Gene 15780 (Tetrahymena)

15780

Species: Tetrahymena
Alias: 15780, TTHERM_01365650, 719, PreTt15780, 349.m00007
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
15780.AA Protein None 1182 None Fasta, JSON
15780.kin_dom Protein Kinase Domain None 215 None Fasta, JSON
15780.kin_dom2 Protein Kinase Domain None 177 None Fasta, JSON
15780.NA RNA None 3549 None Fasta, JSON

Protein domain

Protein domains of 15780.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15780.AA C8 42-253 60 1.1e-117 397.26 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-253
Range on HMM: 1-226/226
Sequence Identity: 60% (136 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLMEEQE---DDGNDIIVQTGVKSFFVMEME
|.||.|||.|||..||||.|.|.||...|||. ..|..|...|||..|||||.|.|.|..|.||.|||||.|.|..   ...|..|||| .||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEKNLKQLFEILRKQQVPPPKQMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDSYFAP
|||.|||||.. .|..|....|.||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..|||    ||. ||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEEG------QSRIQSDLFSLGLVL
|.|..      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 15780.AA Ciliate-C8 51-253 55 1.9e-116 393.16 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-253
Range on HMM: 1-238/238
Sequence Identity: 55% (131 aa)

GAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLM-EEQEDD--GNDIIVQTGVK---SFFVMEMELCEKN-
||...||||.|.||||.|||||. ..|....|..|...|||||...|.|..|.|.|||||||| |....|  |||.|||| .|   ||||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFEILRKQQVPPPKQMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDSY---
 |||.|. .||.|..| .|||||||||||...|.||..|||||||||.|||||....|...|||||      .||||...|.|| ..|||  ||| |   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEEGQSRIQSDLFS-------LGLVL
        ||||||..|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 15780.AA C2 51-266 39 1.5e-69 236.67 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-266
Range on HMM: 1-245/245
Sequence Identity: 39% (97 aa)

GAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLMEEQEDD----GNDIIVQTGV--------KSFFVMEME
|| .|||||.| ||||.||||     .. | || ... |||....... . ....||..||| .....|     ......           |.|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEKNLKQLFEILRKQQVPPPKQMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYGFSIKLCD----------LGFASAVSKSKS--FMSK-K
 |..|||| |. .|||.  | .|||.|.||||. . | || ..| ||||||.|||.  ...    |||||          . |||.....||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDSY----FAPEVEEGQSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||...  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 15780.AA Pkinase 42-256 22 2.7e-27 97.58 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-205/293
Sequence Identity: 22% (50 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLK-KEYEMLQKFSQSQFLVNVYDCFYLMEEQEDDGNDIIVQTGVKSFFVMEMELC
..  . . ||... | |... . ...||.| .  ......  .. ..  | ...... .. . |  ||.|.                  |.   | ||.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-----------------KDHIYMVMEYC

EKN--LKQLFEILR--KQQVP--PPKQMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDSYFA
|.   .  ||....  .. .   .... | ..  |...||. .| ..|.|||.||.|.|.    . . ..|.|| |.|      ..  ...  ||  | |
EGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMA

PEV--EEGQSRIQSDLFSLGLVLLEL
|||  .       .| .|.|..| |.
PEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 15780.AA CMGC 42-217 15 1.7e-25 79.92 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-217
Range on HMM: 1-256/513
Sequence Identity: 15% (40 aa)

FQNFEYLSSGAYSLVLKAYN--------------SKQNRQVALKFLGSSNQEDNNGI---------ESLKKEYEMLQKFS----------------QSQF
... ... .|.|. | |...               . |..||.| . .   ... .           .   | ..|....                .   
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLME--EQEDDGNDIIVQTGVKSFFVMEMELCEKNLKQLFEILR------KQQVPPPKQ------------MKEII-----AIQMIEGLN--
.|. ||.||  .   .|...  || .      . . .|.....|.|. .  .      ...  .. .             | ..     . |...||.  
IVKLYDIFYHKNSDGNEYEDKHII-SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

NLHVKN--IMHRDIKPQNFLVCPSEEY----------------GFSIKLCDLGFASAVSK
 .| ..  |.|||.||.| |...  |.                 . .|.|| |.| ....
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 15780.AA STE 42-256 19 3.4e-24 82.41 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-261/359
Sequence Identity: 19% (54 aa)

FQNFEYLSSGAYSLVLKAYNS------KQNRQ---------VALKFLGSSNQE----------DNNG----IESLKKEYEMLQKFSQ-SQFLVNVYDCFY
... | . .||.  | ||.|       | ...         .| | .  .|..          ..|     .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEQEDDGNDIIVQTGVKSFFVMEMELCE-KNLKQLFEILRKQQVPPPKQM--------KEI--IAIQMIEG-LNNLHVKNIMHRDIKPQNFLVCPSEE
   .           .. ..   . ||...   | .. .   . . | ...         ..|  |. | ..| |. || ..|.||||||.| |.     
KEGHN----------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----

YGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDSYFAPEVEEG-QSR------IQSDLFSLGLVLLEL
    .|||| |... ...                 ..   .  ||  . |||| .. ..       ...|  |||....|.
----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 15780.AA Ciliate-E1 48-247 22 4.3e-24 75.56 In-house 1-202 (202) Show / Hide 
Range on Protein: 48-247
Range on HMM: 1-202/202
Sequence Identity: 22% (50 aa)

LSSGAYSLVLKAYNSKQN-RQVALKFLGSSNQEDNNGIESLKKEYE-MLQKFSQSQFLVNVYDCFYLMEEQEDDGNDIIVQTGVKSFFVMEMELCEKNLK
...| .|.|.||.. ..| .|||.|.     ... | .....|||  ... | . . .....|.... . .               ...  .|.|...||
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNY---------------ICIIIFECCCCSLK

QLFE---------ILRKQQVPPPKQMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYGFSIKLCDLGFAS-AVSKSKSFMSKKGTDSYFAPEV
. ..         .....|     | |. |..|.|.||. || .||.|||||||| |.. ...| ..    |.| ..   ..... . .||  .|..|. 
DYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYYPPE

E--------EGQ--SRIQSDLF
.        . .    ..||..
QYNCPEQEHNKNQKINYKSDIY
Kinase 15780.AA Ciliate-E2 137-256 23 3.3e-22 73.0 In-house 113-289 (365) Show / Hide 
Range on Protein: 137-256
Range on HMM: 113-289/365
Sequence Identity: 23% (44 aa)

MELCEK-NLKQLFEILRKQQVPPPK-----QMKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCPSEEYGFSIKLCDLGFA
||.|.  .|... .. .|..   ..      .|||  |  | ..               .|. || || |.||||||.| |.         ||..|.|..
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLS

SAVSKS----------KSFMSKK-----------------------GTDSYFAPEVEEGQSR----------IQSDLFSLGLVLLEL
  ....          | .|  |                       ||  | |||. .|..            ..|..||| .| |.
KKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 15780.AA S_TKc 42-320 21 5.1e-22 80.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-320
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKFSQSQFLVNVYDCFYLMEEQEDDGNDIIVQTGVKSFFVMEMELCE
..  . . .||.. | |... | .|.||.| .           |....| ..|.|  .  ..|. ||.|.                   ... | ||.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD------------------DHLYMVMEYCD

KNLKQLFEILRKQQVP------PPKQMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYGFSIKLCDLGFASAVSKSKSFMSKKGTDSYFAPEV
 .|  ||....|.. .      |. . . ... |....|. .| ..|.|||.||.| |..        ||.|| |.|  .      ..  ||  | ||||
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEV

EEGQSRIQSDLFSLGLVLLELDNLKTLNENWIDTKIRYYLFNGENITKEKYQIDKNSNIYKIAQICLKPKYLDRTTAGELLT--------QLI
  | ..  .|  |.| .| |.   ... .   . ..   .                .    . . ||.    .| || |.|.        . .
L-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15780.AA CAMK 47-235 15 5e-21 63.86 In-house 1-291 (425) Show / Hide 
Range on Protein: 47-235
Range on HMM: 1-291/425
Sequence Identity: 15% (46 aa)

YLSSGAYSLVLKAYNSKQN------------RQVALKF-------------------LGSSNQED------NNGIESLKKEYEMLQKFS------QSQFL
 | .|... | .... . .            ..|| |.                   .  |.. .       .  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY------------LMEEQEDDGNDIIVQTGVKSFFVMEM---ELCEKN--LKQLFEILRKQ-----------QVPPPKQMKEIIAI----QMI
.. |. .               . |        |    .....| |   |.|.    .  ||. ....            |   . ..|  |     |..
IKLYEVYEDPHYFKNTNDYET-SKQ--------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQIC

EGLNNLHVKNIMHRDIKPQNFLVCPSEEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDSYFA-P
.... .| .||.|||.|| | |.. ...               . ||..| |||  . ...                         .    || .| | |
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

EV
||
EV
Kinase 15780.AA Ciliate-E3 166-257 36 1.1e-19 58.28 In-house 108-202 (202) Show / Hide 
Range on Protein: 166-257
Range on HMM: 108-202/202
Sequence Identity: 36% (35 aa)

IAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYG-FSIKLCDLGFASAVSKSK--SFMSKKGTDSYFA-PEVEE-GQSRIQSDLFSLGLVLLELD
|.||.|.|.  .| ||| | ||||.|.||  .....   || ||.| .   .| |  .     |. ...| ||. . .|    ||. |.| |...| 
ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 15780.AA TKL 166-256 21 1.9e-19 66.72 In-house 137-282 (364) Show / Hide 
Range on Protein: 166-256
Range on HMM: 137-282/364
Sequence Identity: 21% (32 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCPSEE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DSYFAPEV-----------------EEGQSRIQSDLFSLGLVLLEL
  . ||||                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 15780.AA TyrKc 42-319 18 2e-09 -70.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 42-319
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQEDNNGIESLKKEYEMLQKF-SQSQFLVNVYDCFYLMEEQEDDGNDIIVQTGVKSF-----FVM
 .  . | .||.  | |.  .   .||| | | ..       .| . .| ... |.  . . .|. | .    ...               |       .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---------------FMYIEPLMI

EMELCEK-NLKQLFEILRKQQVPPPKQMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSEEYGFSIKLCDLGFASAVSKS-------KSFMSKK--
 ||.... .||.     |..    . . .  ...|  .| . || ||. |||.   | ||         .| .| | . ..          .  ..|.  
VMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

GTDS-----YFAPEVE-EGQSRIQSDLFSLGLVLLELDNL-KTLNEN-----WIDTKIRYYLFNGENITKEKY-----QIDKNSNIYKIAQICLKPKYLD
|...       |||.  .|   ..|| .| | .. |.  . ..  ..       .. .. |. .|.   . ..          . .|.| . | . .  |
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RTTAGELLTQL
| |  |.  ..
RPTFSEIHECF
Kinase 15780.AA Ciliate-E3 42-111 24 3e-06 15.88 In-house 1-72 (202) Show / Hide 
Range on Protein: 42-111
Range on HMM: 1-72/202
Sequence Identity: 24% (18 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALKFLGSSNQED---NNGIESLKKEYEMLQKFSQSQFLVNVYDCFY
.     |  | ...| ||... .|..|| | .  .|| .         . .|  . |..  ||..| ..| .|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYY
Kinase 15780.AA Ciliate-E2 42-116 14 1.9e-05 14.64 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (15 aa)

FQNFEYLSSGAYSLVLKAYNSKQNRQVALK-----------------FLGSSNQEDNNGIESLKKEYEMLQ---------------KFSQSQFLVNVYDC
.   . . .|... | |. . |...|.|.|                 ..   ..  .|.||..|.|  ...               .. .. .... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYLMEEQ
|. . ..
FQEKDDN
Kinase 15780.AA C8 400-563 47 3.3e-76 259.49 In-house 1-186 (226) Show / Hide 
Range on Protein: 400-563
Range on HMM: 1-186/226
Sequence Identity: 47% (89 aa)

SNNFQIISFGNFGMVLATKKAKLDNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGTDRYSVFELEKCS-----------CSLDE-
.||||..|||..||||..|..| ||.|||||.||....| |||..|||.....|.|.|.||.|..|. .. ..|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQNHDGQLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQA-EIKLCDFGLSAQIPDNQDSIQT
          |.||.|...|.....|..||||.||.|||||..||.||||||.||||.||...  ||||||||...|...|...||.
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQS
Kinase 15780.AA Ciliate-C8 409-575 33 3.3e-76 259.51 In-house 1-238 (238) Show / Hide 
Range on Protein: 409-575
Range on HMM: 1-238/238
Sequence Identity: 33% (80 aa)

GNFGMVLAT------KKAKLDNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGTDR-----------------YSVFELEKCS--C
|.|||||..      .| .|...|.|.||||...|..|.....|||....|.|||.||......    ..                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLER-QNHDGQLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLD-GKQAEIKLCD------FGLSAQIPDNQD---------SIQT---
.|..|..| .. ....... |..||||.||||||.|.|||.||||||.||||..| ..| .|||||      ||...|.|.|..         ..|.   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

-------------------IESDSYS-------VGLLL
                   |.|| .|       |||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 15780.AA C2 409-563 27 7.2e-40 133.92 In-house 1-195 (245) Show / Hide 
Range on Protein: 409-563
Range on HMM: 1-195/245
Sequence Identity: 27% (54 aa)

GNFGMVLATKKAKLDNKEIVLKIQKIED-----EQLIQNEISIMQKLK-EPLVVQLYDSYIIENTLGTD-------------R----------YSVFELE
| ||.|| .   | .|....||||....     .. .|.|..||....  |.....|...    .   |             .            |.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLERQNHDG-QLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQA-EIKLCD----------FGLSAQIPDNQDSIQT
.|.. |  |..|. ..  ..... | ..|||..||.||.|.|.|.||||||.|||. .| ..   |||||          |  .  .. |.  | .
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHF
Kinase 15780.AA CAMK 405-560 18 4.2e-29 90.36 In-house 1-252 (425) Show / Hide 
Range on Protein: 405-560
Range on HMM: 1-252/425
Sequence Identity: 18% (47 aa)

IISFGNFGMVLATKKAKLDN-----------KEIVLKI---QKIE----------------------------DEQLIQNEISIMQK-------LKEPLV
..  |.|| |   .  .  .           ..   ||   .|.                             |.. ...||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYIIEN---------TLGT-----DRYSVFEL---EKCSC-----SLDEYLERQNH------------DGQLNEDNKFQIAIQIIDSVNYIHQFN
..||. |  ..         |  .     |.. .. .   | ||       | .|. .. .            .| ..|.   ..  ||.. |.|.|. |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVYLDG--------------KQAEIKLCDFGLSAQIPDNQDS
|.|||.|||| |.  ..              ... ||..|||...........
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENN
Kinase 15780.AA Ciliate-E1 406-592 24 2.5e-27 86.16 In-house 1-202 (202) Show / Hide 
Range on Protein: 406-592
Range on HMM: 1-202/202
Sequence Identity: 24% (52 aa)

ISFGNFGMVLATKKAKLDNKEIVLKIQKIEDEQ-------LIQNEISIMQKLKEPL-VVQLYDSYIIENTLGTDRYSVFELEKCSCSLDEYLE-------
|. | |..|.  |. .  .... .||..... .       .|.....||. .|.   ..|..| ..|.. ...    .. .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYIC----IIIFECCCCSLKDYLQNHNRLEY

---RQNHDGQLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSA--QIPDNQDSIQTIESDSYSVGLLLA---LLDNYQ
    |. ..|.....| ||..|.|| ....||.|||||||||.| |.. . ..   ..||||.|   .  .||.. .. . ..|.    .    .  |..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKN

DLKTNTTSIF
.  .  . |.
QKINYKSDIY
Kinase 15780.AA CMGC 400-551 17 8.3e-23 70.96 In-house 1-251 (513) Show / Hide 
Range on Protein: 400-551
Range on HMM: 1-251/513
Sequence Identity: 17% (44 aa)

SNNFQIISFGNFGMVLATKKAKLD-------------NKEIVLKIQKIEDEQLIQ---------------NEISIMQKLK-----------------EPL
  . . |  | .|.|   .  . .             |... .|. | .    .|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYIIENTLGT-----------DRYSVFELEKCSCSLDEYLERQN--HDG----QLNEDN------------KFQIA------IQIIDSVN--YI
.|.|||..  .|. |.           ...  .  | . ..| .|.....  . |     |.|              .  .        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQFN--IIHRDIKPENFLVYLDGKQ-----------------AEIKLCDFGLS
|. .  |||||.|||| |.  ...                   ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 15780.AA STE 401-554 23 8.1e-21 70.32 In-house 1-197 (359) Show / Hide 
Range on Protein: 401-554
Range on HMM: 1-197/359
Sequence Identity: 23% (49 aa)

NNF-QIISFGNFG-MVLATKKAKL-------------DNKEIVLKIQKI--------------------EDEQLIQNEISIMQKLK--EPLVVQLYDSYI
  . ..|  |.||  ..| .. .               .. .  |. ..                    |..| |..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEN--TLGTDRYSVFELEKCSC-SLDEYLE-RQNHDGQLN----------EDNKFQIAIQIIDS-VNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDF
 |.  .   |   .. .| ..  |||. .. .  . ..||          |.    |. ||.    .|.|. .|||||||| | |.        .|||||
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDF

GLSAQI
|...|.
GVCGQL
Kinase 15780.AA S_TKc 400-646 22 2e-20 75.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 400-646
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

SNNFQIISFGNFGMVLATKKAKLDNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGTDRYSVFELEKCSC---SLDEYLERQNHDG
    ..|  | || |   .. | ....  .|| |    . |..||.|..| . | .|.|||..       .. | |.|.  |.    .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEY--CDGDLGDLFDYIKKRGRHG

Q---LNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNQDSIQTI-------------ESDSYSVGLLLALLDN
    ..|     .. ||.. ..|.|. .|||||.|||| |.       .||.|||||..|.      . |              ..| .|.| .|. .  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLC

----YQDLKTNTTSIFALMTQMQLDKPFEKSNIQITKNSEIYKFINLLVVSDSDQRASLYDIVK-----QSDEIF
    ..    .   .| ..                   .|   ||. . . | ..| .  .. .      ... |
GYPPFP----QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15780.AA Pkinase 400-558 27 9.6e-19 67.35 Pfam 1-167 (293) Show / Hide 
Range on Protein: 400-558
Range on HMM: 1-167/293
Sequence Identity: 27% (50 aa)

SNNFQIISFGNFGMVLATKKAKLDNKE--IVLKIQKIEDEQLIQN-------EISIMQKLKEPLVVQLYDSYIIENTLGTDRYSVFELEKCSC-----SL
    ..|  |.|| |   .|..  . .   ..|| | ..|   ..       ||.||..|. | .|.|||..        ...  . .| | .     .|
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL

DEYLERQNHDGQL--NEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEI----KLCDFGLSAQ--IPDNQ
 .|...   .| .   |.    .. ||.  ..|.|. .|||||.||||.|  .| .. .|    |.|||||..|  .  |.
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFDY-NNS
Kinase 15780.AA Ciliate-E2 400-562 20 1.3e-17 57.07 In-house 1-214 (365) Show / Hide 
Range on Protein: 400-562
Range on HMM: 1-214/365
Sequence Identity: 20% (49 aa)

SNNFQIISFGNFG-----MVLATKKA-----------------KLDNKEIVLKIQKIEDEQLIQNEISIMQ----------------KLKEPLVVQLYDS
 .  ..| .||||      |  ..|                  | ..|.. .||.|  . . | .||.||.                .|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI-------------IEN-TLGT-----DRYSVFELEKCSCSLDEYLERQNHDGQLNEDNKFQIAIQIID---------------SVNYIHQFN-IIHRD
..             ..  .|       .  . .|.|            .   ....|    .|  ||..                ..|.|. | |||||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRD

IKPENFLVYLDGKQAEIKLCDFGLSAQIPDNQDSIQ
||||| |.        ||..||||| .. |... ..
IKPENILF--------IKIIDFGLSKKYDDDNQNRT
Kinase 15780.AA TKL 484-551 27 2.9e-14 47.8 In-house 124-201 (364) Show / Hide 
Range on Protein: 484-551
Range on HMM: 124-201/364
Sequence Identity: 27% (24 aa)

S-LDEYLERQNHDGQLNEDNKFQIAIQIIDSVNYIHQFN--------IIHRDIKPENFLVYLDGK-----------QAEIKLCDFGLS
| |. ..           . ....|..|   .|| |. |        |||||.|..| ||  ...           .  .|.||||||
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS
Kinase 15780.AA Ciliate-E3 479-551 44 6.2e-14 40.11 In-house 84-153 (202) Show / Hide 
Range on Protein: 479-551
Range on HMM: 84-153/202
Sequence Identity: 44% (33 aa)

EKCSC-SLDEYLERQNHDGQLNEDNKFQIAIQIIDSVNYIHQFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLS
| ||  .| .|.  ||    . .    .|.|||| ..  ||. |||| ||||.|.||     |  || ||||.|
EYCSNGDLYHYIKQQN----KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGES
Kinase 15780.AA C8 564-575 66 0.000304 10.76 In-house 215-226 (226) Show / Hide 
Range on Protein: 564-575
Range on HMM: 215-226/226
Sequence Identity: 66% (8 aa)

IESDSYSVGLLL
|.||..||||.|
IQSDLFSVGLVL
Kinase 15780.AA Ciliate-E3 565-579 53 0.162871 0.84 In-house 188-202 (202) Show / Hide 
Range on Protein: 565-579
Range on HMM: 188-202/202
Sequence Identity: 53% (8 aa)

ESDSYSVGLLLALLD
||| ||||  . .| 
ESDYYSVGAVFCQLC
LRR_RI 15780.AA LRR_RI 688-715 21 0.00443 15.15 SMART 1-28 (28) Show / Hide 
Range on Protein: 688-715
Range on HMM: 1-28/28
Sequence Identity: 21% (6 aa)

NYNIVTINLGNNSINDKDLKDLSTAIAQ
| .. ...|.|| . |.  . |. ....
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 15780.AA LRR_RI 718-745 28 0.02854 9.44 SMART 1-28 (28) Show / Hide 
Range on Protein: 718-745
Range on HMM: 1-28/28
Sequence Identity: 28% (8 aa)

NITSLALYLRNNSIGVLGAKDLGTAIAY
| . . |.|.|| .|  |.. |  ... 
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 15780.AA LRR_RI 752-775 25 0.020798 10.41 SMART 5-28 (28) Show / Hide 
Range on Protein: 752-775
Range on HMM: 5-28/28
Sequence Identity: 25% (6 aa)

LTLDLEYNSIGTLGAKYLGAAISQ
..|.|..| .|  |.. | .....
RELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 15780.AA LRR_RI 868-895 17 0.449386 0.99 SMART 1-28 (28) Show / Hide 
Range on Protein: 868-895
Range on HMM: 1-28/28
Sequence Identity: 17% (5 aa)

QFNIYSFIQSDNGIATQGAKYLAKSLAQ
  ..     |.|..   |.. |...|..
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 15780.AA LRR_RI 898-925 25 0.048892 7.79 SMART 1-28 (28) Show / Hide 
Range on Protein: 898-925
Range on HMM: 1-28/28
Sequence Identity: 25% (7 aa)

NITSLELYLSDNAIATQGAQYIVKSIAQ
| . .||.||.| .   |.. . .....
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 15780.AA LRR_RI 1069-1096 32 0.000265 21.54 SMART 1-28 (28) Show / Hide 
Range on Protein: 1069-1096
Range on HMM: 1-28/28
Sequence Identity: 32% (9 aa)

NIKILELNLQYNSIGDQGAKDLGIAIAQ
| ...||.|..| .|| |.. |  ....
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 15780.AA LRR_RI 1099-1126 32 0.316991 2.06 SMART 1-28 (28) Show / Hide 
Range on Protein: 1099-1126
Range on HMM: 1-28/28
Sequence Identity: 32% (9 aa)

NVMKLIIDLCNNSIDDEGAKDLCTEIAQ
|   . ..| || . |||.. ||  ...
NCSLRELWLSNNKLGDEGCRQLCEGLKH