Gene 6998 (Tetrahymena)
6998
Sequence
Protein domains of 6998.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 6998.AA | C8 | 42-256 | 61 | 5.6e-121 | 408.22 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 42-256 Range on HMM: 1-226/226 Sequence Identity: 61% (140 aa) FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEKSFFVMEME |.. .|||.|||..||||||...|| ..|||....|..| ..||||.|||||.|.| |.||.||.|||||.|.|..||....|||...|||||.|||||| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCKQNLKQLFDFFRNTQSP-PNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKSKSHYLSKK----GTDAYFAP ||.||||||.|..||.| . ..|.|| |||||..|.|..|.||||||||||||||| ..|.|||.|||||.||||.|.|.|||..||| ||.||||| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP EVEKG------QSRIQSDIFSLGLVL |.||. |.|||||.||.|||| EIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 6998.AA | Ciliate-C8 | 51-256 | 55 | 8.9e-120 | 404.23 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 51-256 Range on HMM: 1-238/238 Sequence Identity: 55% (132 aa) GAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEK---SFFVMEMELCKQN- ||...||||.|...||.|||||....|... |..|...|||||...| |..|.|.||||||||||...||..||.|.. |.|| ||||||||.|.|| GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC -LKQLFDFFRNTQSP-PNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCD------LGFASAVTKSKSHYLSKK--GTDAY--- |||.||..|..||. ...||.|||||....|.||..||||||||||||||...|.|..|||||| .||||...|.||||.||| |||.| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --------FAPEVEKGQSRIQSDIFS-------LGLVL |||||||.|||||||||| .|||| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 6998.AA | C2 | 51-269 | 37 | 2e-67 | 229.32 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 51-269 Range on HMM: 1-245/245 Sequence Identity: 37% (93 aa) GAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEK---------SFFVMEME || .||||| | ..||.|||| . .. | || ... |||...... . ....||..||| ... | ..| |. . ..|. .|.|.|.| GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE LCKQNLKQLFDFFRNTQ-SPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCD----------LGFASAVTKSKS-HYLSK-K |. |||| |. |. . | ...|...||||. . | || ..| |||||| |||.. .| |||||| . |||.. ..|| . || | FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK GTDAY----FAPEVEKGQSRIQSDIFS-LGLVLLELDNLNVLNDNW .| .| |||||... . .||.|| .|.||||||| . . . WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 6998.AA | Pkinase | 42-259 | 23 | 1.4e-31 | 112.78 | Pfam | 1-205 (293) | Show / Hide |
Range on Protein: 42-259 Range on HMM: 1-205/293 Sequence Identity: 23% (55 aa) FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIK-KEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEKSFFVMEM .. .. . ||... | |... ...|||.| . .... .. .. | ...... .... | ||.|. |. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM ELCKQNLKQLFDFF------RNTQS--PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAV-TKSKSHYLSKKGTD |.| |. ..| | |.. ...|.| .. |.|.||. .| ..|.|||.|| |.|.. . . ..|.|| |.| . . ..| . . || EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP AYFAPEV--EKGQSRIQSDIFSLGLVLLEL | |||| . .|..|.|..| |. WYMAPEVIRGGQYYGPKVDMWSCGCILYEM |
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Kinase | 6998.AA | CMGC | 42-224 | 15 | 7.9e-28 | 87.77 | In-house | 1-285 (513) | Show / Hide |
Range on Protein: 42-224 Range on HMM: 1-285/513 Sequence Identity: 15% (47 aa) FQDLEYLSSGAYALVLKAKN--------------TQENRIVALKFLTST-NQEDAN------GIE-SIKKEYEMLQKFG---------------QSDF-L .. .... .|.|. | |... .. |.|||.| . . ..|.| |. .. | ..|... . . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI VNVYDCFYLMEEDVEEDE-----EGNEKTILTEEKSFFVMEMELCKQNLKQLFDFFR-------NTQSPPNE------------IKEVI-----AIQMLE |. ||.|| ..| .|.| . . . .|.. ..|.|. . . . .. . || . . |.|. VKLYDIFYHKNSDGNEYEDKHIIS-------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILR GLN--NLHVKN--IMHRDIKPHNFLVSPSQTY----------------GFTIKLCDLGFASAVTKS------------------------KSHY ||. .| .. |.|||.|| | |... .. ...|.|| |.| .. . .|| GLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHY |
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Kinase | 6998.AA | STE | 42-259 | 20 | 3.9e-27 | 92.92 | In-house | 1-261 (359) | Show / Hide |
Range on Protein: 42-259 Range on HMM: 1-261/359 Sequence Identity: 20% (57 aa) FQDLEYLSSGAYALVLKAKNT------QENRI---------VALKFLTSTNQE----------DANG----IESIKKEYEMLQKFGQ-SDFLVNVYDCFY ....| . .||. | ||.| . ... .| | . |.. . | ...|.|| ....|. . ... |. |.|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF LMEEDVEEDEEGNEKTILTEEKSFFVMEMELCK-QNLKQLFDFFRNTQSPP-----------NEIKEVIAIQMLEG-LNNLHVKNIMHRDIKPHNFLVSP .. ..... . ||.. | .. . .. | .. .|. | |.| |. || ..|.|||||| | |. KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-- SQTYGFTIKLCDLGFASAVTKS----------------KSHYLSKKGTDAYFAPEVEKG-QSR------IQSDIFSLGLVLLEL .|||| |... .|.| ... . || . |||| .. .. ...|| |||....|. -------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM |
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Kinase | 6998.AA | Ciliate-E2 | 42-259 | 17 | 4.3e-26 | 86.54 | In-house | 1-289 (365) | Show / Hide |
Range on Protein: 42-259 Range on HMM: 1-289/365 Sequence Identity: 17% (57 aa) FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTN------------------QEDANGIESIKKEYEMLQ---------------KFGQSDFLVNVYD . .. . .|... | |.|. .... .|.|. . .. . |.||.||.| ... .. ....... |. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE CFY-------------LMEEDVEE-----DEEGNEK----TILTEEKSFFVMEMELC----KQNLKQLFDFFRNTQSPPNEIKEVIAIQMLEGLNNLHVK ||. . | .. . |.. .||.. ..|. | |. | .. .....|. || | CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA--------------------EFYIACIILALEYLHSK N-IMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKS---------KSHYLSKK-----------------------GTDAYFAPEVEKGQSR----- | |.|||||| | |. ||..|.|.. .... |. | || | |||. .|.. NNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK -----IQSDIFSLGLVLLEL ..||.||| .| |. QKGYDYKCDIWSLGVILYEM |
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Kinase | 6998.AA | S_TKc | 42-322 | 21 | 1.9e-22 | 81.8 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-322 Range on HMM: 1-231/231 Sequence Identity: 21% (63 aa) FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQEDANGIESIKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEEGNEKTILTEEKSFFVMEME .. |. . .||.. | |.... .||||.| . |.|..| ..|.| . ...|. ||.|. ... | || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME LCKQNLKQLFDFFRNTQS-------PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKSKSHYLSKKGTDAYF .| ..| |||. .. .. |. ... ... |....|. .| ..|.|||.|| | |.. .||.|| |.| . . || | YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYM APEVEKGQSRIQSDIFSLGLVLLELDNLNVLNDNWIDLDTKAEIHKGKAIASKYQIDRKSNIYKIAEICLKPNYLERKSSGDLLY--------ELI |||| | .. .|. |.| .| |. . . . .. ..| . . . . ||. . .| . ..| . . APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 6998.AA | CAMK | 47-256 | 14 | 4.7e-22 | 67.23 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 47-256 Range on HMM: 1-324/425 Sequence Identity: 14% (48 aa) YLSSGAYALVLKAKNTQEN------------RIVALKFLTSTNQED-------------------------ANGIESIKKEYEMLQKFG------QSDFL | .|... | ...... . . || |.. . | .. .....|.|...| . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNVYDCFY-------LMEEDVEEDEEG-NEKT-ILTEEKSFFVMEM---ELCKQN--LKQLFDFFR-NTQ---------------SPPNEIKEVIAIQML .. |. . .. . . .. . . .....| | |.| . |||. . ... . | . .. |.. IKLYEVYEDPHYFKNT-------ND-YET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QIC EGLNNLHVKNIMHRDIKPHNFLVSPSQTYG-------------FTIKLCDLGFASAVTKSKSHYLS-----------------------KKGTDAYFA-P .... .| .||.|||.|| | |.. . . ..||..| ||| ...... . || .| | | SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP EVEKG-------------QSRI--QSDIFSLGLVL || .| . . ..|. |.| .| EVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL |
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Kinase | 6998.AA | TKL | 168-259 | 21 | 5.5e-21 | 72.32 | In-house | 137-282 (364) | Show / Hide |
Range on Protein: 168-259 Range on HMM: 137-282/364 Sequence Identity: 21% (31 aa) IAIQMLEGLNNLHV--------KNIMHRDIKPHNFLVSPSQT----------YGFTIKLCDLGFASAVTKSKS-------------------HYLSKKGT .|... |.| || ..| |||.|..| || | . ..|.||.|.. ...|.. . .. || WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT DAYFAPEV-----------------EKGQSRIQSDIFSLGLVLLEL .. |||| .... ..|..| |.|| |. PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI |
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Kinase | 6998.AA | Ciliate-E3 | 162-260 | 36 | 3.7e-19 | 56.65 | In-house | 103-202 (202) | Show / Hide |
Range on Protein: 162-260 Range on HMM: 103-202/202 Sequence Identity: 36% (37 aa) NEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKSKSHYLSK-KGTDAYFA-PEVEK-GQSRIQSDIFSLGLVLLE |.|.. |.||...|. .| ||| | |||| |.||. .. .|| ||.| . | | | . |. ..| ||. . .| ||. |.| |... NIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQ-LIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQ LD | LC |
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Kinase | 6998.AA | Ciliate-E1 | 131-250 | 22 | 1.6e-16 | 50.63 | In-house | 67-202 (202) | Show / Hide |
Range on Protein: 131-250 Range on HMM: 67-202/202 Sequence Identity: 22% (32 aa) EEKSFFVMEMELCKQNLKQLFD---------FFRNTQSPPNEI-KEVIAIQMLEGLNNLHVKNIMHRDIKPHNFLVSPSQTYGFTIKLCDLGFASAVTKS .. ... .|.|...||. .. ....| .. |. |..|...||. || .||.||||||.| |.. . | .. |.| .. .. DQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNN KSHYLSKKGTDAYFAPEVEKG----------QSRIQSDIF . .. .|| |..|. .. . ..|||. QNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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Kinase | 6998.AA | Ciliate-E1 | 48-112 | 22 | 2.5e-07 | 20.39 | In-house | 1-66 (202) | Show / Hide |
Range on Protein: 48-112 Range on HMM: 1-66/202 Sequence Identity: 22% (15 aa) LSSGAYALVLKAKNTQEN-RIVALKFLTSTNQEDANGIESIKKEYE-MLQKFGQSDFLVNVYDCFYL ...| ...|.|||. . | . ||.|. ... | .....||| ... | . . .....|.... IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI |
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Kinase | 6998.AA | Ciliate-E3 | 42-111 | 24 | 4e-06 | 15.56 | In-house | 1-72 (202) | Show / Hide |
Range on Protein: 42-111 Range on HMM: 1-72/202 Sequence Identity: 24% (18 aa) FQDLEYLSSGAYALVLKAKNTQENRIVALKFLTSTNQED---ANGIESIKKEYEMLQKFGQSDFLVNVYDCFY . . | | . .| || ..| |..|| | .. .|| . .| . |.. | ..| ..| .| YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYY |
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Kinase | 6998.AA | TKL | 48-77 | 26 | 0.268825 | 0.44 | In-house | 1-38 (364) | Show / Hide |
Range on Protein: 48-77 Range on HMM: 1-38/364 Sequence Identity: 26% (10 aa) LSSGAYALVLKAKNTQEN--------RIVALKFLTSTN . ||... | |.| ... . || | . |.| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHN |
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Kinase | 6998.AA | C8 | 390-591 | 48 | 2.8e-103 | 349.43 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 390-591 Range on HMM: 1-226/226 Sequence Identity: 48% (110 aa) VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCS-----------CSLQD- .||||.|.||..||||..|.|. .|.||.||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.|||| |.... FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM ----------YLERQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCDFGLSVQLGKDCEQIEVQCM--VGNMTYSA |.||..|...||.|.|..||.|.||.||||||.||.||||||.|||||||.|.. ||||||||.. |..|....|. . | .|...|.| ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA PEIIAKEDDQNKIYSKKSDSYSVGLLL |||..|.|.|.|.|...||..||||.| PEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 6998.AA | Ciliate-C8 | 399-591 | 40 | 1e-98 | 334.25 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 399-591 Range on HMM: 1-238/238 Sequence Identity: 40% (97 aa) GSFGMVLST------KKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEK-----------------YVVFELEKCS--C |.|||||.. .||.|...|...||||.....||.....|||....|.|||.||..........|. ..|.|.|||. | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC SLQDYLER-QTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLD-GNQLEIKLCD------FGLSVQLGKDCE---------QIEVQCM .|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.| ..|..||||| ||.. || |... ......| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --VGNMTYSAPEIIAK-EDDQNKIYSKKSDSYSVGLLL .||..|.|||...| ...|..|.|||||||||||.| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 6998.AA | C2 | 399-591 | 30 | 1.5e-48 | 163.94 | In-house | 1-232 (245) | Show / Hide |
Range on Protein: 399-591 Range on HMM: 1-232/245 Sequence Identity: 30% (73 aa) GSFGMVLSTKKVNLN-NKEIALKIQKIVN-----DQEIQNEIRIMQQLK-TPLVVQLYD-HYVIEKATAP------------EK----------YVVFEL |.||.|| | | . |...|||||.. .|.|.|..||.|.. |.....|. |. .. |. ||.|. GAFGLVL--KAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQ EKCSCSLQDYLERQTKEG-EFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCD----------FGLSVQLGKDCEQIEVQCM |.|.. |. |..|..|. ......| .| |..||.||.|.|.|.||||||.|||. .| ... ||||| | . | .. ..| .. . EFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKF VGNMTY----SAPEIIAKEDDQNKIYSKKSDSYS-VGLLL .. .| .|||.. .|| |.|| .| ||. | KWTQQYYQHIFAPEVYQ------NIYKKNSDLFSTVGYVL |
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Kinase | 6998.AA | CAMK | 395-591 | 19 | 4.7e-38 | 119.7 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 395-591 Range on HMM: 1-324/425 Sequence Identity: 19% (63 aa) ILNFGSFGMVLSTKKVNLNN-----------KEIALKI---QKIV----------------------------NDQEIQNEIRIMQQ-------LKTPLV .| |||| | . | .. .. | || .|. . .....||.||.. |. | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQLYDHYVIEKA--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQTK------------EGEFSDEQKLNIALQIIDSVNYIHCFN ..||..| .. | .|.... . | || | ||. .... .| |. .. . ||.. |.|.| | IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IIHRDIKPENFLVCLDG--------------NQLEIKLCDFGLSVQLGKDCEQI---------------------EVQCMVGNMTYSA-PEIIAKE---- |.|||.|||| |.. .. |. ||..|||.. .. .. .. . ..| | | ||.. .. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN -----DDQNKIYSKKSDSYSVGLLL |.... |..|.| |.| .| MQNATDEEKPYYGPKCDMWSCGVIL |
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Kinase | 6998.AA | S_TKc | 393-661 | 24 | 2e-32 | 114.96 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 393-661 Range on HMM: 1-231/231 Sequence Identity: 24% (70 aa) FQILNF---GSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC---SLQDYLERQTKEG ..||. |.|| | .... ... |.|| | . |..||.|... . | .|.|||... ... . .| |. .| ||.... ..| YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG E---FSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDDQNKIYSK-KS |. . .. ||.. ..|.| .|||||.|||| |.. .||.|||||. || ..| | |||.. |.| |. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC DSYSVG-LLLSLLDNYLILNEIVGITFPSMAFEQQNEPFNNINIKRNSEIFKFIKLLVVWERVNRASLSTIVE----QNTNQFK | .|.| .| .| | |... |..| .| ||. . ... .| . . . . .. DWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 6998.AA | Ciliate-E1 | 396-585 | 28 | 1.1e-31 | 100.46 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 396-585 Range on HMM: 1-202/202 Sequence Identity: 28% (60 aa) LNFGSFGMVLSTKKVNLNNKEIALKIQKIV---N----DQEIQNEIRIMQQLKTPL-VVQLYDHYVIEKATAPEKYVVFELEKCSCSLQDYLE------- . |||..|. |. | |....|.||... | ..||.... ||. .|. ..|..| . |... . .. .|.|.|||.|||. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY ---RQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEII---AKEDDQ |.....|...||..|. |.|| ....| .|||||||||.| |.. . ... . |||.| .| . .| .. .. |. ... | .. WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK NKIYSKKSDSY |.....||| | NQKINYKSDIY |
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Kinase | 6998.AA | Pkinase | 390-591 | 27 | 9.2e-30 | 106.32 | Pfam | 1-202 (293) | Show / Hide |
Range on Protein: 390-591 Range on HMM: 1-202/293 Sequence Identity: 27% (61 aa) VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQN-------EIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC-----SLQD ... |||| | .... ..|. |.|| | ... . .. ||.||. |. | .|.||| . .... . .| | . .| | YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD YLERQTKEGEF--SDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL--EIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDD |... ..| | |... ....||. ..|.| .|||||.||||.|. . ... .|.|||||. |. . . .| | |||.| YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR---- QNKIYSKKSDSYSVGLLL .. |..|.| .|.|..| GGQYYGPKVDMWSCGCIL |
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Kinase | 6998.AA | CMGC | 390-541 | 17 | 1.5e-29 | 93.53 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 390-541 Range on HMM: 1-251/513 Sequence Identity: 17% (44 aa) VNNFQILNFGSFGMVLSTKKVNLN-------------NKEIALKIQKIVNDQEIQ---------------NEIRIMQQLK-----------------TPL . . . |..|.| . . . | |...|.|. | . |.| ||.|...|. . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVQLYDHYVIEKATAPEK-----------YVVFELEKCSCSLQDYLERQT--KEG----EFSDEQ------------KLNIA------LQIIDSVN--YI .|.|||... .. . .|. .. . | . ..| .|.... . | ..|. . . .. ||. ... |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HCFN--IIHRDIKPENFLVCLDGNQ-----------------LEIKLCDFGLS | . |||||.|||| |.. .. ..|.|||||. HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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Kinase | 6998.AA | Ciliate-E2 | 390-591 | 22 | 1.3e-27 | 91.79 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 390-591 Range on HMM: 1-286/365 Sequence Identity: 22% (67 aa) VNNFQILNFGSFG-----MVLSTKKVN-----------------LNNKEIALKIQKIVNDQEIQNEIRIMQ----------------QLKTPLVVQLYDH . ... .|.|| | ...| ..|..|.||.| . ..| .||.||. ||. | ....|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YVIEKATAPEKYVVFELEKCSC-SLQDYLERQ-TKE-------GEFSDEQKLNIALQIID---------------SVNYIHCFN-IIHRDIKPENFLVCL . .. .... . .| |. .|.||.. . .|. . |.... ..| ||.. ..|.| | |||||||||| |. FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-- DGNQLEIKLCDFGLSVQLGKD---CEQIEVQCM---------------------------VGNMTYSAPEIIAKEDDQN----KIYSKKSDSYSVGLLL ||..||||| .. .| . . .|| .|. | ||||. .....| | |..|.| .|.| .| ------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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Kinase | 6998.AA | STE | 391-591 | 22 | 4.8e-25 | 85.44 | In-house | 1-258 (359) | Show / Hide |
Range on Protein: 391-591 Range on HMM: 1-258/359 Sequence Identity: 22% (60 aa) NNF-QILNFGSFG-MVLSTKKVNL-------------NNKEIALKIQKIVN--------------------DQEIQNEIRIMQQLK--TPLVVQLYDHYV . ... |.|| .. .. | ... .| |. .. | |.|..||.||.... | .|. |..|. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF IE---KATAPEKYVVFELEKCSC-SLQDYLER--QTKE---------GEFSDEQKLNIALQIIDS-VNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCD | . | ... |. .. || | ... ... . |. .| |. ||. .|.| .|||||||| | |. .|||| KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD FGLSVQLGKDCE------------QIEVQC--MVGNMTYSAPEIIAKEDDQ-NKIYSKKSDSYSVGLLL ||.. || ... . .. .|| . |||.| ... .| |. |.| .|.|... FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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Kinase | 6998.AA | TKL | 491-591 | 24 | 1.5e-24 | 85.37 | In-house | 132-279 (364) | Show / Hide |
Range on Protein: 491-591 Range on HMM: 132-279/364 Sequence Identity: 24% (36 aa) EQKLNIALQIIDSVNYIHCFN--------IIHRDIKPENFLVCLDGN-----------QLEIKLCDFGLSVQLGKDCEQIEVQCM--------------- .|....||.| .|| | | |||||.|..| || ... . .|.|||||| . .. .. . . HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM --VGNMTYSAPEIIAKEDDQNK-----------IYSKKSDSYSVGLLL .|. . |||.. .... .. ||.|.| || |..| TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL |
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Kinase | 6998.AA | Ciliate-E3 | 394-595 | 35 | 1.2e-16 | 48.65 | In-house | 5-202 (202) | Show / Hide |
Range on Protein: 394-595 Range on HMM: 5-202/202 Sequence Identity: 35% (75 aa) QILNFGSFGMVLSTKKVNLNNKEIALKIQ--KIVND-------QEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC-SLQDYLERQT |||. |.|| | . ||...| | . . .. |. |.|. ||.. ||. .| |. .. .| |. || .|. |. | QILGCGQFGRVYKAFDFQ-NNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKM--IFIVQEY--CSNGDLYHYIKQQN KEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDC--EQIEVQCMVGNMTYSAPEIIAKEDDQNKIYSKK | . . . |. ||| .. || |||| ||||.|.|| ||| || ||||.| || |. . | . |.|||. .||..| || K----TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWT--PFYAAPEQ----NDQQQI-SKE SDSYSVGLLLSLLD || |||| . .| SDYYSVGAVFCQLC |
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Kinase | 6998.AA | TyrKc | 390-656 | 19 | 2.8e-11 | -40.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 390-656 Range on HMM: 1-280/280 Sequence Identity: 19% (60 aa) VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQK-IVNDQEIQNEIRIMQQL--KTPLVVQLYDHYVIEK----ATAPEKYVVFELEKCSCSLQDYLERQ . ..| | || | . . | | | ... .|.||| .| . | .|.|| ..... .. ..|.|. . .|.||| . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH TKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKD------CEQIEV----QCM-VGNMTYSAPEIIAKE .. .. ...|....|| . .|.| |.||||. | || .. .| .||||| .. | . . . .. . ||| | RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--- DDQNKIYSKKSDSYSVGLLL-----------SL-----LDNYLILNEIVGITFPSMAFE----QQNEPFNNINIKRNSEIFKFIKLLVVWERVNRASLST . .... ||| .| | .. . ..|. ... . . . | .|... .| . .| . |. --NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----F----VCCPDEMYQIMKQCWHEDPEDRPTFSE IVEQN |.|. IHECF |