Gene 23995 (Tetrahymena)

23995

Species: Tetrahymena
Alias: 23995, 1141, TTHERM_01153610, n.23995, 257.m00020, PreTt23995
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
23995.AA Protein None 886 None Fasta, JSON
23995.kin_dom Protein Kinase Domain None 182 None Fasta, JSON
23995.kin_dom2 Protein Kinase Domain None 221 None Fasta, JSON
23995.NA RNA None 4014 None Fasta, JSON

Protein domain

Protein domains of 23995.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23995.AA C8 127-349 44 6.7e-84 285.04 In-house 1-226 (226) Show / Hide 
Range on Protein: 127-349
Range on HMM: 1-226/226
Sequence Identity: 44% (103 aa)

LQNFEYLSSGAYALVLKAKNINKNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQDVEEDKDGNEKIIVTEEKSFFVMEME
..||.|||.|||..||||||...||...|||..|..|.  ..|||..||||..|.|.|.||.||.|||||.|....||.|..||||..|||||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQRHNYPLKKQRKQQLF-KCQKDQIPFISKISCTETSNLTISQFVLLKLMDLPQKSVKKFNFYNIYNQKNIDNQGDLGFASAVTKSKSYYLSKN----
||||...   ...|..|.  . .. .|  |  | . .. .... ..  .|....  .  .. .|             |.||||.|.|.|| ..||.    
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC--------DFGFASQVSKNKSHIQSKKMNTC

GTDTYFAPEVEKG------QSRIQSDLFSLGLVL
||..|||||.||.      |.||||||||.||||
GTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 23995.AA Ciliate-C8 136-349 40 2e-75 256.92 In-house 1-238 (238) Show / Hide 
Range on Protein: 136-349
Range on HMM: 1-238/238
Sequence Identity: 40% (98 aa)

GAYALVLKAKNINKNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQDVEEDKDGNEKIIVTEEK---SFFVMEMELCEQR-
||...||||.|...||.|||||..|..|.  ...|...||||....|.|..|.|.|||||||||....||.|||.||..|.||   ||||||||.|.|. 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-HNYPLKKQRKQQ-LFKCQKDQIPFISKISCTETSNLTISQFVLLKLMDLPQKSVKKFNFYNIYNQKNIDNQGDLGFASAVTKSKSYYLSKN--GTDTY-
 ..  ....||.|  .. |.  |  |  | .  . .     .   |....     .. ..           |.|.||||...|.||.|.||.  |||.| 
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-FK-KQCDFGFASQLPKNKSHYHSKKFKGTDQYI

----------FAPEVEKGQSRIQSDLFS-------LGLVL
          |||||||.|||||||.||       .||||
EMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23995.AA C2 136-252 28 1.5e-24 80.89 In-house 1-127 (245) Show / Hide 
Range on Protein: 136-252
Range on HMM: 1-127/245
Sequence Identity: 28% (37 aa)

GAYALVLKAKNINKNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQDVEEDKDGNEKIIVTEEK---------SFFVMEME
|| .||||| | ..|| ||||   | | . ..| ... |||....... . ....||..||| ... | .   |. .....|.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQRHNYPLKKQRKQQ--LFKCQKDQI
 |.      ....|||.  . . .| ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIM
Kinase 23995.AA C2 290-362 33 1.7e-12 39.08 In-house 168-245 (245) Show / Hide 
Range on Protein: 290-362
Range on HMM: 168-245/245
Sequence Identity: 33% (27 aa)

YNIYNQKNIDNQGDLGFASAVTKSKSYYLSKN--GTDTY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLNVLNENW
.. . |  .  ..|. |||.. ..||.   ..  .| .|    |||||...  . .||||| .|.||||||| .  . . 
CDYHIQY-QK-KCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 23995.AA Ciliate-E1 133-197 23 3.1e-08 23.4 In-house 1-66 (202) Show / Hide 
Range on Protein: 133-197
Range on HMM: 1-66/202
Sequence Identity: 23% (16 aa)

LSSGAYALVLKAKNINKN-RMVALKFLTCTSKEGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFYL
...| ...|.|||..| | . ||.|.  |  ..    .....|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 23995.AA CMGC 127-196 13 2.3e-07 19.26 In-house 1-108 (513) Show / Hide 
Range on Protein: 127-196
Range on HMM: 1-108/513
Sequence Identity: 13% (15 aa)

LQNFEYLSSGAYALVLKAKN--------------INKNRMVALKFLTCTSKEGLKGI---------ESLKKEYELLQKFS---------------QSDF-
 .. ... .|.|. | |...              .. |..||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFY
.|. ||.||
IVKLYDIFY
Kinase 23995.AA CAMK 132-229 10 8.4e-07 17.18 In-house 1-143 (425) Show / Hide 
Range on Protein: 132-229
Range on HMM: 1-143/425
Sequence Identity: 10% (16 aa)

YLSSGAYALVLKAKNINKN------------RMVALKFLTCTSKEG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | .....| .            . || |..  .   .                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEQDVEEDKDGNEKIIVTEEKSFFVMEM---ELCE
.. |. .               ...          .. . .....| |   |.|.
IKLYEVYEDPHYFKNTNDYET-SKQ----------VF-TKDKHMYMVMEIMEYCS
Kinase 23995.AA Pkinase 127-196 18 3e-06 22.97 Pfam 1-70 (293) Show / Hide 
Range on Protein: 127-196
Range on HMM: 1-70/293
Sequence Identity: 18% (13 aa)

LQNFEYLSSGAYALVLKAKNINKNRMVALKFLTCTSKEGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFY
..  . . ||... | |..... ...||.| .   ...  | .. ..  | ...... .... |  ||.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFE
Kinase 23995.AA STE 127-196 16 4e-06 17.77 In-house 1-100 (359) Show / Hide 
Range on Protein: 127-196
Range on HMM: 1-100/359
Sequence Identity: 16% (17 aa)

LQNFEYLSSGAYALVLKAKNIN---------------KNRMVALKFLT---CTSKEGL------------KGIESLKKEYELLQKFSQ-SDFLVNVYDCF
... | . .||.  | ||.|..               .....| | .    |..|.              . .....|| ....|... ... |. |.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

Y
.
F
Kinase 23995.AA Ciliate-E2-Unclassified 303-352 21 4.9e-05 13.44 In-house 190-263 (352) Show / Hide 
Range on Protein: 303-352
Range on HMM: 190-263/352
Sequence Identity: 21% (16 aa)

DLGFASAVTKS---------------KSYYLSKNGTDTYF----APEVEKG-QSR----IQSDLFSLGLVLLEL
|.|...   ..               .  . .. ||  |     |||| .| .      ...| .||| .| |.
DFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase 23995.AA Ciliate-E2 303-352 20 0.000203 11.06 In-house 199-289 (365) Show / Hide 
Range on Protein: 303-352
Range on HMM: 199-289/365
Sequence Identity: 20% (19 aa)

DLGFASAVTKS----------KSYYLSKN----------------------GTDTYFAPEVEKGQSR----------IQSDLFSLGLVLLEL
|.|..  ....          | |   ||                      ||  | |||. .|..            ..|..||| .| |.
DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 23995.AA Ciliate-E2 127-196 12 0.000261 10.68 In-house 1-102 (365) Show / Hide 
Range on Protein: 127-196
Range on HMM: 1-102/365
Sequence Identity: 12% (13 aa)

LQNFEYLSSGAYALVLKAKNINKNRMVALKFLTCTS----------------KEGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD
    . . .|... | |.|........|.|. . .                 .. .  ..||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFY
||.
CFQ
Kinase 23995.AA TKL 302-352 17 0.001603 8.56 In-house 196-282 (364) Show / Hide 
Range on Protein: 302-352
Range on HMM: 196-282/364
Sequence Identity: 17% (15 aa)

GDLGFASAVTKSKSYYLS-------------------KNGTDTYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL
.|.|..  ...|..   .                   . ||  . ||||                 ....   ..| .| |.|| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 23995.AA STE 322-352 28 0.073169 2.51 In-house 225-261 (359) Show / Hide 
Range on Protein: 322-352
Range on HMM: 225-261/359
Sequence Identity: 28% (11 aa)

GTDTYFAPEVEKG-QSR------IQSDLFSLGLVLLEL
||  . |||| .. ..       ...|  |||....|.
GTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 23995.AA Pkinase 302-352 29 0.099746 7.19 Pfam 154-205 (293) Show / Hide 
Range on Protein: 302-352
Range on HMM: 154-205/293
Sequence Identity: 29% (16 aa)

GDLGFASAV-TKSKSYYLSKNGTDTYFAPEV--EKGQSRIQSDLFSLGLVLLEL
.| |.|  . . ..| . .  ||  | ||||  .       .| .|.|..| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 23995.AA C8 517-736 46 1.2e-100 340.7 In-house 1-226 (226) Show / Hide 
Range on Protein: 517-736
Range on HMM: 1-226/226
Sequence Identity: 46% (113 aa)

VNNFQILNFGNFGMVLSTKKVEFNNKEIVLKIQKIVDEQQIQNEIRIMQQLKAPLVVQLYDNYIIEKATAPEKYVVFELEKCS-----------CSLQE-
.||||.|.||..||||..|.|. .|.|||||.||....|.|||...||.... |.|.|.||.|..|.....|.|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLEIQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPENFLVCLDGNEL-EVKLCDFGLSTQLEKNCEQIEILDVNNLVSIQLSR
          |.| . |...||.|.|..||||.||.||||||.||.||||||.|||||||.|.. |.||||||...|..||...|.. ..|.        
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT--------

NLNISQMVGNWAYMAPEILTKNKDDQYKIYSKKSDSYSVGLLL
       .|.|||.||||..| .|.|||.|...||..||||.|
-------CGTWAYFAPEIEKK-QDNQYKQYRIQSDLFSVGLVL
Kinase 23995.AA Ciliate-C8 526-736 37 3.3e-97 329.26 In-house 1-238 (238) Show / Hide 
Range on Protein: 526-736
Range on HMM: 1-238/238
Sequence Identity: 37% (96 aa)

GNFGMVLST------KKVEFNNKEIVLKIQKIVDEQQIQNEIRIMQQLKAPLVVQLYDNYIIEKATAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.....|.|.||||...|..|.....|||... |.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQEYLEI-QGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPENFLVCLD-GNELEVKLCD------FGLSTQLEKNCE---------QIEILDV
.|..|..  . |....|...|..||||.||||||.|||||.||||||.|||||.| .. ...||||      ||...||.||..         .......
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

NNLVSIQLSRNLNISQMVGNWAYMAPEILTKNKDDQYKIYSKKSDSYSVGLLL
.                .|||.|.|||...| ...|..|.|||||||||||.|
YF---------------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23995.AA C2 526-749 27 9.5e-41 136.97 In-house 1-245 (245) Show / Hide 
Range on Protein: 526-749
Range on HMM: 1-245/245
Sequence Identity: 27% (72 aa)

GNFGMVLSTKKVEFNNKEIVLKIQKIVD-----EQQIQNEIRIMQQLK-APLVVQLYD-------NYII------EKATAPEK----------YVVFELE
| ||.|| .   .  |....||||.. .     ....|.|..||.|..  |.....|.       . ..      |.    |.           ||.|.|
GAFGLVLKAFNKK-QNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLQEYLEIQGKEG-EFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPENFLVCLDGNEL-EVKLCDFGLSTQLEKNCEQIEILDVNNLVSIQLSRN
.|.. |. |.. . |.  ......|  .|||..||.||.|.|.|.||||||.|||. .| ...  .||||. .  |  |        |.     .... .
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQK-K-------CDFDFASKLKYNKS

-LNISQMVGNWAY----MAPEILTKNKDDQYKIYSKKSDSYS-VGLLLCLLDNYLNLKENT
 ...|....  .|    .|||.       . .|| |.|| .| ||. |  |||      . 
RIHFSKFKWTQQYYQHIFAPEV-------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 23995.AA CAMK 522-736 18 2.9e-34 107.3 In-house 1-324 (425) Show / Hide 
Range on Protein: 522-736
Range on HMM: 1-324/425
Sequence Identity: 18% (61 aa)

ILNFGNFGMVLSTKKVEFNN-----------KEIVLKI---QKIV----------------------------DEQQIQNEIRIMQQ-------LKAPLV
.|  |.|| |   .  . ..           ..   ||   .|.                             |......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYIIEKA--------TAP------EKYVVFEL---EKCSC-----SLQEYLEIQGK------------EGEFSDEEKLNIAIQVIDSVNYIHCFN
..||. |  ..         |        .|.... .   | ||       | .|.  .|.            .| |. .|   .  |... |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVCLDGNE--------------LEVKLCDFGLSTQLEKNCEQIEILDVNNLVSIQLS------RNLNISQMVGNWAYMA-PEILTKNKD
|.|||.|||| |.. ....                .|..|||........ ..  . |...   .  .       .   . ..|  .||| ||.| ... 
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

DQY--------KIYSKKSDSYSVGLLL
...        . |..|.|  |.| .|
CNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 23995.AA S_TKc 520-808 22 1.3e-27 98.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 520-808
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

FQILNF---GNFGMVLSTKKVEFNNKEIVLKIQKIVDEQQIQNEIRIMQQLKAPLVVQLYDNYIIEKATAPEKYVVFELEKCSC---SLQEYLEIQGKEG
..||.    | || |   ....  ...  .|| |    ..|..||.|... . | .|.||| .         ... . .| |.    .| .|.. .|..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPENFLVCLDGNELEVKLCDFGLSTQLEKNCEQIEILDVNNLVSIQLSRNLNISQMVGNWAYMAPE
    |.  .   .. |... ..|.|  .|||||.|||| |..      ..|.|||||..||                          . ..|   |||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------------------TTFCGTPWYMAPE

ILTKNKDDQYKIYSK-KSDSYSVG-LLLCLLDNYLNLKENTGSTFMNMTLNQYEEPFKKQKINIKQDTEIFKFIKLLVVWERVKRASLSIIVE----QNS
.|          |.| |.| .|.| .|  .|  |     .   .| ..                  . |   ||. . ...  || .   . .     ..
VL---------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

KKFK
  . 
HPWF
Kinase 23995.AA Ciliate-E2 517-736 23 7.3e-26 85.75 In-house 1-286 (365) Show / Hide 
Range on Protein: 517-736
Range on HMM: 1-286/365
Sequence Identity: 23% (70 aa)

VNNFQILNFGNFG-----MVLSTKKVE-----------------FNNKEIVLKIQKIVDEQQIQNEIRIMQ----------------QLKAPLVVQLYDN
 .  ... .||||      | ...| .                 ...|.. .||.|  . .|| .||.||.                ||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YIIEKATAPEKYVVFELEKCSC-SLQEYLEIQGKE--------GEFSDEEKLNIAIQVID---------------SVNYIHCFN-IIHRDIKPENFLVCL
.. ..    .... . .| |.  .|..|.... |         . |...| ..|  |...                ..|.|  | |||||||||| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNELEVKLCDFGLSTQL-EKNCEQI------EILDVNNLVSIQLSRNLNISQ---------MVGNWAYMAPEILTKNKDD---QYKIYSKKSDSYSVGL
      .|..|||||... ..|....      .... .|  |.. . .    |          .|.  ||||||| . |.|   . | |..|.| .|.| 
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD---QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LL
.|
IL
Kinase 23995.AA Ciliate-E1 523-674 27 5.1e-25 78.6 In-house 1-162 (202) Show / Hide 
Range on Protein: 523-674
Range on HMM: 1-162/202
Sequence Identity: 27% (47 aa)

LNFGNFGMVLSTKKVEFNNKEIVLKIQKIVDEQ-------QIQNEIRIMQQLKAPL-VVQLYDNYIIEKATAPEKYVVFELEKCSCSLQEYLE-------
.  | |..|.  |. . |.... .||... . .       .|.... ||. .|    ..|..| ..|...    .  .. .|.|.|||..||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---IQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPENFLVCLDGNELEVKLCDFGLSTQLEKN
   .| ....|....|..|..| || ....| .|||||||||.| |.. . ...  ..||||.| .| .|
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNY--VYCDFGISKFLKNN
Kinase 23995.AA Pkinase 545-736 25 1.5e-24 87.86 Pfam 31-202 (293) Show / Hide 
Range on Protein: 545-736
Range on HMM: 31-202/293
Sequence Identity: 25% (53 aa)

VLKIQKIVDEQQIQN----EIRIMQQLKAPLVVQLYDNYIIEKATAPEKYVVFELEKCSC-----SLQEYLEIQGKEGEF--SDEEKLNIAIQVIDSVNY
..| ... .......    ||.||. |. | .|.||| .        .... . .| | .     .| .|..   ..| |  |..|  ... |..  ..|
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEY

IHCFNIIHRDIKPENFLVCLDGNEL--EVKLCDFGLSTQLEKNCEQIEILDVNNLVSIQLSRNLNISQMVGNWAYMAPEILTKNKDDQYKIYSKKSDSYS
.|  .|||||.||||.|.  . ...   ||.|||||. |..                  . .|   .  .|   |||||..       .. |..|.| .|
CHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------------------Y-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWS

VGLLL
.|..|
CGCIL
Kinase 23995.AA CMGC 517-674 15 1.6e-24 76.69 In-house 1-257 (513) Show / Hide 
Range on Protein: 517-674
Range on HMM: 1-257/513
Sequence Identity: 15% (40 aa)

VNNFQILNFGNFGMVLSTKKVE-------------FNNKEIVLKIQKIVDEQQIQ---------------NEIRIMQQLK-----------------APL
  . . .  | .|.| . .  .              .|... .|. | .   ..|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYIIEKATAPEK-----------YVVFELEKCSCSLQEYLEIQG--KEG----EFSDEE------------KLNIA------IQVIDSVN--YI
.|.||| .  .. . .|.           .. .  | . ..| .|.. .   . |    ..|. .            . ..        |.. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPENFLVCLDGNE-----------------LEVKLCDFGLSTQLEKN
|  .  |||||.|||| |.. ..                    ..|.|||||.......
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 23995.AA STE 518-737 21 1.5e-23 80.13 In-house 1-259 (359) Show / Hide 
Range on Protein: 518-737
Range on HMM: 1-259/359
Sequence Identity: 21% (62 aa)

NNF-QILNFGNFGMVLSTKKVE-----FNNKE---------IVLKIQKIVD--------------------EQQIQNEIRIMQQLK--APLVVQLYDNYI
  . ...  |.|| |   ....      ....         .  |. .. .                    .|||..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-SLQEYLE---IQGKE--------GEFSDEEKLNIAIQVIDS-VNYIHCFNIIHRDIKPENFLVCLDGNELEVKLCD
 |   .    | ... |.  ..  || . ..   . ||.        . |. ..   |. |..    .|.|  .|||||||| | |.        |||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSTQLEK-----------NCEQIEILDVNNLVSIQLSRNLNISQMVGNWAYMAPEILTKNKDDQY-KIYSKKSDSYSVGLLLC
||...||..           .|             | ...  .   .||   .||||....|. . . | |. |.| .|.|....
FGVCGQLTDSMANIQSNNIIDC-------------I-ETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTII
Kinase 23995.AA TKL 620-737 23 3.1e-23 80.51 In-house 134-280 (364) Show / Hide 
Range on Protein: 620-737
Range on HMM: 134-280/364
Sequence Identity: 23% (36 aa)

KLNIAIQVIDSVNYIHCFN--------IIHRDIKPENFLVCLDGN-----------ELEVKLCDFGLSTQLEKNCEQIEIL-------DVNNLVSIQLSR
....|...   .|| |  |        |||||.|..| ||  ...           .  .|.||||||. .... ..  .               .| ..
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE------HQ-NN

NLNISQMVGNWAYMAPEILTKN-KDDQY---------KIYSKKSDSYSVGLLLC
. . .  .|. ..||||.| .. .....         . ||.|.| || |..|.
RKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW
Kinase 23995.AA Ciliate-E2-Unclassified 540-736 21 1.9e-18 60.59 In-house 22-260 (352) Show / Hide 
Range on Protein: 540-736
Range on HMM: 22-260/352
Sequence Identity: 21% (54 aa)

NNKEIV-----LKIQKIVDEQQIQNEIRIMQQLKAPLVVQ-----------------LYDNYIIEKATAP--EKYVVFELEKC-SCSLQEYLEIQGK---
..|  .     .| ..|.. .||.|...||...|.    .                 ... .|. .  .   .... . .|.|   .|..|.....|   
KQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQ

-----------EGEFSDEEKL-----NIAIQVIDSVNYIHCFN-IIHRDIKPENFLVCLDGNELEVKLCDFGLSTQLEKN--CEQIEILDVNNLVSIQLS
             .|.... .     ... |...  .|.|  | |||||||||| |.  .|. ...|..|||.| ....|  |.  . .     . .|  
KGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQ-----QKMQIW

RNLNISQMVGNWAYM----APEILTKNKDDQYKIYSKKSDSYSVGLLL
.. ......|.  ||    |||.| ... |. |   .|.| .|.| .|
KQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA--YKCDIWSLGVIL
Kinase 23995.AA TyrKc 517-803 18 7.7e-10 -63.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 517-803
Range on HMM: 1-280/280
Sequence Identity: 18% (59 aa)

VNNFQILNFGNFGMVLSTKKVEFNNKEIVL--KIQKIVDEQQIQNEIRIMQQL--KAPLVVQLYDNYIIEKA-----TAPEKYVVFELEKCSCSLQEYLE
.   ..|  |.|| |   .       . |   ....   .. . .|.||| .|  . | .|.||   .. .       ..  ..|.|. .   .|..|| 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

IQGKEGEFSDEEKLNIAIQVIDSVNYIHCFNIIHRDIKPENFLVCLDGNELEVKLCDFGLSTQLEKN-CEQIEILDVNNLVSIQL--SRN--LNISQMVG
  ...  .. ...|....|. .  .|.|  |.||||.   | ||  ..    || .|||||  ..   ..           . .   ...  | |     
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPI-----

NWAYMAPEILTKNKDDQYKIYSKKSDSYSVGLLL------CLLDNYL---NLKENTGSTFMNMTLNQYEEPFKKQ-----KINIKQDTEIFKFIKLLVVW
    |||| .      .|.... ||| .| | ..      .    .    .    . .  ..   . |  |  .             .|... .|     
--RWMAPECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHE

ERVKRASLSIIVEQN
.  .| . | |.|. 
DPEDRPTFSEIHECF