Gene 23667 (Tetrahymena)

23667

Species: Tetrahymena
Alias: 855, PreTt23667, TTHERM_00959810, 23667, 178.m00048
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
23667.AA Protein None 1218 None Fasta, JSON
23667.kin_dom Protein Kinase Domain None 153 None Fasta, JSON
23667.kin_dom2 Protein Kinase Domain None 182 None Fasta, JSON
23667.NA RNA None 3657 None Fasta, JSON

Protein domain

Protein domains of 23667.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23667.AA C8 42-250 51 1.7e-103 350.1 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-250
Range on HMM: 1-226/226
Sequence Identity: 51% (117 aa)

FKNFEYISNGSFALILKAYNSKENRQVALKFLVCCSEGYQDQMESLKKEYEILQKFGQSQFLVDVYDCFYLMEEEEDEDEDGNEIIVQNEYKSFFVLEME
|.||.|.|.|.....|||.|.|.||...|||. |...  ....||..||||..|.| |..|.| .|||||.|.|...|....||.|||.|.||.|| |||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

CCEHNLKGLFDYFRKQQVPPSKEIKEIIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQEYA------DLGFATHVSKSKS-FCSRK----GSDEYLAP
.||.||| |.|..|..|...|||.||||||||..|.|.||.|||.|||||..|.||...|.|       |.|||..|||.|| ..|.|    | ..|.||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EAEKG------QYRIQSDLFSLGLIL
| ||.      ||||||||||.||.|
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 23667.AA Ciliate-C8 51-250 47 3.6e-100 339.09 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-250
Range on HMM: 1-238/238
Sequence Identity: 47% (113 aa)

GSFALILKAYNSKENRQVALKFLVCCSEGYQDQMESLKKEYEILQKFGQSQFLVDVYDCFYLMEEEEDEDEDGNEIIVQNEYK---SFFVLEMECCEHN-
|.|...|||.|.|.||.|||||. |...  ..|||...|||| ...| |..|.|.||||||||||...||.|||..|||.. |   ||||.|||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKGLFDYFRKQQVPPSKEIKEIIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQEY------AD------LGFATHVSKSKS-FCSRK--GSDEY---
 || .||..||.|..||...||||||||....|..|..||.|||||..|.|| ..|.|      .|      .|||....|.|| ..|.|  |.|.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------LAPEAEKGQYRIQSDLFS-------LGLIL
         ||| ||.|.|||||.||       .||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23667.AA C2 51-263 36 6.1e-60 203.44 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-263
Range on HMM: 1-245/245
Sequence Identity: 36% (89 aa)

GSFALILKAYNSKENRQVALKFLVCCSEGYQDQMESLKKEYEILQKFGQSQFLVDVYDCFYLMEE-EEDEDEDGNEIIVQ--------NEYKSFFVLEME
|.|.|.|||.| |.||.||||  . | .    .|... |||.|....  . ....||..||| .. .|||||| .|....        || |.|.|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

CCEHNLKGLFDYFRKQQVPPSKEIKEIIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQEY------AD----------LGFATHVSKSKSFCSR---K
 |. |||  |.  |||.  |....|.|.||||. . | .| ..|.|||||.||.|.  .|.       .|          . ||  ....||  .    |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GSDEY----LAPEAEKGQYRIQSDLFS-LGLILLELDNVMTLNEDW
..  |     ||| ... |. .||||| .|..||||||  . .   
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 23667.AA Pkinase 42-253 23 1.6e-26 94.83 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-253
Range on HMM: 1-205/293
Sequence Identity: 23% (54 aa)

FKNFEYISNGSFALILKAYNSKENRQVALKFLVCCSEGYQDQMESLK-KEYEILQKFGQSQFLVDVYDCFYLMEEEEDEDEDGNEIIVQNEYKSFFVLEM
..  . |  |||.   |... .....||.| .  ..|  . ... ..  | .|.... .. . |  ||.|.                     |.   . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ECCEHNLKGLFDYF-----RKQQVP--PSKEIKEIIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQEY------ADLGFATH--VSKSKSFCSRKGSD
|.||. |. ..| |     ... .   . .|.| ..  |.|.||. .| ..|||||.|..|||.    .       .| |.| .    ..  . .. |. 
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

EYLAPEA--EKGQYRIQSDLFSLGLILLEL
.|.|||   .   |   .| .|.|.|| |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 23667.AA Ciliate-E2a 150-250 27 1.4e-18 51.35 In-house 86-206 (275) Show / Hide 
Range on Protein: 150-250
Range on HMM: 86-206/275
Sequence Identity: 27% (34 aa)

LFDYFRKQQVPPSK--EIKEIIAIQML-EGLNNIHVKNIIHRDIKLSNILVR--PSQEY-------ADLGFATHV--SKSKSFCSRKGSDEYLA------
|.|......   ..  ||..|.  |.| .||...| .||.|||.|. ||| .   .. .       .| |.|| .   . |   .. |.  |.|      
LYDKIKQCKRFFEEIQEICDIMQ-QLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNN

PEA-EKGQYRIQSDLFSLGLIL
.|  .. ||  . |..|.|.|.
KEVLKHKQYDTKCDMWSCGVIF
Kinase 23667.AA ULK 168-250 30 2.5e-18 61.7 In-house 130-242 (324) Show / Hide 
Range on Protein: 168-250
Range on HMM: 130-242/324
Sequence Identity: 30% (35 aa)

IIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQE--------------YADLGFATHVSK-SKSFCSR---------KGSDEYLAPEAEKGQ-----YR
.. .| ..|.  .| .||||||||..|||.   |.               || ||| || . ... . .         ||.  | ||.  .||     | 
QFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYY

-IQSDLFSLGLIL
 . .|..||| |.
DYKCDIWSLGCIF
Kinase 23667.AA Ciliate-E2 150-253 24 8.1e-18 57.73 In-house 121-289 (365) Show / Hide 
Range on Protein: 150-253
Range on HMM: 121-289/365
Sequence Identity: 24% (43 aa)

LFDYFRKQQVPPSKE--------IKEI--IAIQMLE---------------GLNNIHVKN-IIHRDIKLSNILVRPSQEY--ADLGFATHVSKS------
|||| ....    .|        .|||  |  | |.               .|. .| || |||||||..|||.        .|.|... ....      
LFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH

----KSFCSRK-----------------------GSDEYLAPEAEKGQ----------YRIQSDLFSLGLILLEL
    | .   |                       |. .|.|||  .|.          |  ..|..||| || |.
KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 23667.AA Ciliate-E1 112-244 23 9.8e-16 48.06 In-house 48-202 (202) Show / Hide 
Range on Protein: 112-244
Range on HMM: 48-202/202
Sequence Identity: 23% (36 aa)

LMEEEEDEDEDGNEIIVQN-EYKSFFVLEMECCEHNLKGLFD---------YFRKQQVPPSKEIKEIIAIQMLEGLNNIHVKNIIHRDIKLSNILV--RP
.|.  . |.   . | ..  ..  .... .|||...||  ..          ....|   . . |. |..|...||. .| .|||||||| .|||.    
IMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQG

SQEYADLGFAT-HVSKSKSFCSRKGSDEYLAPEAEKG----------QYRIQSDLF
   |.|.| .    ..... |  ||  .|..|. ..           .. ..||..
NYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 23667.AA S_TKc 42-317 21 1.3e-15 51.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-317
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

FKNFEYISNGSFALILKAYNSKENRQVALKFLVCCSEGYQDQMESLKKEYEILQKFGQSQFLVDVYDCFYLMEEEEDEDEDGNEIIVQNEYKSFFVLEME
..  . |  |.|.   |... | .|.||.| .           |....| .||.|  .  ..|  ||.|.                      ... . ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

CCEHNLKGLFDYFRKQQVP------PSKEIKEIIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQE--YADLGFATHVSKSKSFCSRKGSDEYLAPEAE
.|...|  |||| .|.. .      |  ... ... |....|. .| ..|||||.| .|||.    .   .| |.|...       .  |. .|.|||  
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL

KGQYRI-QSDLFSLGLILLELDNVMTLNEDWIDFETKLNLFNGKEIPDEKYQIDKNSNIYKIAQICLKPSYLERTTAGDLLS--------QLI
  .|    .|  |.| || |.    .. .      .   .|.              .    . . ||.    .| || ..|         . .
--GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23667.AA TKL 169-253 19 8.5e-15 49.71 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-253
Range on HMM: 137-282/364
Sequence Identity: 19% (28 aa)

IAIQMLEGLNNIHV--------KNIIHRDIKLSNILVR-PSQEY---------------ADLGFATHVSKSKS--------------------FCSRKGS
.|...  |.|  |         ..|||||.| .||||    . .               .|.|... .|.|..                     ... |.
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DEYLAPEA-----------------EKGQYRIQSDLFSLGLILLEL
  ..|||.                 ....|  ..| .| |..| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 23667.AA STE 168-253 26 2e-14 47.43 In-house 155-261 (359) Show / Hide 
Range on Protein: 168-253
Range on HMM: 155-261/359
Sequence Identity: 26% (29 aa)

IIAIQMLEG-LNNIHVKNIIHRDIKLSNILVRPSQEYADLGFATHVSKS----------------KSFC-SRKGSDEYLAPEAEKG-------QYRIQSD
.|. | |.| |. .| ..||||||| .|||.      .| |... ...|                .. . .  |.  . |||  ..       .| ...|
YICRQILKGLLYYLHSHHIIHRDIKPANILL---VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCD

LFSLGLILLEL
  |||. ..|.
IWSLGCTIIEM
Kinase 23667.AA CAMK 47-231 13 1.1e-13 39.79 In-house 1-290 (425) Show / Hide 
Range on Protein: 47-231
Range on HMM: 1-290/425
Sequence Identity: 13% (43 aa)

YISNGSFALILKAYNSKEN------------RQVALKFLVC---------------------CSEGYQD----QMESLKKEYEILQKFG------QSQFL
 .  |||.   .... . .            ..|| |..                       |. .|..     ......|.||..|        .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VDVYDCFY-------LMEEEEDEDEDGNEIIVQNEY---------KSFFVLEM---ECCEHN--LKGLFDYFRKQ---------------QVPPSKEIKE
.  |. .                         .  |         ...... |   | |.    .  |||| ...                  . .| . 
IKLYEVYEDPHYFKNT----------------ND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARR

IIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQE---------------Y----ADLGFATHVSKSK------------------------SFCSRKGS
..  |...... .| .||.|||.|. |||.  . .               .    .| |||... ...                         .  . |.
YFR-QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGT

DEYLA-PE
 || | ||
PEYMAAPE
Kinase 23667.AA Ciliate-E1 48-111 31 1.2e-09 28.05 In-house 1-65 (202) Show / Hide 
Range on Protein: 48-111
Range on HMM: 1-65/202
Sequence Identity: 31% (21 aa)

ISNGSFALILKAYNSKEN-RQVALKFLVCCSEGYQDQMESLKKEYE-ILQKFGQSQFLVDVYDCFY
|.||||....||.. . | .|||.|.  ||    |.. ....|||  |.. | . . .....|...
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIK
Kinase 23667.AA TyrKc 42-316 18 3e-08 -89.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 42-316
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FKNFEYISNGSFALILKAYNSKENRQVALKFLVCCSEGYQDQMESLKKEYEILQKFG-QSQFLVDVYDCFYLMEEEEDEDEDGNEIIVQNEYKSFFVLEM
 .  . . .| |  . |.  .   .||| | |  ..      .| . .| .|. |.| . . .|  | .    ..                   . |.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----------FMYIEPLMIVMEY

ECCEHNLKGLFDYFRKQQVPPSKEIKEIIAIQMLEGLNNIHVKNIIHRDIKLSNILVRPSQ--EYADLGFATHVSKS-------KSFCSRK--GSDE---
 ..  .||   || || .   . . .  ...|  .| . .| ||.||||.   |.||   .    .| | .  .          .   ...  |..    
-MPHGDLK---DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

--YLAPEAE-KGQYRIQSDLFSLGLILLEL-DNVMTLNED-----WIDFETKLNLFNG--KEIPDEKYQID-----KNSNIYKIAQICLKPSYLERTTAG
   .|||.  .| . ..|| .| |  . |.  . ..  ..       ..|   .. .|   ..|.. |          . .|.| . | .    .| |  
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

DLLSQL
.. ...
EIHECF
Kinase 23667.AA STE 42-119 18 2e-06 18.58 In-house 1-111 (359) Show / Hide 
Range on Protein: 42-119
Range on HMM: 1-111/359
Sequence Identity: 18% (20 aa)

FKNFEYISNGSFALILKAYNS------KENRQ---------VALKFLVCCSE--------------GYQDQMESLKKEYEILQKFGQ-SQFLVDVYDCFY
... | | .|.|    ||.|       | ...         .| | .  ...                ...|....|| .|..|. . ... |  |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LM---EEEEDE
     ....||
KEGHNHKNDDE
Kinase 23667.AA ULK 42-111 22 0.00106 9.08 In-house 1-85 (324) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-85/324
Sequence Identity: 22% (19 aa)

FKNFEYISNGSFA-LILKAYNSKE---NRQVALKFLV---CCSEGYQDQ----MESLKKEYEILQKFG--QSQF--LVDVYDCFY
.   . .  |||.    |..| |    | .|| |           ....    ...||.| .|..|.   ....   |  ||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFE
Kinase 23667.AA Ciliate-E2 42-111 16 0.005912 5.96 In-house 1-102 (365) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-102/365
Sequence Identity: 16% (17 aa)

FKNFEYISNGSFALILKAYNSKENRQVALK-----------------FLVCCSEGYQDQMESLKKEYEILQ---------------KFGQSQFLVDVYDC
.|  . | .|.|. . |. . |...|.|.|                 ...      ..| |..|.|  |..               .. .. ...  |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY
|.
FQ
Kinase 23667.AA Ciliate-C8 385-556 33 2.3e-74 253.39 In-house 1-238 (238) Show / Hide 
Range on Protein: 385-556
Range on HMM: 1-238/238
Sequence Identity: 33% (80 aa)

GSQGMILAT------KKVNLDNKEI---------------------KLKEPLVVQLYDSYIIENIVGSDR-----------------YSVLELEKCS--C
|. ||.|..      .||.|...|.                     ....|.|||.||......   ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

TLDEYLDR-KNKDGQFSEDDKFQIAIKIIDSVNYIHSLNFIHRDIKPQNFLVCLN-ENEVEIKLCD------FGVSAQIPDNRN---------SIQTKEF
.|..|.|| ..|....|...|..||| .||||||.|  |..||||||.|||||.. ..  .|||||      || ..|.|.| .         ..|. |.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNLGYSAPEILNK-KDNELKFYTKKSDSYSVGLLL
  .||.||.|||...| .........||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 23667.AA C8 407-556 45 3.8e-68 232.71 In-house 52-226 (226) Show / Hide 
Range on Protein: 407-556
Range on HMM: 52-226/226
Sequence Identity: 45% (79 aa)

EPLVVQLYDSYIIENIVGSDRYSVLELEKCS-----------CTLDE-----------YLDRKNKDGQFSEDDKFQIAIKIIDSVNYIHSLNFIHRDIKP
.|.|.|.||.|..|. .. ..|.| |.||||           |...|           |..|.||..|||...|..|||..||.|||||. |..||||||
MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKP

QNFLVCLNENEV-EIKLCDFGVSAQIPDNRNSIQTKEF--VGNLGYSAPEILNKKDNELKFYTKKSDSYSVGLLL
.||||||..|.. ||||||||...|...|...||.|..  .|...|.||||..|.||..|.|...||..||||.|
HNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 23667.AA C2 408-569 25 5.8e-31 103.08 In-house 50-245 (245) Show / Hide 
Range on Protein: 408-569
Range on HMM: 50-245/245
Sequence Identity: 25% (51 aa)

PLVVQLYDSYIIENIVGSD-------------R----------YSVLELEKCSCTLDEYLDRKNKDG-QFSEDDKFQIAIKIIDSVNYIHSLNFIHRDIK
|.....|...       .|             .            |.|.|.|...|  |..|. |.  ..... | ..|| ..||.||.|  ...|||||
PYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIK

PQNFLVCLNENEV-EIKLCD----------FGVSAQIPDNRNSIQTKEFVGNLGY----SAPEILNKKDNELKFYTKKSDSYS-VGLLLTLIDNYYILNK
|.|||. ......  |||||          |  .  .. | . | ...|..   |    .|||.      . . | |.|| .| ||. |  .||  . . 
PSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTI

NA
. 
CC
Kinase 23667.AA CAMK 404-556 22 1.7e-29 91.61 In-house 94-324 (425) Show / Hide 
Range on Protein: 404-556
Range on HMM: 94-324/425
Sequence Identity: 22% (53 aa)

KLKEPLVVQLYDSYIIEN-------------IVGS-DRYSVLEL---EKCSCT-----LDEYLDRKNK------------DGQFSEDDKFQIAIKIIDSV
||. | ...||. |  ..             .. . |.. .. .   | ||       | .|. .. .            .| |.|..  ..   |.. |
KLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAV

NYIHSLNFIHRDIKPQNFLVCLNENEVE--------------IKLCDFGVSAQIPDNRNSI---------------------QTKEFVGNLGYSA-PEIL
.|.||.| .|||.|| | |.. |... .              ||..||| ....... |.                        |.|.| ..| | ||.|
HYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL

NKK---------DNELKFYTKKSDSYSVGLLL
|.|         |.| . |..|.|  |.| .|
NGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 23667.AA Ciliate-E2 447-556 26 6.1e-25 82.55 In-house 138-286 (365) Show / Hide 
Range on Protein: 447-556
Range on HMM: 138-286/365
Sequence Identity: 26% (42 aa)

KNKDGQFSEDDKFQIAIKIID---------------SVNYIHSLN-FIHRDIKPQNFLVCLNENEVEIKLCDFGVSAQIPDNRNSI--------------
| . ..|.|    .|  .|..                ..|.|| |  |||||||.| |.        ||..||| | .. |... .              
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKND

---------------QTKEFVGNLGYSAPEILNKKDNE----LKFYTKKSDSYSVGLLL
               ... ..|..|| ||||||.|...     | |..|.| .|.| .|
TSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 23667.AA Pkinase 410-556 28 2e-23 83.94 Pfam 62-202 (293) Show / Hide 
Range on Protein: 410-556
Range on HMM: 62-202/293
Sequence Identity: 28% (44 aa)

VVQLYDSYIIENIVGSDRYSVLELEKCSC-----TLDEYLDRKNKDGQF--SEDDKFQIAIKIIDSVNYIHSLNFIHRDIKPQNFLVCLNENEV--EIKL
.|.|||..        ...  . .| | .      | .|. .  ..| |  ||..   ..  |.  ..|.|| ..||||.||.|.|.  |....   .|.
IVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKI

CDFGVSAQIPDNRNSIQTKEFVGNLGYSAPEILNKKDNELKFYTKKSDSYSVGLLL
||||...|.  . |.  .. |.| ..| |||...    . . |..|.| .|.|..|
CDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCIL
Kinase 23667.AA Ciliate-E2a 447-556 31 1e-21 60.69 In-house 91-206 (275) Show / Hide 
Range on Protein: 447-556
Range on HMM: 91-206/275
Sequence Identity: 31% (37 aa)

KNKDGQFSE-DDKFQIAIKII-DSVNYIHSLNFIHRDIKPQNFLVC-LNENE---VEIKLCDFGVSAQIPDNRN-SIQTKEFVGNLGYSAPEILNKKDN-
|... .|.|  .  .|  ... . ..|.|..| .|||.||.|.|   .. |     .||. ||| . .|... .  . .|  .|  || |||.|| |.  
KQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQK--CGTPGYVAPEVLNNKEVL

ELKFYTKKSDSYSVGLLL
. |.|..| |  |.|. .
KHKQYDTKCDMWSCGVIF
Kinase 23667.AA STE 439-556 28 1.6e-21 72.82 In-house 123-258 (359) Show / Hide 
Range on Protein: 439-556
Range on HMM: 123-258/359
Sequence Identity: 28% (41 aa)

TLDEYLDRKNKDGQ-----------FSEDDKFQIAIKIIDS-VNYIHSLNFIHRDIKPQNFLVCLNENEVEIKLCDFGVSAQIPDN--------------
.||. ...| . |.           |.|.    |.  |.    .|.||.. |||||||.| |.        .|||||||..|. |.              
SLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIE

RNSIQTKEFVGNLGYSAPEILNKKDNE-LKFYTKKSDSYSVGLLL
 .. ... |||   . |||.... ..   | |. |.| .|.|...
TMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 23667.AA TKL 439-556 24 1.3e-20 70.9 In-house 124-279 (364) Show / Hide 
Range on Protein: 439-556
Range on HMM: 124-279/364
Sequence Identity: 24% (40 aa)

TLDEYLDRKNKDGQFSEDDKFQIAIKIIDSVNYIHSLN--------FIHRDIKPQNFLVCLNEN-----------EVEIKLCDFGVSAQIPDN-------
.| .||           . ....|. |   .|| || |         ||||.|..| ||  | .           .. .|.|||| |  .  .       
SLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM

----------RNSIQTKEFVGNLGYSAPEILNKKDNELKF-----------YTKKSDSYSVGLLL
          .|. .|   .|.... |||.|....|  .            |..|.| || |..|
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 23667.AA Ciliate-E1 397-550 26 2.1e-20 63.44 In-house 40-202 (202) Show / Hide 
Range on Protein: 397-550
Range on HMM: 40-202/202
Sequence Identity: 26% (45 aa)

NLDNKEIKLKEPLVVQLYDSYIIENIV-GSDRYSVLELEKCSCTLDEYLD----------RKNKDGQFSEDDKFQIAIKIIDSVNYIHSLNFIHRDIKPQ
.. ....|... .  . |  .||. |   .   ... .|.|.|.| .||.           .....||... | ||.. .|| ....|..|.||||||||
DEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQ

NFLVCLNENEVEIKLCDFGVSA-QIPDNRNSIQTKEFVGNLGYSAPEILNK---KDNELKFYTKKSDSY
| |.. . ..  .   |||.|  ..  . ...| | .     |. || .|    . |. . ...||| |
NILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGY--THYYYPPEQYNCPEQEHNKNQKINYKSDIY
S_TKc 23667.AA S_TKc 376-628 20 1.8e-15 49.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 376-628
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

SNYYQILSFGSQGMILATKKVN------------LDNKEIKLKE---PLVVQLYDSYIIENIVGSDRYSVLELEKCSC---TLDEYLDRKNKDGQ---FS
    ...  |. |     ....               .||.. .   | .|.|||..          .  . .| |.    .| .|...... |    |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EDDKFQIAIKIIDSVNYIHSLNFIHRDIKPQNFLVCLNENEVEIKLCDFGVSAQIPDNRNSIQTKEFVGNLGYSAPEILNKKDNELKFYTK-KSDSYSVG
| .   ..  |.. ..|.||...||||.||.| |..      .||.||||...|.         . |.| . | |||.|         |.| |.| .|.|
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCG

-LLLTLIDNYYILNKNASLTFALMTQKQLDKPFEKSNIKINKNSKIYKLIKLLVVSDCDKRVSLYDIVE----KSGYQFF
 .|  ..  |         . ..| .| .              .    .|. . . | .|| .  .. .        ..|
CILYEMLCGYPPFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23667.AA ULK 471-556 28 1.5e-13 44.52 In-house 141-242 (324) Show / Hide 
Range on Protein: 471-556
Range on HMM: 141-242/324
Sequence Identity: 28% (29 aa)

YIHSLNFIHRDIKPQNFLVCLNENE---------VEIKLCDFGVSAQIPDN-RNSIQTKEFV------GNLGYSAPEILNKKDNELKFYTKKSDSYSVGL
..|. | ||||||||| |.  .            . .|..||| . .. .|  .  .....|      |   | ||.||...  . ..|..|.| .|.| 
ELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC

LL
..
IF
Kinase 23667.AA C8 376-406 54 8.9e-11 33.74 In-house 1-30 (226) Show / Hide 
Range on Protein: 376-406
Range on HMM: 1-30/226
Sequence Identity: 54% (17 aa)

SNYYQILSFGSQGMILATKKVNLDNKEIKLK
.| .|.||||. ||.|..|.|. ||.|| ||
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLK