Gene 17858 (Tetrahymena)
17858
Sequence
Protein domains of 17858.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 17858.AA | Ciliate-C8 | 51-285 | 53 | 1.4e-111 | 376.96 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 51-285 Range on HMM: 1-238/238 Sequence Identity: 53% (136 aa) GAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEK---SYFVMEMELCQQN- ||...||.|||.|.||.|||||..|.||..||..|...|||||...|.|..|.|.|.||||||||...||.|||.|.| |.|| |.||||||.|||| GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC -LKQLFDFLRNAQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFQFLQKLSIQKIIQNQGDLGFASAVTKSKSHYI |||.||..|. |.. |...||||||||....|.||..|||||||||||||||..|.|..|||||. | . .| .|.||||...|.||||. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH SKK--GTEAY-----------FAPEIEKGQSRIQ-DQFYLSSIIQKCQMKIGLTL ||| ||..| ||||.||.||||| |.| . | .. . || | SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSY----SVGLVL |
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Kinase | 17858.AA | C8 | 42-274 | 57 | 2.3e-111 | 376.3 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 42-274 Range on HMM: 1-226/226 Sequence Identity: 57% (140 aa) FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEKSYFVMEME |.||.|||.|||..||.|.|.|.|| ..|||..|.||.|...|||..|||||.|.|.|.||.||. ||||.|.|..||....|||.|.|.|||.|||||| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCQQNLKQLFDFLRNAQLP-SKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLCKKFQFLQKLSIQKIIQNQGDLGFASAVTKSK ||.||||||.|..|| |.. |||.||||||||..|.|..|.||||||||||||||||..|.|||.|||| |.||||.|.|.| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK SHYISKK----GTEAYFAPEIEKG------QSRIQ-DQFYLSSII ||..||| || |||||||||. |.||| | | . . SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 17858.AA | C2 | 51-260 | 37 | 9.8e-55 | 185.4 | In-house | 1-216 (245) | Show / Hide |
Range on Protein: 51-260 Range on HMM: 1-216/245 Sequence Identity: 37% (86 aa) GAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEE-DEDGNEKVVLTDE--------KSYFVMEME || .||| | | |.||.|||| | . | || .. |||....... . ....|...||| ... | ||| .|. . .. |. .|.|.| GAFGLVLKAFNKKQNRHVALKIQEC-QSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE LCQQNLKQLFDFLRNAQ-LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC-KKFQFLQKLSIQKIIQNQGDLGFASAVTKS || |||| |. .|. . |....|.|.||||. . | || ..| |||||| |||. .| ||||| |. || .|. |||.. .. FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN KS-HYISK-KGTEAY----FAPEIEKG || ..|| |.|..| ||||.... KSRIHFSKFKWTQQYYQHIFAPEVYQN |
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Kinase | 17858.AA | CMGC | 42-209 | 16 | 2.8e-23 | 72.52 | In-house | 1-246 (513) | Show / Hide |
Range on Protein: 42-209 Range on HMM: 1-246/513 Sequence Identity: 16% (42 aa) FSNFEYLSSGAYALVLRAQN--------------TKENRIVALKFLTCT-NKED------KNGIE-SMKKEYEMLQKFS---------------QSDF-L . . ... .|.|. | .... .. |.|||.| . ..|. |.|. . | ..|.... . . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI VNVFDCFYLMEEDVEEDEDGNE-KVVLTDEKSYFVMEMELCQQNLKQLFDFLR-------NAQLPSKE------------IKEII-----AIQMLEGLN- |. .|.|| ..| .|.|| .. . . .. . .|.....|.|. . . . |. . || .. . |.|.||. VKLYDIFYHKNSDGNEYEDKHIIS---Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL -NLHVKN--IMHRDIKPHNFLVCPSQTY----------------GFTIKLC .| .. |.|||.|| | |... .. ...|.| KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC |
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Kinase | 17858.AA | Pkinase | 42-209 | 20 | 1.2e-18 | 67.07 | Pfam | 1-154 (293) | Show / Hide |
Range on Protein: 42-209 Range on HMM: 1-154/293 Sequence Identity: 20% (36 aa) FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMK-KEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEKSYFVMEM . . . ||... | .... ....|||.| . ..... .. . | ...... .... | .|.|. |.. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM ELCQQNLKQLFDFL------RNAQL--PSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC |.|. |. ..| |. . . .|.| .. |.|.||. .| ..|.|||.|| |.|. . . ..|.| EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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Kinase | 17858.AA | CAMK | 47-209 | 14 | 2e-17 | 52.01 | In-house | 1-238 (425) | Show / Hide |
Range on Protein: 47-209 Range on HMM: 1-238/425 Sequence Identity: 14% (37 aa) YLSSGAYALVLRAQNTKEN------------RIVALKFLTCTNKEDKN-------------------------GIESMKKEYEMLQKFS------QSDFL | .|... | ...... . . || |.. . ||. .....|.|...| . . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNVFDCFYL-----------MEEDVEEDEDGNEKVVLT-DEKSYFVM-EMELCQQN--LKQLFDFLRNA----------------QLPSKEIKEIIAIQM .. .. . ... |. | |.. |.|| ||.|. . |||... .. .| . .. |. IKLYEVYEDPHYFKNTNDYET-SKQ---------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QI LEGLNNLHVKNIMHRDIKPHNFLVCPSQTYG-------------FTIKLC ..... .| .||.|||.|| | |.. . . ..||.. CSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII |
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Kinase | 17858.AA | STE | 42-209 | 18 | 1e-13 | 44.94 | In-house | 1-189 (359) | Show / Hide |
Range on Protein: 42-209 Range on HMM: 1-189/359 Sequence Identity: 18% (40 aa) FSNFEYLSSGAYALVLRAQNTK---------------ENRIVALKFLTCTNKE----------DKNG----IESMKKEYEMLQKFSQ-SDFLVNVFDCFY . . | . .||. | .| | | ..|.| | . |.. ..| ... .|| ....|... ... |. ..|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF LMEEDVEEDEDGNEKVVLTDEKSYFVMEMELCQ-QNLKQLFDFLRNAQLPSK-----------EIKEIIAIQMLEG-LNNLHVKNIMHRDIKPHNFLVCP .. ...... . ||.. | .. . . | . .. .|. | |.| |. || ..|.|||||| | |. KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-- SQTYGFTIKLC .||| -------VKLC |
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Kinase | 17858.AA | S_TKc | 42-322 | 16 | 1.9e-13 | 20.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-322 Range on HMM: 1-231/231 Sequence Identity: 16% (54 aa) FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTNKEDKNGIESMKKEYEMLQKFSQSDFLVNVFDCFYLMEEDVEEDEDGNEKVVLTDEKSYFVMEME . . . .||.. | .....| .||||.| . |....| ..|.| . ...|. .|.|. ... | || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME LCQQNLKQLFDFLRNAQ-------LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFTIKLC-----KKFQFLQKLSIQKIIQNQGD .| ..| |||.... . .| ... ... |....|. .| ..|.|||.|| | |.. .||.| ... YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------------- LGFASAVTKSKSHYISKKGTEAYFAPEIEKGQSR----------------IQDQFYLSSIIQKCQMKIGLTLLQKKRFTKEKQQLQ--TKICLKPNYLER . || | |||. | .. . .|. ||| ... . ||. . .| --------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKR TSSGDLLS--------ELI . ..| . . PTA-EALQDEWDIKCHPWF |
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Kinase | 17858.AA | Ciliate-E1 | 136-222 | 26 | 5.4e-12 | 35.74 | In-house | 72-169 (202) | Show / Hide |
Range on Protein: 136-222 Range on HMM: 72-169/202 Sequence Identity: 26% (26 aa) FVMEMELCQQNLKQLFD----------FLRNAQLPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLVCPSQTYGFT-IKLCKKFQFLQKLSIQK .. .|.|...||. .. . .| . . . |. |..|...||. || .||.||||||.| |.. . | .. . ..|... |. ..|. CIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY |
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Kinase | 17858.AA | Ciliate-A1 | 140-196 | 39 | 8.1e-12 | 36.45 | In-house | 80-134 (301) | Show / Hide |
Range on Protein: 140-196 Range on HMM: 80-134/301 Sequence Identity: 39% (23 aa) MELCQQNLKQLFDFLRNAQ-LPSKEIKEIIAIQMLEGLNNLHVKNIMHRDIKPHNFLV || || .. ||.. . . || || |. ||. .| .||.|||.|| | |. MEYCQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILI |
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Kinase | 17858.AA | Ciliate-E2 | 140-209 | 30 | 6e-10 | 30.32 | In-house | 113-198 (365) | Show / Hide |
Range on Protein: 140-209 Range on HMM: 113-198/365 Sequence Identity: 30% (30 aa) MELCQQNLKQLFDFLRNAQLPSKEI---------KEI--IAIQMLE---------------GLNNLHVKN-IMHRDIKPHNFLVCPSQTYGFTIKLC ||.||. . |||...| .. .... ||| | | |. .|. || || |.|||||| | |. ||.. MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKII |
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Kinase | 17858.AA | Ciliate-E1 | 48-112 | 20 | 8.6e-08 | 21.93 | In-house | 1-66 (202) | Show / Hide |
Range on Protein: 48-112 Range on HMM: 1-66/202 Sequence Identity: 20% (14 aa) LSSGAYALVLRAQNTKEN-RIVALKFLTCTNKEDKNGIESMKKEYE-MLQKFSQSDFLVNVFDCFYL ...| ...|..| . . | . ||.|. | ....| ... .||| ... | . . .....|.... IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI |
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Kinase | 17858.AA | TKL | 168-196 | 35 | 4.3e-07 | 21.59 | In-house | 137-173 (364) | Show / Hide |
Range on Protein: 168-196 Range on HMM: 137-173/364 Sequence Identity: 35% (13 aa) IAIQMLEGLNNLHV--------KNIMHRDIKPHNFLV .|... |.| || ..| |||.|..| || WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV |
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Kinase | 17858.AA | Ciliate-E2 | 42-116 | 12 | 2e-06 | 18.48 | In-house | 1-107 (365) | Show / Hide |
Range on Protein: 42-116 Range on HMM: 1-107/365 Sequence Identity: 12% (14 aa) FSNFEYLSSGAYALVLRAQNTKENRIVALKFLTCTN--------KED----------KNGIESMKKEYEMLQ---------------KFSQSDFLVNVFD . . . .|... | .... |... .|.|. . .. | . ||.||..|.| ... .. ....... .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE CFYLMEED ||. . .. CFQEKDDN |
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Kinase | 17858.AA | Ciliate-A1 | 42-79 | 23 | 0.002009 | 7.44 | In-house | 1-39 (301) | Show / Hide |
Range on Protein: 42-79 Range on HMM: 1-39/301 Sequence Identity: 23% (9 aa) FSNFEYLSSGAYALVLRAQNTKENR-IVALKFLTCTNKE . . .| . |.|| . .. ...| . |||.| YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE |
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Kinase | 17858.AA | TKL | 48-104 | 11 | 0.270526 | 0.43 | In-house | 1-88 (364) | Show / Hide |
Range on Protein: 48-104 Range on HMM: 1-88/364 Sequence Identity: 11% (10 aa) LSSGAYALVLRAQNTKEN--------RIVALKFLTCTNKEDKNGIES----------------------MKKEYEMLQKFSQ-SDFLV . ||... | ... .. . || | . .| .. .. ..|.|.... . . .| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIV |
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Kinase | 17858.AA | C8 | 407-608 | 48 | 7.1e-104 | 351.39 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 407-608 Range on HMM: 1-226/226 Sequence Identity: 48% (109 aa) VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCS-----------CSLQD- .||||.||||..||||..|.|. .|.|||||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.|||| |.... FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM ----------YLERQAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-QIKLCDFGLSAQLEKNCEQIEILDW--VGNIGYMA |.||. |...||.|.|..||.|.||.||||||.||.||||||.|||||||.|.. .|||||||...|..||...|.. .. .|. .|.| ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA PEILTKKEHENKIYSKKSDSYSVGLLL |||..|.....|.|...||..||||.| PEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 17858.AA | Ciliate-C8 | 416-608 | 41 | 7.4e-101 | 341.38 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 416-608 Range on HMM: 1-238/238 Sequence Identity: 41% (98 aa) GSFGMVLST------KKVELSNKEIVLKIQKIVNEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEK-----------------YVVFELEKCS--C |.|||||.. .||.| ..|.|.||||...|. |.....|||....|.|||.||..........|. ..|.|.|||. | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC SLQDYLER-QAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLD-GNQLQIKLCD------FGLSAQLEKNCE---------QIEILDW .|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.| ..|..||||| ||...||.||.. ....... NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --VGNIGYMAPEILTK-KEHENKIYSKKSDSYSVGLLL .||.||.|||...| ......|.|||||||||||.| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 17858.AA | C2 | 416-621 | 28 | 1.3e-44 | 150.35 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 416-621 Range on HMM: 1-245/245 Sequence Identity: 28% (71 aa) GSFGMVLSTKKVELSNKEIVLKIQKIVN-----EQTIQNEIRIMQQLK-TPLVVQLYD-NYVIEKVTAP------------EK----------YVVFELE |.||.|| . . .|....||||.. .. .|.|..||.|.. |.....|. |. .. |. ||.|.| GAFGLVLKAFNKK-QNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE KCSCSLQDYLERQAKEG-EFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-QIKLCD----------FGLSAQLEKNCEQIEILDWV .|.. |. |..|. |. ......| .| |..||.||.|.|.|.||||||.|||. .| ... ||||| | . |..| ..| . . FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK GNIGYMAPEILTKKEHENKIYSKKSDSYS-VGLLLSLLDNYLILKEKE . |. . ... | . .|| |.|| .| ||. | ||| . .. WTQQYY--QHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 17858.AA | CAMK | 412-608 | 20 | 1e-35 | 112.06 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 412-608 Range on HMM: 1-324/425 Sequence Identity: 20% (65 aa) ILSFGSFGMVLSTKKVELSN-----------KEIVLKI---QKIV----------------------------NEQTIQNEIRIMQQ-------LKTPLV .| |||| | . . . .. || .|. ... ...||.||.. |. | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQLYDNYVIEKV--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQAK------------EGEFSDEEKLNIALQIIDSVNYIHCFN ..||. | ... | .|.... . | || | ||. .. . .| |. .| . ||.. |.|.| | IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IIHRDIKPDNFLVCLDG--------------NQLQIKLCDFGLSAQLEKNCEQI---------------------EILDWVGNIGYMA-PEILTKKEHEN |.|||.||.| |.. .. |. .||..|||........ .. ...| .||| ||.| .| | | IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN KI---------YSKKSDSYSVGLLL . |..|.| |.| .| MQNATDEEKPYYGPKCDMWSCGVIL |
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Kinase | 17858.AA | Pkinase | 407-608 | 27 | 2.1e-31 | 112.13 | Pfam | 1-202 (293) | Show / Hide |
Range on Protein: 407-608 Range on HMM: 1-202/293 Sequence Identity: 27% (61 aa) VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQN-------EIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSC-----SLQD ... |||| | ... ..|. ..|| | ..| .. ||.||. |. | .|.||| . .... . .| | . .| | YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD YLERQAKEGEF--SDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL--QIKLCDFGLSAQLEKNCEQIEILDWVGNIGYMAPEILTKKEH |... ..| | |..| ....||. ..|.| .|||||.||.|.|. . ... .|.|||||..|.. . . . .| ..|||||.. YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR---- ENKIYSKKSDSYSVGLLL ... |..|.| .|.|..| GGQYYGPKVDMWSCGCIL |
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Kinase | 17858.AA | S_TKc | 407-679 | 24 | 4.5e-29 | 103.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 407-679 Range on HMM: 1-231/231 Sequence Identity: 24% (70 aa) VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSC---SLQDYLERQAKEG ... |.|| | .... .... .|| | ..|..||.|... . | .|.||| .. ... . .| |. .| ||.... ..| YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG E---FSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKNCEQIEILDWVGNIGYMAPEILTKKEHENKIYSK-KS |. . .. ||.. ..|.| .|||||.||.| |.. .||.|||||..|| .| |||||.| |.| |. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC DSYSVG-LLLSLLDNYLILKEKEGYTFMTMTLKQYDEPFKKQKINIKRDTEIFKFIKLLVVWERVNRASLSIIVG-----QNSKNF | .|.| .| .| | |... ||| . . | ||. . ... .| . . . | DWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 17858.AA | Ciliate-E1 | 413-602 | 26 | 2.4e-28 | 89.52 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 413-602 Range on HMM: 1-202/202 Sequence Identity: 26% (54 aa) LSFGSFGMVLSTKKVELSNKEIVLKIQKIV---NEQTIQNEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVV-FELEKCSCSLQDYLE----------R .. |||..|. |. . ..... .||... |....|.||. .... . . | ..|. . |. . .|.|.|||.|||. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC QAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKNCEQIEILDWVGNIGYMAPEIL---TKKEHENKIY | ....|....|..|. |.|| ....| .|||||||||.| |.. . ..... |||.| .| .| .| . . | ... .. .|... QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKI SKKSDSY ..||| | NYKSDIY |
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Kinase | 17858.AA | Ciliate-E2 | 407-608 | 23 | 1.1e-27 | 92.1 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 407-608 Range on HMM: 1-286/365 Sequence Identity: 23% (69 aa) VNNFQILSFGSFG-----MVLSTKKVE-----------------LSNKEIVLKIQK------IVNEQTIQNEIR----------IMQQLKTPLVVQLYDN . ... .|.|| | ...| . .|.. .||.| | .|. | .||. |..||. | ....|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YVIEKVTAPEKYVVFELEKCSC-SLQDYLERQAKE--------GEFSDEEKLNIALQIID---------------SVNYIHCFN-IIHRDIKPDNFLVCL . .. .... . .| |. .|.||.. . | . |...| ..| ||.. ..|.| | ||||||||.| |. FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-- DGNQLQIKLCDFGLSAQL-EKNCEQI------EILDWV-----------------------GNIGYMAPEILTKKEHEN----KIYSKKSDSYSVGLLL ||..||||| .. ..|.... .... |. |||||||| .|. .| | |..|.| .|.| .| ------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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Kinase | 17858.AA | CMGC | 407-558 | 15 | 2.4e-26 | 82.81 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 407-558 Range on HMM: 1-251/513 Sequence Identity: 15% (40 aa) VNNFQILSFGSFGMVLSTKKVE-------------LSNKEIVLKIQKIVNEQTIQ---------------NEIRIMQQLK-----------------TPL . . . |..|.| . . . .|... .|. | . ..| ||.|...|. . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVQLYDNYVIEKVTAPEK-----------YVVFELEKCSCSLQDYLERQA--KEG----EFSDEE------------KLNIA------LQIIDSVN--YI .|.||| .. .. . .|. .. . | . ..| .|.... . | ..|. . . .. ||. ... |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LQIKLCDFGLS | . |||||.|| | |.. .. ..|.|||||. HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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Kinase | 17858.AA | STE | 408-608 | 22 | 5.3e-26 | 88.86 | In-house | 1-258 (359) | Show / Hide |
Range on Protein: 408-608 Range on HMM: 1-258/359 Sequence Identity: 22% (60 aa) NNF-QILSFGSFG-MVLSTKKVEL-------------SNKEIVLKIQKIVN--------------------EQTIQNEIRIMQQLK--TPLVVQLYDNYV . ... |.|| .. .. ... . |. .. | .| |..||.||.... | .|. |. |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF IEK--VTA-PEKYVVFELEKCSC-SLQDYLE------------RQAKEGEFSDEEKLNIALQIIDS-VNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLC | . | ... |. .. || | .. ||. .. |. .. |. ||. .|.| .||||||||.| |. .||| KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLC DFGLSAQLEKNCE--------------QIEILDWVGNIGYMAPEILTKKEHE-NKIYSKKSDSYSVGLLL |||...||.... | . .|| .||||.... .. .| |. |.| .|.|... DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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Kinase | 17858.AA | TKL | 510-608 | 25 | 3.1e-25 | 87.81 | In-house | 134-279 (364) | Show / Hide |
Range on Protein: 510-608 Range on HMM: 134-279/364 Sequence Identity: 25% (37 aa) KLNIALQIIDSVNYIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLQIKLCDFGLSAQLEKNCEQIEILD-----------------W ....||.| .|| | | |||||.|..| || ... . .|.|||||| .... .. . RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ VGNIGYMAPEILTKKEHENK-----------IYSKKSDSYSVGLLL .|....||||.| ... .. ||.|.| || |..| CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL |
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Kinase | 17858.AA | Ciliate-A1 | 407-608 | 27 | 4e-17 | 54.8 | In-house | 1-218 (301) | Show / Hide |
Range on Protein: 407-608 Range on HMM: 1-218/301 Sequence Identity: 27% (62 aa) VNNFQILSFGSFGMVLSTKKVELSNKEIVLKIQKIVNEQTIQ---NEIRIMQQLKTPLVVQLYDNYVIEKVTAPEKYVVFELEKCSCSLQDYLERQAKEG | . |||| |. .. . | . .|| .. | . .| |...|. . |. |. .. | . |.| .. . | . YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQ--LYYNTNNKECMFIIMEYCQYGNLFNYCYQND-- EFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKNC-------------------EQIEILDWVGNIGYMAPEI . || | .||| . || ||.|||.||.| |. .. ..|.||.|.| ||| | . .. . || ||.|| YMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILI---HFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKG---GNLYYMSPEQ ----L-TKKEHENKIYSKKSDSYSVGLLL . .. ||||| |.|| ||.|. . YQMHYRDQMFIENKIY-KQSDMYSLGCII |
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Kinase | 17858.AA | TyrKc | 407-675 | 19 | 5.7e-11 | -45.35 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 407-675 Range on HMM: 1-280/280 Sequence Identity: 19% (61 aa) VNNFQILSFGSFGMVLSTKKVELSNKEIVL--KIQKIVNEQTIQNEIRIMQQL--KTPLVVQLYDNYVIEKV-----TAPEKYVVFELEKCSCSLQDYLE . ..| | || | . . | .... .. . .|.||| .| . | .|.|| |. . .. ..|.|. . .|.||| ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR RQAKEGEFSDEEKLNIALQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLQIKLCDFGLSAQLEKN------CEQIEI----LDW-VGNIGYMAPEILT . .. .. ...|....|| . .|.| |.||||. | || .. ..| .||||| .. . . . | |||| . KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI- KKEHENKIYSKKSDSYSVGLLL-----------SL-----LDNYLILKEKEGYTFMTMTLKQYDEP--FKKQKINIKRDTEIFKFIKLLVVWERVNRASL .... ||| .| | .. . ..|. ... . | | | | .|... .| . .| . ----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF------VCCPDEMYQIMKQCWHEDPEDRPTF SIIVGQN | |. . SEIHECF |