Gene 13310 (Tetrahymena)
13310
Sequence
Protein domains of 13310.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 13310.AA | Ciliate-C8 | 51-256 | 57 | 3e-121 | 409.11 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 51-256 Range on HMM: 1-238/238 Sequence Identity: 57% (138 aa) GAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNK---SYFVMEMELCEKN- ||...||||||..|||.|||||. |.|| .|...|...|||||...|.|..|.|.||||||||||...|||||||.|||||.| |.||||||.|..| GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC -LKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCD------LGFASAVSKSKS-FLSKK--GTDAY--- |||.||..||.|..||. .||.||||||...|.||..|||||||||.|||||..|.|...||||| .||||...|.|| ..||| |||.| NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --------FAPEVEKGQSRIQSDLFS-------LGLVL |||||||.|||||||.|| .|||| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 13310.AA | C8 | 42-256 | 61 | 1.2e-120 | 407.08 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 42-256 Range on HMM: 1-226/226 Sequence Identity: 61% (138 aa) FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEME |.|..|||.|||..||||.|...||...|||. |.||.|...|||..|||||.|.|.|..|.| .|||||.|.|...|....|..||||..||.|||||| FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKSKS-FLSKK----GTDAYFAP |||.|||||.|..|..|...|. .|| ||||||.|.|..|.||||||||||.|||||..|.|||.|||||.||||.|||.|| ..||| ||.||||| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP EVEKG------QSRIQSDLFSLGLVL |.||. |.||||||||.|||| EIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 13310.AA | C2 | 51-269 | 39 | 1.6e-69 | 236.6 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 51-269 Range on HMM: 1-245/245 Sequence Identity: 39% (98 aa) GAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEE-KEDEDDDGNDIIVQTQN--------KSYFVMEME || .||||| | .|||.|||| | . | | ... |||....... . ...|||..||| .. ||||| | ...... .| |. .|.|.| GAFGLVLKAFNKKQNRHVALKIQEC-QSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE LCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCD----------LGFASAVSKSKSFLSK---K |..|||| |. .|||. |.. .|...||||. . | || ..| ||||||.|||. .|. ||||| . |||.....|| .. | FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK GTDAY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLKTLNENW .| .| |||||... . .||||| .|.||||||| .. . . WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 13310.AA | CMGC | 42-220 | 16 | 2.3e-27 | 86.22 | In-house | 1-256 (513) | Show / Hide |
Range on Protein: 42-220 Range on HMM: 1-256/513 Sequence Identity: 16% (42 aa) FKNYEYLSSGAYALVLKAQN--------------SQQNRQVALKFLGCSNKDDKDGI---------ESLKKEYEMLQKFS---------------QSEF- ... ... .|.|. | |... . |..||.| . .. .. . | ..|.... . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEMELCEKNLKQLFDFLR------KQQVPPSNV------------IKEVI-----AIQMIEGLN- .|| ||.|| ... .|..| . | . . .. . .|.....|.|. . . ... . . || . . |...||. IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL -NLHVKN--IMHRDIKPQNFLVCPSQEY----------------GFSIKLCDLGFASAVSK .| .. |.|||.||.| |... |. . .|.|| |.| .... KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP |
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Kinase | 13310.AA | Pkinase | 42-259 | 22 | 2.5e-27 | 97.69 | Pfam | 1-205 (293) | Show / Hide |
Range on Protein: 42-259 Range on HMM: 1-205/293 Sequence Identity: 22% (51 aa) FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLK-KEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEM .. . . ||... | |... ...||.| . ...... .. .. | ...... .... |. ||.|. |.. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM ELCEKN--LKQLFDFLR--KQQVP--PSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASA--VSKSKSFLSKKGTDA |.||. . |||... .. . . ...| .. |...||. .| ..|.|||.||.|.|. . . ..|.|| |.| .. . . || EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW YFAPEV--EKGQSRIQSDLFSLGLVLLEL | |||| . .| .|.|..| |. YMAPEVIRGGQYYGPKVDMWSCGCILYEM |
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Kinase | 13310.AA | STE | 42-259 | 18 | 2.6e-26 | 90.0 | In-house | 1-261 (359) | Show / Hide |
Range on Protein: 42-259 Range on HMM: 1-261/359 Sequence Identity: 18% (53 aa) FKNYEYLSSGAYALVLKAQNS------QQNRQ---------VALKFLGCSNKD--------------DKDGIESLKKEYEMLQKFSQ-SEFLVKVYDCFY ... | . .||. | || | . ... .| | . .|.. ... .....|| ....|... ... || |.|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF LMEEKEDEDDDGNDIIVQTQNKSYFVMEMELCE-KNLKQLFDFLRKQQVPPS----------NVIKEVIAIQMIEG-LNNLHVKNIMHRDIKPQNFLVCP .. ..|... . ||... | .. . . . | . . .|. | ..| |. || ..|.||||||.| |. KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-- SQEYGFSIKLCDLGFASAVSK-----------------SKSFLSKKGTDAYFAPEVEKG-QSR------IQSDLFSLGLVLLEL .|||| |... ... .. . || . |||| .. .. ...| |||....|. -------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM |
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Kinase | 13310.AA | CAMK | 47-238 | 16 | 5.4e-24 | 73.59 | In-house | 1-291 (425) | Show / Hide |
Range on Protein: 47-238 Range on HMM: 1-291/425 Sequence Identity: 16% (50 aa) YLSSGAYALVLKAQNSQQN------------RQVALKFLGCSNKDDKD-------------------------GIESLKKEYEMLQKFS------QSEFL | .|... | .... . . ..|| |.. . .|| .....|.|...| . . . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKVYDCFYL-----------MEEKEDEDDDGNDIIVQTQNKSYFVM-EMELCEKN--LKQLFDFLRKQ-----------QVPPSNVIKEVIAI----QMI .| |. . .| .. .... |.|| ||.|. . |||..... | . ..| | |.. IKLYEVYEDPHYFKNTNDYET-SKQ--------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQIC EGLNNLHVKNIMHRDIKPQNFLVCPSQEYG-------------FSIKLCDLGFASAVSKSK------------------------SFLSKKGTDAYFA-P .... .| .||.|||.|| | |.. . . . ||..| ||| . ... . || .| | | SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP EV || EV |
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Kinase | 13310.AA | Ciliate-E2 | 167-259 | 25 | 1.5e-22 | 74.22 | In-house | 163-289 (365) | Show / Hide |
Range on Protein: 167-259 Range on HMM: 163-289/365 Sequence Identity: 25% (35 aa) EVIAIQMIEGLNNLHVKN-IMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKS----------KSFLSKK-----------------------GTDA | .. ..|..|. || || |.||||||.| |. ||..|.|.. .... | .. | || EFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPG YFAPEVEKGQSR----------IQSDLFSLGLVLLEL | |||. .|.. ..|..||| .| |. YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM |
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Kinase | 13310.AA | S_TKc | 42-323 | 21 | 2.4e-22 | 81.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-323 Range on HMM: 1-231/231 Sequence Identity: 21% (63 aa) FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEME .. . . .||.. | |... .|.||.| . |....| ..|.| . ...|| ||.|. ... | || YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME LCEKNLKQLFDFLRKQQ-------VPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKSKSFLSKKGTDAYF .|. .| |||...|.. |. . . .. |....|. .| ..|.|||.||.| |.. ||.|| |.| . . || | YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF--YMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYM APEVEKGQSRIQSDLFSLGLVLLELDNLKTLNENWIDVEIKNNLFKGQEIPNDIYQIDKKSNIYKIAQICLKPSYLDRTSAGELLS--------KLI |||| | .. .| |.| .| |. ... . . .. ... . . . ||. .| .| |.| . APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 13310.AA | Ciliate-A1 | 129-259 | 26 | 1.9e-19 | 62.82 | In-house | 69-221 (301) | Show / Hide |
Range on Protein: 129-259 Range on HMM: 69-221/301 Sequence Identity: 26% (43 aa) QTQNKSYFVMEMELCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKSK------ .|.|| . . || |.... ||.. | | | |.|||. .| .||.|||.|||| |. . |.|||| .. NTNNKECMFIIMEYCQYGN--LFNYCYQNDYMKKEEIYE-ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKW----KICDLGMSKQLEQNQDCCDDV -------------SFLSKKGTDAYFAPEV----------EKGQSRIQSDLFSLGLVLLEL .| |. | .|| .. |||..|||.....| NGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL |
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Kinase | 13310.AA | TKL | 169-259 | 21 | 1.6e-18 | 63.28 | In-house | 137-282 (364) | Show / Hide |
Range on Protein: 169-259 Range on HMM: 137-282/364 Sequence Identity: 21% (31 aa) IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCPSQE----------YGFSIKLCDLGFASAVSKSKS--------------------FLSKKGT .|... |.| || ..| |||.|..| || . . .|.||.|.. .|.|.. .. || WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT DAYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL .. |||| .... ..| .| |.|| |. PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI |
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Kinase | 13310.AA | Ciliate-E1 | 140-250 | 25 | 3.5e-15 | 46.22 | In-house | 76-202 (202) | Show / Hide |
Range on Protein: 140-250 Range on HMM: 76-202/202 Sequence Identity: 25% (34 aa) MELCEKNLKQLFD---------FLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFAS--AVSKSKSFLSKK .|.|...||. .. ....| . |. |..|.|.||. || .||.|||||||| |.. . .| .. |.| .. .. .. | FECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKG GTDAYFAPEVEK------GQS---RIQSDLF |. | ||. . .. ..||.. YTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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Kinase | 13310.AA | TyrKc | 42-322 | 18 | 3.3e-10 | -57.65 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 42-322 Range on HMM: 1-280/280 Sequence Identity: 18% (58 aa) FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKF-SQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEM . . | .||. | |.. . .||| | | . .| . .| ... |. . . .|. | . ... . | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------------FMYIEPLMIVM ELCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKS-------KSFLSKK--GTD |.... | |.||| . .. . ...| .| . || ||. |||. | || . .| .| | . .. . .|. |.. EYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK -----AYFAPEVE-KGQSRIQSDLFSLGLVLLELDNL-KTLNEN-----WIDVEIKNNLFKG--QEIPNDIYQID-----KKSNIYKIAQICLKPSYLDR |||. .| ..|| .| | .. |. . .. .. . |. ... .| ..| ..| . .|.| . | . || TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDR TSAGELLSKL . |. ... PTFSEIHECF |
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Kinase | 13310.AA | Ciliate-E1 | 48-136 | 19 | 1.7e-08 | 24.26 | In-house | 1-108 (202) | Show / Hide |
Range on Protein: 48-136 Range on HMM: 1-108/202 Sequence Identity: 19% (21 aa) LSSGAYALVLKA-QNSQQNRQVALKFLGCSNKDDKDGIESLKKEYE-MLQKFSQSEFLVKVYDCFY---------LMEEKEDEDDDGND---------II ...| ...|.|| |......|||.|. | ..... .....||| ... | . . .....|... ..|. .... | .. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC VQTQNKSYF |.||. .| QQNQNQFTF |
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Kinase | 13310.AA | Ciliate-E2 | 42-116 | 15 | 1.4e-07 | 22.04 | In-house | 1-107 (365) | Show / Hide |
Range on Protein: 42-116 Range on HMM: 1-107/365 Sequence Identity: 15% (17 aa) FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSN--------KDD----------KDGIESLKKEYEMLQ---------------KFSQSEFLVKVYD .| . . .|... | |... ....|.|.|. . |.. |..||..|.| ... .. .. ...| |. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE CFYLMEEK ||. . .. CFQEKDDN |
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Kinase | 13310.AA | Ciliate-A1 | 42-79 | 17 | 0.000393 | 9.89 | In-house | 1-39 (301) | Show / Hide |
Range on Protein: 42-79 Range on HMM: 1-39/301 Sequence Identity: 17% (7 aa) FKNYEYLSSGAYALVLKAQNSQQNR-QVALKFLGCSNKD . . .| . |..| ..| .. ...| . |.|.. YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE |
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Kinase | 13310.AA | TKL | 48-107 | 13 | 0.023115 | 4.33 | In-house | 1-91 (364) | Show / Hide |
Range on Protein: 48-107 Range on HMM: 1-91/364 Sequence Identity: 13% (12 aa) LSSGAYALVLKAQNSQQN--------RQVALKFLGCSNKDDKDGIES----------------------LKKEYEMLQKFSQ-SEFLVKVY . ||... | |.. ... . || | . | | .. .. ..|.|.... . . .|. . IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM |
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Kinase | 13310.AA | Ciliate-E1 | 260-298 | 19 | 0.216423 | 0.87 | In-house | 157-202 (202) | Show / Hide |
Range on Protein: 260-298 Range on HMM: 157-202/202 Sequence Identity: 19% (9 aa) DNLKTLNENWIDVEIKNNLFKGQEIPN-------DIYQIDKKSNIY ..|| ... .... . .. .| | . ..|..||.|| KFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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Kinase | 13310.AA | C8 | 410-611 | 47 | 1.1e-99 | 337.52 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 410-611 Range on HMM: 1-226/226 Sequence Identity: 47% (108 aa) TNNFQILSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQEIQNEISIMQKLKEPLVVQIYDSYIIENKLGPDRYSVFELEKCS-----------CSLDE- .||||.||||..|.||..|.|| ||.|||||.||....|.|||..|||.....|.|.| ||.|..|.......|.|||.|||| |...| FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM ----------YLERSNIDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQP-EIKLCDFGLSAQIPDNEDSIQTIEH--IGNLGYSA |.|| | ..||....|..||||.||.|||||..||.||||||.||||.|..... ||||||||...|...|...||.... .|...|.| ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA PEILNKKDNELKFYTKKSDSYSVGLLL |||..|.||..|.|...||..||||.| PEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 13310.AA | Ciliate-C8 | 419-611 | 39 | 5.1e-96 | 325.3 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 419-611 Range on HMM: 1-238/238 Sequence Identity: 39% (94 aa) GSFGIVLST------KKVKLDNKEIVLKIQKIVDEQEIQNEISIMQKLKEPLVVQIYDSYIIENKLGPDR-----------------YSVFELEKCS--C |.||.||.. .||.|...|.|.||||...|.||.....|||....|.||| ||....... ... ..|.|.|||. | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC SLDEYLER-SNIDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLE-GKQPEIKLCD------FGLSAQIPDNED---------SIQTIEH .|..|..| . ........|..||||.||||||.| |||.||||||.||||... ..||.||||| ||...|.|.|.. ..|.||. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --IGNLGYSAPEILNK-KDNELKFYTKKSDSYSVGLLL .||.||.|||...| .........||||||||||.| YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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Kinase | 13310.AA | C2 | 419-624 | 28 | 3.2e-42 | 142.07 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 419-624 Range on HMM: 1-245/245 Sequence Identity: 28% (71 aa) GSFGIVLSTKKVKLDNKEIVLKIQKIVD-----EQEIQNEISIMQKLK-EPLVVQIYDSYIIENKLGPD-------------R----------YSVFELE |.||.|| . | .|....||||.. . ..|.|.|..||.... |.....|... . | . |.|.| GAFGLVLKAFN-KKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE KCSCSLDEYLERSNIDG-QFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQ-PEIKLCD----------FGLSAQIPDNEDSIQTIEHI .|.. | |..| . ..... | ..|||..||.||.| |.|.||||||.|||. . .. | ||||| | . .. |. | . . FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK GNLGY----SAPEILNKKDNELKFYTKKSDSYS-VGLLLALLDNYQDLKTNT . | .|||. . . | |.|| .| ||. | ||| | . WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC |
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Kinase | 13310.AA | CAMK | 415-611 | 20 | 2e-34 | 107.78 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 415-611 Range on HMM: 1-324/425 Sequence Identity: 20% (66 aa) ILSFGSFGIVLSTKKVKLDN-----------KEIVLKI---QKIV----------------------------DEQEIQNEISIMQK-------LKEPLV .| ||||.| . . . .. || .|. |......||.||.| |. | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQIYDSYIIEN--------------KLGPDRYSVFEL---EKCSCS------LDEYLERSNI-----------DGQFNEDDKFQIAIQIIDSVNYIHSFN ...|. | .. .|.. .. . | || .| |... .| |.|.. .. ||.. |.|.|| | IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN ILHRDIKPENFLVYLEGKQPE--------------IKLCDFGLSAQIPDNEDSI---------------------QTIEHIGNLGYSA-PEILNKK---- | |||.|||| |. .. . ||..|||........|.. . | ..| | ||.||.| IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN -----DNELKFYTKKSDSYSVGLLL |.| . |..|.| |.| .| MQNATDEEKPYYGPKCDMWSCGVIL |
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Kinase | 13310.AA | S_TKc | 410-683 | 22 | 1.3e-29 | 105.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 410-683 Range on HMM: 1-231/231 Sequence Identity: 22% (66 aa) TNNFQILSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQEIQNEISIMQKLKEPLVVQIYDSYIIENKLGPDRYSVFELEKCSC---SLDEYLERSNIDG ... |.|| | ...| .... .|| | . |..||.|..| . | .|..||.. . . .| |. .| .|... . | YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG Q---FNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSAQIPDNEDSIQTIEHIGNLGYSAPEILNKKDNELKFYTK-KS |.| . .. ||.. ..|.|| .|.|||.|||| |. .||.|||||..|. .| . | |||.| |.| |. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC DSYSVGLLLALLDN----YQDLKTNTTSNFALMTLKQLDKPFEKSNIQINKNSQIYKFINLLVVSDSSQRASLYDIVE-QSD---IKFL | .|.| .|. . .. . ..| | . .. ||. . . | ..| . .. . ..| .. DWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 13310.AA | Ciliate-E2 | 410-611 | 22 | 2.2e-27 | 91.08 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 410-611 Range on HMM: 1-286/365 Sequence Identity: 22% (68 aa) TNNFQILSFGSFG-----IVLSTKKV-----------------KLDNKEIVLKIQKIVDEQEIQNEISIMQ----------------KLKEPLVVQIYDS . ... .|.|| | ...| | ..|.. .||.| . ..| .||.||. .|. | ....|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YI--IENKLGPDRYSVFELEKCSC-SLDEYLE------RSNID--GQFNEDDKFQIAIQIID---------------SVNYIHSFN-ILHRDIKPENFLV .. .|.. . .| |. .| .|.. ..|. ..|.| .| ||.. ..|.|| | |.|||||||| |. FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF YLEGKQPEIKLCDFGLSAQIPDNED--------SIQTIEH----------------------IGNLGYSAPEILNKKDNE----LKFYTKKSDSYSVGLL ||..||||| .. |... . . . .|..|| ||||||.|... | |..|.| .|.| . --------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI L | L |
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Kinase | 13310.AA | Ciliate-E1 | 416-605 | 26 | 2.7e-27 | 86.1 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 416-605 Range on HMM: 1-202/202 Sequence Identity: 26% (57 aa) LSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQE-------IQNEISIMQKLKEPL-VVQIYDSYIIENKLGPDRYSVFELEKCSCSLDEYLE------- .. |||.||. |. . .... .||... . .. |.....||. .|. ..||.| ..|.. .. ... .|.|.||| .||. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY ---RSNIDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSA-QIPDNEDSIQTIEHIGNLGYSAPEILNK---KDN .. ..||... | ||..|.|| ....|..||.||||||.| |.. . .. ..||||.| .. .....| .. . |. || .| . | WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYKGYTHY--YYPPEQYNCPEQEHN ELKFYTKKSDSY . . ...||| | KNQKINYKSDIY |
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Kinase | 13310.AA | Pkinase | 410-612 | 26 | 3.1e-25 | 90.32 | Pfam | 1-203 (293) | Show / Hide |
Range on Protein: 410-612 Range on HMM: 1-203/293 Sequence Identity: 26% (59 aa) TNNFQILSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQEIQN-------EISIMQKLKEPLVVQIYDSYIIENKLGPDRYSVFELEKCSC-----SLDE ... |||| | .... ..|. ..|| | ..| . .. ||.||..|. | .|..||.. ... . .| | . .| . YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD YLERSNIDGQF--NEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEI----KLCDFGLSAQIPDNEDSIQTIEHIGNLGYSAPEILNKK |... .| | |.. .. ||. ..|.|| .|.|||.||||.| . ....| |.|||||..|. . . . | ..| |||... YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR-- DNELKFYTKKSDSYSVGLLLA . . |..|.| .|.|..|. --GGQYYGPKVDMWSCGCILY |
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Kinase | 13310.AA | STE | 410-611 | 21 | 1.9e-24 | 83.35 | In-house | 1-258 (359) | Show / Hide |
Range on Protein: 410-611 Range on HMM: 1-258/359 Sequence Identity: 21% (57 aa) TNNFQILSFGSFG-IVLSTKKVKL-------------DNKEIVLKIQKIVD--------------------EQEIQNEISIMQKLK--EPLVVQIYDSYI . ... |.|| .. .. . .. . |. .. . .|.|..||.||.|.. | .|. |..|. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF IEN--KLGPDRYSVFELEKCSC-SLDEYLERSNIDGQ-----------FNEDDKFQIAIQIIDS-VNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDF |. . | .. .| .. |||. ... . |. |.|. |. ||. .|.|| .| |||||| | |. .||||| KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDF GLSAQIPDN--------------EDSIQTIEHIGNLGYSAPEILNKKDNE-LKFYTKKSDSYSVGLLL |...|. |. . .. .| . |||.... .. | |. |.| .|.|... GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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Kinase | 13310.AA | CMGC | 413-561 | 16 | 5.8e-24 | 74.82 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 413-561 Range on HMM: 1-251/513 Sequence Identity: 16% (43 aa) FQILS---FGSFGIVLSTKK-------------VKLDNKEIVLKIQKIVDEQEIQ---------------NEISIMQKLK-----------------EPL ..|.. |..|.| . . . .|... .|. | . |.| ||.|...|. .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VVQIYDSYIIENKLGP-----------DRYSVFELEKCSCSLDEYLERSN--IDG----QFNEDD------------KFQIA------IQIIDSVN--YI .|..||.. .| |. ... . | . ..| .|... . | ..| . . ||. ... |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSFN--ILHRDIKPENFLVYLEGKQ-----------------PEIKLCDFGLS || . |.|||.|||| |. ... ..|.|||||. HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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Kinase | 13310.AA | TKL | 494-611 | 23 | 7e-21 | 71.92 | In-house | 124-279 (364) | Show / Hide |
Range on Protein: 494-611 Range on HMM: 124-279/364 Sequence Identity: 23% (39 aa) S-LDEYLERSNIDGQFNEDDKFQIAIQIIDSVNYIHSFN--------ILHRDIKPENFLVYLEGKQPE-----------IKLCDFGLSA------QIPDN | |. .. . ....|..| .|| || | |.|||.|..| || .. .|.|||||| . |. SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT EDSIQ-----------TIEHIGNLGYSAPEILNKKDNELKF-----------YTKKSDSYSVGLLL . ... |. .|.... |||.|....| . |..|.| || |..| MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL |
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Kinase | 13310.AA | Ciliate-A1 | 516-619 | 33 | 4.9e-17 | 54.5 | In-house | 106-226 (301) | Show / Hide |
Range on Protein: 516-619 Range on HMM: 106-226/301 Sequence Identity: 33% (42 aa) IAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSAQIPDNE----------------DSIQTIEHIGNLGYSAPEI----L-NKKDNE | ||| . ||. ||||||.||.| |. . | .|.||.|.| | . | .|.. ||| | .|| . .. | ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDK---WKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIE LKFYTKKSDSYSVGLLLALLDNYQD | | |.|| ||.|. . | . | NKIY-KQSDMYSLGCIICFLCYKED |