Gene 26387 (Tetrahymena)
26387
Sequence
Protein domains of 26387.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26387.AA | C8 | 42-254 | 57 | 5e-112 | 378.49 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 42-254 Range on HMM: 1-226/226 Sequence Identity: 57% (131 aa) FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEME |.||.|||.|||..||||.|...||...|||....||. ...|||..|||||.|.|.|....||.|||||.|.|. .|....|..||||..||.|||||| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDAYFAP |||.|||||.|..|..|....||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..||| ||.||||| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP EVEAG------QSRIQ--VFNNSVIL |.|.. |.||| .| ..| EIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 26387.AA | Ciliate-C8 | 51-256 | 55 | 6.1e-112 | 378.19 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 55% (131 aa)
GAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNK---SYFVMEMELCENN-
||...||||||..|||.|||||.|..||. |...|...|||||...|.|....|.||||||||||...|||||||.|||||.| |.||||||.|..|
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC
-LKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDAY---
|||.||..||.|..| ..||||||||||...|.||..|||||||||.||||| ...|...||||| .||||...|.|| ..||| |||.|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM
--------FAPEVEAGQSRIQVFNNS-------VILFF
||||||..||||| | | | .
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
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| Kinase | 26387.AA | C2 | 51-241 | 39 | 1.3e-56 | 191.87 | In-house | 1-216 (245) | Show / Hide |
Range on Protein: 51-241 Range on HMM: 1-216/245 Sequence Identity: 39% (85 aa) GAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEE-KDDEDDDGNDIIVQTQN--------KSYFVMEME || .||||| | .|||.|||| | . . | ... |||....... . ...||..||| .. |.||| | ...... .| |. .|.|.| GAFGLVLKAFNKKQNRHVALKIQECQSNDIN-GMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD----------LGFASAVSKSKS--FMSK-K |. |||| |. .|||. | ..||.|.||||. . | || ..| ||||||.|||. ... ||||| . |||.....|| .|| | FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK GTDAY----FAPEVEAG .| .| |||||. . WTQQYYQHIFAPEVYQN |
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| Kinase | 26387.AA | CMGC | 42-220 | 16 | 2.3e-29 | 92.92 | In-house | 1-256 (513) | Show / Hide |
Range on Protein: 42-220 Range on HMM: 1-256/513 Sequence Identity: 16% (44 aa) FKNFEYLSSGAYALVLKAQN--------------SQQNRQVALKFLESS-NKEG------KDGIE-SLKKEYEMLQKFS---------------QSEC-L ... ... .|.|. | |... . |..||.| . . ..|. |||. . | ..|.... . . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI VNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEMELCENNLKQLFDFLR------KQQVPPPKE------------MKEII-----AIQMIEGLN-- |. ||.|| ... .|..| . | . . .. . .|.....|.|. . . ... .. . | .. . |...||. VKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK NLHVKN--IMHRDIKPQNFLVCASKEY----------------GFSIKLCDLGFASAVSK .| .. |.|||.||.| |.. .|. . .|.|| |.| .... YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP |
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| Kinase | 26387.AA | Pkinase | 42-238 | 22 | 3.4e-27 | 97.23 | Pfam | 1-182 (293) | Show / Hide |
Range on Protein: 42-238 Range on HMM: 1-182/293 Sequence Identity: 22% (47 aa) FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLK-KEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEM .. . . ||... | |... ...||.| .. .... . .. .. | ...... .... | ||.|. |.. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM ELCENN--LKQLFDFLR--KQQVP--PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDA |.||. . |||... .. . ...| | .. |...||. .| ..|.|||.||.|.|. . . ..|.|| |.| .. ... || EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW YFAPEV | |||| YMAPEV |
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| Kinase | 26387.AA | CAMK | 47-238 | 15 | 1.8e-26 | 81.72 | In-house | 1-291 (425) | Show / Hide |
Range on Protein: 47-238 Range on HMM: 1-291/425 Sequence Identity: 15% (46 aa) YLSSGAYALVLKAQNSQQN------------RQVALKFLESS----------------NKEGKDG---------IESLKKEYEMLQKFS------QSECL | .|... | .... . . ..|| |... . .|..... .....|.|...| . . ... TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNVYDCFYL-----------MEEKDDEDDDGNDIIVQTQNKSYFVM-EMELCENN--LKQLFDFLRKQ---------------QVPPPKEMKEIIAIQMI .. |. . .| .. .... |.|| ||.|.. . |||..... . .| . .. |.. IKLYEVYEDPHYFKNTNDYET-SKQ--------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QIC EGLNNLHVKNIMHRDIKPQNFLVCASKEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDAYFA-P .... .| .||.|||.|| | |.. ... . ||..| ||| . ... . || .| | | SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP EV || EV |
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| Kinase | 26387.AA | STE | 42-238 | 18 | 4.4e-23 | 78.44 | In-house | 1-233 (359) | Show / Hide |
Range on Protein: 42-238
Range on HMM: 1-233/359
Sequence Identity: 18% (47 aa)
FKNFEYLSSGAYALVLKAQNS------QQNRQ---------VALKFLESSNKEG--------------KDGIESLKKEYEMLQKFSQ-SECLVNVYDCFY
... | . .||. | || | . ... .| | .. .|.. .. .....|| ....|... .. |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
LMEEKDDEDDDGNDIIVQTQNKSYFVMEMELCE-NNLKQLFDFLRKQQVPPP------KEMKEIIA----IQMIEG-LNNLHVKNIMHRDIKPQNFLVCA
.. ..|... . ||... | .. . . . | . . ..| . | ..| |. || ..|.||||||.| |.
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--
SKEYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDAYFAPEV
.|||| |... ... .. . || . ||||
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEV
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| Kinase | 26387.AA | Ciliate-E2 | 129-243 | 23 | 1.3e-18 | 60.52 | In-house | 102-263 (365) | Show / Hide |
Range on Protein: 129-243
Range on HMM: 102-263/365
Sequence Identity: 23% (41 aa)
QTQNKSYFVMEMELCENNLKQLFDFLRKQQVPPPKE--------MKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCASKE
|....... . ||.|. . |||...... ..| .||| | | .. .|. || || |.||||||.| |.
QEKDDNNIYLVMEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----
YGFSIKLCDLGFASAVSKS----------KSFMSKK-----------------------GTDAYFAPEVEAGQS
||..|.|.. .... | .| | || | |||. |..
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK
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| Kinase | 26387.AA | TKL | 169-238 | 24 | 1.1e-16 | 56.58 | In-house | 137-244 (364) | Show / Hide |
Range on Protein: 169-238 Range on HMM: 137-244/364 Sequence Identity: 24% (26 aa) IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCASKE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT .|... |.| || ..| |||.|..| || . . .|.||.|.. .|.|.. |.. || WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT DAYFAPEV .. |||| PRWMAPEV |
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| Kinase | 26387.AA | Ciliate-E1 | 140-237 | 28 | 2.3e-15 | 46.85 | In-house | 76-179 (202) | Show / Hide |
Range on Protein: 140-237 Range on HMM: 76-179/202 Sequence Identity: 28% (31 aa) MELCENNLKQLFD---------FLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFAS-AVSKSKSFMSKKG .|.|. .||. .. ....| . |. |..|.|.||. || .||.|||||||| |.. ...| .. |.| .. ..... . .|| FECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKG TDAYFAPE |..|. YTHYYYPP |
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| Kinase | 26387.AA | S_TKc | 42-274 | 18 | 1.2e-13 | 23.27 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-274 Range on HMM: 1-231/231 Sequence Identity: 18% (53 aa) FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEME .. . . .||.. | |... .|.||.| . |....| ..|.| . . .|. ||.|. ... | || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME LCENNLKQLFDFLRKQQVP------PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKSFMSKKGTDAYFA .|...| |||...|.. . |. . . ... |....|. .| ..|.|||.||.| |.. ||.|| |.| . .. || | | YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA PEVEAGQSR-------------------------IQVFNNSVILFFKVYLHQIVRSLFT------------R-------THFI ||| | .. ..|.. . . ...| ... . .. PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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| Kinase | 26387.AA | ULK | 168-238 | 29 | 3e-13 | 43.4 | In-house | 130-218 (324) | Show / Hide |
Range on Protein: 168-238 Range on HMM: 130-218/324 Sequence Identity: 29% (26 aa) IIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEY--------GFSIKLCDLGFASAVSKS----KSFMSKK------GTDAYFAPEV .. .| ..|. || .||.|||||||| |. ... .|..| ||| | . ... . || | ||.. QFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQI |
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| Kinase | 26387.AA | Ciliate-E1 | 48-136 | 18 | 1.6e-08 | 24.35 | In-house | 1-108 (202) | Show / Hide |
Range on Protein: 48-136 Range on HMM: 1-108/202 Sequence Identity: 18% (20 aa) LSSGAYALVLKA-QNSQQNRQVALKFLESSNKEGKDGIESLKKEYE-MLQKFSQSECLVNVYDCFY---------LMEEKDDEDDDGND---------II ...| ...|.|| |......|||.|. . .. .. .....||| ... | . .......|... ..|. .... | .. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC VQTQNKSYF |.||. .| QQNQNQFTF |
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| Kinase | 26387.AA | ULK | 42-111 | 22 | 1e-06 | 19.54 | In-house | 1-85 (324) | Show / Hide |
Range on Protein: 42-111 Range on HMM: 1-85/324 Sequence Identity: 22% (19 aa) FKNFEYLSSGAYA-LVLKAQNSQQ---NRQVALKFLE-----SSNKE--GKDGIESLKKEYEMLQKFS--QSEC--LVNVYDCFY . . | .|... | |. | .. | .|| | . ...| |. ...||.| . ..|. ... | ||.|. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFE |
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| Kinase | 26387.AA | TyrKc | 42-267 | 14 | 5e-06 | -124.64 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 42-267
Range on HMM: 1-280/280
Sequence Identity: 14% (45 aa)
FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKF-SQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEM
. . | .||. | |.. . .||| | | .. .| . .| ... |. . ...|. | . ... . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------------FMYIEPLMIVM
ELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKS-------KSFMSKK--GTD
|.... | |.||| . . . . ...| .| . || ||. |||. | || . . .| .| | . .. . ..|. |..
EYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK
-----AYFAPEVE------------------------AGQSRIQV----FNNSVILFFKVYL-------H------------------------------
|||. .| . .|. .. . .
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT
--QIVRSL
.|.. .
FSEIHECF
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| Kinase | 26387.AA | Ciliate-E2 | 42-116 | 14 | 1.1e-05 | 15.47 | In-house | 1-107 (365) | Show / Hide |
Range on Protein: 42-116 Range on HMM: 1-107/365 Sequence Identity: 14% (15 aa) FKNFEYLSSGAYALVLKAQNSQQNRQVALK-----------------FLESSNKEGKDGIESLKKEYEMLQ---------------KFSQSECLVNVYDC .| . . .|... | |... ....|.|.| .. . |..||..|.| ... .. .. ... |.| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FYLMEEK |. . .. FQEKDDN |
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| Kinase | 26387.AA | TKL | 48-107 | 13 | 0.024933 | 4.21 | In-house | 1-91 (364) | Show / Hide |
Range on Protein: 48-107 Range on HMM: 1-91/364 Sequence Identity: 13% (12 aa) LSSGAYALVLKAQNSQQN--------RQVALKFLESSNKEGKDGIES----------------------LKKEYEMLQKFSQ-SECLVNVY . ||... | |.. ... . || | . | | .. .. ..|.|.... . . .| . IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM |
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