Gene 6997 (Tetrahymena)

6997

Species: Tetrahymena
Alias: 779, 6997, PreTt06997, 258.m00016, TTHERM_01156750
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
6997.AA Protein None 1324 None Fasta, JSON
6997.kin_dom Protein Kinase Domain None 165 None Fasta, JSON
6997.kin_dom2 Protein Kinase Domain None 204 None Fasta, JSON
6997.NA RNA None 3975 None Fasta, JSON

Protein domain

Protein domains of 6997.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6997.AA C8 157-371 61 6.6e-121 407.97 In-house 1-226 (226) Show / Hide 
Range on Protein: 157-371
Range on HMM: 1-226/226
Sequence Identity: 61% (140 aa)

FQNFEYLSSGAYSLVLKAKNIQKNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYNCFYLMEQDVEEDKYGNEKLIVTEEKSFFVMEME
|.||.|||.|||..||||||...||...|||..|..|.  ..|||..||||..|.|.|.||.||.|.|||.|....||.| .|||...|||||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQNLKQLFDYLRKTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRNIKPHNFLVCPSQTYGFSIKICDLGFASTVTKSKSHYQSKN----GTDTFFAP
|||||||||.|..|..|.. |.|.||||||||..|.|..|.|||||| |||||||||..|.|||.||.||.||||.|.|.|||.|||.    ||...|||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EIEKG------QSRIQSDLFSLGLVL
||||.      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 6997.AA Ciliate-C8 166-371 52 7.4e-115 387.88 In-house 1-238 (238) Show / Hide 
Range on Protein: 166-371
Range on HMM: 1-238/238
Sequence Identity: 52% (126 aa)

GAYSLVLKAKNIQKNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYNCFYLMEQDVEEDKYGNEKLIVTEEK---SFFVMEMELCEQN-
||...||||.|...||.|||||..|..|.  ...|...||||....|.|..|.|.||.||||||....||. ||.| ..|.||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDYLRKTQLP-SQEIKEIIAIQMLEGLNTLHIKNIMHRNIKPHNFLVCPSQTYGFSIKICD------LGFASTVTKSKSHYQSKN--GTDTF---
 |||.||..||.|.. ||..||||||||....|.||..||||| |||||||||..|.|...||.||      .|||| ..|.|||| ||.  |||.    
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEIEKGQSRIQSDLFS-------LGLVL
        ||||.||.|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 6997.AA C2 166-384 36 1.5e-62 212.49 In-house 1-245 (245) Show / Hide 
Range on Protein: 166-384
Range on HMM: 1-245/245
Sequence Identity: 36% (90 aa)

GAYSLVLKAKNIQKNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYNCFYLMEQDVEEDKYGNEKLIVTEEK---------SFFVMEME
|| .||||| | ..|| ||||   | | . ..| ... |||....... . ....|||.||| ... | .   |.  ....|.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQNLKQLFDYLRKTQ-LPSQEIKEIIAIQMLEGLNTLHIKNIMHRNIKPHNFLVCPSQTYGFSIKICD----------LGFASTVTKSKS--HYQSKN
 |. |||| |. .|| .  |.|..|.|.||||. . | ||...| || ||| |||.  .|     ||.||          . ||| . ..||  | .  .
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDTF----FAPEIEKGQSRIQSDLFS-LGLVLLELDNLNVLNENW
.| .     ||||....  . .||||| .|.||||||| .  . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 6997.AA Pkinase 157-374 23 9.4e-27 95.68 Pfam 1-205 (293) Show / Hide 
Range on Protein: 157-374
Range on HMM: 1-205/293
Sequence Identity: 23% (53 aa)

FQNFEYLSSGAYSLVLKAKNIQKNRMVALKFLTCTSKEGLKGIESLK-KEYELLQKFSQSDFLVNVYNCFYLMEQDVEEDKYGNEKLIVTEEKSFFVMEM
..  . . ||... | |....  ...||.| .   ...  | .. ..  | ...... .... |  | .|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEQN--LKQLFDYLR---KTQL--PSQEIKEIIAIQMLEGLNTLHIKNIMHRNIKPHNFLVCPSQTYGFSIKICDLGFASTV-TKSKSHYQSKNGTDT
|.||    .  ||||..   .. .  . .|.| ..  |.|.||. .| ..|.|| .|| |.|.    . . ..|||| |.|  . . ..| ...  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

FFAPEI--EKGQSRIQSDLFSLGLVLLEL
. |||.  .       .| .|.|..| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 6997.AA CMGC 157-329 15 7e-24 74.55 In-house 1-251 (513) Show / Hide 
Range on Protein: 157-329
Range on HMM: 1-251/513
Sequence Identity: 15% (40 aa)

FQNFEYLSSGAYSLVLKAKN--------------IQKNRMVALKFLTCTSKEGLKGI---------ESLKKEYELLQKFS---------------QSDF-
... ... .|.|. | |...              .. |..||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYNCFYLMEQDVEEDK-----YGNEKLIVTEEKSFFVMEMELCEQNLKQLFDYLRK-------TQLPSQE------------IKEII-----AIQML
.|. |..||  . | .|..     .         .   . . .|.....|.|. .  ..         |.  .            || ..     . |.|
IVKLYDIFYHKNSDGNEYEDKHIIS-------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQIL

EGLN--TLHIKN--IMHRNIKPHNFLVCPSQTY----------------GFSIKICDLGFA
.||.   .| ..  |.|| .|| | |...  ..                 . .|||| |.|
RGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 6997.AA CAMK 162-353 13 9.4e-22 66.23 In-house 1-291 (425) Show / Hide 
Range on Protein: 162-353
Range on HMM: 1-291/425
Sequence Identity: 13% (42 aa)

YLSSGAYSLVLKAKNIQKN------------RMVALKFLTCTSKEG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | ...... .            . || |..  .   .                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYNCFYL-----------MEQDVEEDKYGNEKLIVTEEKSFFVMEM---ELCEQN--LKQLFDYLRKT----------------QLPSQEIKEIIAIQ
.. |  .               ...          .. . .....| |   |.|.    .  ||||...                  .. .| . ..  |
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-Q

MLEGLNTLHIKNIMHRNIKPHNFLVCPSQTYG-------------FSIKICDLGFASTVTKSKSH-----------------------YQSKNGTDTFFA
...... .| .||.|| .|| | |.. . .               . |||.| |||  ......                        ..   ||  . |
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PEI
 ||.
APEV
Kinase 6997.AA STE 157-374 18 3.1e-21 71.84 In-house 1-261 (359) Show / Hide 
Range on Protein: 157-374
Range on HMM: 1-261/359
Sequence Identity: 18% (54 aa)

FQNFEYLSSGAYSLVLKAKNI------QKNRM---------VALKFLT---CTSKEGL------------KGIESLKKEYELLQKFSQ-SDFLVNVYNCF
... | . .||.  | ||.|.      ....          .| | .    |..|.              . .....|| ....|... ... |. | |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YLMEQDVEEDKYGNEKLIVTEEKSFFVMEMELCE-QNLKQLFDYLRKTQLPS-----------QEIKEIIAIQMLEG-LNTLHIKNIMHRNIKPHNFLVC
.    .             .....   . ||...   | .. .   ... |             ..  .|. | |.| |. || ..|.|| ||| | |. 
FKEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-

PSQTYGFSIKICDLGFASTVTKSKS------------HYQSKN----GTDTFFAPEIEKG-QSR------IQSDLFSLGLVLLEL
        .|.|| |... .|.| .              |.|.    ||  . |||. .. ..       ...|  |||....|.
--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 6997.AA Ciliate-E2 255-374 24 5.5e-21 68.75 In-house 113-289 (365) Show / Hide 
Range on Protein: 255-374
Range on HMM: 113-289/365
Sequence Identity: 24% (47 aa)

MELCEQNLKQLFDYLRKTQLPSQEI---------KEI--IAIQMLE---------------GLNTLHIKN-IMHRNIKPHNFLVCPSQTYGFSIKICDLG
||.|..  . ||||... .. ....         |||  |  | |.               .|. || || |.||.||| | |.         |||.|.|
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

FASTVTKS----------KSHYQSKN----------------------GTDTFFAPEIEKGQSR----------IQSDLFSLGLVLLEL
..  ....          |   . ||                      ||  . |||| .|..            ..|..||| .| |.
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 6997.AA S_TKc 157-437 20 5.9e-18 66.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 157-437
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

FQNFEYLSSGAYSLVLKAKNIQKNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYNCFYLMEQDVEEDKYGNEKLIVTEEKSFFVMEME
..  . . .||.. | |....  .| ||.| .           |....| ..|.|  . ...|. | .|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEQNLKQLFDYLRKTQ-------LPSQEIKEIIAIQMLEGLNTLHIKNIMHRNIKPHNFLVCPSQTYGFSIKICDLGFASTVTKSKSHYQSKNGTDTFF
.|...|  ||||..| .       .|  ... ... |....|. .| ..|.|| .|| | |..        ||||| |.|  .        .  ||  . 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYM

APEIEKGQSRIQSDLFSLGLVLLELDNLNVLNENWIDFDIKEEIYQGKGIASKYQIDRNSNIYKIAKICLKPNYLERKTSGDLL--------FELI
|||.  | ..  .|  |.| .| |.     . .        .....  |          .    . . ||. .  .| |  ..|         . .
APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6997.AA ULK 244-371 26 7.9e-18 58.89 In-house 86-246 (329) Show / Hide 
Range on Protein: 244-371
Range on HMM: 86-246/329
Sequence Identity: 26% (43 aa)

VTEEK--SFFVMEMELCEQ-NLKQLFDYLRK--------TQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRNIKPHNFLVCPSQTY--------GFSIKIC
..|..    . . ||.|.. .|.|.    .|          |. ||..... .| |.|.  || .||.|| ||| | |.   |..           .||.
WFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFF-KQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIA

DLGFASTVTKS---KSHYQSKN------GTDTFFAPEIEKGQ------SRIQSDLFSLGLVL
| ||| .|...   .  ...        ||  . ||.| .||      .   .|..||| ..
DFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 6997.AA Ciliate-E1 241-365 19 3.5e-17 52.83 In-house 59-202 (202) Show / Hide 
Range on Protein: 241-365
Range on HMM: 59-202/202
Sequence Identity: 19% (29 aa)

KLIVTEEKSFFVMEMELCEQNLKQLFDYLR-------------KTQLPSQEIKEIIAIQMLEGLNTLHIKNIMHRNIKPHNFLVCPSQTYGFSIKICDLG
..| . .. .  ......|   ..|.|||.             . .  ... |. |..|...||. ||..||.||.|||.| |.. .  | ..    |.|
QIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFG

FASTVTKSKSHYQSKNGTDTFFAPEIEKG----------QSRIQSDLF
 ...  ... ... ..|  . ..|. ..           .  ..||..
ISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 6997.AA TKL 283-374 20 4.5e-17 58.01 In-house 137-282 (364) Show / Hide 
Range on Protein: 283-374
Range on HMM: 137-282/364
Sequence Identity: 20% (30 aa)

IAIQMLEGLNTLHI--------KNIMHRNIKPHNFLVCPSQT----------YGFSIKICDLGFASTVTKSKS-------------------HYQSKNGT
.|...  |.| ||         ..| ||..|..| ||    |          .   .||||.|.. ....|..                   .  .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DTFFAPEI-----------------EKGQSRIQSDLFSLGLVLLEL
  . |||.                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 6997.AA Ciliate-E1 163-227 22 6.9e-08 22.23 In-house 1-66 (202) Show / Hide 
Range on Protein: 163-227
Range on HMM: 1-66/202
Sequence Identity: 22% (15 aa)

LSSGAYSLVLKAKNIQKN-RMVALKFLTCTSKEGLKGIESLKKEYE-LLQKFSQSDFLVNVYNCFYL
...| .|.|.|||... | . ||.|.  |  ..    .....|||  ... | . . ..........
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 6997.AA Ciliate-E2 157-226 12 0.000169 11.34 In-house 1-102 (365) Show / Hide 
Range on Protein: 157-226
Range on HMM: 1-102/365
Sequence Identity: 12% (13 aa)

FQNFEYLSSGAYSLVLKAKNIQKNRMVALKFLTCTS----------------KEGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYN
.   . . .|... | |.|........|.|. . .                 .. .  ..||..|.|  ...               .. ....... | 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFY
||.
CFQ
Kinase 6997.AA ULK 157-226 19 0.043158 3.2 In-house 1-88 (329) Show / Hide 
Range on Protein: 157-226
Range on HMM: 1-88/329
Sequence Identity: 19% (17 aa)

FQNFEYLSSGAYSLVLKAKNIQK----NRMVALKFLT---CTSKEGLKG----IESLKKEYELLQKFS---QSDF----LVNVYNCFY
..  . | .|..  | |..|...    | .|| | .    .  |. .      ...||.| ....|     .. .     |  | .|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFE
Kinase 6997.AA C8 502-704 49 5.6e-103 348.41 In-house 1-226 (226) Show / Hide 
Range on Protein: 502-704
Range on HMM: 1-226/226
Sequence Identity: 49% (112 aa)

VNNFQILNFGSFGMVLSTKKVEFNNKEIVLKIQKIVDEQEIKNEIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCS-----------CTLQE-
.||||.|.||..||||..|.|. .|.|||||.||....|.|.|...||.....|.|.|.||.|..|.....|.|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLDGNQL-EVKLCDFGLSTQLEKNCEQIEILDW--VGNWAYMA
          |.||. |...||.|.|..||||.||.||||||.||.||||||.| |||||.|.. |.||||||...|..||...|.. ..  .|.|||.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILTKIEDNQYKIYSKKSDSYSVGLLL
|||..| .|||||.|...||..||||.|
PEIEKK-QDNQYKQYRIQSDLFSVGLVL
Kinase 6997.AA Ciliate-C8 511-704 41 1e-101 344.2 In-house 1-238 (238) Show / Hide 
Range on Protein: 511-704
Range on HMM: 1-238/238
Sequence Identity: 41% (99 aa)

GSFGMVLST------KKVEFNNKEIVLKIQKIVDEQEIKNEIRIMQQLKTPLVVQLYDNYIIEKATAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.....|.|.||||...|.|||....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

TLQEYLER-QGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLD-GNQLEVKLCD------FGLSTQLEKNCE---------QIEILDW
.|..|..| . |....|...|..||||.||||||.|||||.||||||.| |||.| ..|...||||      ||...||.||..         .......
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNWAYMAPEILTKIEDNQYKIYSKKSDSYSVGLLL
  .|||.|.|||...|....|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 6997.AA C2 511-717 26 1.4e-45 153.73 In-house 1-245 (245) Show / Hide 
Range on Protein: 511-717
Range on HMM: 1-245/245
Sequence Identity: 26% (68 aa)

GSFGMVLSTKKVEFNNKEIVLKIQKIVD-----EQEIKNEIRIMQQLK-TPLVVQLYD-------NYII------EKATAPEK----------YVVFELE
|.||.|| .   .  |....||||.. .     ..|. .|..||.|..  |.....|.       . ..      |.    |.           ||.|.|
GAFGLVLKAFNKK-QNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCTLQEYLERQGKEG-EFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLDGNQL-EVKLCD----------FGLSTQLEKNCEQIEILDWV
.|...|. |..|. |.  ......|  .|||..||.||.|.|.|.||||||.| |. .| ...  .||||          |  .  |..| ..| .   .
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNWAY----MAPEILTKIEDNQYKIYSKKSDSYSVGLLLSLLDNYLILKENT
.  .|    .|||.  .|  .. ...|       ||. |  |||  .   . 
WTQQYYQHIFAPEVYQNIYKKNSDLFS------TVGYVLLELDNMQQYTICC
Kinase 6997.AA CAMK 507-704 18 1.2e-32 101.95 In-house 1-324 (425) Show / Hide 
Range on Protein: 507-704
Range on HMM: 1-324/425
Sequence Identity: 18% (61 aa)

ILNFGSFGMVLSTKKVEFNN-----------KEIVLKI---QKIV----------------------------DEQEIKNEIRIMQQ-------LKTPLV
.|  |||| |   .  . ..           ..   ||   .|.                             |......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYIIEKA--------TAP------EKYVVFEL---EKCSCT-----LQEYLERQGK------------EGEFSDEEKLNIAIQVIDSVNYIHCFN
..||. |  ..         |        .|.... .   | ||       | .|. ..|.            .| |. .|   .  |... |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNVLVCLDG--------------NQLEVKLCDFGLSTQLEKNCEQI---------------------EILDWVGNWAYMA-PEILTKIEDNQ
|.|||.||.|.|.. ..              |.  .|..|||........ ..                         ...|  .||| ||.| .    .
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

Y--------KIYSKKSDSYSVGLLL
.        . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 6997.AA S_TKc 505-774 23 1.3e-28 102.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 505-774
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

FQILNF---GSFGMVLSTKKVEFNNKEIVLKIQKIVDEQEIKNEIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCSC---TLQEYLERQGKEG
..||.    |.|| |   ....  ...  .|| |    . |..||.|... . | .|.||| .         ... . .| |.    .| .|....|..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLDGNQLEVKLCDFGLSTQLEKNCEQIEILDWVGNWAYMAPEILTKIEDNQYKIYSK-K
    |.  .   .. |... ..|.|  .|||||.||.|.|..      ..|.|||||..||            .|   |||||.|          |.| |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---------GYGKCK

SDSYSVG-LLLSLLDNYLILKENTGSTFIMMTSNQYDEPFKDINIKRDTEIFKFIQLLVVWERDKRTSLSVIVE----QNSEKFK
.| .|.| .|  .|  |     .   .| ..                . |   ||. . ... .|| .   . .     ..  . 
CDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6997.AA Ciliate-E1 508-698 25 2.4e-28 89.52 In-house 1-202 (202) Show / Hide 
Range on Protein: 508-698
Range on HMM: 1-202/202
Sequence Identity: 25% (54 aa)

LNFGSFGMVLSTKKVEFNNKEIVLKIQKIVDEQE-------IKNEIRIMQQLKTPL-VVQLYDNYIIEKATAPEKYVVFELEKCSCTLQEYLE-------
.  |||..|.  |. . |.... .||... . ..       ||... ||. .|.   ..|..| ..|...    .  .. .|.|.|.|..||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---RQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLDGNQLEVKLCDFGLST--QLEKNCEQ---IEILDWVGNWAYMAPEILTKIE
    | ....|....|..|..| || ....| .|||||||||.|.|.. . ...  ..||||.|   ....| ..    ..     .. |. ||  . ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNY--VYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK

DNQYKIYSKKSDSY
......   ||| |
NQKINY---KSDIY
Kinase 6997.AA CMGC 502-659 15 1.4e-27 86.89 In-house 1-257 (513) Show / Hide 
Range on Protein: 502-659
Range on HMM: 1-257/513
Sequence Identity: 15% (39 aa)

VNNFQILNFGSFGMVLSTKKVE-------------FNNKEIVLKIQKIVDEQEIK---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  .              .|... .|. | .   |.                 ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYIIEKATAPEK-----------YVVFELEKCSCTLQEYLERQG--KEG----EFSDEE------------KLNIA------IQVIDSVN--YI
.|.||| .  .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        |.. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNVLVCLDGNQ-----------------LEVKLCDFGLSTQLEKN
|  .  |||||.|| |.|.. ..                    ..|.|||||.......
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 6997.AA Ciliate-E2 502-704 21 2.6e-26 87.32 In-house 1-286 (365) Show / Hide 
Range on Protein: 502-704
Range on HMM: 1-286/365
Sequence Identity: 21% (63 aa)

VNNFQILNFGSFG-----MVLSTKKVE-----------------FNNKEIVLKIQKIVDEQEIKNEIRIMQ----------------QLKTPLVVQLYDN
 .  ... .|.||      | ...| .                 ...|.. .||.|  . ..||.||.||.                ||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YIIEKATAPEKYVVFELEKCSC-TLQEYLE----RQGKE----GEFSDEEKLNIAIQVID---------------SVNYIHCFN-IIHRDIKPDNVLVCL
.. ..    .... . .| |.  .|..|..     ...|    . |...| ..|  |...                ..|.|  | ||||||||.|.|.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEVKLCDFGLSTQL-EKNCEQI------EILDWV-----------------------GNWAYMAPEILTKIEDN---QYKIYSKKSDSYSVGLLL
      .|..|||||... ..|....      ....                         |.  ||||||| . ...   . | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 6997.AA Pkinase 502-704 27 9.9e-26 92.06 Pfam 1-202 (293) Show / Hide 
Range on Protein: 502-704
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

VNNFQILNFGSFGMVLSTKKVEFNNKEIVLKIQKIVDEQEIKN-------EIRIMQQLKTPLVVQLYDNYIIEKATAPEKYVVFELEKCSC-----TLQE
    ...  |||| |   ...  ..|. ..|| | ..| . |.       ||.||. |. | .|.||| .        .... . .| | .      | .
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQGKEGEF--SDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLDGNQL--EVKLCDFGLSTQLEKNCEQIEILDWVGNWAYMAPEILTKIED
|...  ..| |  |..|  ... |..  ..|.|  .|||||.||.|.|.  . ...   ||.|||||. |.. .  .    . .|   |||||..     
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----

NQYKIYSKKSDSYSVGLLL
  .. |..|.| .|.|..|
-GGQYYGPKVDMWSCGCIL
Kinase 6997.AA TKL 605-704 23 1.6e-25 88.87 In-house 134-279 (364) Show / Hide 
Range on Protein: 605-704
Range on HMM: 134-279/364
Sequence Identity: 23% (35 aa)

KLNIAIQVIDSVNYIHCFN--------IIHRDIKPDNVLVCLDGN-----------QLEVKLCDFGLSTQLEKNCEQIEILD-----------------W
....|...   .|| |  |        |||||.|..|.||  ...           .  .|.||||||. .... ..  .                    
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

VGNWAYMAPEILT-KIEDNQY---------KIYSKKSDSYSVGLLL
.|. ..||||.|  .......         . ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 6997.AA STE 503-704 21 3.4e-24 82.41 In-house 1-258 (359) Show / Hide 
Range on Protein: 503-704
Range on HMM: 1-258/359
Sequence Identity: 21% (58 aa)

NNF-QILNFGSFGMVLSTKKVE-----FNNKE---------IVLKIQKIVD--------------------EQEIKNEIRIMQQLK--TPLVVQLYDNYI
  . ...  |.|| |   ....      ....         .  |. .. .                    .|.|..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-TLQEYLE---RQGKE--------GEFSDEEKLNIAIQVIDS-VNYIHCFNIIHRDIKPDNVLVCLDGNQLEVKLCD
 |   .    | ... |.  ..  .| . ..     ||.        . |. ..   |. |..    .|.|  .||||||||.|.|.        |||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSTQLEKNCE--------------QIEILDWVGNWAYMAPEILTKIEDNQY-KIYSKKSDSYSVGLLL
||...||....               | .   .||   .||||.... . . . | |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTI
Kinase 6997.AA ULK 511-704 26 2e-17 57.46 In-house 10-246 (329) Show / Hide 
Range on Protein: 511-704
Range on HMM: 10-246/329
Sequence Identity: 26% (64 aa)

GSFGMVLSTKKVEFN---NKEIVLKIQK----IVDEQE---------IKNEIRIMQQLK--------TPLVVQLYDNYIIEKATAPEKYVVFELEKCSC-
|||| |   .... .   |. .. |.      . ...|         .||||.||..||         | .|.||| .     |. .... . .| |   
GSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFE----TSNHNNIYIIMEYCNGG

TLQEYLERQGKEGE-------FSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLDGNQ---------LEVKLCDFGLSTQLEKN-CEQIEILDW
.|..|.....|..|       .| .| ... .| .    ..|  |||||||||.|.|.  .  .           .|..|||.. .....  ||  ..  
DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTC

V------GNWAYMAPEILTKIEDNQ--YKIYS-KKSDSYSVGLLL
|      |   ||||.||     .|   | |. .|.| .|.| ..
VNEKRLCGTPLYMAPQILQ----GQGEQKPYYDYKCDIWSLGCIF
Kinase 6997.AA TyrKc 502-773 19 8.3e-11 -47.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 502-773
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

VNNFQILNFGSFGMVLSTKKVEFNNKEIVL--KIQKIVDEQEIKNEIRIMQQL--KTPLVVQLYDNYIIEKA-----TAPEKYVVFELEKCSCTLQEYLE
.   ..|  | || |   .       . |   ....   .... .|.||| .|  . | .|.||   .. .       ..  ..|.|. .    |..|| 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

RQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLVCLDGNQLEVKLCDFGLSTQLEKN------CEQIEI----LDW-VGNWAYMAPEILT
. ...  .. ...|....|. .  .|.|  |.||||.   |.||  ..    || .|||||  ..         . .          .     |||| . 
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

KIEDNQYKIYSKKSDSYSVGLLL-----------SL-----LDNYLILKENTGSTFIMMTSNQYDEP--FKDINIKRDTEIFKFIQLLVVWERDKRTSLS
     .|.... ||| .| | ..           .      ..|. ...        .   | |  |  |        .|... ..     . ..| . |
-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF----VCCPDEMYQIMKQCWHEDPEDRPTFS

VIVEQNSEKF
 |     |.|
EI----HECF
Kinase 6997.AA Pkinase_Tyr 540-653 29 0.000515 14.22 Pfam 48-158 (270) Show / Hide 
Range on Protein: 540-653
Range on HMM: 48-158/270
Sequence Identity: 29% (34 aa)

QEIKNEIRIMQQL-KTPLVVQLYDNYIIEKATAP-EKYVVFELEKCSCTLQEYLERQ-GKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPDNVLV
..  .|..|| || . | .|.||   .. .   | . |.|.|. ..   | .|| ..   .. .. ...|....|. .  .| .  |.||||.   |.||
EDFMREAKIMKQLGHHPNIVRLY--GVCTDQGEPNQIYIVMEYMPHG-DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLV

CLDGNQLEVKLCDFGLS
     .. || |||||.
TE---NNVVKICDFGLA