKIKPLTI-NVDMFGVGQILLEAL
.  ... ...|.... . . .. ||.  .||| || ..   .  | || .||.|         . |   |.||||     . .   .|.  .| || | |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

IQQHPLNMMQWISLKERNLFDVMPQLLQSQYKQFAQKILLNMIVVNPNSRSNADELLI-----NLNEFN
  . |          .  .|...        ... . .. .. ...|. |  | |.|      .. .. 
CGYPPFP-------QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5185.AA Ciliate-E1 4-71 34 6.2e-08 22.39 In-house 8-82 (202) Show / Hide 
Range on Protein: 4-71
Range on HMM: 8-82/202
Sequence Identity: 34% (26 aa)

MLVLAFSQKLS-IQVAIKIY-------QNDNQFEIQNQLKMIELVKKKKYILQAIEVVKDDQIGITALVLELCDCN
. . |..|. . .|||.||        ||..|.||... |. . .||..||.| |.. |.||. |.....|.|.|.
IVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCS
Kinase 5185.AA C8 16-201 22 3.6e-07 21.07 In-house 26-226 (226) Show / Hide 
Range on Protein: 16-201
Range on HMM: 26-226/226
Sequence Identity: 22% (45 aa)

QVAIKIYQNDNQFEIQNQLKMIELVKKKKYILQAIEVVKD-DQIGITALVLELCDCNKNHIFFHSLFIKIFIYLTIYLSXGSLKEIFEDNKMNFQQ----
....|. .  |. .|||  ..   ..  . . |   .| . |       | |. .| .. |       | .    . |.   ||..... . . ||    
EIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTE--EKSCFVMEMELCEQNLKQLYDERRNKQQQFSKE

-VCALACQLLKGFAALKDKSIIYGNIKPEKILYSSIRNEF---LINDFSIARLLNDINSGKEELE----GNMMYVAPEVNEK----IKPLTINVDMFGVG
    .| |.. |   .. | |.   |||. .|     |.     . || .|  . .  |  .  .    |.. |.|||. .|     |  .|  |.| ||
MKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVG

QIL
 .|
LVL
Kinase 5185.AA Ciliate-C8 114-201 23 1e-06 20.25 In-house 124-238 (238) Show / Hide 
Range on Protein: 114-201
Range on HMM: 124-238/238
Sequence Identity: 23% (27 aa)

LACQLLKGFAALKDKSIIYGNIKPEKILYSSI-RNEFLI--ND------FSIARLLNDINS--------GKEEL-----EGNMMYVAPEVNEK-----IK
.| | . . . |. . |.   |||. .|..    . . |   |      |  |. | .  |        |...       ||. | |||| .|      .
IAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSD

PLTINVDMFGVGQIL
  ... |.. || .|
IFSKKSDSYSVGLVL
Kinase 5185.AA Ciliate-F2 96-160 26 8e-06 17.29 In-house 82-146 (200) Show / Hide 
Range on Protein: 96-160
Range on HMM: 82-146/200
Sequence Identity: 26% (17 aa)

SLKEIFEDNKMNFQQVCALACQLLKGFAALKDKSIIYGNIKPEKILYSSIRNEFLINDFSIARLL
..|.. .  |.  .|.     |.. | | |    .| | || | ..| . .. |.. ||  .  |
CIKQQLQSCKLTDNQQYEEIQQFINGLAELENLGLIHGDIKIENMIYNRPKQRFMFDDFQLIQIL
Kinase 5185.AA STE-Unique 160-267 17 1.1e-05 15.51 In-house 498-616 (616) Show / Hide 
Range on Protein: 160-267
Range on HMM: 498-616/616
Sequence Identity: 17% (21 aa)

LNDINSGKEELEGNMMYVAPEVNEKI----KPLTINVDMFGVGQILLEALIQQHPLNMMQWI-SLKERNLFDVMPQL------LQSQYKQFAQKILLNMI
||. |..   . |.. | .||| ..     .|    ||..  | .... . . .| .  . . .. | ..    ...       ......  | ..   .
LNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCL

VVNPNSRSNADELLINLNE
  ||. |..| .||  .. 
ERNPHHRPSAHQLLHHFWL
Kinase 5185.AA DRAK 109-198 30 1.8e-05 12.37 In-house 99-188 (259) Show / Hide 
Range on Protein: 109-198
Range on HMM: 99-188/259
Sequence Identity: 30% (28 aa)

QQVCALACQLLKGFAALKDKSIIYGNIKPEKILYSSIRNE--FLINDFSIARLLNDINSGKEELEGNMMYVAPEVNEKIKPLTINVDMFGVG
..|  .  | |.|   | ...|.    ||  || .|.. |    | || ..| ...      |. |   |||||. .   |.|.  ||  .|
KDVQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVR-EIMGTPDYVAPEILN-YDPITMATDMWSIG
Kinase 5185.AA Ciliate-C5 86-102 52 0.009152 4.65 In-house 1-17 (260) Show / Hide 
Range on Protein: 86-102
Range on HMM: 1-17/260
Sequence Identity: 52% (9 aa)

IYLTIYLSXGSLKEIFE
|||| |.| |.   .||
IYLTSYISQGGFGCVFE