Gene 5060 (Tetrahymena)

5060

Species: Tetrahymena
Alias: TTHERM_01461130, PreTt05060, 5060, 79, 401.m00007
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
5060.AA Protein None 1709 None Fasta, JSON
5060.kin_dom Protein Kinase Domain None 218 None Fasta, JSON
5060.kin_dom2 Protein Kinase Domain None 202 None Fasta, JSON
5060.NA RNA None 5130 None Fasta, JSON

Protein domain

Protein domains of 5060.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5060.AA C8 42-256 58 8.9e-117 394.25 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 58% (133 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEME
|.||.|||.|||..||||.|.|..|...|||. ..|..|...|||..||||..|.|. ..|.||.|||||.|.|........|...||| .||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKSKS-FVSKK----GTDAYFAP
||| ||||| | .|..|....||.|||||||||.|.|..|.||||||||||.||||| .|.|||.|||||.||||..||.|| . |||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEQG------KSRIQSDLFSLGLVL
|.|..      ..||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 5060.AA Ciliate-C8 51-256 53 8.10000000001e-115 387.74 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 53% (128 aa)

GAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVK---SFFVMEMELCEYN-
||...||||.|.||.|.|||||. ..|....|..|...||||....|....|.|.||||||||||....|||||...||| .|   ||||||||.|. | 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCD------LGFASALSKSKS-FVSKK--GTDAY---
 |||..| .||.|..| ...|||||||||...|.||..|||||||||.||||| .|.|...|||||      .||||.|.|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEQGKSRIQSDLFS-------LGLVL
        ||||||...||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 5060.AA C2 51-269 40 4.6e-68 231.56 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 40% (99 aa)

GAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEE-QEDKDDDGNNIVVQTGV--------KSFFVMEME
|| .|||||.| ||.|.||||     .. | || ... |||....... . ....||..||| .. .|| | | ... ..           |.|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQ-ECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCD----------LGFASALSKSKS--FVSK-K
 |. |||| .. .|||.  | ...|.|.||||. . | || ..| ||||||.|||.  .|.    |||||          . |||.|...||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEQGKSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||.|.  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 5060.AA Pkinase 42-259 23 7.7e-29 103.05 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 23% (53 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLK-KEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEM
..  . . ||... | |... .  ..||.| .  ..|...  .. ..  | ...... .. . |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEYNLKQLLDIL-----RKQQVP--PEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASA--LSKSKSFVSKKGTD
|.||  |. ..|       ... .   .|.|.| ..  |...||. .| ..|.|||.||.|.|. .  . . ..|.|| |.|    . ..  . .  || 
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

AYFAPEV--EQGKSRIQSDLFSLGLVLLEL
 | ||||  .. .    .| .|.|..| |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 5060.AA STE 42-259 19 2.1e-27 93.85 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 19% (56 aa)

FQNFEYLSSGAYSLVLKAYNS------KQKRQ---------VALKFLGSSNEE----------DNNG----IESLKKEYELLQKFSK-SQFLVNVYDCFY
... | . .||.  | ||.|       | ...         .| | .  .|..          ..|     .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEQEDKDDDGNNIVVQTGVKSFFVMEMELCE-YNLKQLLD-ILRKQQVPP----------EKEIKEIIAIQMIEG-LNNLHVKNIMHRDIKPQNFLVC
   .              .. ..   . ||...   | ....    ...  .          |..|. .|. | ..| |. || ..|.||||||.| |. 
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIA-YICRQILKGLLYYLHSHHIIHRDIKPANILL-

SSQEYGFSIKLCDLGFASALSK-----------------SKSFVSKKGTDAYFAPEV-EQGKSR------IQSDLFSLGLVLLEL
        .|||| |... |..                 ..   .  ||  . |||| .|...       ...|  |||....|.
--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 5060.AA CMGC 42-220 15 3.9e-27 85.43 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 15% (41 aa)

FQNFEYLSSGAYSLVLKAYN--------------SKQKRQVALKFLGSSNEEDNNGI---------ESLKKEYELLQKFS---------------KSQF-
... ... .|.|. | |...               . ...||.| . .   ... .           .   | ..|....               |    
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEMELCEYNLKQLLDILR------KQQVPPEKE------------IKEII-----AIQMIEGLN-
.|. ||.||  ... . ..| . |  .      . . .|.....|.|...  .      ...  .| .            || ..     . |...||. 
IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPQNFLVCSSQEY----------------GFSIKLCDLGFASALSK
  .| ..  |.|||.||.| |...  |.                 . .|.|| |.| ....
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 5060.AA S_TKc 42-323 22 2.8e-24 87.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKFSKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSFFVMEME
..  . . .||.. | |... | .|.||.| .           |....| ..|.|  .  ..|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEYNLKQLLDILRKQQVP------PEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKSKSFVSKKGTDAYFA
.|. .|  |.|...|.. .      || ... ... |....|. .| ..|.|||.||.| |...       ||.|| |.|  |       .  ||  | |
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA

PEVEQGKSRIQSDLFSLGLVLLELDNLKTLNENWIDFETKKYLFDGQEIPNEKYEIDKKSNIYKIAQICLKHRYLDRTTAGELLS--------QLI
|||  | ..  .|  |.| .| |.   ... .   .... | .                .    . . ||.    .| || |.|         . .
PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5060.AA Ciliate-E2 140-259 24 1.3e-23 77.89 In-house 113-289 (365) Show / Hide 
Range on Protein: 140-259
Range on HMM: 113-289/365
Sequence Identity: 24% (46 aa)

MELCEY-NLKQLLDILRKQQ--------VPPEKEIKEI--------------IAIQMIEGLNNLHVKN-IMHRDIKPQNFLVCSSQEYGFSIKLCDLGFA
||.|.. .|.... . .|..         . |||||.|              .. ..|..|. || || |.||||||.| |.         ||..|.|..
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLS

SALSKS----------KSFVSKK-----------------------GTDAYFAPEVEQGKSR----------IQSDLFSLGLVLLEL
  ....          | .   |                       ||  | |||. .||.            ..|..||| .| |.
KKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 5060.AA CAMK 47-256 14 2.4e-23 71.48 In-house 1-324 (425) Show / Hide 
Range on Protein: 47-256
Range on HMM: 1-324/425
Sequence Identity: 14% (50 aa)

YLSSGAYSLVLKAYNSKQK------------RQVALKF-------------------------LGSSNEEDNNGIESLKKEYELLQKFSK------SQFL
 | .|... | .... . .            ..|| |.                          ....... .  .....|.|...| ..         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY------------LMEEQEDKDDDGNNIVVQTGVKSFFVMEM---ELCEYN--LKQLLDILRKQ---------------QVPPEKEIKEIIAI
.. |. .               . |           |    .....| |   |.|.    .  |.| ....                  .|.| . ..  
IKLYEVYEDPHYFKNTNDYET-SKQ-----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-

QMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYG-------------FSIKLCDLGFASALSKSK------------------------SFVSKKGTDAYF
|...... .| .||.|||.|| | |.... .               . ||..| |||  . ...                         .    || .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVEQG-------------KSRI--QSDLFSLGLVL
| ||| .|             |  .  ..|  |.| .|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 5060.AA Ciliate-A1 140-259 28 1.2e-20 67.03 In-house 80-221 (301) Show / Hide 
Range on Protein: 140-259
Range on HMM: 80-221/301
Sequence Identity: 28% (43 aa)

MELCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKSK-----------------
|| |.|..  | .         . || ||   |.|||.  .| .||.|||.|||| |.     .    |.||||    |  ..                 
MEYCQYGN--LFNYCYQNDYMKKEEIYEIC-YQIIEGYADIHDHNILHRDLKPQNILIHFDDKW----KICDLGMSKQLEQNQDCCDDVNGCSFSKQVNK

--SFVSKKGTDAYFAPEV----------EQGKSRIQSDLFSLGLVLLEL
    ..| |.  | .||             .|   |||..|||.....|
HYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL
Kinase 5060.AA Ciliate-E1 135-250 26 1.8e-19 60.38 In-house 71-202 (202) Show / Hide 
Range on Protein: 135-250
Range on HMM: 71-202/202
Sequence Identity: 26% (36 aa)

FFVMEMELCEYNLKQLLD---------ILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFAS--ALSKSKS
...  .|.|...||. |.         .....|     . |. |..|.|.||. || .||.|||||||| |.... .| ..    |.| ..   ... ..
ICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQ

FVSKKGTDAYFAPEV---------EQGKSRIQSDLF
 . |  |. |  ||.         .. |  ..||..
CQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 5060.AA TKL 169-259 21 4.2e-19 65.44 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 21% (31 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCSSQE----------YGFSIKLCDLGFASALSKSKS--------------------FVSKKGT
.|...  |.| ||         ..| |||.|..| || .  .          .   .|.||.|..  .|.|..                      .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EQGKSRIQSDLFSLGLVLLEL
 .. ||||                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 5060.AA TyrKc 42-322 19 5.5e-10 -61.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 42-322
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALKFLGSSNEEDNNGIESLKKEYELLQKF-SKSQFLVNVYDCFYLMEEQEDKDDDGNNIVVQTGVKSF-----
 .  . | .||.  | |.  .   .||| | | ..       .| . .| ... |.  . . .|. | .    ...                  |     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------------------FMYIEP

FVMEMELCEYNLKQLLDILRKQQVPPEKEIKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCSSQEYGFSIKLCDLGFASALSKS-------KSFVSKK
  . ||....    |.| ||| .     . .  ...|  .| . || ||. |||.   | || . .     .| .| | . ..          .  ..|.
LMIVMEYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKE

--GTD-----AYFAPEVE-QGKSRIQSDLFSLGLVLLELDNL-KTLNEN-----WIDFETKKYLFDGQEIPNEKY--EI---DKKSNIYKIAQICLKHRY
  |..        |||.   ||  ..|| .| | .. |.  . ..  ..       ..|  .|. .|   |  ..  ..      . .|.| . | ..  
HKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

LDRTTAGELLSQL
 || |  |. ...
EDRPTFSEIHECF
Kinase 5060.AA Ciliate-E1 48-112 23 1.8e-08 24.18 In-house 1-66 (202) Show / Hide 
Range on Protein: 48-112
Range on HMM: 1-66/202
Sequence Identity: 23% (16 aa)

LSSGAYSLVLKAYNSKQK-RQVALKFLGSSNEEDNNGIESLKKEYE-LLQKFSKSQFLVNVYDCFYL
...| .|.|.||.. ... .|||.|.      .. | .....|||  ... | | . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 5060.AA Ciliate-E2 42-116 14 4.1e-05 13.48 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (15 aa)

FQNFEYLSSGAYSLVLKAYNSKQKRQVALK-----------------FLGSSNEEDNNGIESLKKEYELLQ---------------KFSKSQFLVNVYDC
.   . . .|... | |. . |...|.|.|                 ..   .   .|.||..|.|  ...               .. .. .... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYLMEEQ
|. . ..
FQEKDDN
Kinase 5060.AA Ciliate-A1 42-79 23 0.002536 7.09 In-house 1-39 (301) Show / Hide 
Range on Protein: 42-79
Range on HMM: 1-39/301
Sequence Identity: 23% (9 aa)

FQNFEYLSSGAYSLVLKAYNSK-QKRQVALKFLGSSNEE
.     . .| .. |..||..  ||. ...| .  .| |
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE
Kinase 5060.AA Ciliate-E1 261-298 20 0.00902 5.41 In-house 160-202 (202) Show / Hide 
Range on Protein: 261-298
Range on HMM: 160-202/202
Sequence Identity: 20% (9 aa)

NLKTLNENWIDFETKKYLFDGQEI-----PNEKYEIDKKSNIY
.......  .. .|..|    |       .|....|..||.||
KNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 5060.AA C8 403-603 46 3.7e-98 332.41 In-house 1-226 (226) Show / Hide 
Range on Protein: 403-603
Range on HMM: 1-226/226
Sequence Identity: 46% (106 aa)

QNDFQILSFGNYGMVLATKKAMLNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGPDRYSVFELEKCS-----------CSLDE--
 |.||.||||.|||||..|..  |.|||||.||....| |||..|||.....|.|.|.||.|..|. .....|.|||.||||           |...|  
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

---------YLERSNKDGQINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQA-EIKLCDFGLSAQIPDNSDSIQTIEP--IGNFGYSAP
         |.|| ||..|........||||.||.|||||..||.||||||.||||.||...  ||||||||...|...| ..||...   .|...|.||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EILNKKDNELKIYTKKSDSYSVGLLL
||..|.||..|.|...||..||||.|
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 5060.AA Ciliate-C8 412-603 39 1.6e-91 310.34 In-house 1-238 (238) Show / Hide 
Range on Protein: 412-603
Range on HMM: 1-238/238
Sequence Identity: 39% (93 aa)

GNYGMVLAT------KKAMLN-KEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGPDR-----------------YSVFELEKCS--C
|..||||..      .|  |. .|.|.||||...|..|.....|||....|.|||.||......   ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLER-SNKDGQINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLD-GKQAEIKLCD------FGLSAQIPDNSD---------SIQTIEP
.|..|..|  .|... .... ..||||.||||||.| |||.||||||.||||..| ..| .|||||      ||...|.|.| .         ..|.|| 
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNFGYSAPEILNK-KDNELKIYTKKSDSYSVGLLL
  .||.||.|||...| ......|..||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 5060.AA C2 412-616 27 4.2e-41 138.2 In-house 1-245 (245) Show / Hide 
Range on Protein: 412-616
Range on HMM: 1-245/245
Sequence Identity: 27% (69 aa)

GNYGMVLATKKAMLNKEIVLKIQKIED-----EQLIQNEISIMQKLK-EPLVVQLYDSYIIENTLGPD-------------R----------YSVFELEK
|  |.|| .     |....||||....     .. .|.|..||....  |.....|...    .   |             .            |.|.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSCSLDEYLERSNKDG-QINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQA-EIKLCD----------FGLSAQIPDNSDSIQTIEPIG
|.. |  |..|  |.  . ...   ..|||..||.||.| |.|.||||||.|||. .| ..   |||||          |  .  .. |   | . .  .
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

NFGY----SAPEILNKKDNELKIYTKKSDSYS-VGLLLALLDNYQVLKTNT
   |    .|||.      . .|| |.|| .| ||. |  ||| |    . 
TQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 5060.AA CAMK 408-603 19 4e-36 113.38 In-house 1-324 (425) Show / Hide 
Range on Protein: 408-603
Range on HMM: 1-324/425
Sequence Identity: 19% (64 aa)

ILSFGNYGMVLATKKAMLN------------KEIVLKI---QKIE----------------------------DEQLIQNEISIMQK-------LKEPLV
.|  |..| |   .    .            ..   ||   .|.                             |.. ...||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYIIEN---------TLGP-----DRYSVFEL---EKCSC-----SLDEYLERSNK------------DGQINEDDRFQIAIQIIDSVNYIHSFN
..||. |  ..         |        |.. .. .   | ||       | .|. .  .            .| ..|..  ..  ||.. |.|.|| |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVYLDG--------------KQAEIKLCDFGLSAQIPDNSDSI---------------------QTIEPIGNFGYSA-PEILNKK----
|.|||.|||| |.  ..              ... ||..|||...........                         .. |  .| | ||.||.|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DNELKIYTKKSDSYSVGLLL
     |.| . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 5060.AA S_TKc 403-674 23 9.1e-31 109.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 403-674
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

QNDFQILSFGNYGMVLATKKAMLNKEIVLKIQKIEDEQLIQNEISIMQKLKEPLVVQLYDSYIIENTLGPDRYSVFELEKCSC---SLDEYLERSNKDGQ
    ...  | .| |   ..   ...  .|| |    . |..||.|..| . | .|.|||..          .  . .| |.    .| .|... .. | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---INEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNSDSIQTIEPIGNFGYSAPEILNKKDNELKIYTK-KSD
   ..| .   .. ||.. ..|.|| .|||||.|||| |.       .||.|||||..|.            .|   | |||.|         |.| |.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCD

SYSVGLLLA-LLDNYQVLKTNTSLNFALMTQKQLDQPFEKSNILINKNSQIYKFINLLVVSDSYQRASLYDIVE-----KSDITF
 .|.| .|. .|  |         . ..| .| .              ..   ||. . . |  .| .  .. .     |..  |
WWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5060.AA STE 403-603 23 9.6e-30 102.25 In-house 1-258 (359) Show / Hide 
Range on Protein: 403-603
Range on HMM: 1-258/359
Sequence Identity: 23% (62 aa)

QNDFQILSFGNYG-MVLA-------------------TKKAMLNKEIVLKIQK---------------IEDEQLIQNEISIMQKLK--EPLVVQLYDSYI
. . ...  |..|  ..|                   |.. |  |.. |. ..               .|..| |..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEN--TLGPDRYSVFELEKCSC-SLDEYLERSNKDGQ-----------INEDDRFQIAIQIIDS-VNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDF
 |.  .   |   .. .| ..  |||. ...  . |.           ..|.    |. ||.    .|.|| .|||||||| | |.        .|||||
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDF

GLSAQIPDNSDSI--------------QTIEPIGNFGYSAPEILNKKDNE-LKIYTKKSDSYSVGLLL
|...|. |....|              ..   .|   . |||.... ..   | |. |.| .|.|...
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 5060.AA Ciliate-E1 409-597 25 2.3e-26 83.04 In-house 1-202 (202) Show / Hide 
Range on Protein: 409-597
Range on HMM: 1-202/202
Sequence Identity: 25% (53 aa)

LSFGNYGMVLATKKAMLN-KEIVLKIQKIEDEQ-------LIQNEISIMQKLKEPL-VVQLYDSYIIENTLGPDRYSVFELEKCSCSLDEYLE-------
.. | ...|.  |.   | ... .||..... .       .|.....||. .|.   ..|..| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RSNKDGQINEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNSDSIQTIEPIGNFGYSAPEILNK---KDNE
    .....| ...   ||..|.|| ....|..|||||||||.| |.. . ..   ..||||.| ..  |... . ..      |. || .|    . |.
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYK-GYTHYYYPPEQYNCPEQEHNK

LKIYTKKSDSY
 .....||| |
NQKINYKSDIY
Kinase 5060.AA Pkinase 430-604 27 1e-25 92.0 Pfam 31-203 (293) Show / Hide 
Range on Protein: 430-604
Range on HMM: 31-203/293
Sequence Identity: 27% (52 aa)

VLKIQKIEDEQLIQN----EISIMQKLKEPLVVQLYDSYIIENTLGPDRYSVFELEKCSC-----SLDEYLERSNKDGQI--NEDDRFQIAIQIIDSVNY
..| ...........    ||.||..|. | .|.|||..        ...  . .| | .     .| .|...  ..| .   |..   .. ||.  ..|
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEY

IHSFNIIHRDIKPENFLVYLDGKQAEI----KLCDFGLSAQIPDNSDSIQTIEPIGNFGYSAPEILNKKDNELKIYTKKSDSYSVGLLLA
.|| .|||||.||||.|  .| .. .|    |.|||||..|.  .  .  .  . |  .| |||...    . . |..|.| .|.|..|.
CHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILY
Kinase 5060.AA TKL 486-603 24 2.7e-24 84.37 In-house 124-279 (364) Show / Hide 
Range on Protein: 486-603
Range on HMM: 124-279/364
Sequence Identity: 24% (41 aa)

S-LDEYLERSNKDGQINEDDRFQIAIQIIDSVNYIHSFN--------IIHRDIKPENFLVYLDGK-----------QAEIKLCDFGLSA------QIPDN
| |. ..           . |...|..|   .|| || |        |||||.|..| ||  ...           .  .|.||||||       .  |.
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT

SDSIQ-----------TIEPIGNFGYSAPEILNKKDN-----------ELKIYTKKSDSYSVGLLL
. ...           |. ..|.... |||.|....|           . . |..|.| || |..|
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 5060.AA CMGC 406-553 17 8.3e-24 74.31 In-house 1-251 (513) Show / Hide 
Range on Protein: 406-553
Range on HMM: 1-251/513
Sequence Identity: 17% (45 aa)

FQILS---FGNYGMVLATKK--------------AMLNKEIVLKIQKIEDEQLIQ---------------NEISIMQKLK-----------------EPL
..|..    | ||.|   .                  |... .|. | .    .|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYIIENTLGP-----------DRYSVFELEKCSCSLDEYLERSNKD-----GQINEDDR---------------FQ----IAIQIIDSVN--YI
.|.|||..  .|. |.           ...  .  | . ..| .|... ..|     ..  ..                 |     .. ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSFN--IIHRDIKPENFLVYLDGKQ-----------------AEIKLCDFGLS
|| .  |||||.|||| |.  ...                   ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 5060.AA Ciliate-E2 407-603 22 5.8e-23 75.64 In-house 5-286 (365) Show / Hide 
Range on Protein: 407-603
Range on HMM: 5-286/365
Sequence Identity: 22% (66 aa)

QILSFGNYG-----MVLATKKAML------------------NKEIVLKIQKIEDEQLIQNEISIMQ----------------KLKEPLVVQLYDSYI--
... .||.|      |  ..|                     .|.. .||.|  . . | .||.||.                .|. | ....|....  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

IENTLGPDRYSVFELEKCSC-SLDEYLE--RSN-------KDGQINEDDRFQIAIQIID---------------SVNYIHSFN-IIHRDIKPENFLVYLD
 .|..       . .| |.  .| .|..  . .       . ....|  . .|  ||..                ..|.|| | |||||||||| |.   
DDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

GKQAEIKLCDFGLSAQIPDNSD--------SIQTIEP----------------------IGNFGYSAPEILNKKDNE----LKIYTKKSDSYSVGLLL
     ||..||||| .. |...         . .                         .|. || ||||||.|...     | |..|.| .|.| .|
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 5060.AA Ciliate-A1 500-606 32 2.5e-17 55.5 In-house 98-221 (301) Show / Hide 
Range on Protein: 500-606
Range on HMM: 98-221/301
Sequence Identity: 32% (41 aa)

INEDDRFQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQAEIKLCDFGLSAQIPDNS----------------DSIQTIEPIGNFGYSAPEI----
. ...   |  |||  .  ||. ||.|||.||.| |.  | |   .|.||.|.| | . |                    .|..  ||  | .||     
MKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDK---WKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMH

L-NKKDNELKIYTKKSDSYSVGLLLALL
.  ..  | ||| |.|| ||.|. .  |
YRDQMFIENKIY-KQSDMYSLGCIICFL