Gene 2815 (Tetrahymena)
2815
Sequence
Protein domains of 2815.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 2815.AA | C8 | 130-363 | 58 | 1.1e-119 | 403.9 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 130-363 Range on HMM: 1-226/226 Sequence Identity: 58% (143 aa) FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEME |.||.|||.|||..||||||||.||...|||..|.||. ..|||..||||..|.|.|.||.||.|||||.|....||.|..||| ..|.|||.|||||| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCEQNLKQLFDYLRKTQLP-SKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKICKKFKFLQNLSIQKIIDNQGDLGFASAVTKSK |||||||||.|..|..|.. ||..||||||||..|.|..|.||||||||||||||||..|.|||.||.| |.||||.|.|.| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK SHYLSKK----GTDSYFAPEVEKG------QSRIQSDLFSLGLIL ||..||| ||. |||||.||. |.||||||||.||.| SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 2815.AA | Ciliate-C8 | 139-363 | 54 | 6.2e-117 | 394.77 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 139-363 Range on HMM: 1-238/238 Sequence Identity: 54% (136 aa) GAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEK---SFFVMEMELCEQN- ||...||||.| |.||.|||||..|.|| ...|...||||....|.|..|.|.|||||||||....||.|||.| . |||| ||||||||.|.|| GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC -LKQLFDYLRKTQLP-SKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKICKKFKFLQNLSIQKIIDNQGDLGFASAVTKSKSHYL |||.||..||.|.. |.|.||||||||....|.||..|||||||||||||||..|.|.. ||.|. | . .| .|.||||...|.||||. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH SKK--GTDSY-----------FAPEVEKGQSRIQSDLFS-------LGLIL ||| ||| | |||||||.|||||||.|| .||.| SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 2815.AA | C2 | 139-376 | 37 | 7.2e-62 | 210.12 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 139-376 Range on HMM: 1-245/245 Sequence Identity: 37% (96 aa) GAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEK---------SFFVMEME || .||||| | | || |||| | | ..| ... |||....... . ....||..||| ... | . |. .. .||. .|.|.|.| GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE LCEQNLKQLFDYLRKTQ-LPSKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKIC-KKFKFLQNLSIQKIIDNQGDLGFASAVTKS |. |||| |. .|| . |..|.|.|.||||. . | ||...| |||||| |||. .| ||.| .. |. .|. |||.. .. FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN KS-HYLSK-KGTDSY----FAPEVEKGQSRIQSDLFS-LGLILLELDNLNVLYENW || . || |.| .| |||||... . .||||| .|..|||||| . . KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 2815.AA | CMGC | 130-297 | 16 | 2.5e-23 | 72.7 | In-house | 1-246 (513) | Show / Hide |
Range on Protein: 130-297 Range on HMM: 1-246/513 Sequence Identity: 16% (41 aa) FQNFEYLSSGAYALVLKAKN--------------VKNNRMVALKFLTCTNKDGLKGI---------ESLKKEYELLQKFS---------------QSDF- ... ... .|.|. | |... ..|..||.| . . . . | ..|.... . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEMELCEQNLKQLFDYLRK-------TQLPSKQ------------IKEII-----AIQMLEGLN- .|. ||.|| . . .|..| .. | |. . . .|.....|.|. . .. |. . || .. . |.|.||. IVKLYDIFYHKNSDGNEYEDKHI--I-SQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL -TLHIKN--IMHRDIKPHNFLVCPSQTY----------------GFNIKIC .| .. |.|||.|| | |... .. ...||| KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC |
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Kinase | 2815.AA | Pkinase | 130-284 | 22 | 6.2e-23 | 82.18 | Pfam | 1-141 (293) | Show / Hide |
Range on Protein: 130-284 Range on HMM: 1-141/293 Sequence Identity: 22% (37 aa) FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEM .. . . ||... | |.........||.| . ... | .. .. | ...... .... | ||.|. |. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM ELCEQN--LKQLFDYLR---KTQL--PSKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLV |.|| . ||||.. .. . . ...| .. |.|.||. .| ..|.|||.|| |.|. EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILI |
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Kinase | 2815.AA | Ciliate-E1 | 136-310 | 24 | 5.2e-19 | 58.82 | In-house | 1-169 (202) | Show / Hide |
Range on Protein: 136-310 Range on HMM: 1-169/202 Sequence Identity: 24% (44 aa) LSSGAYALVLKAKNVKNN-RMVALKFLTCTNKDGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFY----LMEQEVEEDKDGNEKSIITQEKSFFVMEME ...| ...|.|||. .|| . ||.|. | .. .....||| ... | . . .....|... ... .. | . . | .... IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH--------- LCEQNLKQLFDYLRKTQLPSKQI-KEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFN-IKICKKFKFLQNLSIQK . | .... ....| .. |. |..|...||. ||..||.||||||.| |.. . | .. . |.|..| || ..|. ---NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY |
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Kinase | 2815.AA | CAMK | 135-297 | 13 | 1.6e-18 | 55.59 | In-house | 1-238 (425) | Show / Hide |
Range on Protein: 135-297 Range on HMM: 1-238/425 Sequence Identity: 13% (34 aa) YLSSGAYALVLKAKNVKNN------------RMVALKFLTCTNKDG-------------------------LKGIESLKKEYELLQKFS------QSDFL | .|... | .... ... . || |.. . .. | .....|.|...| . . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNVYDCFY------------LMEQEVEEDKDGNEKSIITQEKSFFVMEM---ELCEQN--LKQLFDYLRKT----------------QLPSKQIKEIIAI .. |. . .. .. .....| | |.|. . ||||... .. .. . .. IKLYEVYEDPHYFKNTNDYET-SKQ-----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR- QMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYG-------------FNIKIC |...... .| .||.|||.|| | |.. . . .||||. QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII |
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Kinase | 2815.AA | S_TKc | 130-429 | 19 | 4e-16 | 59.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 130-429 Range on HMM: 1-231/231 Sequence Identity: 19% (63 aa) FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEME .. . . .||.. | |....| .| ||.| . |....| ..|.| . ...|. ||.|. ... | || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME LCEQNLKQLFDYLRKTQ-------LPSKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKIC-----KKFKFLQNLSIQKIIDNQGD .|...| ||||..| . .| ... ... |....|. .| ..|.|||.|| | |.. .|||| ... YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------------- LGFASAVTKSKSHYLSKKGTDSYFAPEVEKGQSRIQSDLFSLGLILLELDNLNVLYENWIDFDIKGEIYQGKGIASKYQIDRNSNIYKIAEICLKPKYLE . || | |||| | .. .| |.| || |. ... .... | . . . ||. . --------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEK RTTSGNLLS--------ELI | | .| . . RPTA-EALQDEWDIKCHPWF |
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Kinase | 2815.AA | STE | 130-297 | 18 | 1.3e-15 | 51.75 | In-house | 1-189 (359) | Show / Hide |
Range on Protein: 130-297 Range on HMM: 1-189/359 Sequence Identity: 18% (39 aa) FQNFEYLSSGAYALVLKAKNVK---------------NNRMVALKFLTCTNKDG--------------LKGIESLKKEYELLQKFSQ-SDFLVNVYDCFY ... | . .||. | ||.|.| .....| | . |.. . .....|| ....|... ... |. |.|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF LMEQEVEEDKDGNEKSIITQEKSFFVMEMELCE-QNLKQLFDYLRKTQLPSK-----------QIKEIIAIQMLEG-LNTLHIKNIMHRDIKPHNFLVCP . ..... . ||... | .. . ... | . .. .|. | |.| |. || ..|.|||||| | |. KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-- SQTYGFNIKIC .|.| -------VKLC |
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Kinase | 2815.AA | Ciliate-E2 | 228-460 | 15 | 2.2e-11 | 35.34 | In-house | 113-344 (365) | Show / Hide |
Range on Protein: 228-460 Range on HMM: 113-344/365 Sequence Identity: 15% (50 aa) MELCEQNLKQLFDYLRKTQLPSKQI---------KEI--IAIQMLE---------------GLNTLHIKN-IMHRDIKPHNFLVCPSQTYGFNIKICKKF ||.|.. . ||||... .. .... ||| | | |. .|. || || |.|||||| | |. MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------------- KFLQNLSIQKIIDNQGDLGFASAVTKS---------KSHYLSKK-----------------------GTDSYFAPEVEKGQSR----------IQSDLFS ||| |.|.. .... |. | || | |||. .|.. ..|..| --------IKII----DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS LGLILLELDNLNVLYENWIDFDIKGEIYQGKGIASKYQIDRNSNIYKIAEICLKPKYLERTTSGNLLSELIKLHGEPLKFTLASMI-----------LEE || || |. . . ... . ...| . .. . LGVILYEMLFGKPPF------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWK QIPQQAQQIFNR----I ...|........ . KWSQECKDLIKKFGKRM |
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Kinase | 2815.AA | TKL | 256-297 | 28 | 3.6e-08 | 25.53 | In-house | 137-196 (364) | Show / Hide |
Range on Protein: 256-297 Range on HMM: 137-196/364 Sequence Identity: 28% (17 aa) IAIQMLEGLNTLHI--------KNIMHRDIKPHNFLVCPSQT----------YGFNIKIC .|... |.| || ..| |||.|..| || | . ..||| WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC |
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Kinase | 2815.AA | STE20 | 130-203 | 18 | 1.6e-07 | 23.91 | In-house | 1-82 (288) | Show / Hide |
Range on Protein: 130-203 Range on HMM: 1-82/288 Sequence Identity: 18% (15 aa) FQNFEYLSSGAYALVLKAKNVKNNRM----VALKFLTCTNKDGL-KGIESLKKEYELLQKFSQSDFLVNVYDCFYLM----EQ ....| . .|.| | || ...... || | . ..| . .|...||. .... . |. |.... . .. YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDE |
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Kinase | 2815.AA | Ciliate-E2 | 130-199 | 13 | 1e-06 | 18.56 | In-house | 1-102 (365) | Show / Hide |
Range on Protein: 130-199 Range on HMM: 1-102/365 Sequence Identity: 13% (14 aa) FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTN----------------KDGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD . . . .|... | |.|. |.....|.|. . .. . . ..||..|.| ... .. ....... |. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE CFY ||. CFQ |
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Kinase | 2815.AA | TKL | 316-366 | 16 | 0.00023 | 11.64 | In-house | 196-282 (364) | Show / Hide |
Range on Protein: 316-366 Range on HMM: 196-282/364 Sequence Identity: 16% (14 aa) GDLGFASAVTKSKS-------------------HYLSKKGTDSYFAPEV-----------------EKGQSRIQSDLFSLGLILLEL .|.|.. ...|.. . .. || . |||| .... ..| .| |..| |. CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI |
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Kinase | 2815.AA | STE20 | 259-281 | 52 | 0.00097 | 9.89 | In-house | 125-147 (288) | Show / Hide |
Range on Protein: 259-281 Range on HMM: 125-147/288 Sequence Identity: 52% (12 aa) QMLEGLNTLHIKNIMHRDIKPHN ..|.||. || ..|.||||| | EVLQGLDYLHSNHIIHRDIKADN |
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Kinase | 2815.AA | STE | 317-366 | 20 | 0.011317 | 5.41 | In-house | 190-261 (359) | Show / Hide |
Range on Protein: 317-366 Range on HMM: 190-261/359 Sequence Identity: 20% (15 aa) DLGFASAVTKS----------------KSHYLSKKGTDSYFAPEVEKG-QSR------IQSDLFSLGLILLEL | |... .|.| ... . || . |||| .. .. ...| |||. ..|. DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM |
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Kinase | 2815.AA | Pkinase | 316-366 | 31 | 0.072026 | 7.69 | Pfam | 154-205 (293) | Show / Hide |
Range on Protein: 316-366 Range on HMM: 154-205/293 Sequence Identity: 31% (17 aa) GDLGFASAV-TKSKSHYLSKKGTDSYFAPEV--EKGQSRIQSDLFSLGLILLEL .| |.| . . ..| . . || | |||| . .| .|.|.|| |. CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM |
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Kinase | 2815.AA | TKL | 136-195 | 14 | 0.170714 | 1.16 | In-house | 1-91 (364) | Show / Hide |
Range on Protein: 136-195 Range on HMM: 1-91/364 Sequence Identity: 14% (13 aa) LSSGAYALVLKAKNVKNN--------RMVALKFLTCTNKDGLKGIES----------------------LKKEYELLQKFSQ-SDFLVNVY . ||... | |.| .. . || | . .| | .. ..|.|.... . . .| . IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM |
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Kinase | 2815.AA | C8 | 515-713 | 50 | 3.9e-103 | 348.94 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 515-713 Range on HMM: 1-226/226 Sequence Identity: 50% (113 aa) VNNFQILNFGSFGMVLSTKKVD--KEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKATAPEKYVVFELEKCS-----------CSLQE-- .||||.|.||..||||..|.|. .|||||.||....|.|||...||.....|.|.|.||.||.|.....|.|.|||.|||| |...| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME ---------YLESQGKEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCDFGLSAQLEKNCEQIEILEM--VGNWAYMAP |.| . |...||.|.|..||||.||.||||||.||.||||||.|||||||.|.. ||||||||...|..||...|.. .| .|.|||.|| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP EILTKEDHQNKIYSKKSDSYSVGLLL ||..|.|.|.|.|...||..||||.| EIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 2815.AA | Ciliate-C8 | 524-713 | 42 | 2.5e-98 | 332.96 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 524-713 Range on HMM: 1-238/238 Sequence Identity: 42% (101 aa) GSFGMVLST------KKVD---KEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKATAPEK-----------------YVVFELEKCS--C |.|||||.. .|| .|.|.||||...|.||.....|||....|.|||.||..........|. ..|.|.|||. | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC SLQEYLES-QGKEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLD-GNQLEIKLCD------FGLSAQLEKNCE---------QIEILEM .|..|.. . |....|...|..||||.||||||.|||||.||||||.|||||.| ..|..||||| ||...||.||.. .....|| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --VGNWAYMAPEILTK-EDHQNKIYSKKSDSYSVGLLL .|||.|.|||...| ...|..|.|||||||||||.| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 2815.AA | C2 | 524-726 | 29 | 1.5e-49 | 167.46 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 524-726 Range on HMM: 1-245/245 Sequence Identity: 29% (75 aa) GSFGMVLST--KKVDKEIVLKIQKIVD-----EQEIQNEIRIMQQLK-TPLVVQLYD-NYVIEKATAP------------EK----------YVVFELEK |.||.|| . || ....||||.. . ..|.|.|..||.|.. |.....|. |. .. |. ||.|.|. GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CSCSLQEYLESQGKEG-EFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCD----------FGLSAQLEKNCEQIEILEMVG |.. |. |.. . |. ......| .|||..||.||.|.|.|.||||||.|||. .| ... ||||| | . |..| ..| . .... CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW NWAY----MAPEILTKEDHQNKIYSKKSDSYS-VGLLLSLLDNYFILKENT .| .|||. . .|| |.|| .| ||. | ||| .. . TQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 2815.AA | CAMK | 520-713 | 20 | 9.4e-34 | 105.6 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 520-713 Range on HMM: 1-324/425 Sequence Identity: 20% (65 aa) ILNFGSFGMVLSTKKV-D-------------KEIVLKI---QKIV----------------------------DEQEIQNEIRIMQQ-------LKTPLV .| |||| | . . .. || .|. |......||.||.. |. | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQLYDNYVIEKA--------TAP------EKYVVFEL---EKCSC-----SLQEYLESQGK------------EGEFSNEEKLNIAIQIIDSVNYIHCFN ..||. | .. | .|.... . | || | .|. ..|. .| |. .| . ||.. |.|.| | IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IIHRDIKPDNFLVCLDG--------------NQLEIKLCDFGLSAQLEKNCEQI---------------------EILEMVGNWAYMA-PEILTKEDHQN |.|||.||.| |.. .. |. ||..|||........ .. ...| .||| ||.| .. |.| IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN KI---------YSKKSDSYSVGLLL . |..|.| |.| .| MQNATDEEKPYYGPKCDMWSCGVIL |
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Kinase | 2815.AA | S_TKc | 518-783 | 24 | 5e-29 | 103.68 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 518-783 Range on HMM: 1-231/231 Sequence Identity: 24% (68 aa) FQILNF---GSFGMVLSTKKVD--KEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKATAPEKYVVFELEKCSC---SLQEYLESQGKEGE ..||. |.|| | .... .. .|| | . |..||.|... . | .|.||| .. ... . .| |. .| .|....|..| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---FSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEKNCEQIEILEMVGNWAYMAPEILTKEDHQNKIYSK-KSD |. . .. ||.. ..|.| .|||||.||.| |.. .||.|||||..|| ..| |||||.| |.| |.| RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCD SYSVG-LLLSLLDNYFILKENTGSTFMMMTLNQYDESFKQINIKRNTEIFKFIQLLVVWERVNRASLSIIVE----QNSKKFK .|.| .| .| | . .| .. | ||. . ... .| . . . .. . WWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 2815.AA | Pkinase | 515-713 | 27 | 6e-28 | 99.9 | Pfam | 1-202 (293) | Show / Hide |
Range on Protein: 515-713 Range on HMM: 1-202/293 Sequence Identity: 27% (59 aa) VNNFQILNFGSFGMVLSTKKVDKE--IVLKIQKIVDEQEIQN-------EIRIMQQLKTPLVVQLYDNYVIEKATAPEKYVVFELEKCSC-----SLQEY ... |||| | .... . ..|| | ..| . .. ||.||. |. | .|.||| . .... . .| | . .| .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY LESQGKEGEF--SNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL--EIKLCDFGLSAQLEKNCEQIEILEMVGNWAYMAPEILTKEDHQ .. ..| | | .| ... ||. ..|.| .|||||.||.|.|. . ... .|.|||||..|.. . . .| |||||. .. IST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV-----IR -NKIYSKKSDSYSVGLLL .. |..|.| .|.|..| GGQYYGPKVDMWSCGCIL |
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Kinase | 2815.AA | Ciliate-E1 | 521-707 | 24 | 6.9e-27 | 84.73 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 521-707 Range on HMM: 1-202/202 Sequence Identity: 24% (53 aa) LNFGSFGMVLST-------KKVDKEIVLKIQKIV---DEQEIQNEIRIMQQLKTPL-VVQLYDNYVIEKATAPEKYVVFELEKCSCSLQEYLE------- . |||..|. ..| . |.. ..... ...||.... ||. .|. ..|..| . |... . .. .|.|.|||..||. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY ---SQGKEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSA--QLEKNCEQ---IEILEMVGNWAYMAPEILTKED | ....|. ..|..|..|.|| ....| .|||||||||.| |.. . ... . |||.| ....| .. .. . .. |. | . | WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP--EQ-EH HQNKIYSKKSDSY .|.....||| | NKNQKINYKSDIY |
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Kinase | 2815.AA | TKL | 596-713 | 24 | 6.9e-26 | 90.21 | In-house | 124-279 (364) | Show / Hide |
Range on Protein: 596-713 Range on HMM: 124-279/364 Sequence Identity: 24% (40 aa) SLQEYLESQGKEGEFSNEEKLNIAIQIIDSVNYIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLEIKLCDFGLSAQLEKNCEQIEIL || .|| . ....|..| .|| | | |||||.|..| || ... . .|.|||||| .... .. . SLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM EM-----------------VGNWAYMAPEILTKEDHQNK-----------IYSKKSDSYSVGLLL . .|. ..||||.| ... .. ||.|.| || |..| TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL |
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Kinase | 2815.AA | STE | 516-713 | 21 | 1.2e-25 | 87.56 | In-house | 1-258 (359) | Show / Hide |
Range on Protein: 516-713 Range on HMM: 1-258/359 Sequence Identity: 21% (58 aa) NNF-QILNFGSFG-MVLSTKK----------------VDKEIVLKIQKIVD--------------------EQEIQNEIRIMQQLK--TPLVVQLYDNYV . ... |.|| .. .. . . |. .. . .|.|..||.||.... | .|. |. |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF IE---KATAPEKYVVFELEKCSC-SLQEYLE---SQGKEGEFSN-------EEKL-NIAIQIIDS-VNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCD | . | ... |. .. || . .. . ||. ... |. . |. ||. .|.| .||||||||.| |. .|||| KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD FGLSAQLEKNCE--------------QIEILEMVGNWAYMAPEILTKEDHQ-NKIYSKKSDSYSVGLLL ||...||.... | . .|| .||||....... .| |. |.| .|.|... FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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Kinase | 2815.AA | CMGC | 515-663 | 15 | 1.4e-25 | 80.27 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 515-663 Range on HMM: 1-251/513 Sequence Identity: 15% (40 aa) VNNFQILNFGSFGMVLSTKKVD----------------KEIVLKIQKIVDEQEIQ---------------NEIRIMQQLK-----------------TPL . . . |..|.| . . . ... .|. | . |.| ||.|...|. . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVQLYDNYVIEKATAPEK-----------YVVFELEKCSCSLQEYLESQG--KEG----EFSNEE------------KLNIA------IQIIDSVN--YI .|.||| .. .. . .|. .. . | . ..| .|.... . | ..| . . .. ||. ... |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LEIKLCDFGLS | . |||||.|| | |.. .. ..|.|||||. HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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Kinase | 2815.AA | Ciliate-E2 | 515-713 | 21 | 2.5e-24 | 80.43 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 515-713 Range on HMM: 1-286/365 Sequence Identity: 21% (65 aa) VNNFQILNFGSFG-----MVLSTKK-------------------VD-KEIVLKIQKIVDEQEIQNEIRIMQ----------------QLKTPLVVQLYDN . ... .|.|| | ...| |. |.. .||.| . ..| .||.||. ||. | ....|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YVIEKATAPEKYVVFELEKCSC-SLQEYLESQGKE--------GEFSNEEKLNIAIQIID---------------SVNYIHCFN-IIHRDIKPDNFLVCL . .. .... . .| |. .|..|.... | . |. .| ..| ||.. ..|.| | ||||||||.| |. FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-- DGNQLEIKLCDFGLSAQL-EKNCEQIEILEM-----------------------------VGNWAYMAPEILTKED----HQNKIYSKKSDSYSVGLLL ||..||||| .. ..|..... . . .|. ||||||| ... . | |..|.| .|.| .| ------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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Kinase | 2815.AA | STE20 | 627-710 | 40 | 1.2e-16 | 57.57 | In-house | 131-214 (288) | Show / Hide |
Range on Protein: 627-710 Range on HMM: 131-214/288 Sequence Identity: 40% (36 aa) NYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEK--NCEQIEI---LEMVGNWAYMAPEILTKEDHQNKIYSKKSDSYSVG .|.| .||||||| || |. || |.||.|||..|||.| . . .|| .||||.. ... | | |.| .|.| DYLHSNHIIHRDIKADNILLTEDG---EVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLG |
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Kinase | 2815.AA | TyrKc | 515-778 | 19 | 5e-11 | -44.33 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 515-778 Range on HMM: 1-280/280 Sequence Identity: 19% (60 aa) VNNFQILNFGSFGMVLSTKKVDKEIVL--KIQKIVDEQEIQNEIRIMQQL--KTPLVVQLYDNYVIEKA-----TAPEKYVVFELEKCSCSLQEYLESQG . ..| | || | . . | .... .... .|.||| .| . | .|.|| |. . .. ..|.|. . .|..|| . . ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHR KEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEKN------CEQIEI-----LEMVGNWAYMAPEILTKED .. ......|....|| . .|.| |.||||. | || .. .| .||||| .. . . .. |||| . PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---- HQNKIYSKKSDSYSVGLLL-----------SL-----LDNYFILKENTGSTFMMMTLNQYDE-SFKQINIKRNTEIFKFIQLLVVWERVNRASLSIIVEQ . .... ||| .| | .. . ..|. ... |. | | . || .|... .. . .| . | |.|. -NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC N F |
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Kinase | 2815.AA | STE20 | 548-577 | 40 | 0.000136 | 13.05 | In-house | 47-76 (288) | Show / Hide |
Range on Protein: 548-577 Range on HMM: 47-76/288 Sequence Identity: 40% (12 aa) DEQEIQNEIRIMQQLKTPLVVQLYDNYVIE ....||.||.||.|.| | .|. |. |. . EWEDIQKEISIMKQCKHPNIVKYYGSYLKD |